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DE60315847D1 - Varianten des menschliche koagulationsfaktors vii - Google Patents

Varianten des menschliche koagulationsfaktors vii

Info

Publication number
DE60315847D1
DE60315847D1 DE60315847T DE60315847T DE60315847D1 DE 60315847 D1 DE60315847 D1 DE 60315847D1 DE 60315847 T DE60315847 T DE 60315847T DE 60315847 T DE60315847 T DE 60315847T DE 60315847 D1 DE60315847 D1 DE 60315847D1
Authority
DE
Germany
Prior art keywords
variants
coagulation factor
human coagulation
factor vii
polynucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60315847T
Other languages
English (en)
Other versions
DE60315847T2 (de
Inventor
Egon Persson
Ole Hvilsted Olsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk Health Care AG
Original Assignee
Novo Nordisk Health Care AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk Health Care AG filed Critical Novo Nordisk Health Care AG
Application granted granted Critical
Publication of DE60315847D1 publication Critical patent/DE60315847D1/de
Publication of DE60315847T2 publication Critical patent/DE60315847T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
DE60315847T 2002-09-25 2003-09-24 Varianten des menschliche koagulationsfaktors vii Expired - Lifetime DE60315847T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK200201423 2002-09-25
DKPA200201423 2002-09-25
PCT/DK2003/000625 WO2004029090A1 (en) 2002-09-25 2003-09-24 Human coagulation factor vii polypeptides

Publications (2)

Publication Number Publication Date
DE60315847D1 true DE60315847D1 (de) 2007-10-04
DE60315847T2 DE60315847T2 (de) 2008-05-15

Family

ID=32039052

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60315847T Expired - Lifetime DE60315847T2 (de) 2002-09-25 2003-09-24 Varianten des menschliche koagulationsfaktors vii
DE60330923T Expired - Lifetime DE60330923D1 (de) 2002-09-25 2003-09-24 Menschliche Koagulationsfaktor VII Polypeptide

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60330923T Expired - Lifetime DE60330923D1 (de) 2002-09-25 2003-09-24 Menschliche Koagulationsfaktor VII Polypeptide

Country Status (7)

Country Link
EP (2) EP1908782B1 (de)
JP (1) JP4597678B2 (de)
AT (2) ATE454403T1 (de)
AU (1) AU2003266214A1 (de)
DE (2) DE60315847T2 (de)
ES (2) ES2293088T3 (de)
WO (1) WO2004029090A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100882482B1 (ko) 2000-09-13 2009-02-06 노보 노르디스크 헬스 케어 악티엔게젤샤프트 사람 응고 인자 ｖｉｉ 변이체
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US20070026485A1 (en) 2003-04-09 2007-02-01 Neose Technologies, Inc. Glycopegylation methods and proteins/peptides produced by the methods
WO2005012484A2 (en) 2003-07-25 2005-02-10 Neose Technologies, Inc. Antibody-toxin conjugates
CN101870729A (zh) 2003-09-09 2010-10-27 诺和诺德医疗保健公司 凝固因子ⅶ多肽
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
WO2006010143A2 (en) 2004-07-13 2006-01-26 Neose Technologies, Inc. Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]
US20090176967A1 (en) * 2004-08-02 2009-07-09 Novo Nordisk Healthcare A/G Conjugation of FVII
DK1781782T3 (da) 2004-08-17 2010-08-23 Csl Behring Gmbh Modificerede vitamin K-afhængige polypeptider
ES2566670T3 (es) 2004-10-29 2016-04-14 Ratiopharm Gmbh Remodelación y glucopegilación del factor de crecimiento de fibroblastos (FGF)
EP2360171A1 (de) 2004-12-23 2011-08-24 Novo Nordisk Health Care AG Reduktion des Gehaltes an kontaminierenden Proteinen in Zusammensetzungen, die Vitamin K-abhängige Proteine von Interesse umfassen
JP4951527B2 (ja) 2005-01-10 2012-06-13 バイオジェネリックス アーゲー 糖ｐｅｇ化顆粒球コロニー刺激因子
US20070154992A1 (en) 2005-04-08 2007-07-05 Neose Technologies, Inc. Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
EP1893632B1 (de) 2005-06-17 2015-08-12 Novo Nordisk Health Care AG Selektive reduktion und derivatisierung manipulierter faktor vii proteine mit mindestens einem nichtnativen zystein
JP5147692B2 (ja) 2005-07-13 2013-02-20 ノボ ノルディスク ヘルス ケア アーゲー 治療用タンパク質生成のための宿主細胞タンパク質ノックアウト細胞
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
WO2007031559A2 (en) 2005-09-14 2007-03-22 Novo Nordisk Health Care Ag Human coagulation factor vii polypeptides
WO2007039475A1 (en) * 2005-09-21 2007-04-12 Novo Nordisk Health Care Ag Human coagulation factor vii polypeptides
US20090048440A1 (en) 2005-11-03 2009-02-19 Neose Technologies, Inc. Nucleotide Sugar Purification Using Membranes
US20080248959A1 (en) 2006-07-21 2008-10-09 Neose Technologies, Inc. Glycosylation of peptides via o-linked glycosylation sequences
ES2531934T3 (es) 2006-09-01 2015-03-20 Novo Nordisk Health Care Ag Glicoproteínas modificadas
EP2054521A4 (de) 2006-10-03 2012-12-19 Novo Nordisk As Verfahren zur reinigung von polypeptid-konjugate
PL2144923T3 (pl) 2007-04-03 2013-12-31 Biogenerix Ag Sposoby leczenia z użyciem glikopegilowanego G-CSF
CA2683443A1 (en) 2007-04-13 2008-10-23 Catalyst Biosciences, Inc. Modified factor vii polypeptides and uses thereof
EP2170919B8 (de) 2007-06-12 2016-01-20 ratiopharm GmbH Verbessertes verfahren zur herstellung von nukleotidzuckern
EP2626079A3 (de) 2008-02-27 2014-03-05 Novo Nordisk A/S Konjugierte Faktor-VIII-Moleküle
TWI538916B (zh) 2008-04-11 2016-06-21 介控生化科技公司 經修飾的因子vii多肽和其用途
EP2528943A1 (de) 2010-01-28 2012-12-05 Novo Nordisk Health Care AG Faktor-vii-fusionspolypeptide
JP2013533871A (ja) 2010-06-30 2013-08-29 ノヴォ ノルディスク アー／エス 組織因子経路インヒビターに特異的に結合することが可能な抗体
CA2828769A1 (en) 2011-03-02 2012-09-07 Novo Nordisk A/S Coagulation factor-targeting to tlt-1 on activated platelets
CA2838833A1 (en) 2011-06-10 2012-12-13 Biogen Idec Ma Inc. Pro-coagulant compounds and methods of use thereof
EP2906236A1 (de) 2012-10-10 2015-08-19 Novo Nordisk Health Care AG Flüssige pharmazeutische zusammensetzung aus faktor-vii-polypeptiden
CN107583031A (zh) * 2016-07-06 2018-01-16 陈栋梁 一种清蛋白肽混合物的制备方法及其抑制癌细胞增殖作用
EP3833381B1 (de) 2019-08-15 2022-08-03 Catalyst Biosciences, Inc. Modifizierte faktor-vii-polypeptide zur subkutanen verabreichung

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR860984B (en) 1985-04-17 1986-08-18 Zymogenetics Inc Expression of factor vii and ix activities in mammalian cells
GB8615942D0 (en) 1986-06-30 1986-08-06 Animal & Food Research Council Peptide production
GB8826446D0 (en) 1988-11-11 1988-12-14 Agricultural & Food Res Peptide production
WO1992011757A1 (en) 1991-01-11 1992-07-23 American Red Cross Expression of active human protein c in mammary tissue of transgenic animals
JPH1059866A (ja) * 1996-08-19 1998-03-03 Chemo Sero Therapeut Res Inst 血液凝固第ｖｉｉ因子及び／もしくは活性化血液凝固第ｖｉｉ因子の製造方法
JP4451514B2 (ja) * 1999-08-24 2010-04-14 財団法人化学及血清療法研究所 血液凝固第ｖｉｉ因子改変体
EP1982732A3 (de) * 2000-02-11 2011-06-08 Bayer HealthCare LLC Faktor VII- oder VIIA-ähnliche Konjugate
US6905683B2 (en) * 2000-05-03 2005-06-14 Novo Nordisk Healthcare A/G Human coagulation factor VII variants
EP1282693B1 (de) 2000-05-03 2010-10-20 Novo Nordisk Health Care AG Varianten des menschlichen Koagulationsfaktors VII
EP2253703A1 (de) 2000-09-13 2010-11-24 Novo Nordisk Health Care AG Varianten des menschlichen Gerinnungsfaktors VII
EP1373493B1 (de) * 2001-03-22 2013-07-31 Novo Nordisk Health Care AG Derivat des koagulationsfaktors vii
EP1432794B1 (de) * 2001-09-27 2011-11-09 Novo Nordisk Health Care AG Menschliche gerinnungsfaktor-vii-polypeptide
US6960657B2 (en) * 2001-11-02 2005-11-01 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides

Also Published As

Publication number Publication date
EP1908782B1 (de) 2010-01-06
ATE370968T1 (de) 2007-09-15
EP1908782A1 (de) 2008-04-09
JP4597678B2 (ja) 2010-12-15
DE60315847T2 (de) 2008-05-15
ES2339393T3 (es) 2010-05-19
AU2003266214A1 (en) 2004-04-19
ES2293088T3 (es) 2008-03-16
JP2006516384A (ja) 2006-07-06
WO2004029090A1 (en) 2004-04-08
EP1546202B1 (de) 2007-08-22
DE60330923D1 (de) 2010-02-25
EP1546202A1 (de) 2005-06-29
ATE454403T1 (de) 2010-01-15

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