AR042115A1 - Amidas de acido carboxilico - Google Patents
Amidas de acido carboxilicoInfo
- Publication number
- AR042115A1 AR042115A1 ARP030104308A ARP030104308A AR042115A1 AR 042115 A1 AR042115 A1 AR 042115A1 AR P030104308 A ARP030104308 A AR P030104308A AR P030104308 A ARP030104308 A AR P030104308A AR 042115 A1 AR042115 A1 AR 042115A1
- Authority
- AR
- Argentina
- Prior art keywords
- mono
- con
- hal
- coor3
- coor2
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Los nuevos compuestos de la fórmula (1), donde: D es un carbo- o heterociclo aromático insustituido o mono o polisustituido por Hal, A, OR2, N(R2)2, NO2, CN, COOR2 o CON(R2) con 0 a 4 átomos de N, O y/o S; X es -C=O o C(R3)2; W es -[C(R3)2]n-; R1 es H o A que puede estar sustituido por OR3, S(O)nR3, N(R3)2, CN, COOR3, CON(R3)2, OCON(R3)2, N(R3)COOR3, N(R3)CON(R3)2, N(R3)SO2R3, SO2N(R3)2 o -C:::C-; R2 es H, A, -[C(R3)2]n-Ar', -[C(R3)2]n-Het1, -[C(R3)2]n-cicloalquilo, -[C(R3)2]n-N(R3)2 o -[C(R3)2]n-OR3; R3 es H o A; Y es alquileno, cicloalquileno, Het-diílo o Ar-diílo; T es un carbo- o heterociclo mono o bicíclico saturado, insaturado o aromático con 0 a 4 átomos de N, O y/o S, que está mono o disustituido por =O, =S, =NR2, =N-CN, =N-NO2, =NOR2, =NCOR2, =NCOOR2, =NOCOR2 y además puede estar mono, di o trisustituido por R2, Hal, A, -[C(R3)2]n-Ar, -[C(R3)2]n-Het, -[C(R3)2]n-cicloalquilo, OR2, N(R2)2, NO2, CN, COOR2, CON(R2)2, NR2COA, NR2CON(R2)2, NR2SO2A, COR2, SO2NR2 y/o S(O)nA; A es alquilo no ramificado o ramificado C1-10, donde uno o dos grupos CH2 pueden estar reemplazados por átomos de O o de S y/o por grupos -CH=CH y/o también 1-17 átomos de H pueden estar reemplazados por F; Ar es fenilo, naftilo o bifenilo insustituido o mono, di o trisustituido por Hal, A, OR2, N(R2)2, NO2, CN, COOR2, CON(R2)2, NR2COA, NR2CON(R2)2, NR2SO2A, COR2, SO2N(R2)2, S(O)nA, -[C(R3)2]n-COOR2 u -O-[C(R3)2]o-COOR2; Ar' es fenilo insustituido o mono, di o trisustituido por Hal, A, OR3, N(R3)2, NO2, CN, COOR3, CON(R3)2, NR3COA, NR3CON(R3)2, NR3SO2A, COR3, SO2N(R3)2, S(O)nA, -[C(R3)2]n-COOR3 u -O-[C(R3)2]o-COOR3; Het es un heterociclo mono o bicíclico saturado, insaturado o aromático con 1 a 4 átomos de N, O y/o S, que puede estar insustituido o mono, di o trisustituido por el oxígeno del carbonilo, =S, =N(R2)2, Hal, A, -[C(R3)2]n-Ar, -[C(R3)2]n-Het', -[C(R3)2]n-cicloalquilo, -[C(R3)2]n-OR2, -[C(R3)2]n-N(R3)2, NO2, CN, -[C(R3)2]n-COOR2', -[C(R3)2]n-CON(R2)2, -[C(R3)2]n-NR2COA, NR2CON(R2)2, -[C(R3)2]n-NR2SO2A, COR2, SO2NR2 y/o S(O)nA; Het' es un heterociclo mono o bicíclico saturado, insaturado o aromático con 1 a 4 átomos de N, O y/o S que puede estar insustituido o mono o disustituido por el oxígeno del carbonilo, =S, =N(R3)2, Hal, A, NO2, CN, COOR3, CON(R3)2, NR3COA, NR3CON(R3)2, NR3SO2A, COR3, SO2NR3 y/o S(O)nA; Hal es F, Cl, Br o I; m es 1 ó 2; n es 0, 1 ó 2; o es 1, 2 ó 3; así como sus derivados, solvatos y estereoisómeros de utilidad farmacéutica, incluyendo sus mezclas en todas las proporciones. Son inhibidores del factor de coagulación Xa y pueden emplearse para la profilaxis y/o la terapia de enfermedades tromboembólicas y para el tratamiento de tumores.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10254336A DE10254336A1 (de) | 2002-11-21 | 2002-11-21 | Carbonsäureamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR042115A1 true AR042115A1 (es) | 2005-06-08 |
Family
ID=32240241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030104308A AR042115A1 (es) | 2002-11-21 | 2003-11-21 | Amidas de acido carboxilico |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7579346B2 (es) |
| EP (1) | EP1562939B1 (es) |
| JP (1) | JP4732757B2 (es) |
| AR (1) | AR042115A1 (es) |
| AT (1) | ATE421515T1 (es) |
| AU (1) | AU2003286145B2 (es) |
| CA (1) | CA2506716C (es) |
| DE (2) | DE10254336A1 (es) |
| ES (1) | ES2320876T3 (es) |
| WO (1) | WO2004046138A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1571154A1 (en) * | 2004-03-03 | 2005-09-07 | Aventis Pharma Deutschland GmbH | Beta-aminoacid-derivatives as factor Xa inhibitors |
| JP2007537181A (ja) * | 2004-05-13 | 2007-12-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 置換されたチオフェン−カルボン酸アミド、医薬品の形態におけるこれらの製造及び使用 |
| CA2562714A1 (en) * | 2004-05-13 | 2005-11-24 | Boehringer Ingelheim International Gmbh | Substituted thiophene-2-carboxylic acid amides, the production thereof and the use thereof as drugs |
| KR20070012552A (ko) * | 2004-05-13 | 2007-01-25 | 베링거 인겔하임 인터내셔날 게엠베하 | 신규한 치환된 티오펜카복스아미드, 이의 제조방법 및약제로서의 이의 용도 |
| DE102004047840A1 (de) * | 2004-09-29 | 2006-03-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Thiophencarbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel |
| AU2005300828B2 (en) * | 2004-11-03 | 2012-03-08 | F. Hoffmann-La Roche Ag | Dicarboxamide derivatives and their use as factor Xa inhibitors |
| EP1724269A1 (en) * | 2005-05-20 | 2006-11-22 | Sanofi-Aventis Deutschland GmbH | Heteroaryl-carboxylic acid (sulfamoyl alkyl) amide - derivatives as factor Xa inhibitors |
| PE20070171A1 (es) * | 2005-06-30 | 2007-03-08 | Boehringer Ingelheim Int | GLICINAMIDAS SUSTITUIDAS CON EFECTO ANTITROMBOTICO E INHIBIDOR DEL FACTOR Xa |
| AR057976A1 (es) * | 2005-08-29 | 2008-01-09 | Boehringer Ingelheim Int | Biarilos sustituidos y su uso como medicamentos. |
| CA2815063C (en) * | 2010-10-18 | 2016-11-22 | Apotex Pharmachem Inc. | Processes for the preparation of rivaroxaban and intermediates thereof |
| WO2013031930A1 (ja) * | 2011-08-31 | 2013-03-07 | 味の素株式会社 | イミン誘導体 |
| CN105294669B (zh) * | 2014-10-24 | 2019-01-22 | 山东凯森制药有限公司 | 一种第十因子抑制剂及其制备方法和应用 |
| KR20210108416A (ko) * | 2018-12-19 | 2021-09-02 | 레오 파마 에이/에스 | Il-17의 소분자 조절제로서의 아미노산 아닐라이드 |
