AR047144A1 - Derivados de 1-n-fenilamino-1h-imidazol y composiciones farmaceuticas que los contienen - Google Patents
Derivados de 1-n-fenilamino-1h-imidazol y composiciones farmaceuticas que los contienenInfo
- Publication number
- AR047144A1 AR047144A1 ARP040104657A ARP040104657A AR047144A1 AR 047144 A1 AR047144 A1 AR 047144A1 AR P040104657 A ARP040104657 A AR P040104657A AR P040104657 A ARP040104657 A AR P040104657A AR 047144 A1 AR047144 A1 AR 047144A1
- Authority
- AR
- Argentina
- Prior art keywords
- scsnr10
- tetrazolyl
- scsnr10r11
- sconr10r11
- oso2or10
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
- 125000003831 tetrazolyl group Chemical group 0.000 abstract 5
- IQUPABOKLQSFBK-UHFFFAOYSA-N 2-nitrophenol Chemical group OC1=CC=CC=C1[N+]([O-])=O IQUPABOKLQSFBK-UHFFFAOYSA-N 0.000 abstract 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 3
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 3
- 125000005518 carboxamido group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical group 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 2
- IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical compound C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- NAWXUBYGYWOOIX-SFHVURJKSA-N (2s)-2-[[4-[2-(2,4-diaminoquinazolin-6-yl)ethyl]benzoyl]amino]-4-methylidenepentanedioic acid Chemical compound C1=CC2=NC(N)=NC(N)=C2C=C1CCC1=CC=C(C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C1 NAWXUBYGYWOOIX-SFHVURJKSA-N 0.000 abstract 1
- FURVSEVWPXHUEK-UHFFFAOYSA-N 1,2$l^{6},3-benzoxathiazine 2,2-dioxide Chemical compound C1=CC=C2C=NS(=O)(=O)OC2=C1 FURVSEVWPXHUEK-UHFFFAOYSA-N 0.000 abstract 1
- YSHIPIDAJXCIFS-UHFFFAOYSA-N 1,2,3-benzodithiazine Chemical compound C1=CC=C2C=NSSC2=C1 YSHIPIDAJXCIFS-UHFFFAOYSA-N 0.000 abstract 1
- GDUQJFXEJRHTJT-UHFFFAOYSA-N 1,2lambda4,3-benzoxathiazine 2-oxide Chemical compound C1=CC=C2C=NS(=O)OC2=C1 GDUQJFXEJRHTJT-UHFFFAOYSA-N 0.000 abstract 1
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical group C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 abstract 1
- HXQHRUJXQJEGER-UHFFFAOYSA-N 1-methylbenzotriazole Chemical compound C1=CC=C2N(C)N=NC2=C1 HXQHRUJXQJEGER-UHFFFAOYSA-N 0.000 abstract 1
- DRLUWQXJGGKULE-UHFFFAOYSA-N 3h-1,2$l^{6},3-benzoxathiazole 2,2-dioxide Chemical compound C1=CC=C2OS(=O)(=O)NC2=C1 DRLUWQXJGGKULE-UHFFFAOYSA-N 0.000 abstract 1
- 102000014654 Aromatase Human genes 0.000 abstract 1
- 108010078554 Aromatase Proteins 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 239000002532 enzyme inhibitor Substances 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002460 imidazoles Chemical class 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D419/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Gynecology & Obstetrics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Pregnancy & Childbirth (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se refiere a compuestos y a las composiciones farmacéuticas que contienen a estos compuestos. utiles como inhibidores de la enzima aromatasa. Reivindicacion 1: Un derivado de imidazol de formula (1), y sales de adicion de ácidos y formas estereoisomeras del mismo, en donde: R1 y R2 son cada uno independientemente hidrogeno, un alquilo C1-6 o un cicloalquilo C3-8; o R1 y R2 juntos forman un anillo carbocíclico de 5, 6 o 7 miembros, saturado o insaturado; Q es (CH2)m-X-(CH2)n-A; A es un enlace directo, O, S, SO, SO2, NR5; X es un enlace directo, CF2, O, S, SO, SO2, C(O), NR5 o CR6R7; Z es un grupo seleccionado entre las formulas (2) a (8); m y n son cada uno independientemente 0, 1, 2, 3 o 4; p es 1, 2, 3 o 4; q es 0, 1 o 2; la línea de puntos significa que R8 y/o R9 pueden estar en cualquier posicion del anillo benzotiofeno; R3 y R8 son cada uno independientemente hidrogeno o un grupo hidroxi, ciano, halogeno, nitro, alquilo C1-6, alcoxi C1-6, trifluorometilo, alquiltio C1-6, alquilsulfonilo C1-6, acilo, alcoxicarbonilo C1-6, carboxamido, OPO(OR10)2, NR10R11, SO2NR10R11, OSO2NR10R11, OSO2OR10, SO2OR10, SSO2NR10R11, CF2SO2OR10, CF2SO2NR10R11, CF2-tetrazolilo o NR12SO2NR10R11, OSO2NR10SO2NR11R12, CO2R10, CONR10R11, OCHO, OCONR10R11, OCSNR10R11, SCONR10R11, SCSNR10R11, tetrazolilo, NR12CONR10R11, NR10-CHO; cuando Q-Z es un grupo de formula (9), n es 0, 1 o 2 y p es 1, uno de R3 y R8 es un grupo hidroxi, nitro, OPO(OR10)2, NR10R11, OSO2NR10R11, OSO2OR10, SO2OR10, SSO2NR10R11, CF2SO2OR10, CF2SO2NR10R11, CF2-tetrazolilo o NR12SO2NR10R11, OSO2NR10SO2NR11R12, CO2R10, CONR10R11, OCHO, OCONR10R11, OCSNR10R11, SCONR10R11, SCSNR10R11, tetrazolilo, NR12CONR10R11, NR10-CHO y el otro es hidrogeno o un grupo hidroxi, ciano, halogeno, nitro, alquilo C1-6, alcoxi C1-6, trifluorometilo, alquiltio C1-6, alquilsulfonilo C1-6, acilo, alcoxicarbonilo C1-6, carboxamido, NR10R11, SO2NR10R11, OSO2NR10R11, OSO2OR10, SO2OR10, SSO2NR10R11, CF2SO2OR10, CF2SO2NR10R11, CF2-tetrazolilo o NR12SO2NR10R11, OSO2NR12SO2NR10R11, CO2R10, CONR10R11, OCHO, OCONR10R11, OCSNR10R11, SCONR10R11, SCSNR10R11, tetrazolilo, NR12CONR10R11, NR10-CHO; R4 y R9 son cada uno independientemente hidrogeno o un grupo hidroxi, ciano, halogeno, nitro, OPO(OR10)2, alquilo C1-6, alcoxi C1-6, trifluorometilo, alquiltio C1-6, alquilsulfonilo C1-6, acilo, alcoxicarbonilo C1-6, carboxamido, NR10R11, SO2NR10R11, OSO2NR10R11, OSO2OR10, SO2OR10, SSO2NR10R11, CF2SO2OR10, CF2SO2NR10R11, CF2- tetrazolilo o NR12SO2NR10R11, OSO2NR12SO2NR10R11, CO2R10, CHO, CONR10R11, OCHO, OCONR10R11, OCSNR10R11, SCONR10R11, SCSNR10R11, tetrazolilo, NR12CONR10R11, NR10-CHO; cuando p es 2, 3 o 4, los R9 pueden ser iguales o diferentes; R6 y R7 son independientemente hidrogeno, halogeno, un alquilo C1-6 o un cicloalquilo C3-8; R5, R10, R11 y R12 son cada uno independientemente hidrogeno, hidroxi, un alquilo C1-6 o un cicloalquilo C3-8; R10 puede ser también una sal; R10 y R11 pueden formar también, junto con el átomo de nitrogeno al cual están unidos, un heterociclo de 5 a 7 miembros que contiene uno o dos heteroátomos seleccionados entre O, S y N; cuando Z es una formula (10), y p es 1: a) R8 y R9 pueden formar también junto con el anillo fenilo un dioxido de benzoxatiazina, un dioxido de dihidrobenzoxatiazina, un dioxido de benzoxatiazinona, un dioxido de benzoxatiazol, un tetraoxido de benzoxaditiadiazina, un tetraoxido de benzoditiazina o un tetraoxido de benzodioxaditina; b) R3 y R4 junto con el anillo fenilo que los lleva también puede formar un benzofurano o un N-metilbenzotriazol y luego R8 y R9 son independientemente un grupo hidroxi, nitro, OPO(OR10)2, NR10R11, OSO2NR10R11, OSO2OR10, SO2OR10, SSO2NR10R11, CF2SO2OR10, CF2SO2NR10R11, CF2-tetrazolilo o NR12SO2NR10R11, OSO2NR12SO2NR10R11, CO2R10, CONR10R11, OCHO, OCONR10R11, OCSNR10R11, SCONR10R11, SCSNR10R11, tetrazolilo, NR12CONR10R11, NR10-CHO.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03293152A EP1544195A1 (en) | 2003-12-15 | 2003-12-15 | 1-N-phenyl-amino- 1H-imidazole derivatives and pharmaceutical compositions containing them |
| EP04292681 | 2004-11-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR047144A1 true AR047144A1 (es) | 2006-01-11 |
Family
ID=34702365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040104657A AR047144A1 (es) | 2003-12-15 | 2004-12-15 | Derivados de 1-n-fenilamino-1h-imidazol y composiciones farmaceuticas que los contienen |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8476455B2 (es) |
| EP (1) | EP1694650A1 (es) |
| JP (2) | JP4834557B2 (es) |
| KR (1) | KR20060123186A (es) |
| CN (1) | CN1890221B (es) |
| AR (1) | AR047144A1 (es) |
| AU (1) | AU2004299286B2 (es) |
| BR (1) | BRPI0417407A (es) |
| CA (1) | CA2549603A1 (es) |
| IL (1) | IL176077A0 (es) |
| MA (1) | MA28286A1 (es) |
| MX (1) | MXPA06006837A (es) |
| NO (1) | NO20062710L (es) |
| NZ (1) | NZ548399A (es) |
| OA (1) | OA13336A (es) |
| RU (1) | RU2365586C2 (es) |
| TW (1) | TW200533668A (es) |
| WO (1) | WO2005058842A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0127923D0 (en) | 2001-11-21 | 2002-01-16 | Sterix Ltd | Compound |
| AU2007271486A1 (en) * | 2006-07-05 | 2008-01-10 | Merck Patent Gmbh | Sulfamate benzothiophene derivatives |
| WO2008067892A1 (de) * | 2006-12-04 | 2008-06-12 | Merck Patent Gmbh | Sulfamat-benzothiophen-derivate |
| BRPI0817045A2 (pt) | 2007-09-17 | 2015-03-24 | Preglem Sa | Tratamento de condições estrogênio-dependentes em mulheres pré-menopáusicas |
| GB0914767D0 (en) | 2009-08-24 | 2009-09-30 | Sterix Ltd | Compound |
| CA3008020C (en) | 2015-12-09 | 2024-02-20 | The Board Of Trustees Of The University Of Illinois | Benzothiophene-based selective estrogen receptor downregulators |
| IL267795B2 (en) | 2017-01-06 | 2023-02-01 | G1 Therapeutics Inc | Combination therapy for the treatment of cancer |
| WO2018187414A1 (en) * | 2017-04-05 | 2018-10-11 | The Regents Of The University Of California | Inhibitors of mtor-rictor interactions |
| EP3801221A4 (en) * | 2018-06-11 | 2022-03-30 | Loma Linda University | Methods of delaying and reversing alzheimer's disease progression |
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| JP2500849B2 (ja) * | 1991-09-02 | 1996-05-29 | 山之内製薬株式会社 | トリアゾリル置換３級アミノ化合物又はその塩 |
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-
2004
- 2004-12-15 AR ARP040104657A patent/AR047144A1/es not_active Application Discontinuation
- 2004-12-15 CN CN200480036357.XA patent/CN1890221B/zh not_active Expired - Fee Related
- 2004-12-15 RU RU2006125417/04A patent/RU2365586C2/ru not_active IP Right Cessation
- 2004-12-15 NZ NZ548399A patent/NZ548399A/en unknown
- 2004-12-15 US US10/582,778 patent/US8476455B2/en not_active Expired - Fee Related
- 2004-12-15 OA OA1200600193A patent/OA13336A/en unknown
- 2004-12-15 AU AU2004299286A patent/AU2004299286B2/en not_active Ceased
- 2004-12-15 JP JP2006544394A patent/JP4834557B2/ja not_active Expired - Fee Related
- 2004-12-15 CA CA002549603A patent/CA2549603A1/en not_active Abandoned
- 2004-12-15 TW TW093138979A patent/TW200533668A/zh unknown
- 2004-12-15 KR KR1020067010009A patent/KR20060123186A/ko not_active Ceased
- 2004-12-15 BR BRPI0417407-0A patent/BRPI0417407A/pt not_active IP Right Cessation
- 2004-12-15 WO PCT/EP2004/014847 patent/WO2005058842A1/en not_active Ceased
- 2004-12-15 MX MXPA06006837A patent/MXPA06006837A/es active IP Right Grant
- 2004-12-15 EP EP04804432A patent/EP1694650A1/en not_active Withdrawn
-
2006
- 2006-05-31 IL IL176077A patent/IL176077A0/en unknown
- 2006-06-12 NO NO20062710A patent/NO20062710L/no not_active Application Discontinuation
- 2006-07-07 MA MA29173A patent/MA28286A1/fr unknown
-
2011
- 2011-06-21 JP JP2011137461A patent/JP5209760B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US8476455B2 (en) | 2013-07-02 |
| MA28286A1 (fr) | 2006-11-01 |
| AU2004299286A1 (en) | 2005-06-30 |
| CN1890221B (zh) | 2014-07-16 |
| CA2549603A1 (en) | 2005-06-30 |
| NO20062710L (no) | 2006-06-30 |
| JP4834557B2 (ja) | 2011-12-14 |
| WO2005058842A1 (en) | 2005-06-30 |
| AU2004299286B2 (en) | 2011-06-30 |
| RU2006125417A (ru) | 2008-01-27 |
| BRPI0417407A (pt) | 2007-04-03 |
| TW200533668A (en) | 2005-10-16 |
| JP2011190277A (ja) | 2011-09-29 |
| JP2007515420A (ja) | 2007-06-14 |
| JP5209760B2 (ja) | 2013-06-12 |
| US20070112009A1 (en) | 2007-05-17 |
| NZ548399A (en) | 2011-01-28 |
| OA13336A (en) | 2006-04-13 |
| MXPA06006837A (es) | 2006-09-04 |
| IL176077A0 (en) | 2006-10-05 |
| KR20060123186A (ko) | 2006-12-01 |
| EP1694650A1 (en) | 2006-08-30 |
| RU2365586C2 (ru) | 2009-08-27 |
| CN1890221A (zh) | 2007-01-03 |
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| Date | Code | Title | Description |
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| FA | Abandonment or withdrawal |