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AR046842A1 - Excipientes en vehiculos de administracion de farmaco - Google Patents

Excipientes en vehiculos de administracion de farmaco

Info

Publication number
AR046842A1
AR046842A1 ARP040104211A ARP040104211A AR046842A1 AR 046842 A1 AR046842 A1 AR 046842A1 AR P040104211 A ARP040104211 A AR P040104211A AR P040104211 A ARP040104211 A AR P040104211A AR 046842 A1 AR046842 A1 AR 046842A1
Authority
AR
Argentina
Prior art keywords
gel
polymers
excipient
beneficial agent
polymer
Prior art date
Application number
ARP040104211A
Other languages
English (en)
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of AR046842A1 publication Critical patent/AR046842A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se proporcionan composiciones de gel de depósito inyectables y kits que proveen un excipiente para modular un índice de liberación y estabilizar agentes beneficiosos. También se proveen métodos para administrar y preparar ese tipo de sistemas. Las composiciones de gel comprenden polímeros biodegradables y biocorroible y solventes inmiscibles en agua en cantidades eficaces para plastificar los polímeros y formar geles con los polímeros. Los excipientes adecuados incluyen modificaciones del pH, agentes reductores y antioxidantes. Reivindicación 1: Una composición de gel de depósito inyectable para la administración sostenida de un agente beneficioso que comprende: un vehículo de gel que comprende un polímero biodegradable y biocompatible y un solvente inmiscible en agua en una cantidad eficaz para plastificar al polímero y formar un gel con el mismo; un agente beneficioso disuelto o dispersado en el vehículo en gel; y un excipiente para modular un índice de liberación, en el cual el excipiente estabiliza al agente beneficioso compensando los efectos de la degradación del polímero; en donde la administración sostenida se produce durante un período de entre aproximadamente 24 horas y aproximadamente doce meses después de la administración.
ARP040104211A 2003-11-14 2004-11-15 Excipientes en vehiculos de administracion de farmaco AR046842A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51997203P 2003-11-14 2003-11-14
US10/985,116 US20050281879A1 (en) 2003-11-14 2004-11-10 Excipients in drug delivery vehicles

Publications (1)

Publication Number Publication Date
AR046842A1 true AR046842A1 (es) 2005-12-28

Family

ID=34623114

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040104211A AR046842A1 (es) 2003-11-14 2004-11-15 Excipientes en vehiculos de administracion de farmaco

Country Status (14)

Country Link
US (1) US20050281879A1 (es)
EP (1) EP1691785A4 (es)
JP (1) JP2007511516A (es)
KR (1) KR20060125748A (es)
AR (1) AR046842A1 (es)
AU (2) AU2004291077A1 (es)
BR (1) BRPI0416032A (es)
CA (1) CA2545913C (es)
IL (1) IL175601A0 (es)
MX (1) MXPA06005464A (es)
NO (1) NO20062781L (es)
PE (1) PE20050494A1 (es)
TW (1) TW200524631A (es)
WO (1) WO2005048989A1 (es)

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Also Published As

Publication number Publication date
TW200524631A (en) 2005-08-01
BRPI0416032A (pt) 2007-01-02
IL175601A0 (en) 2006-09-05
AU2011201972A1 (en) 2011-05-19
WO2005048989A1 (en) 2005-06-02
AU2004291077A1 (en) 2005-06-02
EP1691785A1 (en) 2006-08-23
CA2545913A1 (en) 2005-06-02
US20050281879A1 (en) 2005-12-22
PE20050494A1 (es) 2005-08-24
EP1691785A4 (en) 2012-08-29
NO20062781L (no) 2006-08-14
JP2007511516A (ja) 2007-05-10
AU2011201972B2 (en) 2013-06-13
KR20060125748A (ko) 2006-12-06
MXPA06005464A (es) 2006-08-11
CA2545913C (en) 2013-12-31

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