AR048938A1 - Cepas de levadura que producen colesterol y sus aplicaciones - Google Patents
Cepas de levadura que producen colesterol y sus aplicacionesInfo
- Publication number
- AR048938A1 AR048938A1 ARP050101823A ARP050101823A AR048938A1 AR 048938 A1 AR048938 A1 AR 048938A1 AR P050101823 A ARP050101823 A AR P050101823A AR P050101823 A ARP050101823 A AR P050101823A AR 048938 A1 AR048938 A1 AR 048938A1
- Authority
- AR
- Argentina
- Prior art keywords
- cholesterol
- refers
- isotopic
- yeast
- leaves
- Prior art date
Links
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title abstract 10
- 235000012000 cholesterol Nutrition 0.000 title abstract 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 title 1
- 230000000155 isotopic effect Effects 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 241000233866 Fungi Species 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001841 cholesterols Chemical class 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 230000002538 fungal effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0493—Steroids, e.g. cholesterol, testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Biomedical Technology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente se refiere a la produccion de colesterol en organismos del reino de los hongos. Más especialmente, la presente se refiere a hongos genéticamente modificados que producen de forma autonoma colesterol a partir de una fuente de carbono sencilla. La presente se refiere igualmente a la utilizacion de hongos segun la presente para la produccion de colesterol no marcado y marcado. Reivindicacion 20: Composicion que contiene, como marcador de trazabilidad, una mezcla isotopica de colesterol, de intermedios o de metabolitos del colesterol marcados en diferentes posiciones mediante marcadores isotopicos y que presentan un perfil isotopico definido. Reivindicacion 21: Composicion segun la reivindicacion 20, caracterizada porque se destina al campo de la alimentacion o de la terapia humana o animal.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0404890A FR2869914B1 (fr) | 2004-05-06 | 2004-05-06 | Souches de levure produisant du cholesterol et leurs applications |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR048938A1 true AR048938A1 (es) | 2006-06-14 |
Family
ID=34946597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050101823A AR048938A1 (es) | 2004-05-06 | 2005-05-05 | Cepas de levadura que producen colesterol y sus aplicaciones |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US8211676B2 (es) |
| EP (2) | EP2354218B1 (es) |
| JP (2) | JP5053838B2 (es) |
| KR (1) | KR101252304B1 (es) |
| CN (1) | CN1981029B (es) |
| AR (1) | AR048938A1 (es) |
| AU (1) | AU2005252401B2 (es) |
| BR (1) | BRPI0509598B8 (es) |
| CA (1) | CA2562773C (es) |
| CY (2) | CY1113174T1 (es) |
| DK (2) | DK1745123T3 (es) |
| ES (2) | ES2662971T3 (es) |
| FR (1) | FR2869914B1 (es) |
| HR (2) | HRP20120806T1 (es) |
| HU (1) | HUE036218T2 (es) |
| IL (2) | IL178741A (es) |
| LT (1) | LT2354218T (es) |
| MA (1) | MA28570B1 (es) |
| ME (1) | ME01455B (es) |
| MX (1) | MXPA06012840A (es) |
| NO (2) | NO341207B1 (es) |
| NZ (1) | NZ551057A (es) |
| PL (2) | PL1745123T3 (es) |
| PT (2) | PT2354218T (es) |
| RS (2) | RS52444B (es) |
| RU (1) | RU2397245C2 (es) |
| SG (3) | SG150408A1 (es) |
| SI (1) | SI2354218T1 (es) |
| WO (1) | WO2005121315A1 (es) |
| ZA (1) | ZA200609162B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE444756T1 (de) * | 2000-11-14 | 2009-10-15 | Vital Health Sciences Pty Ltd | Zusammensetzungen umfassend komplexe von tocopherolphosphatderivaten |
| FR2869914B1 (fr) * | 2004-05-06 | 2012-11-09 | Aventis Pharma Sa | Souches de levure produisant du cholesterol et leurs applications |
| DE102009022772A1 (de) | 2009-05-21 | 2010-11-25 | Organobalance Gmbh | Mikroorganismus zur Expression eines humanen Membranproteins |
| BR112012013424B1 (pt) | 2009-12-03 | 2021-03-09 | Dsm Ip Assets B.V. | usos de colesterol c25-hidroxilase para hidroxilar ergosterol e 7-desidrocolesterol e métodos de produção de 25-hidróxi-7-desidrocolesterol e 25-hidroxiergosterol |
| FR2961218A1 (fr) * | 2010-06-10 | 2011-12-16 | Sanofi Aventis | Methode de detection de composes modulateurs du metabolisme du cholesterol |
| WO2012095816A1 (en) | 2011-01-14 | 2012-07-19 | Sanofi | Method for detecting the biological activity of alpha-synuclein |
| FR2976949B1 (fr) | 2011-06-21 | 2015-08-28 | Sanofi Sa | Procede de preparation de levures genetiquement transformees capables de produire une molecule d'interet a haut titre |
| US20130316462A1 (en) * | 2012-05-25 | 2013-11-28 | Health Diagnostic Laboratory, Inc. | Rapid and high-throughput analysis of sterols/stanols or derivatives thereof |
| WO2015108058A1 (ja) | 2014-01-17 | 2015-07-23 | 協和発酵バイオ株式会社 | ７デヒドロコレステロール及びビタミンｄ３の製造法 |
| US10329250B2 (en) | 2014-10-08 | 2019-06-25 | Kyowa Hakko Bio Co., Ltd. | Process for producing 7-dehydrocholesterol and vitamin D3 |
| CN104805027B (zh) * | 2015-05-27 | 2018-04-27 | 天津大学 | 一种重组耶氏解脂酵母菌株及其构建方法和应用 |
| ES2954210T3 (es) * | 2015-12-23 | 2023-11-20 | Dsm Ip Assets Bv | Producción de esteroles en levadura modificada |
| CN106754993B (zh) * | 2017-02-17 | 2020-06-30 | 天津大学 | 一种基因、重组酿酒酵母菌株及其构建方法与应用 |
| JP6909466B2 (ja) * | 2017-07-25 | 2021-07-28 | 大陽日酸株式会社 | 標識代謝物の製造方法、代謝物の定量方法、及び標識代謝物製造キット |
| CN112626159B (zh) * | 2021-01-07 | 2022-08-05 | 华东理工大学 | 利用工程酿酒酵母高效生产胆固醇的发酵培养基及其制备方法 |
| CN114577925B (zh) * | 2021-12-29 | 2024-02-02 | 西南大学 | 一种水样中粪甾醇类物质快速检测方法 |
| CN119979588B (zh) * | 2024-12-30 | 2025-12-26 | 江南大学 | 一种降低副产物的甾醇c24-还原酶突变体及产7-脱氢胆固醇的酿酒酵母 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB613778A (en) | 1946-07-02 | 1948-12-02 | United Domestic Ind Ltd | Improvements in or relating to the production of cholesterol |
| GB646227A (en) | 1948-02-27 | 1950-11-15 | Organon Labor Ltd | Process for isolation of cholesterol from wool wax alcohols |
| US2650929A (en) | 1948-02-27 | 1953-09-01 | Hewett Colin Leslie | Process for isolation of cholesterol from wool wax alcohols |
| GB690879A (en) | 1950-07-21 | 1953-04-29 | Organon Labor Ltd | Process for the isolation of cholesterol from wool-wax alcohols |
| US2688623A (en) | 1950-07-21 | 1954-09-07 | Organon Labor Ltd | Process for the isolation of cholesterol from wool-wax alcohols |
| US5460949A (en) * | 1990-11-15 | 1995-10-24 | Amoco Corporation | Method and composition for increasing the accumulation of squalene and specific sterols in yeast |
| IL162476A (en) | 1995-02-15 | 2005-12-18 | Aventis Pharma Sa | Arabidopsis thaliana proteins having delta -5,7- sterol - delta -7- reductase activity |
| FR2774393B1 (fr) | 1998-02-05 | 2000-03-24 | Hoechst Marion Roussel Inc | Souches de levure ayant le gene atf2 interrompu et leurs applications |
| FR2820145B1 (fr) * | 2001-01-31 | 2004-01-23 | Aventis Pharma Sa | Souche de levure produisant des steroides de facon autonome |
| JP2004141125A (ja) * | 2002-08-28 | 2004-05-20 | Mitsubishi Chemicals Corp | 代謝工学的に改変されている真菌類およびそれを用いるステロール類の製造法 |
| FR2869914B1 (fr) * | 2004-05-06 | 2012-11-09 | Aventis Pharma Sa | Souches de levure produisant du cholesterol et leurs applications |
-
2004
- 2004-05-06 FR FR0404890A patent/FR2869914B1/fr not_active Expired - Lifetime
-
2005
- 2005-05-02 DK DK05763706.8T patent/DK1745123T3/da active
- 2005-05-02 ZA ZA200609162A patent/ZA200609162B/xx unknown
- 2005-05-02 NZ NZ551057A patent/NZ551057A/en not_active IP Right Cessation
- 2005-05-02 HR HRP20120806TT patent/HRP20120806T1/hr unknown
- 2005-05-02 EP EP10186024.5A patent/EP2354218B1/fr not_active Expired - Lifetime
- 2005-05-02 PL PL05763706T patent/PL1745123T3/pl unknown
- 2005-05-02 SG SG200706409-0A patent/SG150408A1/en unknown
- 2005-05-02 PT PT101860245T patent/PT2354218T/pt unknown
- 2005-05-02 DK DK10186024.5T patent/DK2354218T3/en active
- 2005-05-02 SG SG2011083565A patent/SG185179A1/en unknown
- 2005-05-02 BR BRPI0509598A patent/BRPI0509598B8/pt not_active IP Right Cessation
- 2005-05-02 WO PCT/FR2005/001090 patent/WO2005121315A1/fr not_active Ceased
- 2005-05-02 ME MEP-2012-114A patent/ME01455B/me unknown
- 2005-05-02 AU AU2005252401A patent/AU2005252401B2/en not_active Ceased
- 2005-05-02 ES ES10186024.5T patent/ES2662971T3/es not_active Expired - Lifetime
- 2005-05-02 CA CA2562773A patent/CA2562773C/fr not_active Expired - Lifetime
- 2005-05-02 PL PL10186024T patent/PL2354218T3/pl unknown
- 2005-05-02 RS RS20120413A patent/RS52444B/sr unknown
- 2005-05-02 MX MXPA06012840A patent/MXPA06012840A/es active IP Right Grant
- 2005-05-02 ES ES05763706T patent/ES2390588T3/es not_active Expired - Lifetime
- 2005-05-02 EP EP05763706A patent/EP1745123B1/fr not_active Expired - Lifetime
- 2005-05-02 JP JP2007512255A patent/JP5053838B2/ja not_active Expired - Fee Related
- 2005-05-02 SG SG10201501156WA patent/SG10201501156WA/en unknown
- 2005-05-02 HU HUE10186024A patent/HUE036218T2/hu unknown
- 2005-05-02 LT LTEP10186024.5T patent/LT2354218T/lt unknown
- 2005-05-02 PT PT05763706T patent/PT1745123E/pt unknown
- 2005-05-02 CN CN2005800227391A patent/CN1981029B/zh not_active Expired - Fee Related
- 2005-05-02 RS RS20180308A patent/RS56952B1/sr unknown
- 2005-05-02 SI SI200532198T patent/SI2354218T1/en unknown
- 2005-05-02 US US11/568,572 patent/US8211676B2/en active Active
- 2005-05-02 RU RU2006143060/13A patent/RU2397245C2/ru active
- 2005-05-02 KR KR1020067023167A patent/KR101252304B1/ko not_active Expired - Fee Related
- 2005-05-05 AR ARP050101823A patent/AR048938A1/es not_active Application Discontinuation
-
2006
- 2006-10-19 IL IL178741A patent/IL178741A/en not_active IP Right Cessation
- 2006-11-02 MA MA29434A patent/MA28570B1/fr unknown
- 2006-11-23 NO NO20065402A patent/NO341207B1/no unknown
-
2011
- 2011-12-21 JP JP2011279322A patent/JP5670310B2/ja not_active Expired - Fee Related
-
2012
- 2012-05-24 US US13/479,355 patent/US8685705B2/en not_active Expired - Lifetime
- 2012-10-04 CY CY20121100926T patent/CY1113174T1/el unknown
-
2015
- 2015-04-19 IL IL238365A patent/IL238365B/en active IP Right Grant
-
2017
- 2017-08-29 NO NO20171396A patent/NO343427B1/no unknown
-
2018
- 2018-03-13 HR HRP20180433TT patent/HRP20180433T1/hr unknown
- 2018-03-13 CY CY20181100308T patent/CY1120394T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |