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AR039467A1 - Procedimiento para preparar gama-butirolactamas y gama-aminoacidos muy funcionalizados - Google Patents

Procedimiento para preparar gama-butirolactamas y gama-aminoacidos muy funcionalizados

Info

Publication number
AR039467A1
AR039467A1 ARP030101461A ARP030101461A AR039467A1 AR 039467 A1 AR039467 A1 AR 039467A1 AR P030101461 A ARP030101461 A AR P030101461A AR P030101461 A ARP030101461 A AR P030101461A AR 039467 A1 AR039467 A1 AR 039467A1
Authority
AR
Argentina
Prior art keywords
range
butirolactamas
aminoacidos
functioned
procedure
Prior art date
Application number
ARP030101461A
Other languages
English (en)
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of AR039467A1 publication Critical patent/AR039467A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/18—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)

Abstract

La presente se refiere a un procedimiento para preparar yeta-butirolactamas y yeta- aminoácidos muy funcionalizados mediante aminación reductora de ácido mucohálico o sus derivados, y describe un procedimiento para preparar pregabalina, o ácido 3-aminometil-5-metiloctanoico, análogos del GABA con deseable actividad medicinal. Como lo indica la fórmula (1).
ARP030101461A 2002-04-30 2003-04-28 Procedimiento para preparar gama-butirolactamas y gama-aminoacidos muy funcionalizados AR039467A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37699102P 2002-04-30 2002-04-30

Publications (1)

Publication Number Publication Date
AR039467A1 true AR039467A1 (es) 2005-02-23

Family

ID=29401429

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030101461A AR039467A1 (es) 2002-04-30 2003-04-28 Procedimiento para preparar gama-butirolactamas y gama-aminoacidos muy funcionalizados

Country Status (15)

Country Link
US (2) US20030225149A1 (es)
EP (1) EP1499583A1 (es)
JP (1) JP2005523932A (es)
KR (1) KR20040106415A (es)
CN (1) CN1649827A (es)
AR (1) AR039467A1 (es)
AU (1) AU2003219425A1 (es)
BR (1) BR0309743A (es)
CA (1) CA2483830A1 (es)
IL (1) IL164781A0 (es)
MX (1) MXPA04010771A (es)
PL (1) PL373296A1 (es)
RU (1) RU2004131840A (es)
TW (1) TW200400929A (es)
WO (1) WO2003093220A1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100491282B1 (ko) 1996-07-24 2005-05-24 워너-램버트 캄파니 엘엘씨 통증 치료용 이소부틸가바 및 그의 유도체
EA011765B1 (ru) * 2004-06-21 2009-06-30 УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл-Эл-Си Получение прегабалина и родственных соединений
AU2005271693A1 (en) * 2004-08-04 2006-02-16 Foam Supplies, Inc. Reactivity drift and catalyst degradation in polyurethane foam
CN101160281A (zh) * 2005-04-06 2008-04-09 特瓦制药工业有限公司 结晶形态的普瑞巴林
EP1768950A2 (en) * 2005-04-11 2007-04-04 Teva Pharmaceutical Industries Ltd. Process for making (s)-pregabalin
US7488846B2 (en) * 2005-04-11 2009-02-10 Teva Pharmaceuical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
KR20090019016A (ko) * 2005-05-10 2009-02-24 테바 파마슈티컬 인더스트리즈 리미티드 3-카르바모일메틸-5-메틸 헥산산의 광학 분할
CA2604602A1 (en) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Method for the preparation of pregabalin and salts thereof
CA2604600A1 (en) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Pregabalin free of isobutylglutaric acid and a process for preparation thereof
CZ297970B6 (cs) * 2005-08-10 2007-05-09 Zentiva, A. S Zpusob výroby (S)-3-(aminomethyl)-5-methyl-hexanové kyseliny (pregabalinu)
EP1802568A1 (en) * 2005-09-19 2007-07-04 Teva Pharmaceutical Industries Ltd. Chiral 3-carbamoylmethyl-5-methyl hexanoic acids, key intermediates for the new synthesis of (s)-pregabalin
KR20080016658A (ko) * 2006-04-24 2008-02-21 테바 파마슈티컬 인더스트리즈 리미티드 3-이소부틸글루타르산의 합성 방법
US7462738B2 (en) * 2006-05-24 2008-12-09 Teva Pharmaceutical Industries Ltd. Processes for the preparation of R-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof
EP1913147A2 (en) * 2006-05-31 2008-04-23 Teva Pharmaceutical Industries Ltd The use of enzymatic resolution for the preparation of intermediates of pregabalin
WO2007143152A2 (en) * 2006-05-31 2007-12-13 Teva Pharmaceutical Industries Ltd. Preparation of (s)-pregabalin-nitrile
KR101036536B1 (ko) * 2007-03-22 2011-05-24 테바 파마슈티컬 인더스트리즈 리미티드 (ｓ)-(+)-3-(아미노메틸)-5-메틸 헥산산의 합성
WO2008127646A2 (en) * 2007-04-11 2008-10-23 Dsm Ip Assets B.V. Transaminase-based processes for preparation of pregabalin
US20080302694A1 (en) * 2007-06-05 2008-12-11 Kenneth J. Gardner Radiation curable coating composition derived from epoxidized vegetable oils
WO2009046309A2 (en) * 2007-10-03 2009-04-09 Teva Pharmaceutical Industries Ltd. Pregabalin -4-eliminate, pregabalin 5-eliminate, their use as reference marker and standard, and method to produce pregabalin containing low levels thereof
JP2011507941A (ja) * 2007-12-26 2011-03-10 ジェネリクス・（ユーケー）・リミテッド プレガバリンの製造方法
EP2116618A1 (en) 2008-05-09 2009-11-11 Agency for Science, Technology And Research Diagnosis and treatment of Kawasaki disease
WO2009158343A1 (en) * 2008-06-23 2009-12-30 Teva Pharmaceutical Industries, Ltd. Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester
US9133292B2 (en) 2009-03-05 2015-09-15 Akzo Nobel Coatings International B.V. Hydroxyl functional oil polyol acrylic graft copolymers
WO2011086565A1 (en) * 2010-01-15 2011-07-21 Lupin Limited Method for preparation of enantiomerically enriched and/or racemic gamma-amino acids
EP2658893B2 (en) 2010-12-28 2019-01-02 Akzo Nobel Coatings International B.V. Radiation curable coating compositions for metal
GB201121317D0 (en) 2011-12-09 2012-01-25 Syngenta Ltd Herbicidal compounds
EP2794703B1 (en) 2011-12-21 2016-07-20 Akzo Nobel Coatings International B.V. Solvent-based coating compositions
RU2606632C2 (ru) 2011-12-21 2017-01-10 Акцо Нобель Коатингс Интернэшнл Б.В. Композиции на водной основе для получения покрытий
CA2905411A1 (en) * 2013-03-27 2014-10-02 Pfizer Ireland Pharmaceuticals Process and intermediates for the preparation of pregabalin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3935210A (en) 1971-07-29 1976-01-27 Sandoz, Inc. Preparation of 1-aryl-4,5-dihalo-pyridazone-6
ES2165857T3 (es) * 1992-05-20 2002-04-01 Univ Northwestern Analogos de gaba y acido l-glutamico para el tratamiento de trastornos del sistema nervioso central.
DZ2770A1 (fr) 1998-04-17 2003-12-01 Lilly Co Eli Procédé de préparation de 1h-indol-3 glyoxamides substituées en position 4.
CA2333024C (en) 1998-07-09 2002-03-26 Warner-Lambert Company Method for the treatment of insomnia
MXPA01012319A (es) * 1999-06-10 2002-07-22 Warner Lambert Co Acidos 3-propil gama aminobutiricos mono y disubstituidos.

Also Published As

Publication number Publication date
BR0309743A (pt) 2005-02-09
AU2003219425A1 (en) 2003-11-17
IL164781A0 (en) 2005-12-18
WO2003093220A1 (en) 2003-11-13
TW200400929A (en) 2004-01-16
RU2004131840A (ru) 2005-05-27
US6924377B2 (en) 2005-08-02
US20030236415A1 (en) 2003-12-25
MXPA04010771A (es) 2005-03-07
CA2483830A1 (en) 2003-11-13
US20030225149A1 (en) 2003-12-04
PL373296A1 (en) 2005-08-22
JP2005523932A (ja) 2005-08-11
KR20040106415A (ko) 2004-12-17
CN1649827A (zh) 2005-08-03
EP1499583A1 (en) 2005-01-26

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