AR048043A1 - Metodo para producir compuestos de aminifenol - Google Patents
Metodo para producir compuestos de aminifenolInfo
- Publication number
- AR048043A1 AR048043A1 ARP050101090A ARP050101090A AR048043A1 AR 048043 A1 AR048043 A1 AR 048043A1 AR P050101090 A ARP050101090 A AR P050101090A AR P050101090 A ARP050101090 A AR P050101090A AR 048043 A1 AR048043 A1 AR 048043A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- group
- formula
- producing
- compound represented
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title 1
- -1 aminophenol compound Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- CDAWCLOXVUBKRW-UHFFFAOYSA-N 2-aminophenol Chemical class NC1=CC=CC=C1O CDAWCLOXVUBKRW-UHFFFAOYSA-N 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/74—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C215/76—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
La presente proporciona un método industrialmente ventajoso para producir compuestos de aminofenol representados por la formula (1) por medio de un procedimiento simple y sencillo con un alto rendimiento y elevada pureza. La presente proporciona un método para producir un compuesto de aminofenol representado por la formula (1), (en donde cada uno de R1, y R2, que pueden ser iguales o diferentes, es un átomo de hidrogeno, un grupo alquilo inferior sustituido o insustituido o similares; R1 y R2, tomados juntos con el átomo de nitrogeno adyacente, pueden formar un heterociclo de 5 o 6 miembros con o sin otros heteroátomos intervinientes; el heterociclo puede estar sustituido con 1 a 3 sustituyentes seleccionados del grupo que consiste en un grupo hidroxilo, un grupo alquilo inferior sustituido o insustituido, un grupo arilo sustituido o insustituido, un grupo ariloxi sustituido o insustituido y similares; y el grupo hidroxilo en la formula (1) está sustituido en la posicion 2 o 4 respecto del grupo amino en el anillo fenilo), que comprende hacer reaccionar un compuesto de ciclohexandiona representado por la formula (2), con un compuesto de amina representado por la formula (3) (en donde R1 y R2 son como se definieron con anterioridad), bajo una condicion neutra o básica.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004089652 | 2004-03-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR048043A1 true AR048043A1 (es) | 2006-03-22 |
Family
ID=34962553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050101090A AR048043A1 (es) | 2004-03-25 | 2005-03-21 | Metodo para producir compuestos de aminifenol |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7750156B2 (es) |
| EP (1) | EP1727782B1 (es) |
| KR (1) | KR100766763B1 (es) |
| CN (1) | CN100478325C (es) |
| AR (1) | AR048043A1 (es) |
| AU (1) | AU2005226409B2 (es) |
| BR (1) | BRPI0509095B1 (es) |
| CA (1) | CA2559488C (es) |
| CY (1) | CY1113246T1 (es) |
| DK (1) | DK1727782T3 (es) |
| EG (1) | EG25686A (es) |
| ES (1) | ES2390079T3 (es) |
| MY (1) | MY143665A (es) |
| PL (1) | PL1727782T3 (es) |
| PT (1) | PT1727782E (es) |
| RU (1) | RU2376280C2 (es) |
| SI (1) | SI1727782T1 (es) |
| TW (1) | TWI380975B (es) |
| UA (1) | UA87301C2 (es) |
| WO (1) | WO2005092832A1 (es) |
| ZA (1) | ZA200607640B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201233389A (en) * | 2005-10-05 | 2012-08-16 | Otsuka Pharma Co Ltd | Antituberculous therapeutic drugs and kit containing the same |
| FR2926297B1 (fr) | 2008-01-10 | 2013-03-08 | Centre Nat Rech Scient | Molecules chimiques inhibitrices du mecanisme d'epissage pour traiter des maladies resultant d'anomalies d'epissage. |
| DE102008053240A1 (de) | 2008-10-25 | 2010-04-29 | Saltigo Gmbh | Herstellung von (N-Heterozyklyl)-Arylethern |
| EP2505198A1 (en) | 2011-04-01 | 2012-10-03 | Société Splicos | Compounds for use as therapeutic agents affecting p53 expression and/or activity |
| FR2995895B1 (fr) * | 2012-09-25 | 2015-01-30 | Fonds De Dev Des Filieres Des Oleagineux Et Proteagineux Fidop | Procede de synthese d'un compose aromatique |
| KR102597449B1 (ko) | 2015-03-27 | 2023-11-03 | 오츠카 세이야쿠 가부시키가이샤 | 1-(4-히드록시페닐)-4-(4-트리플루오로메톡시페녹시)피페리딘 또는 그 염의 제조방법 |
| CN106699635B (zh) * | 2015-11-12 | 2019-10-22 | 北京福元医药股份有限公司 | 一种制备Delamanid中间体的方法 |
| CN106938974A (zh) * | 2017-03-24 | 2017-07-11 | 连云港恒贸化工有限公司 | 一种一锅法生产间二乙氨基苯酚的方法 |
| CN110041334B (zh) * | 2018-01-15 | 2020-10-20 | 江苏恒瑞医药股份有限公司 | 一种氨基苯酚类化合物的制备方法 |
| CN109705022A (zh) * | 2018-12-28 | 2019-05-03 | 上海彩迩文生化科技有限公司 | 一种芳香胺中间体的制备方法 |
| CN110803996B (zh) * | 2019-11-13 | 2022-01-11 | 台州市创源工业技术有限公司 | 一种羟基苄胺的合成方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2402695C3 (de) * | 1974-01-21 | 1980-05-29 | Hoechst Ag, 6000 Frankfurt | Verfahren zur Herstellung von 3-Aminophenolen |
| JPS6229557A (ja) | 1985-07-29 | 1987-02-07 | Otsuka Pharmaceut Factory Inc | ジ低級アルキルフエノ−ル誘導体 |
| US5202488A (en) * | 1991-04-15 | 1993-04-13 | E. I. Du Pont De Nemours And Company | Method for the manufacture of 3-aminophenol |
| US7157458B2 (en) | 2001-04-17 | 2007-01-02 | Cryolife, Inc. | Bifunctional energy-reversible acyl-compositions |
-
2005
- 2005-03-04 TW TW094106689A patent/TWI380975B/zh not_active IP Right Cessation
- 2005-03-12 MY MYPI20051053A patent/MY143665A/en unknown
- 2005-03-21 AR ARP050101090A patent/AR048043A1/es active IP Right Grant
- 2005-03-25 KR KR1020067019609A patent/KR100766763B1/ko not_active Expired - Fee Related
- 2005-03-25 EP EP05727512A patent/EP1727782B1/en not_active Expired - Lifetime
- 2005-03-25 CN CNB2005800096535A patent/CN100478325C/zh not_active Expired - Fee Related
- 2005-03-25 AU AU2005226409A patent/AU2005226409B2/en not_active Ceased
- 2005-03-25 ES ES05727512T patent/ES2390079T3/es not_active Expired - Lifetime
- 2005-03-25 BR BRPI0509095-4A patent/BRPI0509095B1/pt not_active IP Right Cessation
- 2005-03-25 CA CA2559488A patent/CA2559488C/en not_active Expired - Fee Related
- 2005-03-25 SI SI200531617T patent/SI1727782T1/sl unknown
- 2005-03-25 PL PL05727512T patent/PL1727782T3/pl unknown
- 2005-03-25 WO PCT/JP2005/006408 patent/WO2005092832A1/en not_active Ceased
- 2005-03-25 PT PT05727512T patent/PT1727782E/pt unknown
- 2005-03-25 UA UAA200611248A patent/UA87301C2/ru unknown
- 2005-03-25 ZA ZA200607640A patent/ZA200607640B/en unknown
- 2005-03-25 US US10/593,968 patent/US7750156B2/en not_active Expired - Fee Related
- 2005-03-25 DK DK05727512.5T patent/DK1727782T3/da active
- 2005-03-25 RU RU2006137563/04A patent/RU2376280C2/ru not_active IP Right Cessation
-
2006
- 2006-09-04 EG EGNA2006000821 patent/EG25686A/xx active
-
2012
- 2012-10-23 CY CY20121100991T patent/CY1113246T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2006137563A (ru) | 2008-04-27 |
| DK1727782T3 (da) | 2012-10-08 |
| US7750156B2 (en) | 2010-07-06 |
| EP1727782B1 (en) | 2012-08-22 |
| AU2005226409B2 (en) | 2008-04-17 |
| SI1727782T1 (sl) | 2012-12-31 |
| CA2559488A1 (en) | 2005-10-06 |
| HK1097823A1 (zh) | 2007-07-06 |
| BRPI0509095B1 (pt) | 2014-09-16 |
| KR100766763B1 (ko) | 2007-10-17 |
| CN1938261A (zh) | 2007-03-28 |
| CY1113246T1 (el) | 2016-04-13 |
| TW200531958A (en) | 2005-10-01 |
| CN100478325C (zh) | 2009-04-15 |
| US20070219374A1 (en) | 2007-09-20 |
| PL1727782T3 (pl) | 2013-01-31 |
| RU2376280C2 (ru) | 2009-12-20 |
| ES2390079T3 (es) | 2012-11-06 |
| CA2559488C (en) | 2012-06-12 |
| UA87301C2 (ru) | 2009-07-10 |
| MY143665A (en) | 2011-06-30 |
| ZA200607640B (en) | 2008-05-28 |
| KR20060123650A (ko) | 2006-12-01 |
| TWI380975B (zh) | 2013-01-01 |
| EG25686A (en) | 2012-05-17 |
| EP1727782A1 (en) | 2006-12-06 |
| WO2005092832A1 (en) | 2005-10-06 |
| AU2005226409A1 (en) | 2005-10-06 |
| PT1727782E (pt) | 2012-08-30 |
| BRPI0509095A (pt) | 2007-08-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |