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AR036115A1 - Compuesto de n-aroilaminas, composiciones farmaceuticas formuladas con dichos compuestos; uso de los compuestos mencionados en la preparacion de composiciones farmaceuticas para tratar,prevenir enfermedades o trastornos donde se requiere la aplicacion de antagonistas de receptores de la orexina huma - Google Patents

Compuesto de n-aroilaminas, composiciones farmaceuticas formuladas con dichos compuestos; uso de los compuestos mencionados en la preparacion de composiciones farmaceuticas para tratar,prevenir enfermedades o trastornos donde se requiere la aplicacion de antagonistas de receptores de la orexina huma

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Publication number
AR036115A1
AR036115A1 ARP020102413A ARP020102413A AR036115A1 AR 036115 A1 AR036115 A1 AR 036115A1 AR P020102413 A ARP020102413 A AR P020102413A AR P020102413 A ARP020102413 A AR P020102413A AR 036115 A1 AR036115 A1 AR 036115A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
pharmaceutical compositions
compounds
pharmaceutically acceptable
heteroatoms selected
Prior art date
Application number
ARP020102413A
Other languages
English (en)
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0115863A external-priority patent/GB0115863D0/en
Priority claimed from GB0130342A external-priority patent/GB0130342D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of AR036115A1 publication Critical patent/AR036115A1/es

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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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Abstract

Se describen y reivindican compuestos de N-aroil-aminas que responden a la fórmula (1), donde: X representa un enlace, oxígeno, NR3 o un grupo (CH2)n, donde n representa 1, 2 ó 3; Y representa CH2, CO, CH(OH) o CH2CH(OH); Het es un grupo heteroarilo bicíclico opcionalmente sustituido que contiene hasta 4 heteroátomos seleccionados de N, O y S; Ar2 representa un fenilo opcionalmente sustituido o un grupo heterociclilo de 5 ó 6 miembros que contiene hasta 3 heteroátomos seleccionados de N, O y S, donde el fenilo o grupo heterociclilo está sustituido con R1 y sustituyentes opcionales adicionales; o Ar2 representa un grupo aromático bicíclico o un grupo heteroaromático bicíclico opcionalmente sustituido, que contiene hasta 3 heteroátomos seleccionados de N, O y S; R1 representa hidrógeno, alcoxi C1-4 opcionalmente sustituido, halo, ciano, alquilo C1-6 opcionalmente sustituido, fenilo opcionalmente sustituido o un grupo heterociclilo de 5 ó 6 miembros opcionalmente sustituido que contiene hasta 4 heteroátomos seleccionados de N, O y S; R3 representa hidrógeno o un alquilo C1-4 opcionalmente sustituido distinto de cuando Het es indolilo, donde R3 representa hidrógeno o alquilo C1-4; o una sal farmacéuticamente aceptable del mismo, con la condición de que: cuando X es NH, Y es CH2 y Het es indolilo, Ar2 no es 3,5-bis(trifluorometil)fenilo; o el compuesto no es (2R)-1-(3,5-diclorobenzoil)-2-[(1H-indol-3-il)metil]piperazina; (2R)-2-[(1H-indol-3-il)metil]-1-[(3-metoxi-5-trifluorometil)benzoil]piperazina; 1-benzoil-2-[(1H-indol-3-il)metil]piperazina. Se describen y reivindican además, composiciones farmacéuticas que comprenden un compuesto de fórmula (1), o sales farmacéuticamente aceptables del mismo, y un vehículo farmacéuticamente aceptable. Se describe y reivindica además el uso de un compuesto de fórmula (1), o sales farmacéuticamente aceptables de los mismos, para preparar composiciones farmacéuticas para tratar o prevenir enfermedades o trastornos en los que se requiere un antagonista de receptores de la orexina humana.
ARP020102413A 2001-06-28 2002-06-26 Compuesto de n-aroilaminas, composiciones farmaceuticas formuladas con dichos compuestos; uso de los compuestos mencionados en la preparacion de composiciones farmaceuticas para tratar,prevenir enfermedades o trastornos donde se requiere la aplicacion de antagonistas de receptores de la orexina huma AR036115A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0115863A GB0115863D0 (en) 2001-06-28 2001-06-28 Compounds
GB0130342A GB0130342D0 (en) 2001-12-19 2001-12-19 Compounds

Publications (1)

Publication Number Publication Date
AR036115A1 true AR036115A1 (es) 2004-08-11

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ARP020102413A AR036115A1 (es) 2001-06-28 2002-06-26 Compuesto de n-aroilaminas, composiciones farmaceuticas formuladas con dichos compuestos; uso de los compuestos mencionados en la preparacion de composiciones farmaceuticas para tratar,prevenir enfermedades o trastornos donde se requiere la aplicacion de antagonistas de receptores de la orexina huma

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US (5) US7470710B2 (es)
EP (2) EP1399441B1 (es)
JP (1) JP4399256B2 (es)
KR (1) KR20040029326A (es)
CN (1) CN1549816A (es)
AR (1) AR036115A1 (es)
AT (1) ATE332300T1 (es)
BR (1) BR0210609A (es)
CA (1) CA2451464A1 (es)
CO (1) CO5540306A2 (es)
CZ (1) CZ20033437A3 (es)
DE (1) DE60212968T2 (es)
ES (1) ES2266549T3 (es)
HU (1) HUP0400326A2 (es)
IL (1) IL159041A0 (es)
MX (1) MXPA03011706A (es)
NO (1) NO20035739L (es)
PL (1) PL367677A1 (es)
WO (1) WO2003002561A1 (es)

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* Cited by examiner, † Cited by third party
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