AR038331A1 - Anticolinergicos, procedimiento para su preparacion, asi como su uso como medicamentos - Google Patents
Anticolinergicos, procedimiento para su preparacion, asi como su uso como medicamentosInfo
- Publication number
- AR038331A1 AR038331A1 ARP030100253A ARP030100253A AR038331A1 AR 038331 A1 AR038331 A1 AR 038331A1 AR P030100253 A ARP030100253 A AR P030100253A AR P030100253 A ARP030100253 A AR P030100253A AR 038331 A1 AR038331 A1 AR 038331A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- halogen
- alkylene
- alkyloxy
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/06—Anti-spasmodics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Reivindicación 1: Compuestos de la fórmula (1), en donde significan: X- un anión cargado negativamente de forma sencilla; A y B, iguales o diferentes, preferentemente iguales, -O-, -S-, -NH-, -CH2-, -CH=CH- o -N (alquilo C1-4)-; R, hidrógeno, hidroxi, -alquilo C1-4, -alquiloxi C1-4,-alquilen C1-4-halógeno,-O-alquilen C1-4 halógeno, -alquilen C1-4-OH, -CF3, CHF2, -alquileno C1-4-alquiloxi C1-4, -O-CO-alquilo C1-4, -O-CO-alquileno C1-4-halógeno, -alquileno C1-4-cicloalquilo C3-6, -O-COCF3 o halógeno; R1 y R2, iguales o diferentes, -alquilo C1-5, que puede estar eventualmente sustituido con -cicloalquilo C3-6, hidroxi o halógeno, o R1 y R2 juntos, un puente de -alquileno C3-5; R3, R4, R3' y R4', iguales o diferentes, hidrógeno, alquilo C1-4, alquiloxi C1-4, hidroxi, -CF3, -CHF2, CN, NO2 o halógeno; Rx y Rx', iguales o diferentes, hidrógeno, alquilo C1-4, alquiloxi C1-4, hidroxi, -CF3, -CHF2, CN, NO2 o halógeno o Rx y Rx' juntos forman un enlace sencillo o un grupo de puente seleccionado de los puentes -O-, -S-, -NH-, -CH2, -CH2-CH2-, -N(alquilo C1-4)-, -CH(alquiloC1-4)2-.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10203749A DE10203749A1 (de) | 2002-01-31 | 2002-01-31 | Neue Anticholinergika, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR038331A1 true AR038331A1 (es) | 2005-01-12 |
Family
ID=27588163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030100253A AR038331A1 (es) | 2002-01-31 | 2003-01-29 | Anticolinergicos, procedimiento para su preparacion, asi como su uso como medicamentos |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1472250B1 (es) |
| JP (1) | JP4484521B2 (es) |
| KR (1) | KR100950870B1 (es) |
| CN (1) | CN1291986C (es) |
| AR (1) | AR038331A1 (es) |
| AU (1) | AU2003206760B8 (es) |
| BR (1) | BR0307299A (es) |
| CA (1) | CA2474874C (es) |
| CO (1) | CO5601000A2 (es) |
| DE (1) | DE10203749A1 (es) |
| IL (1) | IL162669A0 (es) |
| MX (1) | MXPA04007249A (es) |
| NZ (1) | NZ534927A (es) |
| PE (1) | PE20030964A1 (es) |
| PL (1) | PL211064B1 (es) |
| RU (1) | RU2325388C2 (es) |
| TW (1) | TWI260323B (es) |
| UY (1) | UY27629A1 (es) |
| WO (1) | WO2003064418A1 (es) |
| ZA (1) | ZA200404569B (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004206846B2 (en) * | 2003-01-16 | 2009-05-28 | University Of Rochester | Quaternary antimuscarinic compounds for the treatment of bladder diseases |
| CA2534120C (en) * | 2003-07-31 | 2012-09-11 | Boehringer Ingelheim International Gmbh | Medicaments for inhalation comprising anticholinergics and a betamimetic |
| US7507745B2 (en) | 2004-02-20 | 2009-03-24 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions based on fluorenecarboxylic acid esters and soluble TNF receptor fusion proteins |
| WO2005079794A1 (en) * | 2004-02-20 | 2005-09-01 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions based on anticholinergics and pegsunercept |
| DE102004016179A1 (de) * | 2004-03-30 | 2005-10-20 | Boehringer Ingelheim Pharma | Verbindungen zur Behandlung von proliferativen Prozessen |
| EP1632229B1 (en) * | 2004-08-11 | 2009-04-01 | Boehringer Ingelheim Pharma GmbH & Co. KG | Medicaments for the treatment of urinary tract disorders comprising anticholinergic agents |
| US20080027094A1 (en) * | 2004-08-30 | 2008-01-31 | Ono Pharmaceutical Co., Ltd. | Tropane Compounds and Pharmaceutical Compositions Comprising the Same as an Active Ingredient |
| WO2006087316A1 (en) * | 2005-02-16 | 2006-08-24 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions comprising anticholinergics and etiprednol |
| JP2008532973A (ja) * | 2005-03-09 | 2008-08-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 抗コリン作用薬とｐｄｅ５−阻害剤に基づく新規な医薬組成物 |
| WO2006128847A2 (en) * | 2005-05-31 | 2006-12-07 | Boehringer Ingelheim International Gmbh | Medicament containing a betamimetic in conjunction with an anticholinergic and a pde iv inhibitor |
| DE102005030733A1 (de) | 2005-07-01 | 2007-01-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff |
| US7423146B2 (en) | 2005-11-09 | 2008-09-09 | Boehringer Ingelheim International Gmbh | Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones |
| JP2009091250A (ja) * | 2006-01-30 | 2009-04-30 | Ono Pharmaceut Co Ltd | トロパン化合物およびそれらを有効成分として含有する医薬組成物 |
| CA2660186A1 (en) | 2006-08-07 | 2008-02-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical combinations for the treatment of respiratory diseases |
| PE20080610A1 (es) | 2006-08-22 | 2008-07-15 | Boehringer Ingelheim Int | Nuevos beta-agonistas enantiomericamente puros, procedimientos para su preparacion y uso como medicamentos |
| ES2569359T3 (es) | 2007-07-06 | 2016-05-10 | Vectura Delivery Devices Limited | Inhalador |
| EP2180892A2 (en) * | 2007-07-18 | 2010-05-05 | Boehringer Ingelheim International GmbH | Combinations comprising telmisartan and an anticholinergic such as tiotropium or a glycopyrronium salt for the treatment of respiratory diseases such as copd or asthma |
| EP2082767A1 (en) | 2008-01-24 | 2009-07-29 | Vectura Delivery Devices Limited | Inhaler |
| EP2082766A1 (en) | 2008-01-24 | 2009-07-29 | Vectura Delivery Devices Limited | Blister Strip Coil Forming |
| EP2082768A1 (en) | 2008-01-24 | 2009-07-29 | Vectura Delivery Devices Limited | Inhaler |
| EP2082772A1 (en) | 2008-01-24 | 2009-07-29 | Vectura Delivery Devices Limited | Inhaler |
| EP2082771A1 (en) | 2008-01-24 | 2009-07-29 | Vectura Delivery Devices Limited | Inhaler |
| EP2093219A1 (de) | 2008-02-22 | 2009-08-26 | Boehringer Ingelheim International Gmbh | Kristalline, enantiomerenreine Salzform eines Betamimetikums und dessen Verwendung als Arzneimittel |
| GB0918450D0 (en) | 2009-10-21 | 2009-12-09 | Innovata Ltd | Composition |
| RU2535027C2 (ru) * | 2012-08-10 | 2014-12-10 | Федеральное государственное бюджетное учреждение "Научно-исследовательский институт экспериментальной медицины" Северо-Западного отделения Российской академии медицинских наук (ФГБУ "НИИЭМ" СЗО РАМН) | Антидепрессивное средство |
| CN102964345B (zh) * | 2012-12-06 | 2016-07-13 | 四川理工学院 | 一种2―羟基―2,2―二苯基乙酸―3α―(8―氮杂双环[3,2,1])―3―辛酯的制备方法 |
| JP2018537460A (ja) | 2015-11-23 | 2018-12-20 | シンジェンタ パーティシペーションズ アーゲー | 硫黄およびシクロプロピル含有置換基を有する有害生物防除的に活性な複素環式誘導体 |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| EP3691620B1 (en) | 2017-10-05 | 2022-07-27 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3931041C2 (de) * | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| DE4108393A1 (de) * | 1991-03-15 | 1992-09-17 | Boehringer Ingelheim Kg | Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln |
-
2002
- 2002-01-31 DE DE10203749A patent/DE10203749A1/de not_active Withdrawn
-
2003
- 2003-01-21 KR KR1020047011901A patent/KR100950870B1/ko not_active Expired - Fee Related
- 2003-01-21 JP JP2003564041A patent/JP4484521B2/ja not_active Expired - Lifetime
- 2003-01-21 IL IL16266903A patent/IL162669A0/xx not_active IP Right Cessation
- 2003-01-21 MX MXPA04007249A patent/MXPA04007249A/es active IP Right Grant
- 2003-01-21 RU RU2004126441/04A patent/RU2325388C2/ru not_active IP Right Cessation
- 2003-01-21 BR BR0307299-1A patent/BR0307299A/pt not_active IP Right Cessation
- 2003-01-21 CN CNB038029995A patent/CN1291986C/zh not_active Expired - Fee Related
- 2003-01-21 EP EP03704441.9A patent/EP1472250B1/de not_active Expired - Lifetime
- 2003-01-21 PL PL369889A patent/PL211064B1/pl unknown
- 2003-01-21 NZ NZ534927A patent/NZ534927A/en not_active IP Right Cessation
- 2003-01-21 AU AU2003206760A patent/AU2003206760B8/en not_active Ceased
- 2003-01-21 CA CA2474874A patent/CA2474874C/en not_active Expired - Fee Related
- 2003-01-21 WO PCT/EP2003/000533 patent/WO2003064418A1/de not_active Ceased
- 2003-01-29 PE PE2003000090A patent/PE20030964A1/es not_active Application Discontinuation
- 2003-01-29 TW TW092101967A patent/TWI260323B/zh not_active IP Right Cessation
- 2003-01-29 UY UY27629A patent/UY27629A1/es not_active Application Discontinuation
- 2003-01-29 AR ARP030100253A patent/AR038331A1/es active IP Right Grant
-
2004
- 2004-06-09 ZA ZA200404569A patent/ZA200404569B/en unknown
- 2004-08-06 CO CO04076776A patent/CO5601000A2/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003206760B8 (en) | 2009-05-07 |
| PL369889A1 (en) | 2005-05-02 |
| MXPA04007249A (es) | 2004-10-29 |
| NZ534927A (en) | 2006-10-27 |
| TWI260323B (en) | 2006-08-21 |
| JP2005525323A (ja) | 2005-08-25 |
| JP4484521B2 (ja) | 2010-06-16 |
| CN1291986C (zh) | 2006-12-27 |
| KR100950870B1 (ko) | 2010-04-06 |
| WO2003064418A1 (de) | 2003-08-07 |
| RU2325388C2 (ru) | 2008-05-27 |
| AU2003206760B2 (en) | 2009-03-26 |
| TW200404800A (en) | 2004-04-01 |
| CN1625556A (zh) | 2005-06-08 |
| ZA200404569B (en) | 2006-08-30 |
| EP1472250A1 (de) | 2004-11-03 |
| IL162669A0 (en) | 2005-11-20 |
| UY27629A1 (es) | 2003-08-29 |
| KR20040081168A (ko) | 2004-09-20 |
| RU2004126441A (ru) | 2005-07-10 |
| EP1472250B1 (de) | 2014-11-26 |
| CA2474874C (en) | 2012-10-30 |
| PE20030964A1 (es) | 2003-12-24 |
| HK1077818A1 (en) | 2006-02-24 |
| CA2474874A1 (en) | 2003-08-07 |
| DE10203749A1 (de) | 2003-08-14 |
| PL211064B1 (pl) | 2012-04-30 |
| BR0307299A (pt) | 2004-12-21 |
| CO5601000A2 (es) | 2006-01-31 |
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