[go: up one dir, main page]

AR037880A1 - Derivados de benzodifuranimidazolina y benzofuranimidazolina y su uso para el tratamiento de glaucoma - Google Patents

Derivados de benzodifuranimidazolina y benzofuranimidazolina y su uso para el tratamiento de glaucoma

Info

Publication number
AR037880A1
AR037880A1 ARP020104911A ARP020104911A AR037880A1 AR 037880 A1 AR037880 A1 AR 037880A1 AR P020104911 A ARP020104911 A AR P020104911A AR P020104911 A ARP020104911 A AR P020104911A AR 037880 A1 AR037880 A1 AR 037880A1
Authority
AR
Argentina
Prior art keywords
alkyl
derivatives
link
benzofuranimidazolina
benzodifuranimidazolina
Prior art date
Application number
ARP020104911A
Other languages
English (en)
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Publication of AR037880A1 publication Critical patent/AR037880A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente proporciona derivados de benzodifuran imidazolina y derivados de benzofuran imidazolina para la disminución de la presión intraocular y para proporcionar neuroprotección ocular. Reivindicación 1: Un compuesto de la fórmula (1)en donde A, B y D se seleccionan en forma independiente entre ya sea N o C, con la condición de que por lo menos uno de A, B o D es N; E es C o N; R es H o alquilo C1-4; R2 y R3 son de forma independiente, H, alquilo C1-3, alquenilo C2-3, o R2 y R3 tomados juntos pueden formar un anillo de 5 ó 6 miembros; X es hidrógeno, halógeno, alquilo C1-4 o CF3; y el enlace delinea de puntos puede ser un enlace simple o un enlace doble; y sales farmacéuticamente aceptables y solvatos.
ARP020104911A 2001-12-20 2002-12-17 Derivados de benzodifuranimidazolina y benzofuranimidazolina y su uso para el tratamiento de glaucoma AR037880A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34337801P 2001-12-20 2001-12-20

Publications (1)

Publication Number Publication Date
AR037880A1 true AR037880A1 (es) 2004-12-09

Family

ID=23345873

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020104911A AR037880A1 (es) 2001-12-20 2002-12-17 Derivados de benzodifuranimidazolina y benzofuranimidazolina y su uso para el tratamiento de glaucoma

Country Status (13)

Country Link
US (1) US7208512B2 (es)
EP (1) EP1455780A4 (es)
JP (1) JP2005513103A (es)
KR (1) KR20040068315A (es)
CN (1) CN1268334C (es)
AR (1) AR037880A1 (es)
AU (1) AU2002353088B2 (es)
BR (1) BR0215172A (es)
CA (1) CA2469904A1 (es)
MX (1) MXPA04006029A (es)
TW (1) TW593302B (es)
WO (1) WO2003053436A1 (es)
ZA (1) ZA200404473B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6960579B1 (en) 1998-05-19 2005-11-01 Alcon Manufacturing, Ltd. Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
TW593302B (en) 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
EP1581209A4 (en) 2002-12-13 2009-03-11 Alcon Inc NEW BENZOPYRAN ANALOGUE AND ITS USE FOR THE TREATMENT OF GLAUKOM
WO2005053688A1 (en) * 2003-11-26 2005-06-16 Alcon, Inc. Substituted furo[2,3-g] indazoles for the treatment of glaucoma
TW200520760A (en) 2003-12-15 2005-07-01 Alcon Inc Substituted [1,4] oxazino [2,3-g] indazoles for the treatment of glaucoma
US7338972B1 (en) 2003-12-15 2008-03-04 Alcon, Inc. Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
US7129257B1 (en) 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
WO2006062839A1 (en) 2004-12-08 2006-06-15 Alcon, Inc. Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
TW200744567A (en) * 2005-09-23 2007-12-16 Alcon Inc Phenylethylamine analogs and their use for treating glaucoma
US20070293475A1 (en) * 2006-06-20 2007-12-20 Alcon Manufacturing Ltd. Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES323985A1 (es) 1966-02-26 1966-12-16 Blade Pique Juan Procedimiento para la obtenciën de derivados del imidazol
US5011846A (en) 1988-02-23 1991-04-30 Merrell Dow Pharmaceuticals Inc. Medicament compositions derived from quinolizine and quinolizinone and methods of use thereof
AU7124691A (en) 1990-02-27 1991-08-29 Ciba-Geigy Ag Benzofurans
EP1293525A3 (en) 1990-06-26 2005-09-07 AorTech Biomaterials Pty Ltd Polyurethane or polyurethan-urea elastomeric compositions
US5578612A (en) 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
JPH06508354A (ja) 1991-06-21 1994-09-22 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー トリプタミン類似体、その合成法およびその５−ｈｔ↓１様または５−ｈｔ↓２受容体作用物質としての使用
GB9216380D0 (en) 1992-07-31 1992-09-16 Glaxo Group Ltd Medicaments
US5290781A (en) 1993-01-05 1994-03-01 Iolab Corporation Ketaneserinol as an agent to reduce intraocular pressure
US5891131A (en) 1993-02-01 1999-04-06 Arizona Board Of Regents Method and apparatus for automated simulation and design of corneal refractive procedures
TW334423B (en) 1993-10-22 1998-06-21 Hoffmann La Roche Tricyclic 1-aminoethylpyrrole-derivatives
TW270114B (es) 1993-10-22 1996-02-11 Hoffmann La Roche
US5538974A (en) 1994-01-27 1996-07-23 Senju Pharamceutical Co., Ltd. Ophthalmic composition for lowering intraocular pressure
TW309426B (es) 1994-03-18 1997-07-01 Senju Pharma Co
US5874477A (en) 1994-08-12 1999-02-23 The University Of Hawaii Method of treatment for malaria utilizing serotonin receptor ligands
TW403738B (en) 1994-08-12 2000-09-01 Hoffmann La Roche Tricyclic pyrazole derivatives
US5998467A (en) 1995-10-25 1999-12-07 Mitsubishi Chemical Corporation Medicine for oculopathy
AU2340997A (en) 1996-03-27 1997-10-17 Merck & Co., Inc. A method for inhibiting clot formation
US5902815A (en) 1996-09-03 1999-05-11 Washington University Use of 5HT-2A serotonin agonists to prevent adverse effects of NMDA receptor hypofunction
AU4249297A (en) 1996-10-31 1998-05-22 Alcon Laboratories, Inc. Opthalmological compositions containing serotonin 5-ht1a receptor agonist and their use in the treatment of glaucoma
GB9700899D0 (en) 1997-01-17 1997-03-05 Smithkline Beecham Plc Novel treatment
MXPA00010060A (es) 1998-04-14 2004-04-23 Arena Pharm Inc Receptores de serotonina humana constitutivamente activados, no endogenos y moduladores de molecula pequenos de los mismos.
AU3978899A (en) 1998-05-19 1999-12-06 Alcon Laboratories, Inc. Serotonergic 5HT, receptor compounds for treating ocular and CNS disorders
GB9819035D0 (en) 1998-09-01 1998-10-28 Cerebrus Res Ltd Chemical compounds VII
GB9819033D0 (en) 1998-09-01 1998-10-28 Cerebrus Ltd Chemical compounds VI
ES2252978T3 (es) 1998-09-18 2006-05-16 Alcon Manufacturing Ltd. Agonistas 5ht2 serotonergicos para tratar el glaucoma.
AR022687A1 (es) 1998-12-17 2002-09-04 Wyeth Corp Derivados de 2,3,4,4a-tetrahidro-1h-pirazino[1,2-a] quinoxalin-5(6h)ona, una composicion farmaceutica y el uso de los mismos para la manufactura de losmedicamentos.
GB9902047D0 (en) 1999-01-29 1999-03-17 Cerebrus Ltd Chemical compounds XI
WO2001040183A1 (en) 1999-12-03 2001-06-07 Alcon Universal Ltd. 1-aminoalkyl-1h-indoles for treating glaucoma
CA2401969A1 (en) 2000-03-17 2001-09-27 Alcon, Inc. 5ht2 agonists for controlling iop and treating glaucoma
AU2001216072A1 (en) 2000-03-17 2001-10-03 Alcon, Inc. 6-hydroxy-indazole derivatives for treating glaucoma
WO2001070223A1 (en) * 2000-03-17 2001-09-27 Alcon, Inc. Compounds with 5-ht2 and 5-ht1a agonist activity for treating glaucoma
US6806285B1 (en) 2000-03-17 2004-10-19 Alcon, Inc. 5-Hydroxyl indole derivatives for treating glaucoma
WO2001070705A1 (en) 2000-03-17 2001-09-27 Alcon, Inc. 2-acylaminobenzimidazole derivatives for treating glaucoma
JP4088444B2 (ja) 2000-03-17 2008-05-21 アルコン，インコーポレイテッド 緑内障を処置するためのピラノインドール
AU2001219180B2 (en) 2000-03-17 2005-04-07 Alcon, Inc. 5-hydroxy indazole derivatives for treating glaucoma
WO2002098860A1 (en) 2001-06-01 2002-12-12 Alcon, Inc. Novel fused indazoles and indoles and their use for the treatment of glaucoma
AU2002305732B2 (en) 2001-06-01 2007-02-01 Alcon, Inc. Pyranoindazoles and their use for the treatment of glaucoma
BR0210238A (pt) 2001-06-01 2004-07-20 Alcon Inc Novos análogos de aril-amino-propano e seu uso para o tratamento de glaucoma
US6884816B2 (en) 2001-08-31 2005-04-26 Alcon, Inc. Hydroxy substituted fused naphthyl-azoles and fused indeno-azoles and their use for the treatment of glaucoma
EP1461030A4 (en) 2001-12-14 2005-06-01 Alcon Inc AMINOALKYL-BENZOFURAN-5-OL COMPOUNDS FOR THE TREATMENT OF GLAUCOMA
WO2003051291A2 (en) 2001-12-14 2003-06-26 Alcon, Inc. Substituted 5-hydroxy-indole compounds for the treatment of glaucoma
TW593302B (en) 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
MXPA05002259A (es) 2002-08-30 2005-07-05 Alcon Inc Compuestos de 5-croman-5-il-etilamina sustituidos y uso para el tratamiento de glaucoma.
US20060106106A1 (en) 2002-09-24 2006-05-18 Glennon Richard A Beta-hydroxyphenylalkylamines and their use for treating glaucoma
EP1581209A4 (en) 2002-12-13 2009-03-11 Alcon Inc NEW BENZOPYRAN ANALOGUE AND ITS USE FOR THE TREATMENT OF GLAUKOM
MXPA05006851A (es) 2002-12-23 2005-08-16 Alcon Inc 1-alquil-3-aminoindazolas.

Also Published As

Publication number Publication date
JP2005513103A (ja) 2005-05-12
TW593302B (en) 2004-06-21
EP1455780A1 (en) 2004-09-15
CN1268334C (zh) 2006-08-09
US7208512B2 (en) 2007-04-24
BR0215172A (pt) 2004-10-19
EP1455780A4 (en) 2005-04-06
KR20040068315A (ko) 2004-07-30
CA2469904A1 (en) 2003-07-03
AU2002353088B2 (en) 2006-09-21
US20060009503A1 (en) 2006-01-12
TW200301257A (en) 2003-07-01
WO2003053436A1 (en) 2003-07-03
CN1606441A (zh) 2005-04-13
ZA200404473B (en) 2005-06-07
AU2002353088A1 (en) 2003-07-09
MXPA04006029A (es) 2004-09-27

Similar Documents

Publication Publication Date Title
CR10145A (es) Derivados de tropano útiles en terapia (divisional exp. 6800)
PE20040832A1 (es) Derivados de indolil pirazinona
PE20030199A1 (es) Derivados de n-[benzoil]-fenilsulfonamida
CO5550421A2 (es) Derivados de indol utiles para el tratamiento de enfermeda- des
CO5200848A1 (es) Derivados de 3(5)-ureido-pirazol, proceso para su prepa- racion y su utilizacion como agentes antitumorales
PE20030344A1 (es) 1-ALQUIL O 1-CICLOALQUIL-TRIAZOLO[4,3-a]QUINAZOLIN-5-ONAS COMO INHIBIDORAS DE FOSFODIESTERASA
HRP20090162T1 (en) Quinolinone-carboxamide compounds as 5-ht4 receptor agonists
AR037880A1 (es) Derivados de benzodifuranimidazolina y benzofuranimidazolina y su uso para el tratamiento de glaucoma
NO20013379D0 (no) 4-okso-1,4-dihydro-3-kinolinkarboksamider som antivirusmidler
AR038341A1 (es) Compuestos que son agonistas de receptores alfa-1 preferentemente agonistas de receptores alfa-1a/l
PE20050013A1 (es) Composiciones farmaceuticas como inhibidores de la proteasa del virus de la hepatitis c
AR024145A1 (es) Derivados de 5-fenil-pirimidina
BR0310057A (pt) melhoria do desenvolvimento de catarata e outras doenças oftálmicas
ES2054304T3 (es) Feniletanolaminometiltetralinas, procedimiento para su preparacion y composiciones farmaceuticas que las contienen.
DK0862562T3 (da) Benzoxazepinforbindelser, fremstilling deraf og anvendelse deraf som lipidniveauformindskende midler
DK0677046T3 (da) Piperazinderivater som 5-HT-antagonister.
MY117783A (en) Halogen substituted tetracyclic tetrahydrofuran derivatives
AR029400A1 (es) Derivados de isoxazolcarboxamida, un metodo para su preparacion y una composicion farmaceutica que los comprende
PT1064281E (pt) Derivados de distamicina benzo-heterociclicos processo para os preparar e a sua utilizacao como agentes antitumorais
AR018706A1 (es) Uso de una composicion farmaceutica para tratamiento de infecciones virales
AR035110A1 (es) Compuesto derivado de piperazina, uso del mismo para la preparacion de una composicion farmaceutica, composicion farmaceutica que lo comprende y procedimiento para la preparacion de dicho compuesto
ES2083972T3 (es) Arilalquil-aminas y -amidas con propiedades anticonvulsivas y neuroprotectoras.
AR034400A1 (es) Piranoindoles, composiciones farmaceuticas que los comprenden y el uso de los mismos para la manufactura de medicamentos para el tratamiento de glaucoma
BR0307008A (pt) N-aril-4,5-dia-minopirazóis e agentes de tingimento que contêm esses compostos
PE20001052A1 (es) Inhibidores de hiv proteasa

Legal Events

Date Code Title Description
FB Suspension of granting procedure