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AR036575A1 - Eritropoyetina pegilada y diglicosilada - Google Patents

Eritropoyetina pegilada y diglicosilada

Info

Publication number
AR036575A1
AR036575A1 ARP020103572A ARP020103572A AR036575A1 AR 036575 A1 AR036575 A1 AR 036575A1 AR P020103572 A ARP020103572 A AR P020103572A AR P020103572 A ARP020103572 A AR P020103572A AR 036575 A1 AR036575 A1 AR 036575A1
Authority
AR
Argentina
Prior art keywords
erythropoietin
pegiled
diglicosiled
glycosylated
asn38
Prior art date
Application number
ARP020103572A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR036575A1 publication Critical patent/AR036575A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Se proporciona una muteína de eritropoyetina que tiene la actividad biológica in vivo de hacer que las células de la médula ósea incrementen la producción de reticulocitos y glóbulos rojos, caracterizada por estar N-glicosilada en Asn38 y Asn83 pero no estar N-glicosilada en Asn24. Tales muteínas tienen propiedades farmacéuticas mejoradas.
ARP020103572A 2001-09-25 2002-09-23 Eritropoyetina pegilada y diglicosilada AR036575A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01122555 2001-09-25

Publications (1)

Publication Number Publication Date
AR036575A1 true AR036575A1 (es) 2004-09-15

Family

ID=8178675

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020103572A AR036575A1 (es) 2001-09-25 2002-09-23 Eritropoyetina pegilada y diglicosilada

Country Status (10)

Country Link
US (1) US6930086B2 (es)
EP (1) EP1432802B1 (es)
JP (1) JP4025727B2 (es)
CN (1) CN100365117C (es)
AR (1) AR036575A1 (es)
AU (1) AU2002338743A1 (es)
CA (1) CA2460489C (es)
DE (1) DE60224415T2 (es)
ES (1) ES2298402T3 (es)
WO (1) WO2003029291A2 (es)

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Also Published As

Publication number Publication date
CN100365117C (zh) 2008-01-30
JP4025727B2 (ja) 2007-12-26
WO2003029291A3 (en) 2003-07-24
WO2003029291A2 (en) 2003-04-10
EP1432802A2 (en) 2004-06-30
US6930086B2 (en) 2005-08-16
ES2298402T3 (es) 2008-05-16
JP2005509609A (ja) 2005-04-14
CA2460489A1 (en) 2003-04-10
DE60224415D1 (de) 2008-02-14
EP1432802B1 (en) 2008-01-02
DE60224415T2 (de) 2008-12-18
CA2460489C (en) 2011-12-06
AU2002338743A1 (en) 2003-04-14
CN1558952A (zh) 2004-12-29
US20030077753A1 (en) 2003-04-24

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