AR044821A1 - 4-(aminometil)-piperidin benzamidas como antagonistas de 5ht4 - Google Patents
4-(aminometil)-piperidin benzamidas como antagonistas de 5ht4Info
- Publication number
- AR044821A1 AR044821A1 ARP040102131A ARP040102131A AR044821A1 AR 044821 A1 AR044821 A1 AR 044821A1 AR P040102131 A ARP040102131 A AR P040102131A AR P040102131 A ARP040102131 A AR P040102131A AR 044821 A1 AR044821 A1 AR 044821A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- substituted
- hydroxy
- halo
- independently selected
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 22
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 10
- 125000001475 halogen functional group Chemical group 0.000 abstract 9
- 125000001424 substituent group Chemical group 0.000 abstract 7
- 125000003545 alkoxy group Chemical group 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 3
- -1 amino, aminocarbonyl Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 3
- 101001043818 Mus musculus Interleukin-31 receptor subunit alpha Proteins 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000000532 dioxanyl group Chemical group 0.000 abstract 2
- 125000005879 dioxolanyl group Chemical group 0.000 abstract 2
- 125000002541 furyl group Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000003386 piperidinyl group Chemical group 0.000 abstract 2
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 2
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 abstract 2
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 abstract 1
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 abstract 1
- 125000000815 N-oxide group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000003523 serotonin 4 antagonist Substances 0.000 abstract 1
- RAHZWNYVWXNFOC-UHFFFAOYSA-N sulfur dioxide Inorganic materials O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/06—Anti-spasmodics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos antagonistas de 5HT4, métodos para prepararlos, composiciones farmacéuticas que los contienen, uso de dichos compuestos como medicamentos. Reivindicación 1: Un compuesto de fórmula (1) una forma estereoquímicamente isomérica del mismo, una forma N-óxido del mismo, o una sal de adición de ácido o base farmacéuticamente aceptable del mismo, en donde -R1-R2- es un radical bivalente de fórmula -O-CH2-O- (a-1), -O-CH2-CH2- (a-2), -O-CH2-CH2-O- (a-3), -O-CH2-CH2-CH2- (a-4), -O-CH2-CH2-CH2-O- (a-5), -O-CH2-CH2-CH2-CH2- (a-6), -O-CH2-CH2-CH2-CH2-O- (a-7), -O-CH2-CH2-CH2-CH2-CH2- (a-8), donde en dichos radicales bivalentes opcionalmente uno o dos átomos de H en el mismo átomo de C o en un átomo de C diferente se puede reemplazar por alquilo C1-6 o hidroxi; R3 es H, halo, alquilo C1-4; R4 es alquilo C1-6, alquilo C1-6 sustituido con ciano, o alquiloxi C1-6; alquiloxi C1-6; ciano; amino o mono o di(alquil C1-6)amino; R5 es H o alquilo C1-6, y el radical -OR5 está situado en la posición 3 o 4 del grupo piperidina; L es H, o L es un radical de fórmula -Alq-R6 (b-1), -Alq-X-R7 (b-2), -Alq-Y-C(=O)-R9 (b-3), o Alq-Z-C(=O)-NR11R12 (b-4), donde cada Alq es alcandiilo C1-12; y R6 es H, hidroxi, ciano, cicloalquilo C3-6; alquilsulfonilamino C1-6, arilo o Het; R7 es alquilo C1-6, alquilo C1-6 sustituido con hidroxi, cicloalquilo C346; arilo o Het; X es O, S, SO2 o NR8, siendo dicho R8 H o alquilo C1-6; R9 es H, alquilo c1-6, cicloalquilo C3-6, hidroxi o arilo; Y es un enlace directo, o NR10 donde R10 es H o alquilo C1-6; Z es un enlace directo, O, S, o NR10 donde R10 es H o alquilo C1-6; R11 y R12 son independientemente entre sí H, alquilo C1-6, cicloalquilo C3-6, o R11 y R12 combinados con el átomo de N que porta R11 y R12 pueden formar un anillo pirrolidinilo, piperidinilo, piperazinilo o 4-morfolinilo, estando ambos opcionalmente sustituidos con alquilo C1-; arilo representa fenilo no sustituido o fenilo sustituido con 1, 2, o 3 sustituyentes seleccionados independientemente entre sí de halo, hidroxi, alquilo C1-6, alquiloxi C1-6, alquilcarbonilo C1-6, nitro, trifluorometilo, amino, aminocarbonilo y aminosulfonilo; y Het es furanilo; furanilo sustituido con alquilo C1-6 o halo; tetrahidrofuranilo; tetrahidrofuranilo sustituido con alquilo C1-6; dioxolanilo; dioxolanilo sustituido con alquilo C1-6, dioxanilo; dioxanilo sustituido con alquilo C1-6; tetrahidropiranilo; tetrahidropiranilo sustituido con alquilo C1-6; 2,3-dihidro-2-oxo-1H-imidazolilo; 2,3-dihidro-2-oxo-1H-imidazolilo sustituido con uno o dos sustituyentes seleccionados independientemente entre sí de halo o alquilo C1-6; pirrolidinilo; pirrolidinilo sustituido con uno o dos sustituyentes seleccionados independientemente entre sí de halo, hidroxi o alquilo C1-6; piridinilo; piridinilo sustituido con uno o dos sustituyentes seleccionados independientemente entre sí de halo, hidroxi o alquilo C1-6; pirimidinilo; pirimidinilo sustituido con uno o dos sustituyentes seleccionados independientemente entre sí e halo, hidroxi o alquilo C1-6; piridazinilo; piridazinilo sustituido con uno o dos sustituyentes seleccionados independientemente entre sí de hidroxi, alquiloxi C1-6, alquilo C1-6 o halo; pirazinilo; pirazinilo sustituido con uno o dos sustituyentes seleccionados independientemente entre sí de hidroxi, alquiloxi C1-6, alquilo C1-6 o halo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP0350236 | 2003-06-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR044821A1 true AR044821A1 (es) | 2005-10-05 |
Family
ID=33547568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040102131A AR044821A1 (es) | 2003-06-19 | 2004-06-18 | 4-(aminometil)-piperidin benzamidas como antagonistas de 5ht4 |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US7638535B2 (es) |
| EP (1) | EP1641784B1 (es) |
| JP (1) | JP4688800B2 (es) |
| KR (1) | KR101151645B1 (es) |
| CN (1) | CN100537565C (es) |
| AR (1) | AR044821A1 (es) |
| AT (1) | ATE364602T1 (es) |
| AU (1) | AU2004251825B2 (es) |
| BR (1) | BRPI0411603B1 (es) |
| CA (1) | CA2528590C (es) |
| CY (1) | CY1106857T1 (es) |
| DE (1) | DE602004006997T2 (es) |
| DK (1) | DK1641784T3 (es) |
| EA (1) | EA008504B1 (es) |
| ES (1) | ES2288258T3 (es) |
| HR (1) | HRP20070393T3 (es) |
| IL (1) | IL172604A (es) |
| JO (1) | JO2478B1 (es) |
| MX (1) | MXPA05013772A (es) |
| MY (1) | MY139454A (es) |
| NZ (1) | NZ544592A (es) |
| PA (1) | PA8605101A1 (es) |
| PL (1) | PL1641784T3 (es) |
| PT (1) | PT1641784E (es) |
| SI (1) | SI1641784T1 (es) |
| TW (1) | TWI346107B (es) |
| UA (1) | UA88607C2 (es) |
| WO (1) | WO2005000838A1 (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200533348A (en) | 2004-02-18 | 2005-10-16 | Theravance Inc | Indazole-carboxamide compounds as 5-ht4 receptor agonists |
| US8309575B2 (en) | 2004-04-07 | 2012-11-13 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| US7728006B2 (en) | 2004-04-07 | 2010-06-01 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| TWI351282B (en) | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
| ATE441646T1 (de) | 2004-11-05 | 2009-09-15 | Theravance Inc | 5-ht4-rezeptoragonistenverbindungen |
| ATE431824T1 (de) | 2004-11-05 | 2009-06-15 | Theravance Inc | Chinolinon-carboxamid-verbindungen |
