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AR031074A1 - Una composicion farmaceutica que comprende un derivado de benzamida como ingrediente activo - Google Patents

Una composicion farmaceutica que comprende un derivado de benzamida como ingrediente activo

Info

Publication number
AR031074A1
AR031074A1 ARP000104212A ARP000104212A AR031074A1 AR 031074 A1 AR031074 A1 AR 031074A1 AR P000104212 A ARP000104212 A AR P000104212A AR P000104212 A ARP000104212 A AR P000104212A AR 031074 A1 AR031074 A1 AR 031074A1
Authority
AR
Argentina
Prior art keywords
benzamide derivative
pharmaceutical composition
formulations
additives
mixing
Prior art date
Application number
ARP000104212A
Other languages
English (en)
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of AR031074A1 publication Critical patent/AR031074A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Una composicion farmacéutica que comprende un derivado de benzamida representado por la formula (1) donde A representa una estructura ilustrada por cualquiera de las siguientes formulas (2) o su sal farmacéuticamente aceptable, y uno o más de un aditivo, en que uno o más aditivos es seleccionado del grupo formado por un excipiente, un desintegrante, un aglutinante, un lubricante, un agente para revestimiento y un solvente. Se pueden obtener formulaciones farmacéuticas estables mezclando un derivado de benzamida farmacéuticamente util o su sal farmacéuticamente aceptable con aditivos que no producen fácilmente productos de degradacion, mezclando una sal de ácido orgánico, un compuesto de amina, y una sustancia básica inorgánica, produciendo formulaciones solidas por medio del método de granulacion en seco, y además ajustando el pH de las formulaciones líquidas a un rango entre 4 y 12. Se pueden obtener formulaciones farmacéuticas que producen pocos productos de la degradacion y que son lo suficientemente aceptables como para ser usadas por drogas medicinales.
ARP000104212A 1999-08-16 2000-08-15 Una composicion farmaceutica que comprende un derivado de benzamida como ingrediente activo AR031074A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP22955199A JP2001064177A (ja) 1999-08-16 1999-08-16 ベンズアミド誘導体を有効成分とする製剤

Publications (1)

Publication Number Publication Date
AR031074A1 true AR031074A1 (es) 2003-09-10

Family

ID=16893948

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000104212A AR031074A1 (es) 1999-08-16 2000-08-15 Una composicion farmaceutica que comprende un derivado de benzamida como ingrediente activo

Country Status (29)

Country Link
EP (1) EP1207881B1 (es)
JP (2) JP2001064177A (es)
KR (1) KR100683876B1 (es)
CN (1) CN1205931C (es)
AR (1) AR031074A1 (es)
AU (1) AU780151B2 (es)
BG (1) BG65662B1 (es)
BR (1) BR0013283A (es)
CA (1) CA2380757C (es)
CY (1) CY1116273T1 (es)
CZ (1) CZ302924B6 (es)
DK (1) DK1207881T3 (es)
EE (1) EE05331B1 (es)
ES (1) ES2536705T3 (es)
HK (1) HK1046501B (es)
HR (1) HRP20020181B1 (es)
HU (1) HU230386B1 (es)
IL (1) IL148169A0 (es)
MX (1) MXPA02001575A (es)
NO (1) NO328957B1 (es)
NZ (1) NZ517356A (es)
PL (1) PL201388B1 (es)
PT (1) PT1207881E (es)
RU (1) RU2257206C2 (es)
SK (1) SK287547B6 (es)
TW (1) TWI245630B (es)
UA (1) UA73316C2 (es)
WO (1) WO2001012193A1 (es)
ZA (1) ZA200201466B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001081031A (ja) * 1999-08-30 2001-03-27 Schering Ag 溶解性および経口吸収性を改善したベンズアミド誘導体含有製剤
US20040034039A1 (en) * 2000-09-22 2004-02-19 Yoshinori Nakano Solid preparations
US7566535B2 (en) 2002-03-07 2009-07-28 University Of Delaware Enhanced oligonucleotide-mediated nucleic acid sequence alteration
GB0316206D0 (en) * 2003-07-10 2003-08-13 Glaxo Group Ltd Pharmaceutical formulation
WO2008123395A1 (ja) 2007-03-28 2008-10-16 Santen Pharmaceutical Co., Ltd. ヒストン脱アセチル化酵素阻害作用を有する化合物を有効成分として含有する眼圧下降剤
KR101405615B1 (ko) * 2007-08-27 2014-06-12 (주)아모레퍼시픽 조성물 내 ｐＨ 조절을 통해 안정화된 벤즈아미드 화합물을함유하는 피부 외용제 조성물, 및 그 벤즈아미드 화합물안정화 방법
NZ591387A (en) * 2008-08-29 2012-03-30 Bayer Pharma AG N-(2-aminophenyl)-4-[n-(pyridine-3-yl)-methoxycarbonyl-aminomethyl]-benzamide (ms-275) polymorph b
GB2462893B (en) * 2008-08-29 2010-10-13 Bayer Schering Pharma Ag N-(2-aminophenyl)-4-[N-(pyridine-3-yl)-methoxycarbonyl-aminomethyl]-benzamide (MS-275) polymorph B
KR102142257B1 (ko) * 2013-04-04 2020-08-07 다이이찌 산쿄 가부시키가이샤 아미노카르복실산의 염의 고형 조성물
CN107405322B (zh) 2015-03-19 2020-08-18 第一三共株式会社 含有抗氧化剂的固体制剂
JP6630344B2 (ja) 2015-03-19 2020-01-15 第一三共株式会社 着色剤を含有する固形製剤
KR102849723B1 (ko) 2018-07-30 2025-08-22 다이이찌 산쿄 가부시키가이샤 안정화제를 함유하는 의약품의 고형 제제
CN111867559A (zh) * 2019-01-25 2020-10-30 株式会社爱茉莉太平洋 含有苯甲酰胺化合物以及增溶剂的组合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU706415A1 (ru) * 1978-04-12 1979-12-30 Ташкентский Государственный Университет Им.В.И.Ленина Итаконоил анабазин в качестве дыхательного аналептика
CZ284687B6 (cs) * 1986-04-30 1999-02-17 Dainippon Pharmaceutical Co., Ltd. Substituovaný benzamidový derivát, způsob jeho výroby a farmaceutický prostředek na jeho bázi
JP3354090B2 (ja) * 1996-09-30 2002-12-09 シエーリング アクチエンゲゼルシャフト 分化誘導剤
US6174905B1 (en) * 1996-09-30 2001-01-16 Mitsui Chemicals, Inc. Cell differentiation inducer

Also Published As

Publication number Publication date
BG106516A (en) 2002-10-31
CN1205931C (zh) 2005-06-15
HUP0203226A2 (hu) 2003-01-28
EP1207881B1 (en) 2015-04-01
CA2380757C (en) 2009-01-27
KR100683876B1 (ko) 2007-02-15
CZ2002540A3 (cs) 2002-06-12
EP1207881A1 (en) 2002-05-29
EE200200073A (et) 2003-04-15
BR0013283A (pt) 2002-04-23
CN1370068A (zh) 2002-09-18
CA2380757A1 (en) 2001-02-22
ZA200201466B (en) 2002-09-02
NZ517356A (en) 2003-07-25
HRP20020181B1 (hr) 2016-01-29
UA73316C2 (uk) 2005-07-15
JP4854158B2 (ja) 2012-01-18
WO2001012193A1 (en) 2001-02-22
JP2003507330A (ja) 2003-02-25
HUP0203226A3 (en) 2003-12-29
AU6442700A (en) 2001-03-13
ES2536705T3 (es) 2015-05-27
NO20020774D0 (no) 2002-02-15
HK1046501B (zh) 2005-09-30
CZ302924B6 (cs) 2012-01-18
SK2092002A3 (en) 2002-07-02
HK1046501A1 (en) 2003-01-17
JP2001064177A (ja) 2001-03-13
PL353449A1 (en) 2003-11-17
EE05331B1 (et) 2010-08-16
NO328957B1 (no) 2010-06-28
PL201388B1 (pl) 2009-04-30
BG65662B1 (bg) 2009-05-29
KR20020020815A (ko) 2002-03-15
NO20020774L (no) 2002-03-04
RU2002106815A (ru) 2004-01-27
DK1207881T3 (da) 2015-06-22
IL148169A0 (en) 2002-09-12
HRP20020181A2 (en) 2005-10-31
MXPA02001575A (es) 2003-10-14
RU2257206C2 (ru) 2005-07-27
CY1116273T1 (el) 2017-02-08
HU230386B1 (hu) 2016-03-29
SK287547B6 (sk) 2011-01-04
AU780151B2 (en) 2005-03-03
PT1207881E (pt) 2015-06-05
TWI245630B (en) 2005-12-21

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