AR048778A1 - Derivados de pirrolidinilo como inhibidores de 11-beta hidroxiesteroide deshidrogenasa - Google Patents
Derivados de pirrolidinilo como inhibidores de 11-beta hidroxiesteroide deshidrogenasaInfo
- Publication number
- AR048778A1 AR048778A1 ARP050101844A ARP050101844A AR048778A1 AR 048778 A1 AR048778 A1 AR 048778A1 AR P050101844 A ARP050101844 A AR P050101844A AR P050101844 A ARP050101844 A AR P050101844A AR 048778 A1 AR048778 A1 AR 048778A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkyloxy
- halo
- hydroxy
- optionally substituted
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 101710088194 Dehydrogenase Proteins 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 10
- 125000001475 halogen functional group Chemical group 0.000 abstract 7
- 125000003545 alkoxy group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000001624 naphthyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- 125000005871 1,3-benzodioxolyl group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 102000004277 11-beta-hydroxysteroid dehydrogenases Human genes 0.000 abstract 1
- 108090000874 11-beta-hydroxysteroid dehydrogenases Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000815 N-oxide group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Derivados de pirrolidinillo como inhibidores de 11-beta hidroxiesteroide deshidrogenasa, sus formas de N-oxido, sus sales de adicion farmacéuticamente aceptables y sus formas estereoquímicamente isomeras, en donde; n es 1 o 2; L representa un conector alquilo C1-3 opcionalmente sustituido con uno o dos sustituyentes seleccionados de alquilo C1-4; alquiloxi C1-3- alquilo C1-4-; hidroxi-alquilo C1-4; hidroxi; alquiloxi C1-3- o fenil-alquilo C1-4; M representa un enlace directo o un conector alquilo C1-3 opcionalmente sustituido con uno o dos sustituyentes seleccionados de hidroxi; alquilo C1-4; o alquiloxi C1-4; R1 y R2 representan, cada uno de manera independiente, hidrogeno; halo; ciano; hidroxi; alquilo C1-4 opcionalmente sustituido con halo; alquiloxi C1-4 opcionalmente sustituido con uno, o cuando es posible, con dos o tres sustituyentes seleccionados de hidroxi, Ar1 y halo; o R1 y R2 tomados junto con el anillo fenilo al cual están unidos forman naftilo o 1, 3- benzodioxolilo, en donde dichos naftilo o 1, 3-benzodioxolilo están opcionalmente sustituidos con halo; R3 representa hidrogeno; halo; alquilo C1-4; alquiloxi C1-4-; ciano; o hidroxi; R4 representa hidrogeno; halo; alquilo C1-4; alquiloxi C1-4-; ciano; o hidroxi; R5 representa hidrogeno; alquilo C1-4; o Ar2-alquilo C1-4-; R6 representa hidrogeno; halo; alquilo C1-4; o alquiloxi C1-4-; Ar1 Ar2 representan, cada uno de manera independiente, fenilo o naftilo, en donde dichos fenilo y naftilo están opcionalmente sustituidos con alquilo C1-4; alquiloxi C1-4; o fenil-alquilo C1-4; para uso como un medicamento.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04101991 | 2004-05-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR048778A1 true AR048778A1 (es) | 2006-05-24 |
Family
ID=34929074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050101844A AR048778A1 (es) | 2004-05-07 | 2005-05-06 | Derivados de pirrolidinilo como inhibidores de 11-beta hidroxiesteroide deshidrogenasa |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US9012494B2 (es) |
| EP (1) | EP1747199B1 (es) |
| JP (1) | JP5014983B2 (es) |
