AR039103A1 - Uso de inhibidores de il-18 para el tratamiento y/o prevencion de enfermedades vasculares perifericas - Google Patents
Uso de inhibidores de il-18 para el tratamiento y/o prevencion de enfermedades vasculares perifericasInfo
- Publication number
- AR039103A1 AR039103A1 ARP030101000A ARP030101000A AR039103A1 AR 039103 A1 AR039103 A1 AR 039103A1 AR P030101000 A ARP030101000 A AR P030101000A AR P030101000 A ARP030101000 A AR P030101000A AR 039103 A1 AR039103 A1 AR 039103A1
- Authority
- AR
- Argentina
- Prior art keywords
- inhibitor
- prevention
- treatment
- peripheral vascular
- vascular diseases
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 5
- 208000018262 Peripheral vascular disease Diseases 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title abstract 2
- 102100035904 Caspase-1 Human genes 0.000 abstract 1
- 102000004557 Interleukin-18 Receptors Human genes 0.000 abstract 1
- 108010017537 Interleukin-18 Receptors Proteins 0.000 abstract 1
- 102000001708 Protein Isoforms Human genes 0.000 abstract 1
- 108010029485 Protein Isoforms Proteins 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 102000044166 interleukin-18 binding protein Human genes 0.000 abstract 1
- 108010070145 interleukin-18 binding protein Proteins 0.000 abstract 1
- 108010027775 interleukin-1beta-converting enzyme inhibitor Proteins 0.000 abstract 1
- 238000011542 limb amputation Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Marine Sciences & Fisheries (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Se refiere al uso de inhibidor de IL-18 en la preparación de un medicamento para el tratamiento de las enfermedades vasculares periféricas. Además se refiere al uso de un inhibidor de IL-18 para la prevención de la amputación de extremidades. Reivindicación 10:_ El uso de acuerdo con las reivindicaciones 1 a 9, en donde el inhibidor de la IL-18 se selecciona de un inhibidor de caspasa-1 (ICE), un anticuerpo contra IL-18, un anticuerpo contra cualquiera de las subunidades receptoras de IK-18, un inhibidor de la síntesis de IL-18, un antagonista de IL-18 que compite con IL-18 y bloquea el receptor de IL-18, y una proteína de enlace con IL-18, o isoformo, muteína, proteína fusionada, derivado funcional, fracción activa o derivado circularmente permutado de los mismos que inhiben la actividad biológica de IL-18.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02100290 | 2002-03-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR039103A1 true AR039103A1 (es) | 2005-02-09 |
Family
ID=28051827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030101000A AR039103A1 (es) | 2002-03-22 | 2003-03-21 | Uso de inhibidores de il-18 para el tratamiento y/o prevencion de enfermedades vasculares perifericas |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US9592267B2 (es) |
| EP (1) | EP1487541B1 (es) |
| JP (1) | JP4885424B2 (es) |
| KR (1) | KR20050004809A (es) |
| CN (1) | CN100540058C (es) |
| AR (1) | AR039103A1 (es) |
| AT (1) | ATE414556T1 (es) |
| AU (1) | AU2003219162B2 (es) |
| BR (1) | BRPI0308663B8 (es) |
| CA (1) | CA2478855C (es) |
| CY (1) | CY1108748T1 (es) |
| DE (1) | DE60324777D1 (es) |
| DK (1) | DK1487541T3 (es) |
| EA (1) | EA008495B1 (es) |
| ES (1) | ES2314191T3 (es) |
| HR (1) | HRP20040758B1 (es) |
| IL (2) | IL164211A0 (es) |
| ME (1) | ME00548B (es) |
| MX (1) | MXPA04009135A (es) |
| NO (1) | NO336226B1 (es) |
| PL (1) | PL207303B1 (es) |
| PT (1) | PT1487541E (es) |
| RS (1) | RS51755B (es) |
| SI (1) | SI1487541T1 (es) |
| UA (1) | UA80275C2 (es) |
| WO (1) | WO2003080104A2 (es) |
| ZA (1) | ZA200407022B (es) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7914814B2 (en) | 1997-09-17 | 2011-03-29 | Strategic Science & Technologies, Llc | Topical delivery of arginine of cause beneficial effects |
| CN102206277A (zh) * | 2000-02-10 | 2011-10-05 | 雅培制药有限公司 | 结合人白介素-18的抗体及制备和使用方法 |
| PL207303B1 (pl) | 2002-03-22 | 2010-11-30 | Inst Nat Sante Rech Med | Zastosowanie inhibitora IL-18 do leczenia i/lub zapobiegania chorobom naczyń obwodowych i zastosowanie wektorów ekspresyjnych |
| US7968684B2 (en) | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
| IL159670A0 (en) * | 2003-12-31 | 2004-06-01 | Yeda Res & Dev | Use of il-18 binding protein in inflammations |
| JP2007532697A (ja) * | 2004-04-19 | 2007-11-15 | ストラテジック サイエンス アンド テクノロジーズ， エルエルシー | 局所的血流増大の有益な効果 |
| US9226909B2 (en) | 2004-04-19 | 2016-01-05 | Strategic Science & Technologies, Llc | Beneficial effects of increasing local blood flow |
| PL1885753T3 (pl) | 2005-06-03 | 2011-12-30 | Ares Trading Sa | Wytwarzanie rekombinowanego białka wiążącego IL-18 |
| ATE529433T1 (de) | 2005-06-10 | 2011-11-15 | Ares Trading Sa | Verfahren zur reinigung eines il-18-bindenden proteins |
| US10106587B2 (en) | 2008-02-27 | 2018-10-23 | Biomet Biologics, Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
| US8753690B2 (en) | 2008-02-27 | 2014-06-17 | Biomet Biologics, Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
| US9072659B2 (en) | 2009-06-24 | 2015-07-07 | Strategic Science & Technologies, Llc | Topical composition containing naproxen |
| US11684624B2 (en) | 2009-06-24 | 2023-06-27 | Strategic Science & Technologies, Llc | Treatment of erectile dysfunction and other indications |
| US12138268B2 (en) | 2009-06-24 | 2024-11-12 | Strategic Science & Technologies, Llc | Treatment of erectile dysfunction and other indications |
| ES2607476T3 (es) | 2009-06-24 | 2017-03-31 | Strategic Science & Technologies, Llc | Composición tópica que contiene ibuprofeno |
| US9763875B2 (en) | 2009-08-27 | 2017-09-19 | Biomet Biologics, Llc | Implantable device for production of interleukin-1 receptor antagonist |
| JP2013506686A (ja) | 2009-09-30 | 2013-02-28 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | オートファジー阻害遺伝子産物の変調によりオートファジーを変調する方法 |
| EP2609117B1 (en) | 2010-08-25 | 2015-09-16 | F.Hoffmann-La Roche Ag | Antibodies against il-18r1 and uses thereof |
| JP2014501283A (ja) | 2010-12-29 | 2014-01-20 | ストラテジック サイエンス アンド テクノロジーズ， エルエルシー | アレルギーおよび他の適応症の処置のためのシステムおよび方法 |
| JP2014504592A (ja) | 2010-12-29 | 2014-02-24 | ストラテジック サイエンス アンド テクノロジーズ， エルエルシー | 勃起不全および他の適応症の処置 |
| JOP20200308A1 (ar) | 2012-09-07 | 2017-06-16 | Novartis Ag | جزيئات إرتباط il-18 |
| US9878011B2 (en) | 2013-03-15 | 2018-01-30 | Biomet Biologics, Llc | Treatment of inflammatory respiratory disease using biological solutions |
| US9895418B2 (en) * | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
| US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
| US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
| US9758806B2 (en) | 2013-03-15 | 2017-09-12 | Biomet Biologics, Llc | Acellular compositions for treating inflammatory disorders |
| US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
| US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
| US9833474B2 (en) | 2013-11-26 | 2017-12-05 | Biomet Biologies, LLC | Methods of mediating macrophage phenotypes |
| US10441635B2 (en) | 2014-11-10 | 2019-10-15 | Biomet Biologics, Llc | Methods of treating pain using protein solutions |
| CA2972689A1 (en) | 2015-03-05 | 2016-09-09 | Ab2 Bio Sa | Il-18 binding protein (il-18bp) and antibodies in inflammatory diseases |
| US9763800B2 (en) | 2015-03-18 | 2017-09-19 | Biomet C. V. | Implant configured for hammertoe and small bone fixation |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5877197A (en) * | 1996-12-16 | 1999-03-02 | Karanewsky; Donald S. | C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
| IL121860A0 (en) * | 1997-08-14 | 1998-02-22 | Yeda Res & Dev | Interleukin-18 binding proteins their preparation and use |
| CA2276216A1 (en) * | 1998-06-24 | 1999-12-24 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | An artificial peptide capable of neutralizing the biological activity of interleukin-18 |
| CA2340579A1 (en) * | 1998-09-01 | 2000-03-09 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Interleukin 18-binding protein |
| DE60041432D1 (de) * | 1999-11-16 | 2009-03-12 | Hayashibara Biochem Lab | Antikörper spezifisch für den Interleukin-18 Vorläufer |
| EA007014B1 (ru) | 2000-05-05 | 2006-06-30 | Апплайд Резеч Системз Арс Холдинг Н.В. | Применение il-18 в качестве диагностического маркера |
| PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
| AU2002224417A1 (en) * | 2000-10-18 | 2002-04-29 | Immunex Corporation | Methods for treating il-18 mediated disorders |
| PL207303B1 (pl) | 2002-03-22 | 2010-11-30 | Inst Nat Sante Rech Med | Zastosowanie inhibitora IL-18 do leczenia i/lub zapobiegania chorobom naczyń obwodowych i zastosowanie wektorów ekspresyjnych |
-
2003
- 2003-03-13 PL PL372398A patent/PL207303B1/pl unknown
- 2003-03-13 SI SI200331457T patent/SI1487541T1/sl unknown
- 2003-03-13 PT PT03714958T patent/PT1487541E/pt unknown
- 2003-03-13 DK DK03714958T patent/DK1487541T3/da active
- 2003-03-13 DE DE60324777T patent/DE60324777D1/de not_active Expired - Lifetime
- 2003-03-13 AT AT03714958T patent/ATE414556T1/de active
- 2003-03-13 UA UA20041008590A patent/UA80275C2/uk unknown
- 2003-03-13 AU AU2003219162A patent/AU2003219162B2/en not_active Expired
- 2003-03-13 WO PCT/EP2003/050061 patent/WO2003080104A2/en not_active Ceased
- 2003-03-13 BR BRPI0308663A patent/BRPI0308663B8/pt not_active IP Right Cessation
- 2003-03-13 IL IL16421103A patent/IL164211A0/xx unknown
- 2003-03-13 EP EP03714958A patent/EP1487541B1/en not_active Expired - Lifetime
- 2003-03-13 HR HRP20040758AA patent/HRP20040758B1/hr not_active IP Right Cessation
- 2003-03-13 ES ES03714958T patent/ES2314191T3/es not_active Expired - Lifetime
- 2003-03-13 CA CA2478855A patent/CA2478855C/en not_active Expired - Lifetime
- 2003-03-13 RS YU81504A patent/RS51755B/sr unknown
- 2003-03-13 KR KR10-2004-7014401A patent/KR20050004809A/ko not_active Ceased
- 2003-03-13 EA EA200401240A patent/EA008495B1/ru not_active IP Right Cessation
- 2003-03-13 CN CNB038116510A patent/CN100540058C/zh not_active Expired - Lifetime
- 2003-03-13 US US10/508,574 patent/US9592267B2/en not_active Expired - Lifetime
- 2003-03-13 ME MEP-2008-679A patent/ME00548B/me unknown
- 2003-03-13 JP JP2003577930A patent/JP4885424B2/ja not_active Expired - Lifetime
- 2003-03-13 MX MXPA04009135A patent/MXPA04009135A/es active IP Right Grant
- 2003-03-21 AR ARP030101000A patent/AR039103A1/es not_active Application Discontinuation
-
2004
- 2004-09-02 ZA ZA200407022A patent/ZA200407022B/en unknown
- 2004-09-22 IL IL164211A patent/IL164211A/en active IP Right Grant
- 2004-10-20 NO NO20044459A patent/NO336226B1/no not_active IP Right Cessation
-
2009
- 2009-02-05 CY CY20091100132T patent/CY1108748T1/el unknown
-
2010
- 2010-06-01 US US12/791,052 patent/US9566313B2/en not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |