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AR033918A1 - Composicion para acelerar la soldadura de una fractura osea - Google Patents

Composicion para acelerar la soldadura de una fractura osea

Info

Publication number
AR033918A1
AR033918A1 ARP020101912A ARP020101912A AR033918A1 AR 033918 A1 AR033918 A1 AR 033918A1 AR P020101912 A ARP020101912 A AR P020101912A AR P020101912 A ARP020101912 A AR P020101912A AR 033918 A1 AR033918 A1 AR 033918A1
Authority
AR
Argentina
Prior art keywords
possesses
composition
pde4
welding
compound
Prior art date
Application number
ARP020101912A
Other languages
English (en)
Inventor
N Sakurai
T Takagi
N Yanaka
Y Horikiri
Takashi Tamura
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Publication of AR033918A1 publication Critical patent/AR033918A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

Una composición para acelerar la soldadura de la fractura que comprende un inhibidor de PDE4 como ingrediente activo, específicamente se provee una composición que comprende un inhibidor de PDE4 y un polímero biocompatible y biodegradable, dicha composición, cuando es formulada en una forma conveniente para administración local tal como preparación de microesferas, puede proveer una composición farmacéutica que ilustra un excelente efecto de curación temprana del hueso. El polímero biocompatible y biodegradable puede ser uno o más polímeros seleccioandos del grupo que consiste de ácido poliláctico, copolímero de ácido láctico ácido glicólico y copolímero de ácido 2-hidroxibutírico-ácido glicólico, con un peso molecular promedio de 2.000-800.000. El inhibidor de PDE4 es un compuesto que posee una estructura parcial, que posee actividad inhibitoria de PDE4 es un compuesto que posee una estructura parcial que posee actividad inhibitoria de PDE4 es un compuesto que posee una estructura parcial, que posee actividad inhibitoria de PDE4, como la siguiente: (A) naftaleno o una estructura química análoga al mismo; o (B) 3-ciclopentiloxi-4-metoxifenilo o una estructura química análoga al mismo. La composición es útil en la soldadura de fracturas rebelde de personas mayores y pacientes diabéticos o con osteosporosis.
ARP020101912A 2001-05-23 2002-05-23 Composicion para acelerar la soldadura de una fractura osea AR033918A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2001154064 2001-05-23

Publications (1)

Publication Number Publication Date
AR033918A1 true AR033918A1 (es) 2004-01-07

Family

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Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI221838B (en) 2001-08-09 2004-10-11 Tanabe Seiyaku Co Pyrazinoisoquinoline compound or naphthalene compound
KR20080065704A (ko) 2005-11-09 2008-07-14 콤비네이토릭스, 인코포레이티드 의학적 이상의 치료 방법들, 조성물들, 및 키트들
AR057986A1 (es) * 2005-11-21 2008-01-09 Japan Tobacco Inc Compuesto heterociclico y su uso farmaceutico
US8329761B2 (en) * 2006-02-13 2012-12-11 Eastman Kodak Company Oil-in-oil emulsions
US20100034892A1 (en) 2006-08-30 2010-02-11 The Trustees Of Columbia University In The City Of New York Treatment for bone formation disorders by growth factor delivery
EP2030640B1 (en) * 2007-08-27 2012-01-25 Arthrex, Inc. Capsules for delivery of bone marrow aspirate
CA2749114C (en) * 2009-01-19 2013-12-17 Daiichi Sankyo Company, Limited Heteroatom-containing cyclic compound
US20100291027A1 (en) * 2009-05-14 2010-11-18 Jason Campbell Hyaluronic acid (ha) injection vehicle
WO2011060079A1 (en) * 2009-11-10 2011-05-19 The Trustees Of Columbia University In The City Of New York Compositions and methods for wound treatment
EP2658565A2 (en) * 2010-12-29 2013-11-06 Imperial Innovations Limited Methods for improving fracture healing and bone formation
WO2012169518A1 (ja) * 2011-06-07 2012-12-13 ホソカワミクロン株式会社 液状組成物及びそれを用いた化粧料並びに育毛剤
WO2015147043A1 (ja) * 2014-03-27 2015-10-01 小川香料株式会社 乳化組成物
CA3042009C (en) * 2016-10-28 2020-05-19 SpineThera Pharmaceutical compositions and uses thereof
KR102587602B1 (ko) 2022-12-29 2023-10-13 황만기 골절 회복을 촉진하는 조성물의 제조방법

Family Cites Families (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4193926A (en) * 1974-03-20 1980-03-18 Schering Aktiengesellschaft 4-(Polyalkoxy phenyl)-2-pyrrolidones
JPS5619324A (en) 1979-07-24 1981-02-24 Asahi Electronics Wheel passage type anchoring clamp
US4542025A (en) * 1982-07-29 1985-09-17 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
JPS6067417A (ja) 1983-09-24 1985-04-17 Tetsuo Kato 生体内代謝性マイクロカプセルの製法
JPS60100516A (ja) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
GB8406906D0 (en) 1984-03-16 1984-04-18 Akzo Nv Benzo-thiazole and benzothiophene derivatives
DK159431C (da) 1984-05-10 1991-03-18 Byk Gulden Lomberg Chem Fab 6-phenyl-3(2h)-pyridazinoner, fremgangsmaade til fremstilling deraf, laegemidler indeholdende disse samt anvendelse af forbindelserne til fremstilling af laegemidler
JPH0720859B2 (ja) 1985-02-07 1995-03-08 武田薬品工業株式会社 マイクロカプセルの製造法
US4962091A (en) * 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
US5939388A (en) * 1986-07-01 1999-08-17 Rosen; Vicki A. Methods of administering BMP-5 compositions
ATE63553T1 (de) 1986-08-21 1991-06-15 Pfizer Chinazolindione und pyridopyrimidindione.
JPH0725689B2 (ja) 1986-10-07 1995-03-22 中外製薬株式会社 顆粒球コロニ−刺激因子を含有する徐放性製剤
US5000886A (en) * 1987-05-26 1991-03-19 American Cyanamid Company Silicone-hardened pharmaceutical microcapsules and process of making the same
DE3738228A1 (de) 1987-11-11 1989-05-24 Hoechst Ag Verfahren zur herstellung von bioabbaubaren mikrokapseln wasserloeslicher peptide und proteine sowie nach diesem verfahren erhaltene mikrokapseln
JPH01305929A (ja) 1988-06-02 1989-12-11 Toshiba Corp Ｘ線診断装置
WO1990009783A1 (en) 1989-02-22 1990-09-07 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors
GB8913889D0 (en) 1989-06-16 1989-08-02 May & Baker Ltd New compositions of matter
WO1991001720A1 (en) 1989-08-07 1991-02-21 Herman Wade Schlameus Composition and method of promoting hard tissue healing
JP2578001B2 (ja) 1989-12-11 1997-02-05 明治製菓株式会社 抗痴呆薬
GB8929208D0 (en) * 1989-12-27 1990-02-28 Almirall Lab New xanthine derivatives
DK0482208T3 (da) 1990-04-25 2000-09-18 Nissan Chemical Ind Ltd Pyridazinonderivat
US5288496A (en) * 1990-05-15 1994-02-22 Stolle Research & Development Corporation Growth promoters for animals
ATE203020T1 (de) 1990-05-30 2001-07-15 Takeda Chemical Industries Ltd Schwefel enthaltende heterocyclische verbindungen
ES2094772T3 (es) 1990-06-01 1997-02-01 Kyowa Hakko Kogyo Kk Derivados de imidazonaftiridinas.
IE71647B1 (en) 1991-01-28 1997-02-26 Rhone Poulenc Rorer Ltd Benzamide derivatives
US5171217A (en) * 1991-02-28 1992-12-15 Indiana University Foundation Method for delivery of smooth muscle cell inhibitors
YU48420B (sh) 1991-03-25 1998-07-10 Hoechst Aktiengesellschaft Postupak za dobijanje biološki razgradljivih mikročestica sa dugotrajnim delovanjem
JPH0558882A (ja) 1991-09-04 1993-03-09 Yoshiaki Kawashima ナノカプセルの製造法
JP3205884B2 (ja) 1991-10-01 2001-09-04 武田薬品工業株式会社 凝集防止剤をコーティングした徐放性微粒子製剤
PH31245A (en) 1991-10-30 1998-06-18 Janssen Pharmaceutica Nv 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5291490A (en) * 1992-02-18 1994-03-01 At&T Bell Laboratories Node for a communication network
JP3042156B2 (ja) * 1992-02-20 2000-05-15 田辺製薬株式会社 ナフタレン誘導体、その製法及びその合成中間体
EP0633776B1 (en) * 1992-04-02 2001-05-09 Smithkline Beecham Corporation Compounds useful for treating allergic and inflammatory diseases
US5214008A (en) * 1992-04-17 1993-05-25 Guardian Industries Corp. High visible, low UV and low IR transmittance green glass composition
DE4223169C1 (de) * 1992-07-10 1993-11-25 Ferring Arzneimittel Gmbh Verfahren zur Mikroverkapselung wasserlöslicher Wirkstoffe
JP2651320B2 (ja) 1992-07-16 1997-09-10 田辺製薬株式会社 徐放性マイクロスフェア製剤の製造方法
PL307265A1 (en) * 1992-07-28 1995-05-15 Rhone Poulenc Rorer Ltd Compounds containing a phenyl group bonded with aryl or heteroaryl group through their bonding aliphatic group or that containing heteroatom
JP2911732B2 (ja) 1992-10-01 1999-06-23 田辺製薬株式会社 徐放性多核マイクロスフェア製剤およびその製法
US5455252A (en) 1993-03-31 1995-10-03 Syntex (U.S.A.) Inc. Optionally substituted 6,8-quinolines
JPH06305983A (ja) 1993-04-21 1994-11-01 Sangi Co Ltd 薬剤徐放用製剤
US5459151A (en) 1993-04-30 1995-10-17 American Home Products Corporation N-acyl substituted phenyl piperidines as bronchodilators and antiinflammatory agents
GB9309324D0 (en) 1993-05-06 1993-06-16 Bayer Ag Venzofuranyl-and-thiophenyl-alkanecarboxyclic acids derivatives
GB9312853D0 (en) * 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5605914A (en) * 1993-07-02 1997-02-25 Celgene Corporation Imides
DE69430747T2 (de) * 1993-07-28 2003-03-06 Aventis Pharma Ltd., West Malling Verbindungen als pde iv und tnf inhibitoren
JPH07101861A (ja) * 1993-08-10 1995-04-18 Tanabe Seiyaku Co Ltd 抗喘息薬
US5665754A (en) * 1993-09-20 1997-09-09 Glaxo Wellcome Inc. Substituted pyrrolidines
NZ274244A (en) * 1993-11-26 1997-09-22 Pfizer Isoxazoline derivatives and medicaments
US5502072A (en) * 1993-11-26 1996-03-26 Pfizer Inc. Substituted oxindoles
GB9401460D0 (en) * 1994-01-26 1994-03-23 Rhone Poulenc Rorer Ltd Compositions of matter
GB9412383D0 (en) 1994-06-21 1994-08-10 Celltech Ltd Chemical compound
GB9412672D0 (en) 1994-06-23 1994-08-10 Celltech Ltd Chemical compounds
WO1996000218A1 (en) 1994-06-24 1996-01-04 Euro-Celtique, S.A. Compounds for and method of inhibiting phosphodiesterase iv
CN1043993C (zh) 1994-08-29 1999-07-07 山之内制药株式会社 萘啶衍生物及其医药组合物
JP3790567B2 (ja) 1994-09-30 2006-06-28 武田薬品工業株式会社 徐放剤
US5614515A (en) * 1994-11-17 1997-03-25 University Of Southern California Lazaroid-based compositions and method for preventing adhesion formation using the same
WO1996020698A2 (en) 1995-01-05 1996-07-11 The Board Of Regents Acting For And On Behalf Of The University Of Michigan Surface-modified nanoparticles and method of making and using same
EP0814778B1 (de) * 1995-03-10 2001-06-13 Roche Diagnostics GmbH Polypeptid-enthaltende pharmazeutische darreichungsformen in form von mikropartikeln und verfahren zu deren herstellung
TW332201B (en) * 1995-04-06 1998-05-21 Janssen Pharmaceutica Nv 1,3-Dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatives
DE19514568A1 (de) * 1995-04-20 1996-10-24 Merck Patent Gmbh Arylalkyl-pyridazinone
US5922253A (en) * 1995-05-18 1999-07-13 Alkermes Controlled Therapeutics, Inc. Production scale method of forming microparticles
US5910492A (en) * 1995-06-05 1999-06-08 Takeda Chemical Industries, Ltd. Osteogenic promoting pharmaceutical composition
JP2992677B2 (ja) 1995-06-05 1999-12-20 武田薬品工業株式会社 骨形成促進医薬組成物
JP3033090B2 (ja) * 1995-06-15 2000-04-17 田辺製薬株式会社 ナフタレン誘導体、その製法及びその合成中間体
IL118469A (en) * 1995-06-15 2000-08-13 Tanabe Seiyaku Co Naphthalene derivatives their preparation and intermediates thereof
US5728844A (en) * 1995-08-29 1998-03-17 Celgene Corporation Immunotherapeutic agents
US5942253A (en) * 1995-10-12 1999-08-24 Immunex Corporation Prolonged release of GM-CSF
JPH09110678A (ja) 1995-10-19 1997-04-28 Tanabe Seiyaku Co Ltd 被覆マイクロスフェア製剤およびその製法
GB9523267D0 (en) 1995-11-14 1996-01-17 Sandoz Ltd Organic compounds
JP3765338B2 (ja) 1995-12-15 2006-04-12 武田薬品工業株式会社 注射用徐放性製剤の製造法
EP0873311A1 (en) * 1995-12-15 1998-10-28 Merck Frosst Canada Inc. Tri-aryl ethane derivatives as pde iv inhibitors
JP3191004B2 (ja) 1995-12-15 2001-07-23 武田薬品工業株式会社 マイクロスフェアの製造法
GB9603723D0 (en) 1996-02-22 1996-04-24 Merck & Co Inc Diphenyl pyridyl derivatives as pde iv inhibitors
CA2192773C (en) * 1995-12-15 2008-09-23 Hiroaki Okada Production of sustained-release preparation for injection
JPH09169665A (ja) * 1995-12-21 1997-06-30 Kenichi Miyamoto 骨粗鬆症治療剤
GB9526325D0 (en) 1995-12-22 1996-02-21 Bp Exploration Operating Inhibitors
US6010711A (en) * 1996-01-26 2000-01-04 University Of Rochester Methods, articles and compositions for the pharmacologic inhibition of bone resorption with phosphodiesterase inhibitors
GB9606736D0 (en) 1996-02-19 1996-06-05 Shire International Licensing Therapeutic method
DE19617864A1 (de) 1996-04-23 1997-10-30 Schering Ag Neue chirale Phenyldihydrofuranone
DE69738949D1 (de) * 1996-05-20 2008-10-09 Darwin Discovery Ltd Chinolincarboxamide als tnf-inhibitoren und als pde-iv inhibitoren
CA2252501A1 (en) * 1996-05-20 1997-11-27 Darwin Discovery Limited Quinoline sulfonamides as tnf inhibitors and as pde-iv inhibitors
AU3724497A (en) * 1996-07-12 1998-02-09 Lava, Inc. Digital video system having a data base of coded data for digital audio and ideo information
KR100338610B1 (ko) * 1996-09-04 2002-05-27 디. 제이. 우드, 스피겔 알렌 제이 인다졸 유도체 및 포스포디에스터라제 (pde) 유형 iv 및 종양괴사인자 (tnf) 생산의 억제제로서 그의 용도
JP4354016B2 (ja) * 1996-11-29 2009-10-28 株式会社メディサイエンスプラニング 新規プリン誘導体およびこれを含む医薬組成物
ID19155A (id) * 1996-12-13 1998-06-18 Tanabe Seiyaku Co Turunan-turunan piridin, pembuatannya dan intermediet untuk pembuatannya
JP3951395B2 (ja) 1996-12-13 2007-08-01 田辺製薬株式会社 ピリジン誘導体、その製法及びその合成中間体
US6214008B1 (en) 1997-04-16 2001-04-10 White Spot Ag Biodegradable osteosynthesis implant
FR2762841B1 (fr) * 1997-04-30 1999-07-02 Jouveinal Inst Rech Diazepino-indolones inhibitrices de phosphodiesterases iv
FR2764514B1 (fr) * 1997-06-13 1999-09-03 Biopharmex Holding Sa Implant injectable en sous-cutane ou intradermique a bioresorbabilite controlee pour la chirurgie reparatrice ou plastique et la dermatologie esthetique
US6124314A (en) * 1997-10-10 2000-09-26 Pfizer Inc. Osteoporosis compounds
TW577758B (en) * 1997-10-27 2004-03-01 Ssp Co Ltd Intra-articular preparation for the treatment of arthropathy
JP3240593B2 (ja) 1998-02-16 2001-12-17 株式会社高研 可溶性コラーゲンパウダーを担体とする医薬徐放剤
US6451335B1 (en) * 1998-07-02 2002-09-17 Euro-Celtique S.A. Formulations and methods for providing prolonged local anesthesia
AR028986A1 (es) * 1999-02-23 2003-06-04 Smithkline Beecham Corp USO DE UN INHIBIDOR DE PDE4 EN LA FABRICACIoN DE UNA PREPARACIoN DE LIBERACIoN CONTROLADA; FORMULACION DE LIBERACION CONTROLADA PARA EL TRATAMIENTO DE COPD, UN PROCEDIMIENTO PARA SU PREPARACIoN Y COMPOSICIoN FARMACÉUTICA
FR2792938B1 (fr) * 1999-04-28 2001-07-06 Warner Lambert Co NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV
FR2793684B1 (fr) * 1999-05-17 2001-08-10 Ethypharm Lab Prod Ethiques Utilisation de microspheres biodegradables liberant un agent anticancereux pour le traitement du glioblastome, procede de preparation de ces microspheres et suspension les contenant
SK287231B6 (sk) * 1999-08-21 2010-04-07 Nycomed Gmbh Liečivo zahŕňajúce PDE inhibítor a agonistu beta2 adrenoreceptora
CA2394222A1 (en) 1999-12-22 2001-06-28 Pharmacia Corporation Sustained-release formulation of a cyclooxygenase-2 inhibitor
US6348602B1 (en) * 1999-12-23 2002-02-19 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
JP3718708B2 (ja) 2000-01-19 2005-11-24 独立行政法人物質・材料研究機構 リン酸カルシウム系生体用セラミック焼結体およびその製造方法
CA2398561A1 (en) * 2000-01-27 2001-08-02 American Cyanamid Company Method for preparing alpha-sulfonyl hydroxamic acid derivatives
ATE269860T1 (de) * 2000-01-31 2004-07-15 Pfizer Prod Inc Pyrimidinylcarboxamiden als inhibitoren der pde4 isoenzyme
GB0008660D0 (en) 2000-04-07 2000-05-31 Arakis Ltd The treatment of respiratory diseases
AU2001248825A1 (en) 2000-04-24 2001-11-07 Tanabe Seiyaku Co., Ltd. Process for producing microsphere
CN1190454C (zh) 2000-04-28 2005-02-23 田边制药株式会社 用于制备微球的方法
EP1289557B1 (en) * 2000-06-06 2006-07-12 Glaxo Group Limited Cancer treatment composition containing an anti-neoplastic agent and a pde4 inhibitor
AU2001277738B2 (en) * 2000-08-11 2006-10-05 Ono Pharmaceutical Co., Ltd. Piperidine derivatives and drugs containing these derivatives as the active ingredient
DE10061137B4 (de) * 2000-12-07 2016-10-06 Takeda Gmbh Neue pharmazeutische Zubereitung
NZ526453A (en) * 2001-01-31 2005-01-28 Pfizer Prod Inc Nicotinamide biaryl derivatives useful as inhibitors of PDE4 isozymes
OA12542A (en) * 2001-01-31 2006-06-05 Pfizer Prod Inc Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of PDE4isozymes.
JP4364179B2 (ja) 2005-08-15 2009-11-11 株式会社ソニー・コンピュータエンタテインメント 描画処理装置および描画処理方法

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US20040146561A1 (en) 2004-07-29
WO2002094321A1 (en) 2002-11-28
KR20040007596A (ko) 2004-01-24
EP1389468A4 (en) 2007-01-10
JPWO2002094321A1 (ja) 2004-09-02
US7659273B2 (en) 2010-02-09
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US20080031958A1 (en) 2008-02-07

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