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AR048260A1 - Compuestos de heteroaril- y fenilsulfamoilo sustituidos - Google Patents

Compuestos de heteroaril- y fenilsulfamoilo sustituidos

Info

Publication number
AR048260A1
AR048260A1 ARP050100890A ARP050100890A AR048260A1 AR 048260 A1 AR048260 A1 AR 048260A1 AR P050100890 A ARP050100890 A AR P050100890A AR P050100890 A ARP050100890 A AR P050100890A AR 048260 A1 AR048260 A1 AR 048260A1
Authority
AR
Argentina
Prior art keywords
halo
optionally substituted
phenyl
alkyl
alkoxy
Prior art date
Application number
ARP050100890A
Other languages
English (en)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34960729&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR048260(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AR048260A1 publication Critical patent/AR048260A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
    • C07C323/49—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to sulfur atoms
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
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    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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Abstract

La presente se refiere a compuestos de heteroaril- y fenilsulfamoílo sustituidos, composiciones farmacéuticas que contienen tales compuestos y al uso de tales compuestos como agonistas del receptor activador del proliferador de peroxisoma (PPAR). Reivindicacion 1: Un compuesto que tiene formula (1) o un profármaco de dicho compuesto o una sal farmacéuticamente aceptable de dicho compuesto o profármaco, en el que Q es C: cada R1 es independientemente H, halo, alquilo C1-5, opcionalmente sustituido con uno o más halo o con alcoxi C1-3, alcoxi C1-5 opcionalmente sustituido con uno a once halo, alquiltio C1-5 opcionalmente sustituido con uno o más halo, o R1 junto con los dos átomos de C adyacentes forma un anillo carbocíclico 5-6 de cinco o seis miembros condensado, totalmente saturado, parcialmente insaturado o totalmente insaturado en el que cada C en la cadena de carbono puede reemplazarse opcionalmente por un heteroátomo seleccionado entre O y S; R2 es H o alquilo C1-5 opcionalmente sustituido con alcoxi C1-3; X es -COOR4, -O-(CR32)-COOR4, -S-(CR32)-COOR4, CH2-(CR5w)-COOR4, 1H-tetrazol-5-il-E- o tiazolidindiona-5-il-G-; donde w es 0, 1 o 2; E es (CH2)r y r es 0, 1, 2, o 3, y G es (CH2)s o metilideno y s es 0 o 1; cada R3 es independientemente H, alquilo C1-4 opcionalmente sustituido con uno a nueve halo o con alcoxi C1-3 opcionalmente sustituido con uno o más halo, o R3 y el C al que está unido forman un anillo carbocíclico de 3, 4, 5 o 6 miembros; R4 es H, alquilo C1-4; bencilo o p-nitrobencilo cada R5 es independientemente H, alquilo C1-4 opcionalmente sustituido con uno a mueve halo o con alcoxi C1-3, alcoxi C1-4 opcionalmente sustituido con uno a nueve halo, alquiltio C1-4 opcionalmente sustituido con uno a nueve halo, o con alcoxi C1-3, o R5 y el C al que está unido forman un anillo carbocíclico de 3, 4, 5 o 6 miembros en el que cualquier C de un anillo de 5 o 6 miembros puede reemplazarse por un átomo de O; Ar1 es fenilo o fenilo condensado a un miembro seleccionado entre tiazolilo, furanilo, oxazolilo, pirimidina, fenilo o tienilo, donde Ar1 está opcionalmente mono-, di- o tri-sustituido independientemente con: halo, alquilo C1-3 opcionalmente sustituido con uno a nueve halo o alcoxi C1-3 opcionalmente sustituido con uno a nueve halo o alquiltio C1-3 opcionalmente sustituido con uno a nueve halo; B es un enlace, CO, (CY2)n, CYOH, CY=CY, -L-(CY2)n-, -(CY2)n-L-, -L-(CY2)2-L-, NY-OC-CONY-, -SO2NY-, -NY-SO2- donde cada L es independientemente O, S, SO o SO2, cada Y es independientemente H o alquilo C1-3 y n es 0, 1, 2 o 3; Ar2 es un enlace, fenilo, fenoxibencilo, fenoxifenilo, benciloxifenilo, benciloxibencilo, pirimidilo, piridinilo, pirazolilo, imidazolilo, tiazolilo, tiadiazolilo, oxazolilo, oxadiazolilo o fenilo condensado a un anillo seleccionado entre el grupo compuesto por: fenilo, pirimidinilo, tienilo, furanilo, pirrolilo, tiazolilo, oxazolilo, pirazolilo e imidazolilo; cada J es independientemente H, hidroxi, halo, alquilo C1-8, opcionalmente sustituido con de uno a once halo, alcoxi C1-8 opcionalmente sustituido con uno a once halo, alquiltio C1-8 opcionalmente sustituido con uno a once halo, cicloalquilo C3-7, cicloalcoxi C3-7, cicloalquiltio C3-7 o fenilo opcionalmente sustituido con uno a cuatro sustituyentes seleccionados entre el grupo compuesto por: halo, alquilo C1-3 opcionalmente sustituido con uno a cinco halo, alcoxi C1-3 opcionalmente sustituido con uno a cinco halo, alquiltio C1-3 opcionalmente sustituido con uno a cinco halo; p y q son cada uno independientemente 0, 1, 2 o 3; y con las condiciones: a) si Ar1 es fenilo, B es un enlace, Ar2 es un enlace o fenilo y X es -COOH, entonces q es diferente de 0 y J es diferente de H, halo, alquilo C1-8 o fenilo no sustituido; b) si Ar1 es fenilo, B no es un enlace, Ar2 es fenilo y X es -COOR4 entonces B se une a Ar1 en posicion para a NR2; y c) si B es O, S, SO, NH, CO, CH2 o SO2 entonces R1 no es H.
ARP050100890A 2004-03-10 2005-03-08 Compuestos de heteroaril- y fenilsulfamoilo sustituidos AR048260A1 (es)

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US20060258723A1 (en) 2006-11-16
AU2005225628A1 (en) 2005-10-06
AU2005225628B2 (en) 2008-09-11
NO20064615L (no) 2006-12-07
JP2007528387A (ja) 2007-10-11
CA2559035A1 (en) 2005-10-06
NL1028519A1 (nl) 2005-09-13
BRPI0508555A (pt) 2007-08-07
PE20051147A1 (es) 2006-01-28
ECSP066834A (es) 2006-12-29
US7262318B2 (en) 2007-08-28
KR20070001173A (ko) 2007-01-03
NL1028519C2 (nl) 2006-06-22
TW200610525A (en) 2006-04-01
EA200601442A1 (ru) 2007-02-27
EP1725524A1 (en) 2006-11-29
AP2006003714A0 (en) 2006-08-31
PA8625701A1 (es) 2006-01-25
DOP2005000025A (es) 2006-11-15
DOP2005000034A (es) 2005-12-15
US20050228015A1 (en) 2005-10-13
UY28794A1 (es) 2005-10-31
MA28461B1 (fr) 2007-03-01
WO2005092845A1 (en) 2005-10-06

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