| MX2007007818A (es) | 2004-12-22 | 2007-09-11 | Theravance Inc | Compuestos de indazol-carboxamida. |
| NZ560828A (en) | 2005-03-02 | 2011-01-28 | Theravance Inc | Quinolinone compounds as 5-HT4 receptor agonists |
| US9101160B2 (en) | 2005-11-23 | 2015-08-11 | The Coca-Cola Company | Condiments with high-potency sweetener |
| US8017168B2 (en) | 2006-11-02 | 2011-09-13 | The Coca-Cola Company | High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith |
| US20100081981A1 (en) * | 2008-10-01 | 2010-04-01 | Cheng Shien-Che | Wrist support |
| GB0901487D0 (en) | 2009-01-30 | 2009-03-11 | Movetis N V | Asthma Therapy |
| CA2854266A1 (en) | 2011-11-30 | 2013-06-06 | Actelion Pharmaceuticals Ltd | 3,7-disubstituted octahydro-2h-pyrido[4,3-e][1,3]oxazin-2-one antibiotics |
| GB201403093D0 (en) | 2014-02-21 | 2014-04-09 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| WO2017122722A1 (ja) | 2016-01-15 | 2017-07-20 | 大日本住友製薬株式会社 | ２環性複素環化合物 |
| GB201715194D0 (en) | 2017-09-20 | 2017-11-01 | Carrick Therapeutics Ltd | Compounds and their therapeutic use |
| GB201918541D0 (en) | 2019-12-16 | 2020-01-29 | Carrick Therapeutics Ltd | Therapeutic compounds and their use |
| CN115974856B (zh) * | 2022-12-28 | 2023-08-11 | 北京康立生医药技术开发有限公司 | 一种治疗成人t细胞白血病淋巴瘤药物伐美妥司他的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4186135A (en) * | 1976-08-04 | 1980-01-29 | Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France | Substituted 2,3-alkylene bis (oxy) benzamides and derivatives and method of preparation |
| US5374637A (en) * | 1989-03-22 | 1994-12-20 | Janssen Pharmaceutica N.V. | N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives |
| SG49153A1 (en) * | 1991-09-12 | 1998-05-18 | Smithkline Beecham Plc | 5-HT4 receptor antagonists |
| NZ246915A (en) * | 1992-02-06 | 1996-05-28 | Smithkline Beecham Plc | Benzopyran, benzothiopyran and benzofuran derivatives, preparation and pharmaceutical compositions thereof |
| TW402591B (en) * | 1997-07-11 | 2000-08-21 | Janssen Pharmaceutica Nv | Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives |
| TW570920B (en) * | 1998-12-22 | 2004-01-11 | Janssen Pharmaceutica Nv | 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders |
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2004
- 2004-06-09 JO JO200473A patent/JO2478B1/en active
- 2004-06-10 DK DK04739785T patent/DK1641784T3/da active
- 2004-06-10 US US10/560,479 patent/US7638535B2/en not_active Expired - Fee Related
- 2004-06-10 CN CNB2004800171349A patent/CN100537565C/zh not_active Expired - Fee Related
- 2004-06-10 DE DE602004006997T patent/DE602004006997T2/de not_active Expired - Lifetime
- 2004-06-10 NZ NZ544592A patent/NZ544592A/en not_active IP Right Cessation
- 2004-06-10 MX MXPA05013772A patent/MXPA05013772A/es active IP Right Grant
- 2004-06-10 JP JP2006515886A patent/JP4688800B2/ja not_active Expired - Fee Related
- 2004-06-10 SI SI200430410T patent/SI1641784T1/sl unknown
- 2004-06-10 ES ES04739785T patent/ES2288258T3/es not_active Expired - Lifetime
- 2004-06-10 EA EA200600061A patent/EA008504B1/ru not_active IP Right Cessation
- 2004-06-10 AU AU2004251825A patent/AU2004251825B2/en not_active Ceased
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- 2004-06-10 EP EP04739785A patent/EP1641784B1/en not_active Expired - Lifetime
- 2004-06-15 PA PA20048605101A patent/PA8605101A1/es unknown
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2005
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2007
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