AR031830A1 - Uso de un compuesto benzotiazinona o benzoxazinona para preparar una composicion farmaceutica, compuesto de benzotiazinona o benzoxazinona y composicion farmaceutica que lo comprende - Google Patents
Uso de un compuesto benzotiazinona o benzoxazinona para preparar una composicion farmaceutica, compuesto de benzotiazinona o benzoxazinona y composicion farmaceutica que lo comprendeInfo
- Publication number
- AR031830A1 AR031830A1 ARP000102783A ARP000102783A AR031830A1 AR 031830 A1 AR031830 A1 AR 031830A1 AR P000102783 A ARP000102783 A AR P000102783A AR P000102783 A ARP000102783 A AR P000102783A AR 031830 A1 AR031830 A1 AR 031830A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- unsubstituted
- aralkyl
- benzoxazinone
- pharmaceutical composition
- Prior art date
Links
- -1 BENZOXAZINONE COMPOUND Chemical class 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 4
- HQQTZCPKNZVLFF-UHFFFAOYSA-N 4h-1,2-benzoxazin-3-one Chemical compound C1=CC=C2ONC(=O)CC2=C1 HQQTZCPKNZVLFF-UHFFFAOYSA-N 0.000 title abstract 2
- 239000002131 composite material Substances 0.000 title 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 230000000694 effects Effects 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- MZAGXDHQGXUDDX-JSRXJHBZSA-N (e,2z)-4-ethyl-2-hydroxyimino-5-nitrohex-3-enamide Chemical compound [O-][N+](=O)C(C)C(/CC)=C/C(=N/O)/C(N)=O MZAGXDHQGXUDDX-JSRXJHBZSA-N 0.000 abstract 2
- MJNPHLBKHKJDEF-UHFFFAOYSA-N 2h-1$l^{4},2-benzothiazine 1-oxide Chemical compound C1=CC=C2S(=O)NC=CC2=C1 MJNPHLBKHKJDEF-UHFFFAOYSA-N 0.000 abstract 2
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 2
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 102000009516 Protein Serine-Threonine Kinases Human genes 0.000 abstract 1
- 108010009341 Protein Serine-Threonine Kinases Proteins 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 230000002491 angiogenic effect Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 210000002889 endothelial cell Anatomy 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
Los compuestos de benzotiazionona y benzoxazinona, son inhibidores de actividad de quinasa serina/treonina y tirosina. Varias de las quinasas tirosina, cuya actividad es inhibida por estos compuestos químicos, están involucrados en procesos angiogénicos. Así, estos compuestos químicos pueden mejorar estados de enfermedad donde es un factor la angiogénesis o hiperproliferacion celular endotelial. Estos compuestos pueden usarse para tratar cáncer y desordenes hiperproliferativos. Uso de un compuesto benzotiazinona o benzoxazinona representado por la formula (1) y sales fisiologicamente aceptables del mismo, para preparar una composicion farmacéutica util para inhibir la actividad de proteína quinasa, en donde: el anillo A es sustituido o insustituido, Q es -N= o -CR2=; X es S, O, o NOR3; Y es -O-, -S-, -SO- o -SO2; R y R1 son cada uno, independientemente, hidrogeno o un grupo aralquilo o alifático o aromático, sustituido o no sustituido; R2 es H o un sustituyente; R3 es H o -C(O)R4; R4 es un grupo aralquilo o alifático o aromático, sustituido o no sustituido; y n es un entero de valor 0 a 1. Un compuesto benzotiazinona o benzoxazinona que está representado por la formula estructural (2) y sales fisiologicamente aceptables del mismo, en donde: el anillo A, Q, X, Y, R, R1, R2 y R3 son como se describieron antes, y R4 es un grupo aromático o alifático sustituido o no sustituido; n es de valor 0 o 1; Cuando X es S o NOR3, R es un grupo aralquilo aromático sustituido o no sustituido y R1 es hidrogeno o un grupo alifático sustituido o no sustituido; Cuando X es O y n es 0, R1 es hidrogeno o un grupo alifático sustituido o no sustituido y R es un grupo aralquilo o aromático sustituido o no sustituido, con la condicion que R no sea ninguno de tiofenilo, benzoxadiazolilo, 3-furanilo. 3-piridinilo o de formula (3) donde R14 es como se describe en la memoria y cuando X es O y n es 1, R1 es H o un grupo alifático sustituido o no sustituido y R es un grupo aralquilo o aromático sustituido o no sustituido, con la condicion que R no sea de formula (4) donde R15 es como se describe en la memoria. Una composicion farmacéutica que comprende el compuesto descripto o una sal fisiologicamente aceptable del mismo y un diluyente o vehículo farmacéuticamente aceptable.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13741099P | 1999-06-03 | 1999-06-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR031830A1 true AR031830A1 (es) | 2003-10-08 |
Family
ID=22477310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000102783A AR031830A1 (es) | 1999-06-03 | 2000-06-05 | Uso de un compuesto benzotiazinona o benzoxazinona para preparar una composicion farmaceutica, compuesto de benzotiazinona o benzoxazinona y composicion farmaceutica que lo comprende |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7049312B1 (es) |
| EP (1) | EP1181282A2 (es) |
| JP (1) | JP2003501429A (es) |
| KR (1) | KR20020062808A (es) |
| CN (1) | CN1636005A (es) |
| AR (1) | AR031830A1 (es) |
| AU (1) | AU5179000A (es) |
| BG (1) | BG106238A (es) |
| BR (1) | BR0011063A (es) |
| CA (1) | CA2375734A1 (es) |
| CZ (1) | CZ20014244A3 (es) |
| HK (1) | HK1046402A1 (es) |
| IL (1) | IL146474A0 (es) |
| MX (1) | MXPA01012442A (es) |
| NO (1) | NO20015899L (es) |
| PL (1) | PL352680A1 (es) |
| WO (1) | WO2000075139A2 (es) |
| ZA (1) | ZA200109610B (es) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6951855B2 (en) * | 2001-04-23 | 2005-10-04 | Astrazeneca Ab | Benzoxazinone derivatives for use in the treatment of angiogenesis |
| CA2454080A1 (en) | 2001-08-13 | 2003-02-27 | Robert Edward Detlefsen | Ultraviolet light absorbers |
| BR0309758A (pt) * | 2002-05-03 | 2005-02-15 | Schering Ag | Tiazolidinonas e seu uso como inibidortes de cinase semelhante a polo |
| AR045037A1 (es) | 2003-07-10 | 2005-10-12 | Aventis Pharma Sa | Tetrahidro-1h-pirazolo [3,4-c] piridinas sustituidas, composiciones que las contienen y su utilizacion. |
| SI1696920T1 (sl) | 2003-12-19 | 2015-02-27 | Plexxikon Inc. | Spojine in postopki za razvoj modulatorjev ret |
| US7498342B2 (en) | 2004-06-17 | 2009-03-03 | Plexxikon, Inc. | Compounds modulating c-kit activity |
| EP1831225A2 (en) * | 2004-11-19 | 2007-09-12 | The Regents of the University of California | Anti-inflammatory pyrazolopyrimidines |
| PT1843771E (pt) * | 2005-01-28 | 2011-12-02 | Novartis Ag | Uso de pirimidilaminobenzamidas para o tratamento de doenças que respondem à modulação da atividade da cinase tie-2 |
| US10296720B2 (en) | 2005-11-30 | 2019-05-21 | Gearbox Llc | Computational systems and methods related to nutraceuticals |
| US7827042B2 (en) | 2005-11-30 | 2010-11-02 | The Invention Science Fund I, Inc | Methods and systems related to transmission of nutraceutical associated information |
| US8297028B2 (en) | 2006-06-14 | 2012-10-30 | The Invention Science Fund I, Llc | Individualized pharmaceutical selection and packaging |
| US20080210748A1 (en) * | 2005-11-30 | 2008-09-04 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware, | Systems and methods for receiving pathogen related information and responding |
| US8000981B2 (en) | 2005-11-30 | 2011-08-16 | The Invention Science Fund I, Llc | Methods and systems related to receiving nutraceutical associated information |
| US7974856B2 (en) | 2005-11-30 | 2011-07-05 | The Invention Science Fund I, Llc | Computational systems and methods related to nutraceuticals |
| US8340944B2 (en) | 2005-11-30 | 2012-12-25 | The Invention Science Fund I, Llc | Computational and/or control systems and methods related to nutraceutical agent selection and dosing |
| US7927787B2 (en) | 2006-06-28 | 2011-04-19 | The Invention Science Fund I, Llc | Methods and systems for analysis of nutraceutical associated components |
| KR20130087054A (ko) | 2006-04-04 | 2013-08-05 | 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 | 키나제 길항물질 |
| BRPI0711358A2 (pt) | 2006-05-09 | 2011-09-27 | Pfizer Prod Inc | derivados do ácido cicloalquilamino e suas composições farmacêuticas |
| WO2008053863A1 (en) * | 2006-10-30 | 2008-05-08 | Santen Pharmaceutical Co., Ltd. | Novel compound having 1,4-benzothiazin-3-one skeleton or 3,4-dihydroquinolin-2-one skeleton |
| WO2008053861A1 (en) * | 2006-10-30 | 2008-05-08 | Santen Pharmaceutical Co., Ltd. | Novel compound having 1,4-benzoxazin-3-one skeleton |
| WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| FR2913019A1 (fr) * | 2007-02-23 | 2008-08-29 | Cerep Sa | Composes heterocycliques comme agents anti-neoplasiques ou inhibiteurs de proliferation cellulaire |
| MX2010000617A (es) | 2007-07-17 | 2010-05-17 | Plexxikon Inc | Compuestos y metodos para modulacion de cinasa, e indicaciones de estos. |
| WO2009046448A1 (en) | 2007-10-04 | 2009-04-09 | Intellikine, Inc. | Chemical entities and therapeutic uses thereof |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| JP5869222B2 (ja) | 2008-01-04 | 2016-02-24 | インテリカイン， エルエルシー | 特定の化学的実体、組成物および方法 |
| US8993580B2 (en) | 2008-03-14 | 2015-03-31 | Intellikine Llc | Benzothiazole kinase inhibitors and methods of use |
| WO2009114870A2 (en) * | 2008-03-14 | 2009-09-17 | Intellikine, Inc. | Kinase inhibitors and methods of use |
| CA2728016C (en) * | 2008-06-24 | 2017-02-28 | F. Hoffmann-La Roche Ag | Novel substituted pyridin-2-ones and pyridazin-3-ones |
| WO2010006072A2 (en) | 2008-07-08 | 2010-01-14 | The Regents Of The University Of California | Mtor modulators and uses thereof |
| BRPI0915231A2 (pt) * | 2008-07-08 | 2018-06-12 | Intellikine Inc | compostos inibidores de quinase e métodos de uso |
| CA2734305A1 (en) * | 2008-08-15 | 2010-02-18 | Board Of Regents, The University Of Texas System | 1,4-benzoxazine compounds and derivatives thereof as therapeutic drugs for the treatment of neurodegenerative conditions |
| CA2738429C (en) | 2008-09-26 | 2016-10-25 | Intellikine, Inc. | Heterocyclic kinase inhibitors |
| JP5819195B2 (ja) | 2008-10-16 | 2015-11-18 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 融合環ヘテロアリールキナーゼ阻害剤 |
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| US3635956A (en) | 1968-03-01 | 1972-01-18 | Squibb & Sons Inc | Benzothiazines related compounds derivatives and salts thereof |
| DE2051474A1 (de) * | 1969-10-28 | 1971-05-06 | ER Squibb & Sons Ine , New York, N Y (V St A ) | Heterocyclische Verbindungen, ihre Salze, Verfahren zu ihrer Herstellung und ihre Verwendung |
| US3812114A (en) | 1971-09-29 | 1974-05-21 | Squibb & Sons Inc | Benzothiazines |
| US3865818A (en) * | 1973-10-24 | 1975-02-11 | Squibb & Sons Inc | Substituted benzoxazines |
| US3923709A (en) | 1974-08-30 | 1975-12-02 | Monsanto Co | 3,4-Dihydro-3-oxo-2H-1,4-benzothiazines and benzoxazines |
| JPS6072875A (ja) * | 1983-09-28 | 1985-04-24 | Hamari Yakuhin Kogyo Kk | １，５−ベンゾチアゼピン誘導体およびその製造法 |
| US4490292A (en) * | 1983-10-07 | 1984-12-25 | Hamari Chemicals, Ltd. | 1,5-Benzothiazepine derivatives and production thereof |
| JPS61229874A (ja) * | 1985-04-03 | 1986-10-14 | Toubishi Yakuhin Kogyo Kk | ベンゾチアジン誘導体の製造方法 |
| WO1994005647A1 (fr) * | 1992-08-31 | 1994-03-17 | Santen Pharmaceutical Co., Ltd. | Derive de 3-oxo-1,4-benzothiazine |
| WO1995013269A1 (en) * | 1993-11-12 | 1995-05-18 | Santen Pharmaceutical Co., Ltd. | 1,4-benzothiazine derivative |
-
2000
- 2000-06-02 EP EP00936476A patent/EP1181282A2/en not_active Withdrawn
- 2000-06-02 BR BR0011063-9A patent/BR0011063A/pt not_active Application Discontinuation
- 2000-06-02 WO PCT/US2000/015324 patent/WO2000075139A2/en not_active Ceased
- 2000-06-02 KR KR1020017015588A patent/KR20020062808A/ko not_active Withdrawn
- 2000-06-02 AU AU51790/00A patent/AU5179000A/en not_active Abandoned
- 2000-06-02 HK HK02106280.4A patent/HK1046402A1/zh unknown
- 2000-06-02 CN CNA008111138A patent/CN1636005A/zh active Pending
- 2000-06-02 US US09/585,925 patent/US7049312B1/en not_active Expired - Lifetime
- 2000-06-02 CZ CZ20014244A patent/CZ20014244A3/cs unknown
- 2000-06-02 IL IL14647400A patent/IL146474A0/xx unknown
- 2000-06-02 PL PL00352680A patent/PL352680A1/xx not_active Application Discontinuation
- 2000-06-02 CA CA002375734A patent/CA2375734A1/en not_active Abandoned
- 2000-06-02 JP JP2001502421A patent/JP2003501429A/ja not_active Withdrawn
- 2000-06-02 MX MXPA01012442A patent/MXPA01012442A/es unknown
- 2000-06-05 AR ARP000102783A patent/AR031830A1/es unknown
-
2001
- 2001-11-21 ZA ZA200109610A patent/ZA200109610B/xx unknown
- 2001-12-03 NO NO20015899A patent/NO20015899L/no not_active Application Discontinuation
- 2001-12-19 BG BG106238A patent/BG106238A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ20014244A3 (cs) | 2002-07-17 |
| US7049312B1 (en) | 2006-05-23 |
| WO2000075139A2 (en) | 2000-12-14 |
| KR20020062808A (ko) | 2002-07-31 |
| WO2000075139A3 (en) | 2001-03-29 |
| NO20015899D0 (no) | 2001-12-03 |
| PL352680A1 (en) | 2003-09-08 |
| ZA200109610B (en) | 2003-04-30 |
| BG106238A (en) | 2002-08-30 |
| MXPA01012442A (es) | 2004-09-10 |
| IL146474A0 (en) | 2002-07-25 |
| JP2003501429A (ja) | 2003-01-14 |
| CA2375734A1 (en) | 2000-12-14 |
| EP1181282A2 (en) | 2002-02-27 |
| AU5179000A (en) | 2000-12-28 |
| HK1046402A1 (zh) | 2003-01-10 |
| CN1636005A (zh) | 2005-07-06 |
| BR0011063A (pt) | 2002-04-16 |
| NO20015899L (no) | 2002-01-30 |
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