AR032185A1 - Complejos de cis-platino, utiles como agentes antitumorales, y las composiciones farmaceuticas que los contienen - Google Patents
Complejos de cis-platino, utiles como agentes antitumorales, y las composiciones farmaceuticas que los contienenInfo
- Publication number
- AR032185A1 AR032185A1 ARP010104672A ARP010104672A AR032185A1 AR 032185 A1 AR032185 A1 AR 032185A1 AR P010104672 A ARP010104672 A AR P010104672A AR P010104672 A ARP010104672 A AR P010104672A AR 032185 A1 AR032185 A1 AR 032185A1
- Authority
- AR
- Argentina
- Prior art keywords
- pharmaceutical compositions
- compositions containing
- functional group
- complexes
- platino
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000000524 functional group Chemical group 0.000 abstract 3
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 150000003057 platinum Chemical class 0.000 abstract 2
- 229910052697 platinum Inorganic materials 0.000 abstract 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical group NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 229940041181 antineoplastic drug Drugs 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- -1 carbonate ester Chemical group 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical group OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Fármacos antitumorales de platino, en particular, complejos de platino que poseen la formula (1) o (2) y sus sales aceptables desde el punto de vista farmacéutico, en los cuales, cada A es independientemente un anion; cada B es independientemente halo, hidroxi, carboxilato, carbamato o éster carbonato; Z es un grupo funcional heterocíclico sustituido de 5- o 6- miembros en el cual, el grupo funcional sustituido además comprende un sustituyente que impide estéricamente el acceso del átomo de Pt a una cadena de ADN de una célula tumoral mediante un nivel mensurable más que un grupo funcional heterocíclico no sustituido con la misma estructura cuando se evalua en las mismas condiciones, y donde Z es otro que piridina; y X es NH3, o bien, NH3 sustituido por mono- o dialquilo. También se describen las composiciones farmacéuticas que contienen dichos complejos de platino.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/678,595 US6894049B1 (en) | 2000-10-04 | 2000-10-04 | Platinum complexes as antitumor agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR032185A1 true AR032185A1 (es) | 2003-10-29 |
Family
ID=24723449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010104672A AR032185A1 (es) | 2000-10-04 | 2001-10-03 | Complejos de cis-platino, utiles como agentes antitumorales, y las composiciones farmaceuticas que los contienen |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6894049B1 (es) |
| EP (1) | EP1322654B1 (es) |
| JP (1) | JP2004510778A (es) |
| KR (1) | KR100864596B1 (es) |
| AR (1) | AR032185A1 (es) |
| AT (1) | ATE417855T1 (es) |
| AU (1) | AU2001294969A1 (es) |
| DE (1) | DE60137061D1 (es) |
| DK (1) | DK1322654T3 (es) |
| ES (1) | ES2319258T3 (es) |
| PT (1) | PT1322654E (es) |
| SI (1) | SI1322654T1 (es) |
| WO (1) | WO2002028871A1 (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0011903D0 (en) * | 2000-05-18 | 2000-07-05 | Astrazeneca Ab | Combination chemotherapy |
| DK1720540T3 (da) | 2004-02-18 | 2008-10-06 | Gpc Biotech Ag | Satraplatin til behandling af resistente tumorer eller tumorer, der er vanskelige at behandle |
| CZ296459B6 (cs) * | 2004-09-14 | 2006-03-15 | Pliva-Lachema A. S. | Perorální farmaceutická kompozice pro cílený transport komplexu platiny do kolorektální oblasti, zpusob její prípravy a tato kompozice pro pouzití jako lécivo |
| EP1896491B1 (en) * | 2005-06-30 | 2010-11-17 | Bionumerik Pharmaceuticals, Inc. | Monoazole ligand platinum analogs |
| ES2401441T3 (es) * | 2005-06-30 | 2013-04-19 | Bionumerik Pharmaceuticals, Inc. | Análogos de platino con ligandos de monoimina |
| US8324197B2 (en) * | 2005-08-11 | 2012-12-04 | Virginia Commonwealth University | Transplatinum complexes with N2O2 donor sets as cytotoxic and antitumor agents |
| US8168661B2 (en) * | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8173686B2 (en) | 2006-11-06 | 2012-05-08 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8168662B1 (en) | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8178564B2 (en) * | 2006-11-06 | 2012-05-15 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| BRPI0806362A2 (pt) * | 2007-02-09 | 2011-09-06 | Poniard Pharmaceuticals Inc | formas de dosagem unitária para picoplatina, processo para preparar uma forma de dosagem unitária encapsulada para picoplatina, métodos de tratamentos do cáncer e kit |
| US20110033528A1 (en) * | 2009-08-05 | 2011-02-10 | Poniard Pharmaceuticals, Inc. | Stabilized picoplatin oral dosage form |
| EP2171470A2 (en) * | 2007-06-04 | 2010-04-07 | Diagnoplex | Biomarker combinations for colorectal cancer |
| US20100260832A1 (en) * | 2007-06-27 | 2010-10-14 | Poniard Pharmaceuticals, Inc. | Combination therapy for ovarian cancer |
| TW200916094A (en) * | 2007-06-27 | 2009-04-16 | Poniard Pharmaceuticals Inc | Stabilized picoplatin dosage form |
| CN101809024A (zh) * | 2007-07-16 | 2010-08-18 | 铂雅制药公司 | 吡铂的口服制剂 |
| CN102006875A (zh) * | 2008-02-08 | 2011-04-06 | 帕纳德制药公司 | 吡铂和贝伐单抗治疗结直肠癌的用途 |
| CZ306396B6 (cs) * | 2014-12-16 | 2017-01-04 | Vuab Pharma A.S. | Rozpustný platnatý komplex s pyridinkarboxamidinovým ligandem a způsob jeho přípravy |
| WO2022217255A1 (en) * | 2021-04-07 | 2022-10-13 | Klotho Therapeutics, Inc. | Novel antitumor compounds and related methods of manufacture and use |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4329299A (en) | 1979-08-23 | 1982-05-11 | Johnson, Matthey & Co., Limited | Composition of matter containing platinum |
| US4533502A (en) | 1983-02-22 | 1985-08-06 | Rochon Fernande D | Platinum (II) compounds and their preparation |
| ATE63919T1 (de) | 1984-06-27 | 1991-06-15 | Johnson Matthey Plc | Platinkoordinationsverbindungen. |
| US4921963A (en) * | 1987-04-13 | 1990-05-01 | British Columbia Cancer Foundation | Platinum complexes with one radiosensitizing ligand |
| US5244919A (en) | 1988-02-02 | 1993-09-14 | Johnson Matthey, Inc. | Pt(IV) complexes as anti-tumor agents |
| GB9105037D0 (en) | 1991-03-09 | 1991-04-24 | Johnson Matthey Plc | Improvements in chemical compounds |
| US5624919A (en) * | 1993-09-14 | 1997-04-29 | The University Of Vermont And State Agricultural College | Trans platinum (IV) complexes |
| GB9502799D0 (en) | 1995-02-14 | 1995-04-05 | Johnson Matthey Plc | Improvements in platinum complexes |
| US5547982A (en) | 1995-02-27 | 1996-08-20 | Johnson Matthey, Inc. | Anti-tumor platinum complexes |
| MXPA01009410A (es) | 1999-03-19 | 2003-06-06 | Anormed Inc | Composiciones farmaceuticas que comprenden complejos de metal. |
| SK286374B6 (sk) | 1999-04-13 | 2008-08-05 | Anormed Inc. | Spôsob prípravy cis-komplexu platiny a cis-komplex platiny |
-
2000
- 2000-10-04 US US09/678,595 patent/US6894049B1/en not_active Expired - Lifetime
-
2001
- 2001-10-02 EP EP01975671A patent/EP1322654B1/en not_active Expired - Lifetime
- 2001-10-02 WO PCT/US2001/030838 patent/WO2002028871A1/en not_active Ceased
- 2001-10-02 KR KR1020037004780A patent/KR100864596B1/ko not_active Expired - Fee Related
- 2001-10-02 DE DE60137061T patent/DE60137061D1/de not_active Expired - Lifetime
- 2001-10-02 PT PT01975671T patent/PT1322654E/pt unknown
- 2001-10-02 DK DK01975671T patent/DK1322654T3/da active
- 2001-10-02 AT AT01975671T patent/ATE417855T1/de active
- 2001-10-02 ES ES01975671T patent/ES2319258T3/es not_active Expired - Lifetime
- 2001-10-02 SI SI200130906T patent/SI1322654T1/sl unknown
- 2001-10-02 AU AU2001294969A patent/AU2001294969A1/en not_active Abandoned
- 2001-10-02 JP JP2002532453A patent/JP2004510778A/ja not_active Withdrawn
- 2001-10-03 AR ARP010104672A patent/AR032185A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE417855T1 (de) | 2009-01-15 |
| ES2319258T3 (es) | 2009-05-06 |
| DK1322654T3 (da) | 2009-04-14 |
| KR100864596B1 (ko) | 2008-10-22 |
| AU2001294969A1 (en) | 2002-04-15 |
| EP1322654A1 (en) | 2003-07-02 |
| DE60137061D1 (de) | 2009-01-29 |
| WO2002028871A1 (en) | 2002-04-11 |
| PT1322654E (pt) | 2009-03-20 |
| JP2004510778A (ja) | 2004-04-08 |
| SI1322654T1 (sl) | 2009-06-30 |
| KR20030059174A (ko) | 2003-07-07 |
| US6894049B1 (en) | 2005-05-17 |
| EP1322654B1 (en) | 2008-12-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |