AR038562A1 - 2-amino-4-biciclilamino-6h-1,3,5,-triazinas,procedimiento para su preparacion y su empleo como herbicidas y reguladores de crecimiento de plantas - Google Patents
2-amino-4-biciclilamino-6h-1,3,5,-triazinas,procedimiento para su preparacion y su empleo como herbicidas y reguladores de crecimiento de plantasInfo
- Publication number
- AR038562A1 AR038562A1 ARP030100526A ARP030100526A AR038562A1 AR 038562 A1 AR038562 A1 AR 038562A1 AR P030100526 A ARP030100526 A AR P030100526A AR P030100526 A ARP030100526 A AR P030100526A AR 038562 A1 AR038562 A1 AR 038562A1
- Authority
- AR
- Argentina
- Prior art keywords
- radical
- group
- formula
- case
- groups
- Prior art date
Links
- 239000004009 herbicide Substances 0.000 title abstract 2
- 239000005648 plant growth regulator Substances 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 6
- 125000005842 heteroatom Chemical group 0.000 abstract 5
- 229910052757 nitrogen Inorganic materials 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000006413 ring segment Chemical group 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- 125000002837 carbocyclic group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 2
- 229930195733 hydrocarbon Natural products 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 125000002015 acyclic group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- BWOVZCWSJFYBRM-UHFFFAOYSA-N carbononitridic isocyanate Chemical compound O=C=NC#N BWOVZCWSJFYBRM-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/66—1,3,5-Triazines, not hydrogenated and not substituted at the ring nitrogen atoms
- A01N43/68—1,3,5-Triazines, not hydrogenated and not substituted at the ring nitrogen atoms with two or three nitrogen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Agronomy & Crop Science (AREA)
- General Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Son adecuados como herbicidas y reguladores de crecimiento de plantas, procesamiento para su preparación e intermediarios. Reivindicación 1: Compuestos de la fórmula (1) o sus sales, compuestos de la fórmula (1) y sus sales, en la cual significan: R1 y R2 en cada caso, independientemente entre sí, hidrógeno, un grupo de la fórmula NR'R'', en donde R' y R'' en cada caso, independientemente entre sí, representan H, alquilo (C1-6), alquenilo (C2-6), alquinilo (C2-6), cicloalquilo (C3-6), o cicloalquenilo (C5-6), o un radical hidrocarbonato o radical oxihidrocarbonado con en cada caso de 1 a 10 átomos de carbono, o un radical heterociclilo, radical heterocicliloxilo, radical heterocliltio o radical hetero-ciclil-amino con en cada caso de 3 a 9 átomos anulares y de 1 a 3 heteroátomos anulares del grupo de N, O y S, estando cada uno de los seis radicales últimamente mencionados sin sustituir o sustituido, o un radical acilo de un ácido orgánico con 1 a 20 átomos de carbono; o R1 y R2 conjuntamente con el átomo de nitrógeno del grupo NR1R2 un radical heterocíclico saturado o no saturado, no aromático, con de 3 a 9 átomos de anulares y de 1 a 4 heteroátomos anulares, siendo además del átomo de nitrógeno, los otros eventuales heteroátomos anulares seleccionados del grupo de N, O y S y estando el radical sin sustituir o sustituido, poseyendo cada uno de los radicales hidrocarbonados R1 y R2 incluidos los sustituyentes de 1 a 20 átomos de carbono; R3 hidrógeno, amino, alquil(C1-4)-amino, diaquil(C1-4)-amino, alquilo (C1-6), alcoxilo (C1-6), alquenilo(C2-6), alquinilo (C2-6), cicloalquilo (C3-6), cicloalquenilo (C5-6), fenilo o heterociclilo, estando cada uno de los 10 radicales últimamente mencionados, de forma independiente entre sí, sin sustituir o sustituido, poseyendo el respectivo radical incluidos los sustituyentes de 1 a 12 átomos de carbono, o un radical acilo de la fórmula -B*-A*, en la cual significan: A* hidrógeno o un radical hidrocarbonado acíclico o cíclico con de 1 a 10 átomo de carbono, que está sin sustituir o sustituido, y B* un grupo bivalente de la fórmula -CO-, -CO-O-, -CO-NR', -S(O)p- o -S(O)p-O-, en donde p es = 0, 1 ó 2 y R' es hidrógeno, alquilo C1-6, fenilo, bencilo, cicloalquilo C3-6 o alcanoílo C1-6, poseyendo -B*-A* incluidos los sustituyentes de 1 a 12; R4 un radical de la fórmula -Z1-R6, en donde Z1 y R6 son como se define más adelante; R5 en cada caso, independientemente entre sí, halógeno, ciano, isocianato, nitro, un radical de la fórmula -Z2-R7, en donde Z2 y R7 son como se define más adelante, o dos radicales R5 vecinos representan en forma conjunta un ciclo condensado con 4 a 6 átomos anulares, que es carbocíclico o contiene de 1 a 3 heteroátomos anulares del grupo O, S y N y está sin sustituir o sustituido por uno o varios radicales del grupo halógeno, alquilo (C1-4) y oxo; R6, R7, R8, R9 en cada caso, independientemente entre sí, hidrógeno, excepto R7 =hidrógeno, cuando Z2 = enlace directo, o un radical hidrocarbonado acíclico con de 1 a 20 átomos de carbono, o un radical hidrocarbonado cíclico, o un radical heterocíclico, estando cada uno de los tres radicales últimamente mencionados sin sustituir o sustituido; o R8 y R9 en forma conjuntas con el átomo de carbono de un grupo CR8R9 (para Y1 o Y2) o dos radicales R8 o R9 de dos grupos Y1 y/o Y2 conjuntamente con los átomos asociados de los grupos Y1 y/o Y2 en cada caso un radical carbocíclico C3-8, o un radical heterocíclico, estando cada uno de los dos radicales últimamente mencionados sin sustituir o sustituido; X1, X2, X3, X4 en cada caso, independientemente entre sí, un átomo de carbono, que está sustituido con un átomo de hidrógeno o con uno de los sustituyentes R5 definidos , o un átomo de nitrógeno o dos símbolos vecinos X1, X2, X3 y X4 en cada caso en forma conjunta un grupo bivalente de la fórmula -O-, -S-, -NH- o -NR-, en la cual R es como se ha definido para R3, siempre que los grupos X1, X2, X3, X4 formen conjuntamente con la unidad de C2 asociada del anillo condensado un anillo de cinco miembros o de seis miembros carbocíclico o heterocíclico aromático; (Y1)m m grupos bivalentes Y1, significa cada grupo Y1, independientemente de otros grupos Y1 un grupo de la fórmula -O-, -CO, -C(=NR*)-, -S(O)q-, -NR*, o -N(O)-, siendo q = 0, 1 ó 2 y R* como se ha definido para R3, o un grupo de la fórmula CR8R9, siendo R8 y R9 como se ha definido anteriormente; e Y2 un grupo como se ha definido para Y1 o un enlace directo, representando dos grupos vecinos de los pares de símbolos Y1 e Y1 o de los pares de símbolos Y1 e Y2 grupos no heteroátomicos del mismo significado, formado los grupos (Y1)m e Y2 conjuntamente con la unidad de C2 asociada del anillo aromático y el átomo de carbono ligado con R4 un anillo condensado de cuatro miembros a ocho miembros carbocíclico heterocíclico no aromático; Z1 y los grupos Z2 significan en cada caso, independientemente entre sí, un enlace directo o un grupo bivalente de la fórmula -O-, -S(O)p-, -S(O)p-O-, -O-S(O)p-, -CO-, -O-CO-, -CO-O-, -NR'-, -O-NR'-, -NR'-O-, -NR'-CO-, -CO-NR'-, siendo en este caso p = 0, 1 ó 2 y R' hidrógeno, alquilo C1-6, fenilo, bencilo, cicloalquilo (C3-6) o alcanoílo C1-6; m es 0, 1, 2, 3 ó 4; y n es 0, 1, 2, 3 ó 4.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10207037A DE10207037A1 (de) | 2002-02-20 | 2002-02-20 | 2-Amino-4-bicyclyamino-6H-1,3.5-triazine, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR038562A1 true AR038562A1 (es) | 2005-01-19 |
Family
ID=27635161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030100526A AR038562A1 (es) | 2002-02-20 | 2003-02-18 | 2-amino-4-biciclilamino-6h-1,3,5,-triazinas,procedimiento para su preparacion y su empleo como herbicidas y reguladores de crecimiento de plantas |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7479471B2 (es) |
| EP (1) | EP1478628B1 (es) |
| JP (1) | JP4755396B2 (es) |
| KR (1) | KR101107877B1 (es) |
| CN (1) | CN100491359C (es) |
| AR (1) | AR038562A1 (es) |
| AT (1) | ATE410416T1 (es) |
| AU (2) | AU2003212235A1 (es) |
| BR (1) | BR0307877B1 (es) |
| CA (1) | CA2476828C (es) |
| DE (2) | DE10207037A1 (es) |
| ES (1) | ES2312754T3 (es) |
| MX (1) | MXPA04008044A (es) |
| MY (1) | MY138410A (es) |
| NZ (1) | NZ534737A (es) |
| RU (1) | RU2004127931A (es) |
| TW (1) | TW200303170A (es) |
| WO (1) | WO2003070710A1 (es) |
| ZA (1) | ZA200405699B (es) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19921883A1 (de) * | 1999-05-12 | 2000-11-16 | Bayer Ag | Substituierte Thienocycloalk(en)ylamino-1,3,5-triazine |
| EP1592674B1 (en) * | 2003-02-05 | 2014-03-05 | Bayer CropScience AG | Amino 1, 3, 5-triazines n-substituted with chiral bicyclic radicals, process for their preparation, compositions thereof and their use as herbicides and plant growth regulators |
| DE102004034571A1 (de) * | 2004-07-17 | 2006-02-23 | Bayer Cropscience Gmbh | Herbizide Mittel |
| EP1790227A1 (de) | 2005-11-25 | 2007-05-30 | Bayer CropScience AG | Wässrige Suspensionskonzentrate aus 2,4-Diamino-s-triazinherbiziden |
| EP2295432A1 (en) * | 2006-02-10 | 2011-03-16 | TransTech Pharma Inc. | Process for the preparation of aminobenzimidazole derivatives |
| EP1854355A1 (de) * | 2006-03-15 | 2007-11-14 | Bayer CropScience AG | Wässrige Suspensionskonzentrate |
| DE102006016884A1 (de) * | 2006-04-11 | 2007-10-25 | Bayer Cropscience Ag | Substituierte Diamino-1,3,5-triazine, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
| EP1958509A1 (de) * | 2007-02-19 | 2008-08-20 | Bayer CropScience AG | Herbizid-Kombination |
| EP2147600A1 (en) * | 2008-07-21 | 2010-01-27 | Bayer CropScience AG | Method for weed control in lawn |
| PE20141468A1 (es) | 2010-12-21 | 2014-11-05 | Bayer Cropscience Lp | Mutantes tipo papel de lija de bacillus y metodos de uso de los mismo para mejorar el crecimiento vegetal, promover la salud de plantas y controlar enfermedades y plagas |
| WO2012135166A1 (en) * | 2011-03-28 | 2012-10-04 | Pathway Therapeutics Inc. | (fused ring arylamino and heterocyclylamino) pyrimidynyl and 1,3,5-triazinyl benzimidazoles, pharmaceutical compositions thereof, and their use in treating proliferative diseases |
| BR112013024907A2 (pt) | 2011-03-28 | 2016-12-20 | Mei Pharma Inc | composto, composição farmacêutica, método para o tratamento, prevenção ou atenuação de um ou mais sintomas de um distúrbio, doença ou condição mediada por pi3k em um sujeito, método para modular a atividade enzimática de pi3k |
| MX2014002890A (es) | 2011-09-12 | 2015-01-19 | Bayer Cropscience Lp | Metodo para mejorar la salud y/o promover el crecimiento de una planta y/o mejorar la maduracion de frutos. |
| RU2509770C2 (ru) * | 2012-06-22 | 2014-03-20 | Общество с ограниченной ответственностью "Молекулярные Технологии" | Новые химические соединения производные 2,4-диамино-1,3,5-триазина для профилактики и лечения заболеваний человека и животных |
| WO2015047124A1 (ru) * | 2013-09-26 | 2015-04-02 | Общество с ограниченной ответственностью "Молекулярные Технологии" | Новые химические соединения производные 2,4-диамино-1,3,5-триазина для профилактики и лечения заболеваний человека и животных |
| RU2693484C1 (ru) | 2013-11-22 | 2019-07-03 | СиЭль БАЙОСАЕНСИЗ ЭлЭлСи | Антагонисты гастрина для лечения и профилактики остеопороза |
| SG11201606080SA (en) | 2014-02-03 | 2016-08-30 | Vitae Pharmaceuticals Inc | Dihydropyrrolopyridine inhibitors of ror-gamma |
| CN107074852B (zh) | 2014-10-14 | 2019-08-16 | 生命医药有限责任公司 | ROR-γ的二氢吡咯并吡啶抑制剂 |
| US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| US9845308B2 (en) | 2014-11-05 | 2017-12-19 | Vitae Pharmaceuticals, Inc. | Isoindoline inhibitors of ROR-gamma |
| RU2018106474A (ru) * | 2015-07-24 | 2019-08-27 | Байер Кропсайенс Акциенгезельшафт | Замещенные фурано-/тиеноциклоалкиламино-2-пиримидиновые производные и их применение для борьбы с нежелательным ростом растений |
| US10301261B2 (en) | 2015-08-05 | 2019-05-28 | Vitae Pharmaceuticals, Llc | Substituted indoles as modulators of ROR-gamma |
| EP3377482B1 (en) | 2015-11-20 | 2021-05-12 | Vitae Pharmaceuticals, LLC | Modulators of ror-gamma |
| TWI757266B (zh) | 2016-01-29 | 2022-03-11 | 美商維它藥物有限責任公司 | ＲＯＲ－γ調節劑 |
| US9481674B1 (en) | 2016-06-10 | 2016-11-01 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| US11304953B2 (en) | 2017-05-23 | 2022-04-19 | Mei Pharma, Inc. | Combination therapy |
| MA49685A (fr) | 2017-07-24 | 2021-04-14 | Vitae Pharmaceuticals Llc | INHIBITEURS DE ROR gamma |
| WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
| KR20200041358A (ko) | 2017-08-14 | 2020-04-21 | 메이 파마, 아이엔씨. | 병용 요법 |
| TW202535863A (zh) * | 2020-02-13 | 2025-09-16 | 德商百靈佳殷格翰國際股份有限公司 | 作為血漿激肽釋放酶抑制劑之雜芳族甲醯胺衍生物 |
| IL317728A (en) * | 2022-06-30 | 2025-02-01 | Adama Agan Ltd | Process for preparing biguanide and triazine salts |
| WO2025140655A1 (en) * | 2023-12-30 | 2025-07-03 | Fujian Haixi Pharmaceuticals Co., Ltd. | Heteroaryl compounds as multi-target protein kinase inhibitors |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3816419A (en) | 1972-10-27 | 1974-06-11 | American Cyanamid Co | Substituted s-triazines |
| US3932167A (en) | 1972-10-27 | 1976-01-13 | American Cyanamid Company | Substituted s-triazines as herbicidal agents |
| US3953606A (en) | 1974-02-07 | 1976-04-27 | American Cyanamid Company | Compositions and method of using ureidotetralin compounds or derivatives thereof |
| US3953506A (en) | 1974-02-07 | 1976-04-27 | American Cyanamid Company | Ureidotetralin compounds |
| GB1479544A (en) * | 1974-02-07 | 1977-07-13 | American Cyanamid Co | 1,2,3,4-tetrahydro-1-naphthylurea derivatives their preparation and their use |
| US4156670A (en) * | 1976-03-23 | 1979-05-29 | American Cyanamid Company | Substituted tetrahydrobenzothiophenes and method of preparation thereof |
| WO1988002368A1 (fr) | 1986-09-30 | 1988-04-07 | Idemitsu Kosan Company Limited | Derive de triazine, production de ce derive, et herbicide le contenant en tant que principe actif |
| CA2027562C (en) | 1989-02-20 | 1994-05-10 | Masahiro Nishii | Triazine derivative and a herbicide comprising the same as an effective ingredient |
| US5286905A (en) | 1990-12-28 | 1994-02-15 | Idemitsu Kosan Company Limited | Process for producing biguanide derivative |
| US5250686A (en) | 1991-04-18 | 1993-10-05 | Idemitsu Kosan Company Limited | Process for producing triazine compounds |
| DE69405502T2 (de) * | 1993-04-08 | 1998-01-15 | Idemitsu Kosan Co | Verfahren zur herstellung von 2-fluor isobuttersäure und deren ester |
| JPH08183781A (ja) | 1994-12-28 | 1996-07-16 | Idemitsu Kosan Co Ltd | トリアジン誘導体およびそれを有効成分とする除草剤 |
| CA2238689A1 (en) * | 1995-11-27 | 1997-06-05 | Idemitsu Kosan Co., Ltd. | Triazine derivatives |
| DE19607450A1 (de) | 1996-02-28 | 1997-09-04 | Hoechst Schering Agrevo Gmbh | 2-Amino-4-bicycloamino-1,3,5-triazine, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
| DE19641692A1 (de) * | 1996-10-10 | 1998-04-23 | Bayer Ag | Substituierte 2,4-Diamino-1,3,5-triazine |
| DE19744232A1 (de) * | 1997-10-07 | 1999-04-08 | Bayer Ag | Substituierte 2,4-Diamino-1,3,5-triazine |
| DE19921883A1 (de) * | 1999-05-12 | 2000-11-16 | Bayer Ag | Substituierte Thienocycloalk(en)ylamino-1,3,5-triazine |
| WO2001025220A1 (en) * | 1999-10-07 | 2001-04-12 | Amgen Inc. | Triazine kinase inhibitors |
-
2002
- 2002-02-20 DE DE10207037A patent/DE10207037A1/de not_active Withdrawn
-
2003
- 2003-02-06 BR BRPI0307877-9A patent/BR0307877B1/pt active IP Right Grant
- 2003-02-06 AU AU2003212235A patent/AU2003212235A1/en not_active Abandoned
- 2003-02-06 CN CNB038042738A patent/CN100491359C/zh not_active Expired - Lifetime
- 2003-02-06 JP JP2003569617A patent/JP4755396B2/ja not_active Expired - Lifetime
- 2003-02-06 DE DE50310607T patent/DE50310607D1/de not_active Expired - Lifetime
- 2003-02-06 ES ES03708083T patent/ES2312754T3/es not_active Expired - Lifetime
- 2003-02-06 NZ NZ534737A patent/NZ534737A/xx unknown
- 2003-02-06 CA CA2476828A patent/CA2476828C/en not_active Expired - Fee Related
- 2003-02-06 MX MXPA04008044A patent/MXPA04008044A/es active IP Right Grant
- 2003-02-06 AT AT03708083T patent/ATE410416T1/de not_active IP Right Cessation
- 2003-02-06 EP EP03708083A patent/EP1478628B1/de not_active Expired - Lifetime
- 2003-02-06 RU RU2004127931/04A patent/RU2004127931A/ru not_active Application Discontinuation
- 2003-02-06 WO PCT/EP2003/001157 patent/WO2003070710A1/de not_active Ceased
- 2003-02-06 KR KR1020047013035A patent/KR101107877B1/ko not_active Expired - Fee Related
- 2003-02-18 AR ARP030100526A patent/AR038562A1/es unknown
- 2003-02-18 TW TW092103329A patent/TW200303170A/zh unknown
- 2003-02-18 US US10/368,856 patent/US7479471B2/en not_active Expired - Lifetime
- 2003-02-19 MY MYPI20030581A patent/MY138410A/en unknown
-
2004
- 2004-07-16 ZA ZA200405699A patent/ZA200405699B/en unknown
-
2009
- 2009-12-23 AU AU2009251129A patent/AU2009251129B9/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| KR101107877B1 (ko) | 2012-01-25 |
| NZ534737A (en) | 2006-03-31 |
| WO2003070710A1 (de) | 2003-08-28 |
| AU2003212235A1 (en) | 2003-09-09 |
| AU2009251129B2 (en) | 2011-12-22 |
| JP4755396B2 (ja) | 2011-08-24 |
| ZA200405699B (en) | 2005-07-01 |
| TW200303170A (en) | 2003-09-01 |
| US7479471B2 (en) | 2009-01-20 |
| BR0307877A (pt) | 2004-12-28 |
| RU2004127931A (ru) | 2005-04-10 |
| KR20040089655A (ko) | 2004-10-21 |
| BR0307877B1 (pt) | 2014-12-23 |
| AU2009251129B9 (en) | 2012-05-03 |
| CA2476828A1 (en) | 2003-08-28 |
| CN1636001A (zh) | 2005-07-06 |
| CN100491359C (zh) | 2009-05-27 |
| ATE410416T1 (de) | 2008-10-15 |
| JP2005525351A (ja) | 2005-08-25 |
| CA2476828C (en) | 2012-08-21 |
| US20040002424A1 (en) | 2004-01-01 |
| DE50310607D1 (de) | 2008-11-20 |
| DE10207037A1 (de) | 2003-08-28 |
| EP1478628A1 (de) | 2004-11-24 |
| MY138410A (en) | 2009-05-29 |
| EP1478628B1 (de) | 2008-10-08 |
| ES2312754T3 (es) | 2009-03-01 |
| AU2009251129A1 (en) | 2010-01-21 |
| MXPA04008044A (es) | 2004-11-26 |
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