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AR037635A1 - Formas cristalinas y amorfas de la sal monocitrato de 3-[4-metil-3-[metil-(7h-pirrolo[2,3-d] pirimidin-4-il)-amino]- piperidin-1-il)-3-oxo-propionitrilo, composiciones farmaceuticas que lo contienen, uso en la manufactura de medicamentos y procedimiento para obtener una forma cristalizada - Google Patents

Formas cristalinas y amorfas de la sal monocitrato de 3-[4-metil-3-[metil-(7h-pirrolo[2,3-d] pirimidin-4-il)-amino]- piperidin-1-il)-3-oxo-propionitrilo, composiciones farmaceuticas que lo contienen, uso en la manufactura de medicamentos y procedimiento para obtener una forma cristalizada

Info

Publication number
AR037635A1
AR037635A1 ARP020104686A ARP020104686A AR037635A1 AR 037635 A1 AR037635 A1 AR 037635A1 AR P020104686 A ARP020104686 A AR P020104686A AR P020104686 A ARP020104686 A AR P020104686A AR 037635 A1 AR037635 A1 AR 037635A1
Authority
AR
Argentina
Prior art keywords
methyl
propionitrile
oxo
amino
manufacture
Prior art date
Application number
ARP020104686A
Other languages
English (en)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23326961&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR037635(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AR037635A1 publication Critical patent/AR037635A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Un compuesto que es una forma cristalina o amorfa de la sal mono citrato de 3-{4-metil-3-[metil-(7H-pirrolo[2,3-d]pirimidin-4-il)-amino]-piperidin-1-il}-3-oxo-propionitrilo de la fórmula (1). También se dan a conocer composiciones farmacéuticas que lo contienen, su uso en la manufactura de medicamentos y el procedimiento para obtener una forma cristalizada. Estos compuestos son útiles como inhibidores de proteína quinasas, y en tal sentido son útiles en la prevención o tratamiento de trastornos o enfermedades tales como rechazo en transplante de órganos, y en transplantes, lupus, esclerosis, esclerosis múltiple, artritis reumatoidea, psoriasis, diabetes tipo I, cáncer, asma, dermatitis atípica, colitis ulcerosa, enfermedades de Crohn y Alzheimer, leucemia y otras enfermedades autoinmunes en un mamífero.
ARP020104686A 2001-12-06 2002-12-04 Formas cristalinas y amorfas de la sal monocitrato de 3-[4-metil-3-[metil-(7h-pirrolo[2,3-d] pirimidin-4-il)-amino]- piperidin-1-il)-3-oxo-propionitrilo, composiciones farmaceuticas que lo contienen, uso en la manufactura de medicamentos y procedimiento para obtener una forma cristalizada AR037635A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33898401P 2001-12-06 2001-12-06

Publications (1)

Publication Number Publication Date
AR037635A1 true AR037635A1 (es) 2004-11-17

Family

ID=23326961

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020104686A AR037635A1 (es) 2001-12-06 2002-12-04 Formas cristalinas y amorfas de la sal monocitrato de 3-[4-metil-3-[metil-(7h-pirrolo[2,3-d] pirimidin-4-il)-amino]- piperidin-1-il)-3-oxo-propionitrilo, composiciones farmaceuticas que lo contienen, uso en la manufactura de medicamentos y procedimiento para obtener una forma cristalizada

Country Status (29)

Country Link
US (2) US6965027B2 (es)
EP (1) EP1451192B1 (es)
JP (1) JP4201135B2 (es)
KR (1) KR100691590B1 (es)
CN (1) CN1325498C (es)
AR (1) AR037635A1 (es)
AT (1) ATE497962T1 (es)
AU (1) AU2002348857B2 (es)
BR (1) BR0214761A (es)
CA (1) CA2469350C (es)
CO (1) CO5580780A2 (es)
CY (1) CY1111311T1 (es)
DE (1) DE60239146D1 (es)
DK (1) DK1451192T3 (es)
ES (1) ES2357942T3 (es)
GT (1) GT200200234A (es)
HN (1) HN2002000349A (es)
IL (1) IL161914A0 (es)
MX (1) MXPA04005401A (es)
NO (1) NO20042721L (es)
NZ (1) NZ532366A (es)
PA (1) PA8560201A1 (es)
PE (1) PE20030807A1 (es)
PL (1) PL221493B1 (es)
RU (1) RU2315052C2 (es)
TW (1) TW200300690A (es)
UY (1) UY27567A1 (es)
WO (1) WO2003048162A1 (es)
ZA (1) ZA200404270B (es)

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