| EP4015501A1 (en) * | 2020-12-16 | 2022-06-22 | Consejo Superior de Investigaciones Científicas (CSIC) | N-benzyl-alpha-aminoamides as anaphase-promoting complex/cyclosome (apc/c) inhibitors |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2123246C2 (de) * | 1971-05-11 | 1982-11-25 | Basf Ag, 6700 Ludwigshafen | 6-[p-(β-Phenyläthylaminoacetylamino)-phenyl]-4,5-dihydropyridazon-(3) |
| KR19990076964A (ko) * | 1995-12-29 | 1999-10-25 | 데이비드 이. 프랭크하우저 | 항헤르페스 바이러스 특성을 갖는 페닐 티아졸 유도체 |
| WO2000029399A1 (en) * | 1998-11-12 | 2000-05-25 | Boehringer Ingelheim (Canada) Ltd. | Antiherpes compounds |
| CA2374947A1 (en) | 1999-05-24 | 2000-11-30 | Robert M. Scarborough | Inhibitors of factor xa |
| US6906063B2 (en) * | 2000-02-04 | 2005-06-14 | Portola Pharmaceuticals, Inc. | Platelet ADP receptor inhibitors |
| DE10010425A1 (de) * | 2000-03-03 | 2001-09-06 | Bayer Ag | Substituierte 5-Methyldihydropyridazinone und ihre Verwendung |
| EP1300401B1 (en) * | 2000-06-30 | 2009-12-09 | Dainippon Sumitomo Pharma Co., Ltd. | Thiazole derivatives for use as antiinflammatories |
| DE10035144A1 (de) * | 2000-07-19 | 2002-01-31 | Merck Patent Gmbh | Cyclische Aminosäurederivate |
| DE10063008A1 (de) * | 2000-12-16 | 2002-06-20 | Merck Patent Gmbh | Carbonsäureamidderivate |
| DE10102322A1 (de) * | 2001-01-19 | 2002-07-25 | Merck Patent Gmbh | Phenylderivate |
-
2002
- 2002-11-21 DE DE10254336A patent/DE10254336A1/de not_active Withdrawn
-
2003
- 2003-10-30 JP JP2004552505A patent/JP4732757B2/ja not_active Expired - Fee Related
- 2003-10-30 DE DE50311133T patent/DE50311133D1/de not_active Expired - Lifetime
- 2003-10-30 EP EP03776875A patent/EP1562939B1/de not_active Expired - Lifetime
- 2003-10-30 CA CA2506716A patent/CA2506716C/en not_active Expired - Fee Related
- 2003-10-30 AT AT03776875T patent/ATE421515T1/de not_active IP Right Cessation
- 2003-10-30 WO PCT/EP2003/012080 patent/WO2004046138A1/de not_active Ceased
- 2003-10-30 AU AU2003286145A patent/AU2003286145B2/en not_active Ceased
- 2003-10-30 ES ES03776875T patent/ES2320876T3/es not_active Expired - Lifetime
- 2003-10-30 US US10/535,246 patent/US7579346B2/en not_active Expired - Fee Related
- 2003-11-21 AR ARP030104308A patent/AR042115A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2506716C (en) | 2012-09-04 |
| JP4732757B2 (ja) | 2011-07-27 |
| EP1562939A1 (de) | 2005-08-17 |
| ATE421515T1 (de) | 2009-02-15 |
| JP2006512321A (ja) | 2006-04-13 |
| ES2320876T3 (es) | 2009-05-29 |
| DE50311133D1 (en) | 2009-03-12 |
| AU2003286145A1 (en) | 2004-06-15 |
| US7579346B2 (en) | 2009-08-25 |
| CA2506716A1 (en) | 2004-06-03 |
| DE10254336A1 (de) | 2004-06-03 |
| EP1562939B1 (de) | 2009-01-21 |
| WO2004046138A1 (de) | 2004-06-03 |
| US20060052376A1 (en) | 2006-03-09 |
| AU2003286145B2 (en) | 2009-11-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |