AR047094A1 - Derivados de diarilmetil piperazina, sus preparaciones y sus usos - Google Patents
Derivados de diarilmetil piperazina, sus preparaciones y sus usosInfo
- Publication number
- AR047094A1 AR047094A1 ARP050100061A ARP050100061A AR047094A1 AR 047094 A1 AR047094 A1 AR 047094A1 AR P050100061 A ARP050100061 A AR P050100061A AR P050100061 A ARP050100061 A AR P050100061A AR 047094 A1 AR047094 A1 AR 047094A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- cycloalkyl
- nrc
- diarilmetil
- piperazina
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 8
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 6
- 229910006069 SO3H Inorganic materials 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Reivindicacion 1: Un compuesto de formula (1), una sal aceptable para uso farmacéutico del mismo, diastereomeros, enantiomeros, o mezclas de los mismos: en la cual R1 se selecciona de alquilo C1-6, alquenilo C2-6, cicloalquilo C3-6 y cicloalquil C3- 6-alquilo C1-4, donde dichos alquilo C1-6, alquenilo C2-6, cicloalquilo C3-6, y cicloalquil C3-6-alquilo C1-4 se sustituyen opcionalmente con uno o más grupos seleccionados de -R, -NO2, -OR, -Cl, -Br, -I, -F, -CF3, -C(=O)R, -C(=O)OH, -NH2, -SH, - NHR, -NR2, -SR, -SO3H, -SO2R, -S(=O)R, -CN, -OH, -C(=O)OR, -C(=O)NR2, -NRC(=O)R y -NRC(=O)-OR, donde R es, independientemente, un H, cicloalquilo C3-6 o alquilo C1-6; R2 se selecciona de -H, alquilo C1-6 y cicloalquilo C3-6,donde dichos alquilo C1-6 y cicloalquilo C3-6 se sustituyen opcionalmente con uno o más grupos seleccionados de -OR, -Cl, -Br, -I, -F, -CF3, -C(=O)R, -C(=O)OH, -NH2, -SH, -NHR, -NR2, -SR, -SO3H, -SO2R, -S(=O)R, -CN, -OH, -C(=O)OR, -C(=O)NR2, -NRC(=O)R y -NRC(=O)-OR, donde R es, independientemente, un H, o alquilo C1-6; y R3 se selecciona de alquilo C1-6 y cicloalquilo C3-6, donde dichos alquilo C1-6 y cicloalquilo C3-6 se sustituyen opcionalmente con uno o más grupos seleccionados de: -OR, -Cl, -Br, -I, -F, -CF3, - C(=O)R, -C(=O)OH, -NH2, -SH, -NHR, -NR2, -SR, -SO3H, -SO2R, -S(=O)R, -CN, -OH, -C(=O)OR, -C(=O)NR2, -NRC(=O)R y -NRC(=O)-OR, donde R es, independientemente, un H, o alquilo C1-6.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0400027A SE0400027D0 (sv) | 2004-01-09 | 2004-01-09 | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR047094A1 true AR047094A1 (es) | 2006-01-04 |
Family
ID=31493012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050100061A AR047094A1 (es) | 2004-01-09 | 2005-01-07 | Derivados de diarilmetil piperazina, sus preparaciones y sus usos |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20070293502A1 (es) |
| EP (1) | EP1706393A1 (es) |
| JP (1) | JP2007517873A (es) |
| KR (1) | KR20060123446A (es) |
| CN (1) | CN1926122A (es) |
| AR (1) | AR047094A1 (es) |
| AU (1) | AU2005204010A1 (es) |
| BR (1) | BRPI0506702A (es) |
| CA (1) | CA2552851A1 (es) |
| IL (1) | IL176513A0 (es) |
| MX (1) | MXPA06007664A (es) |
| NO (1) | NO20063619L (es) |
| SA (1) | SA05250441A (es) |
| SE (1) | SE0400027D0 (es) |
| TW (1) | TW200524609A (es) |
| UY (1) | UY28715A1 (es) |
| WO (1) | WO2005066148A1 (es) |
| ZA (1) | ZA200605442B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1395567B1 (en) * | 2001-05-18 | 2009-01-14 | AstraZeneca AB | 4 (phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders |
| SE0203303D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203302D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0401968D0 (sv) * | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
| MX2007001240A (es) | 2004-08-02 | 2007-03-23 | Astrazeneca Ab | Derivados de diarilmetil-piperazina, preparaciones y usos de las mismas. |
| SI2041088T1 (sl) | 2006-06-28 | 2014-05-30 | Amgen Inc. | Inhibitorji transporter-1 glicina |
| US20090291966A1 (en) * | 2008-05-20 | 2009-11-26 | Astrazeneca Ab | Method Of Treating Anxious Major Depressive Disorder |
| KR101516703B1 (ko) * | 2013-02-20 | 2015-05-04 | 김슬기 | 영아 시트 침대 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH585209A5 (es) * | 1973-06-29 | 1977-02-28 | Cermol Sa | |
| US5574159A (en) * | 1992-02-03 | 1996-11-12 | Delta Pharmaceuticals, Inc. | Opioid compounds and methods for making therefor |
| US5807858A (en) * | 1996-06-05 | 1998-09-15 | Delta Pharmaceutical, Inc. | Compositions and methods for reducing respiratory depression |
| GB9202238D0 (en) * | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
| US5681830A (en) * | 1992-02-03 | 1997-10-28 | Delta Pharmaceuticals, Inc. | Opioid compounds |
| SE9504661D0 (sv) * | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
| SE9904674D0 (sv) * | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| SE9904673D0 (sv) * | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| SE0001209D0 (sv) * | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
| SE0101765D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0203303D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
-
2004
- 2004-01-09 SE SE0400027A patent/SE0400027D0/xx unknown
- 2004-12-29 TW TW093141173A patent/TW200524609A/zh unknown
-
2005
- 2005-01-01 SA SA05250441A patent/SA05250441A/ar unknown
- 2005-01-05 MX MXPA06007664A patent/MXPA06007664A/es not_active Application Discontinuation
- 2005-01-05 EP EP05704688A patent/EP1706393A1/en not_active Withdrawn
- 2005-01-05 US US10/596,851 patent/US20070293502A1/en not_active Abandoned
- 2005-01-05 AU AU2005204010A patent/AU2005204010A1/en not_active Abandoned
- 2005-01-05 WO PCT/SE2005/000014 patent/WO2005066148A1/en not_active Ceased
- 2005-01-05 KR KR1020067013696A patent/KR20060123446A/ko not_active Withdrawn
- 2005-01-05 BR BRPI0506702-2A patent/BRPI0506702A/pt not_active IP Right Cessation
- 2005-01-05 CN CNA2005800062543A patent/CN1926122A/zh active Pending
- 2005-01-05 JP JP2006549190A patent/JP2007517873A/ja not_active Abandoned
- 2005-01-05 CA CA002552851A patent/CA2552851A1/en not_active Abandoned
- 2005-01-07 AR ARP050100061A patent/AR047094A1/es unknown
- 2005-01-07 UY UY28715A patent/UY28715A1/es unknown
-
2006
- 2006-06-22 IL IL176513A patent/IL176513A0/en unknown
- 2006-06-30 ZA ZA200605442A patent/ZA200605442B/en unknown
- 2006-08-09 NO NO20063619A patent/NO20063619L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US20070293502A1 (en) | 2007-12-20 |
| TW200524609A (en) | 2005-08-01 |
| SE0400027D0 (sv) | 2004-01-09 |
| UY28715A1 (es) | 2005-08-31 |
| BRPI0506702A (pt) | 2007-05-02 |
| ZA200605442B (en) | 2007-04-25 |
| WO2005066148A1 (en) | 2005-07-21 |
| IL176513A0 (en) | 2008-02-09 |
| CN1926122A (zh) | 2007-03-07 |
| JP2007517873A (ja) | 2007-07-05 |
| KR20060123446A (ko) | 2006-12-01 |
| MXPA06007664A (es) | 2006-09-04 |
| EP1706393A1 (en) | 2006-10-04 |
| NO20063619L (no) | 2006-10-09 |
| AU2005204010A1 (en) | 2005-07-21 |
| CA2552851A1 (en) | 2005-07-21 |
| SA05250441A (ar) | 2005-12-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |