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AR040870A1 - Compuestos inhibidores de proteinquinasas y composicion farmaceutica que los comprende - Google Patents

Compuestos inhibidores de proteinquinasas y composicion farmaceutica que los comprende

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Publication number
AR040870A1
AR040870A1 AR20030102932A ARP030102932A AR040870A1 AR 040870 A1 AR040870 A1 AR 040870A1 AR 20030102932 A AR20030102932 A AR 20030102932A AR P030102932 A ARP030102932 A AR P030102932A AR 040870 A1 AR040870 A1 AR 040870A1
Authority
AR
Argentina
Prior art keywords
independently selected
ring
nitrogen
sulfur
oxygen
Prior art date
Application number
AR20030102932A
Other languages
English (en)
Inventor
John Cochran
Jeremy Green
Michael R Hale
Brian Ledford
Francois Maltais
Suganthini Nanthakumar
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of AR040870A1 publication Critical patent/AR040870A1/es

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Se describen compuestos que son útiles como inhibidores de la proteinquinasa que tienen las fórmulas (1) y (2). Estos compuestos y composiciones de los mismos de aceptación farmacéutica son útiles para tratar o disminuir la gravedad de una variedad de trastornos, incluyendo ataque apopléjico, trastornos inflamatorios, enfermedades autoinmunes tales como lupus eritematoso sistémico y psoriasis, trastornos proliferativos tales como cáncer y condiciones asociadas con el transplante de órganos. Reivindicación 1: Un compuesto de la fórmula (1): o una sal del mismo de aceptación farmacéutica, donde: el anillo B es un anillo arilo de 6 miembros que tiene 0-3 nitrógenos; Z1 y Z2 están seleccionados, cada uno de modo independiente entre sí, de N o CH; T y Q están seleccionados, cada uno de modo independiente entre sí, de una cadena de alquilideno C1-6 saturado o no saturado donde: hasta dos unidades de metileno de la cadena están opcional e independientemente reemplazadas por -C(O)_, C(O)C(O)-, -CONR-, -CONRNR-, -CO2-, -OC(O)-, NRCO2-, -O-, -NRCONR-, -OC(O)NR-, -NRNR-, -NRCO-, -S-, -SO-, -SO2-, -NR-, -SO2NR- o -NRSO2-; cada R está seleccionado, de modo independiente, de hidrógeno o un grupo alifático C1-6 opcionalmente sustituido, o: dos R en el mismo nitrógeno se toman junto con el nitrógeno para formar un anillo heterociclilo o heteroarilo de 5-8 miembros que tiene 1-3 heteroátomos seleccionados, de modo independiente, de nitrógeno, oxígeno o azufre; U está seleccionado de -NR-, -NRCO-, -NRCONR-, -NRCO2-, -O-, -CONR-, -CO-, -CO2-, -OC(O)-, -NRSO2-, -SO2NR-, -NRSO2NR- o -SO2-; m y n están seleccionados, cada uno de modo independiente entre sí, de cero a uno; p está seleccionado de 0, 1 ó 3; R1 está seleccionado de R o Ar; cada Ar es un anillo opcionalmente seleccionado de un anillo arilo de 6-10 miembros, un anillo heteroarilo de 5-10 miembros que tiene 1-4 heteroátomos seleccionados, de modo independiente, de nitrógeno, oxígeno o azufre o un anillo heterociclilo de 3-10 miembros que tiene 1-4 heteroátomos seleccionados, de modo independiente, de nitrógeno, oxígeno o azufre; R2 está seleccionado de -(CH2) y CH(R5)2 o -(CH2) y CH(R4)CH(R5)2; y es 0-6; R3 está seleccionado de R, Ar, -(CH2) y CH(R5)2 o CN; R4 está seleccionado de R, (CH2)wOR, (CH2)wN(R)2 o (CH2)wSR; w es 0-4; cada R5 está seleccionado, de modo independiente, de alifático C1-6 opcionalmente sustituido, Ar, OR, CO2R, (CH2)yN(R)2, N(Ar)(R), SR, NRCOR, NRCON(R)2, CON(R)2, SO2R, NRSO2R, COR, CN o SO2N(R)2; y cada R6 está seleccionado, de modo independiente, de R, F, Cl, N(R)2, OR, SR, NRCOR, NRCON(R)2, CON(R)2, SO2R, NRSO2R, COR, CN o SO2N(R)2.
AR20030102932A 2002-08-14 2003-08-13 Compuestos inhibidores de proteinquinasas y composicion farmaceutica que los comprende AR040870A1 (es)

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BR0313397A (pt) 2005-06-28
CA2495386A1 (en) 2004-02-26
TW200406388A (en) 2004-05-01
KR20050042478A (ko) 2005-05-09
EP1546117A2 (en) 2005-06-29
US7304071B2 (en) 2007-12-04
JP4741948B2 (ja) 2011-08-10
JP2006506462A (ja) 2006-02-23
AU2003262642B2 (en) 2010-06-17
MXPA05001804A (es) 2005-05-27
PL375447A1 (en) 2005-11-28
WO2004016597A3 (en) 2004-04-22
NZ538715A (en) 2007-07-27
AU2003262642A1 (en) 2004-03-03
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US20040106615A1 (en) 2004-06-03
CA2495386C (en) 2011-06-21

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