| KR (1) | KR101192861B1 (es) |
| CN (1) | CN101001836B (es) |
| AR (1) | AR048778A1 (es) |
| AU (1) | AU2005240784C1 (es) |
| CA (1) | CA2565630C (es) |
| EA (1) | EA011097B1 (es) |
| ES (1) | ES2525319T3 (es) |
| IL (1) | IL179065A (es) |
| MX (1) | MXPA06012932A (es) |
| MY (1) | MY161872A (es) |
| NO (1) | NO20065619L (es) |
| NZ (1) | NZ551077A (es) |
| TW (1) | TWI396534B (es) |
| WO (1) | WO2005108360A1 (es) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3162182B2 (ja) | 1992-05-11 | 2001-04-25 | オリンパス光学工業株式会社 | 空隙を有する部材の溶接方法 |
| DE602005017159D1 (de) | 2004-08-30 | 2009-11-26 | Janssen Pharmaceutica Nv | Oxysteroid-dehydrogenase-inhibitoren |
| JP5208505B2 (ja) * | 2004-08-30 | 2013-06-12 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | １１−ベータヒドロキシステロイドデヒドロゲナーゼ阻害剤としてのｎ−２アダマンタニル−２−フェノキシ−アセトアミド誘導体 |
| WO2006024628A1 (en) * | 2004-08-30 | 2006-03-09 | Janssen Pharmaceutica N.V. | Tricyclic lactam derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
| JP5140577B2 (ja) | 2005-03-31 | 2013-02-06 | タケダ カリフォルニア インコーポレイテッド | ヒドロキシステロイドデヒドロゲナーゼ阻害剤 |
| EP2016047B1 (en) | 2006-04-21 | 2013-08-28 | Eli Lilly And Company | Biphenyl amide lactam derivatives as inhibitors of 11- beta-hydroxysteroid dehydrogenase 1 |
| MX2008013484A (es) * | 2006-04-21 | 2008-10-30 | Lilly Co Eli | Derivados de lactamas de ciclohexilpirazol como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1. |
| BRPI0710273A2 (pt) * | 2006-04-21 | 2011-08-09 | Lilly Co Eli | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, intermediário |
| EA015106B1 (ru) * | 2006-04-24 | 2011-06-30 | Эли Лилли Энд Компани | Ингибиторы 11-бета-гидроксистероид дегидрогеназы 1 |
| WO2007127704A1 (en) * | 2006-04-24 | 2007-11-08 | Eli Lilly And Company | Cyclohexyl substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| ES2346925T3 (es) | 2006-04-24 | 2010-10-21 | ELI LILLY & COMPANY | Pirrolidinonas sustituidas como inhibidores de la 11 beta-dihidroesteroide deshidrogenasa 1. |
| DK2021337T3 (da) | 2006-04-25 | 2010-03-29 | Lilly Co Eli | Inhibitorer af 11-beta-hydroxysteroid-dehydrogenase-1 |
| ATE471311T1 (de) * | 2006-04-25 | 2010-07-15 | Lilly Co Eli | Inhibitoren von11-beta- hydroxysteroiddehydrogenase 1 |
| EP2016071B1 (en) | 2006-04-25 | 2013-07-24 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| EA014719B1 (ru) | 2006-04-28 | 2011-02-28 | Эли Лилли Энд Компани | Пиперидинилзамещённые пирролидиноны в качестве ингибиторов 11-бета-гидроксистероид дегидрогеназы 1 |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| JPWO2008120655A1 (ja) | 2007-03-30 | 2010-07-15 | 株式会社医薬分子設計研究所 | Ｉ型１１βヒドロキシステロイド脱水素酵素阻害活性を有するオキサゾリジノン誘導体 |
| EP2172453A4 (en) | 2007-06-27 | 2010-12-22 | Taisho Pharmaceutical Co Ltd | CONNECTION WITH 11-β-HSD1 INHIBITING ACTIVITY |
| EP2183229B1 (en) | 2007-07-26 | 2012-04-18 | Vitae Pharmaceuticals, Inc. | Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 |
| AU2008317107B2 (en) * | 2007-10-23 | 2013-09-12 | Allergan, Inc. | Therapeutic substituted lactams |
| AR069207A1 (es) | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
| TW200927115A (en) | 2007-11-16 | 2009-07-01 | Boehringer Ingelheim Int | Aryl-and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
| WO2009075835A1 (en) | 2007-12-11 | 2009-06-18 | Vitae Pharmaceutical, Inc | CYCLIC UREA INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE 1 |
| TW200934490A (en) * | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
| ES2421537T3 (es) | 2008-05-01 | 2013-09-03 | Vitae Pharmaceuticals Inc | Inhibidores cíclicos de la 11beta-hidroxiesteroide deshidrogenasa 1 |
| JP5711115B2 (ja) | 2008-05-13 | 2015-04-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ベンゾモルファン及び関連骨格のアリサイクリックカルボン酸誘導体、そのような化合物を含有する医薬及びその使用 |
| US8846668B2 (en) | 2008-07-25 | 2014-09-30 | Vitae Pharmaceuticals, Inc. | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| DK2324018T3 (da) * | 2008-07-25 | 2013-10-14 | Boehringer Ingelheim Int | Cykliske inhibitorer af 11 beta-hydroxysteroid dehydrogenase 1 |
| US8680093B2 (en) | 2009-04-30 | 2014-03-25 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| ES2350077B1 (es) | 2009-06-04 | 2011-11-04 | Laboratorios Salvat, S.A. | Compuestos inhibidores de 11beta-hidroxiesteroide deshidrogenasa de tipo 1. |
| EP2440537A1 (en) | 2009-06-11 | 2012-04-18 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure |
| US8912329B2 (en) | 2009-06-25 | 2014-12-16 | BioVersys AG | Composition for treatment of tuberculosis |
| WO2011159760A1 (en) | 2010-06-16 | 2011-12-22 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
| JP5813106B2 (ja) * | 2010-06-25 | 2015-11-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 代謝障害の処置のための１１−β−ＨＳＤ１のインヒビターとしてのアザスピロヘキサノン |
| EA201300522A1 (ru) | 2010-11-02 | 2013-11-29 | Бёрингер Ингельхайм Интернациональ Гмбх | Фармацевтические комбинации для лечения метаболических нарушений |
| JP2014524438A (ja) | 2011-08-17 | 2014-09-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | インデノピリジン誘導体 |
| WO2015135461A1 (zh) * | 2014-03-10 | 2015-09-17 | 四川海思科制药有限公司 | 取代的二氢苯并呋喃-哌啶-甲酮衍生物、其制备及用途 |
| US10531603B2 (en) * | 2017-05-09 | 2020-01-14 | Cnh Industrial America Llc | Agricultural system |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2510945A (en) | 1945-04-24 | 1950-06-13 | Us Agriculture | Nu-cyclohexyl nicotinamide |
| US2524643A (en) | 1947-12-04 | 1950-10-03 | Maltbie Lab Inc | 3-phenyl-2-piperidones |
| FR1399615A (fr) | 1963-03-08 | 1965-05-21 | Chemical Investors Sa | Nouveaux composés chimiques et composition herbicide contenant ceux-ci |
| US3201466A (en) | 1963-03-08 | 1965-08-17 | Gulf Oil Corp | Substituted cyclopropanecarboxanilide herbicides |
| US3526656A (en) | 1967-05-25 | 1970-09-01 | Parke Davis & Co | (1-arylcyclobutyl)carbonyl carbamic acid derivatives |
| US3622567A (en) | 1968-05-13 | 1971-11-23 | Little Inc A | Norcamphane derivatives |
| NL6917600A (es) | 1968-11-29 | 1970-06-02 | ||
| US3919313A (en) | 1973-07-23 | 1975-11-11 | Schering Corp | Novel 1-N-({60 -aminoacetyl) aminoadamantanes |
| HU177576B (en) | 1975-06-02 | 1981-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing 2-amino-cyclohexane carboxylic acid,its amides and similar compounds |
| EP0117462A3 (en) | 1983-02-28 | 1986-08-20 | American Cyanamid Company | N-(2-4-(1h-imidazol-1-yl)alkyl)arylamides |
| CH655103A5 (de) | 1983-03-11 | 1986-03-27 | Sandoz Ag | Azolderivate, verfahren zu ihrer herstellung und ihre verwendung. |
| DD299424A5 (de) | 1989-05-23 | 1992-04-16 | Sankyo Company Limited,Jp | Phenolderivate zur foerderung des menschlichen nervenwachstumsfaktors |
| JPH0386853A (ja) | 1989-05-23 | 1991-04-11 | Sankyo Co Ltd | 置換フェノール誘導体およびその用途 |
| FR2653123B1 (fr) | 1989-10-17 | 1992-01-17 | Roussel Uclaf | Nouveaux derives de la pyridone, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
| CA2053340C (en) | 1990-10-18 | 2002-04-02 | Timothy P. Burkholder | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| DE4035961A1 (de) * | 1990-11-02 | 1992-05-07 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| GB9312893D0 (en) | 1993-06-22 | 1993-08-04 | Boots Co Plc | Therapeutic agents |
| FR2714291B1 (fr) * | 1993-12-24 | 1996-03-01 | Roussel Uclaf | Application des dérivés de la pyridone à titre de médicaments anesthésiques. |
| EP0804425A2 (en) | 1994-07-29 | 1997-11-05 | Fujisawa Pharmaceutical Co., Ltd. | Benzodiazepine derivatives |
| US5776959A (en) | 1995-06-05 | 1998-07-07 | Washington University | Anticonvulsant and anxiolytic lactam and thiolactam derivatives |
| EP0920425B1 (en) | 1995-11-17 | 2003-02-19 | Aventis Pharmaceuticals Inc. | Substituted 4-(1h-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases |
| US6211199B1 (en) * | 1995-11-17 | 2001-04-03 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases |
| WO1997021704A1 (en) | 1995-12-14 | 1997-06-19 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| KR20000064487A (ko) | 1995-12-20 | 2000-11-06 | 게리 디. 스트리트, 스티븐 엘. 네스비트 | 알레르기질환의치료에유용한신규의치환된4-(1h-벤즈이미다졸-2-일)1,4디아제판 |
| US6194406B1 (en) | 1995-12-20 | 2001-02-27 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease |
| US6423704B2 (en) * | 1995-12-20 | 2002-07-23 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases |
| JP2002505660A (ja) | 1996-09-10 | 2002-02-19 | ファルマシア・アンド・アップジョン・カンパニー | 抗ウィルス剤としての８―ヒドロキシ―７―置換キノリン |
| JP2001524468A (ja) | 1997-11-21 | 2001-12-04 | エヌピーエス ファーマシューティカルズ インコーポレーテッド | 中枢神経系疾患を治療するための代謝調節型グルタミン酸受容体アンタゴニスト |
| US6066648A (en) * | 1997-12-17 | 2000-05-23 | Merck & Co., Inc. | Integrin receptor antagonists |
| CO5180581A1 (es) | 1999-09-30 | 2002-07-30 | Pfizer Prod Inc | Compuestos para el tratamiento de la isquemia ciones farmaceuticas que los contienen para el tratamiento de la isquemia |
| US6867299B2 (en) | 2000-02-24 | 2005-03-15 | Hoffmann-La Roche Inc. | Oxamide IMPDH inhibitors |
| US6555572B2 (en) * | 2000-03-16 | 2003-04-29 | Inflazyme Pharmaceuticals Ltd. | Benzylated PDE4 inhibitors |
| SE0001899D0 (sv) | 2000-05-22 | 2000-05-22 | Pharmacia & Upjohn Ab | New compounds |
| US6784167B2 (en) * | 2000-09-29 | 2004-08-31 | Bayer Pharmaceuticals Corporation | 17-beta-hydroxysteroid dehydrogenase-II inhibitors |
| EP1474139B1 (en) | 2002-02-01 | 2007-11-21 | Merck & Co., Inc. | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia |
| AR040241A1 (es) | 2002-06-10 | 2005-03-23 | Merck & Co Inc | Inhibidores de la 11-beta-hidroxiesteroide deshidrogrenasa 1 para el tratamiento de la diabetes obesidad y dislipidemia |
| WO2004056744A1 (en) | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors |
| TW200503994A (en) | 2003-01-24 | 2005-02-01 | Novartis Ag | Organic compounds |
| WO2004075847A2 (en) * | 2003-02-21 | 2004-09-10 | Message Pharmaceuticals, Inc. | METHODS AND COMPOUNDS FOR THE TREATMENT OF Aß ASSOCIATED DISEASES, DISORDERS, AND CONDITIONS |
| WO2004089415A2 (en) | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | COMBINATIONS OF AN 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITOR AND A GLUCOCORTICOID RECEPTOR AGONIST |
| WO2004089416A2 (en) | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | Combination of an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent |
| WO2004089896A1 (en) | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVE COMPOUNDS |
| US20050245534A1 (en) | 2004-04-29 | 2005-11-03 | Link James T | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme |
| WO2005108361A1 (en) | 2004-05-07 | 2005-11-17 | Janssen Pharmaceutica N.V. | Adamantyl pyrrolidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
| JP5208505B2 (ja) | 2004-08-30 | 2013-06-12 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | １１−ベータヒドロキシステロイドデヒドロゲナーゼ阻害剤としてのｎ−２アダマンタニル−２−フェノキシ−アセトアミド誘導体 |
| WO2006024628A1 (en) | 2004-08-30 | 2006-03-09 | Janssen Pharmaceutica N.V. | Tricyclic lactam derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
-
2005
- 2005-04-29 NZ NZ551077A patent/NZ551077A/en not_active IP Right Cessation
- 2005-04-29 ES ES05747202.9T patent/ES2525319T3/es not_active Expired - Lifetime
- 2005-04-29 JP JP2007512175A patent/JP5014983B2/ja not_active Expired - Fee Related
- 2005-04-29 EP EP05747202.9A patent/EP1747199B1/en not_active Expired - Lifetime
- 2005-04-29 MX MXPA06012932A patent/MXPA06012932A/es active IP Right Grant
- 2005-04-29 CN CN2005800226115A patent/CN101001836B/zh not_active Expired - Fee Related
- 2005-04-29 CA CA2565630A patent/CA2565630C/en not_active Expired - Fee Related
- 2005-04-29 WO PCT/EP2005/051968 patent/WO2005108360A1/en not_active Ceased
- 2005-04-29 EA EA200602060A patent/EA011097B1/ru not_active IP Right Cessation
- 2005-04-29 AU AU2005240784A patent/AU2005240784C1/en not_active Ceased
- 2005-04-29 KR KR1020067024451A patent/KR101192861B1/ko not_active Expired - Fee Related
- 2005-04-29 US US11/632,675 patent/US9012494B2/en not_active Expired - Fee Related
- 2005-05-05 MY MYPI20052025A patent/MY161872A/en unknown
- 2005-05-06 AR ARP050101844A patent/AR048778A1/es unknown
- 2005-05-06 TW TW094114611A patent/TWI396534B/zh not_active IP Right Cessation
-
2006
- 2006-11-06 IL IL179065A patent/IL179065A/en not_active IP Right Cessation
- 2006-12-06 NO NO20065619A patent/NO20065619L/no not_active Application Discontinuation
-
2015
- 2015-03-13 US US14/656,752 patent/US9302987B2/en not_active Expired - Fee Related
-
2016
- 2016-02-24 US US15/051,717 patent/US9776965B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20150183735A1 (en) | 2015-07-02 |
| IL179065A (en) | 2012-10-31 |
| TWI396534B (zh) | 2013-05-21 |
| AU2005240784C1 (en) | 2011-12-22 |
| IL179065A0 (en) | 2007-03-08 |
| WO2005108360A1 (en) | 2005-11-17 |
| TW200605879A (en) | 2006-02-16 |
| EP1747199A1 (en) | 2007-01-31 |
| KR20070011528A (ko) | 2007-01-24 |
| US9012494B2 (en) | 2015-04-21 |
| CN101001836B (zh) | 2010-12-22 |
| CA2565630A1 (en) | 2005-11-17 |
| EP1747199B1 (en) | 2014-09-17 |
| CA2565630C (en) | 2013-05-28 |
| US20160168094A1 (en) | 2016-06-16 |
| AU2005240784A1 (en) | 2005-11-17 |
| US9776965B2 (en) | 2017-10-03 |
| MY161872A (en) | 2017-05-15 |
| US9302987B2 (en) | 2016-04-05 |
| EA011097B1 (ru) | 2008-12-30 |
| ES2525319T3 (es) | 2014-12-22 |
| MXPA06012932A (es) | 2007-01-26 |
| NZ551077A (en) | 2009-05-31 |
| JP2007536336A (ja) | 2007-12-13 |
| US20080139625A1 (en) | 2008-06-12 |
| CN101001836A (zh) | 2007-07-18 |
| KR101192861B1 (ko) | 2012-10-19 |
| JP5014983B2 (ja) | 2012-08-29 |
| NO20065619L (no) | 2006-12-06 |
| AU2005240784B2 (en) | 2011-05-12 |
| EA200602060A1 (ru) | 2007-04-27 |
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