AR030938A1 - Proceso de obtencion de los enantiomeros de la cetamina racemica; proceso de obtencion de sales farmaceuticamente aceptables de enantiomeros de la cetamina racemica y utilizacion de las sales farmaceuticamente aceptables obtenidas por el referido proceso - Google Patents
Proceso de obtencion de los enantiomeros de la cetamina racemica; proceso de obtencion de sales farmaceuticamente aceptables de enantiomeros de la cetamina racemica y utilizacion de las sales farmaceuticamente aceptables obtenidas por el referido procesoInfo
- Publication number
- AR030938A1 AR030938A1 ARP010102913A ARP010102913A AR030938A1 AR 030938 A1 AR030938 A1 AR 030938A1 AR P010102913 A ARP010102913 A AR P010102913A AR P010102913 A ARP010102913 A AR P010102913A AR 030938 A1 AR030938 A1 AR 030938A1
- Authority
- AR
- Argentina
- Prior art keywords
- pharmaceutically acceptable
- obtaining
- acceptable salts
- racemic
- ketamine
- Prior art date
Links
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 title abstract 4
- 229960003299 ketamine Drugs 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 230000008569 process Effects 0.000 title abstract 4
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical compound C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 3
- YQEZLKZALYSWHR-ZDUSSCGKSA-N (S)-ketamine Chemical compound C=1C=CC=C(Cl)C=1[C@@]1(NC)CCCCC1=O YQEZLKZALYSWHR-ZDUSSCGKSA-N 0.000 abstract 1
- 238000009776 industrial production Methods 0.000 abstract 1
- 238000010956 selective crystallization Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente describe un proceso de obtencion de los enantiomeros de la cetamina, a partir de la resolucion de la cetamina racémica con auxilio de un agente de resolucion asimétrico, que proporciona la cristalizacion selectiva de sus enantiomeros. El agente de resolucion es empleado en condiciones especiales de concentracion que confieren estabilidad, reproductibilidad y elevada pureza enantiomérica a la sal diastereoisomera precipitada, haciendo viable la produccion industrial de la S-cetamina y sus sales farmacéuticamente aceptables. La cetamina es (R,S)-2-(2-clorofenil)-2-metilamino ciclohexanona.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRPI0002693A BRPI0002693B8 (pt) | 2000-06-19 | 2000-06-19 | processo de obtenção dos enantiômeros da cetamina e seus sais farmaceuticamente aceitáveis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR030938A1 true AR030938A1 (es) | 2003-09-03 |
Family
ID=37515961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010102913A AR030938A1 (es) | 2000-06-19 | 2001-06-19 | Proceso de obtencion de los enantiomeros de la cetamina racemica; proceso de obtencion de sales farmaceuticamente aceptables de enantiomeros de la cetamina racemica y utilizacion de las sales farmaceuticamente aceptables obtenidas por el referido proceso |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6743949B2 (es) |
| EP (1) | EP1294659B1 (es) |
| AR (1) | AR030938A1 (es) |
| AT (1) | ATE378307T1 (es) |
| AU (1) | AU7374401A (es) |
| BR (1) | BRPI0002693B8 (es) |
| DE (1) | DE60131397T2 (es) |
| DK (1) | DK1294659T3 (es) |
| ES (1) | ES2296757T3 (es) |
| PT (1) | PT1294659E (es) |
| WO (1) | WO2001098265A2 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060063802A1 (en) | 2004-03-29 | 2006-03-23 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| US8268866B2 (en) | 2004-03-29 | 2012-09-18 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| US9072662B2 (en) | 2004-03-29 | 2015-07-07 | Auris Medical Ag | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| KR101271263B1 (ko) | 2005-09-28 | 2013-06-07 | 아우리스 메디칼 아게 | 내이 장애 치료용 약학 조성물 |
| US8808263B2 (en) * | 2010-01-14 | 2014-08-19 | The Procter & Gamble Company | Article of commerce including two-piece wearable absorbent article |
| BRPI1003620A2 (pt) | 2010-09-03 | 2012-06-05 | Ouro Fino Participacoes E Empreendimentos S A | associação anestésica, composição anestésica, e, medicamento anestésico de uso veterinário |
| ES2862673T3 (es) | 2011-12-12 | 2021-10-07 | Zilentin AG | Tratamiento del tinnitus mediante la modulación del cotransportador de cloruro NKCC1 en el sistema auditivo |
| HRP20211629T1 (hr) | 2013-09-13 | 2022-02-04 | National University Corporation Chiba University | Primjena r-ketamina i njegove soli kao lijekova |
| US20160332962A1 (en) * | 2015-05-13 | 2016-11-17 | Janssen Pharmaceutica Nv | (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine |
| CN111936127A (zh) | 2018-02-15 | 2020-11-13 | 国立大学法人千叶大学 | 炎症性疾病或骨病的预防或治疗剂及医药组合物 |
| CN110218157B (zh) * | 2018-03-01 | 2022-08-23 | 江苏恒瑞医药股份有限公司 | 一种r-氯胺酮及其可药用盐的制备方法 |
| CN112533595A (zh) | 2018-05-04 | 2021-03-19 | 感知神经科学公司 | 治疗物质滥用的方法 |
| CN119613277A (zh) * | 2023-09-14 | 2025-03-14 | 江苏恩华药业股份有限公司 | 一种(r)-氯胺酮d-酒石酸盐e晶型及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH535201A (de) * | 1969-12-19 | 1973-03-31 | Bristol Myers Co | Verfahren zur Spaltung von racemischen 2-(o-Chlorphenyl)-2-methylaminocyclohexanon in die optisch-aktiven Isomeren |
| EP0787116A1 (en) | 1994-10-17 | 1997-08-06 | Akzo Nobel N.V. | Process for separating enantiomers from a racemic mixture |
| DE19619665C2 (de) * | 1996-05-15 | 2001-03-08 | Goedecke Ag | Racemattrennung von Ketamin |
-
2000
- 2000-06-19 BR BRPI0002693A patent/BRPI0002693B8/pt not_active IP Right Cessation
-
2001
- 2001-06-18 DK DK01940028T patent/DK1294659T3/da active
- 2001-06-18 EP EP01940028A patent/EP1294659B1/en not_active Expired - Lifetime
- 2001-06-18 AT AT01940028T patent/ATE378307T1/de active
- 2001-06-18 DE DE60131397T patent/DE60131397T2/de not_active Expired - Lifetime
- 2001-06-18 WO PCT/BR2001/000075 patent/WO2001098265A2/en not_active Ceased
- 2001-06-18 US US10/297,815 patent/US6743949B2/en not_active Expired - Lifetime
- 2001-06-18 AU AU73744/01A patent/AU7374401A/en not_active Abandoned
- 2001-06-18 PT PT01940028T patent/PT1294659E/pt unknown
- 2001-06-18 ES ES01940028T patent/ES2296757T3/es not_active Expired - Lifetime
- 2001-06-19 AR ARP010102913A patent/AR030938A1/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| DE60131397T2 (de) | 2008-09-18 |
| US20030212143A1 (en) | 2003-11-13 |
| WO2001098265A2 (en) | 2001-12-27 |
| EP1294659A2 (en) | 2003-03-26 |
| EP1294659A4 (en) | 2005-06-22 |
| US6743949B2 (en) | 2004-06-01 |
| WO2001098265A3 (en) | 2002-08-15 |
| BR0002693A (pt) | 2004-07-06 |
| ES2296757T3 (es) | 2008-05-01 |
| PT1294659E (pt) | 2008-02-19 |
| ATE378307T1 (de) | 2007-11-15 |
| EP1294659B1 (en) | 2007-11-14 |
| DK1294659T3 (da) | 2008-03-17 |
| BRPI0002693B8 (pt) | 2021-05-25 |
| DE60131397D1 (de) | 2007-12-27 |
| BR0002693B1 (pt) | 2013-12-24 |
| AU7374401A (en) | 2002-01-02 |
| WO2001098265B1 (en) | 2002-10-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |