AR036044A1 - Compuestos piranoindazoles, composiciones farmaceuticas y su uso para la manufactura de un medicamento para el tratamiento del glaucoma - Google Patents
Compuestos piranoindazoles, composiciones farmaceuticas y su uso para la manufactura de un medicamento para el tratamiento del glaucomaInfo
- Publication number
- AR036044A1 AR036044A1 ARP020102050A ARP020102050A AR036044A1 AR 036044 A1 AR036044 A1 AR 036044A1 AR P020102050 A ARP020102050 A AR P020102050A AR P020102050 A ARP020102050 A AR P020102050A AR 036044 A1 AR036044 A1 AR 036044A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl group
- substituted
- unsubstituted alkyl
- hydrogen
- independently hydrogen
- Prior art date
Links
- 208000010412 Glaucoma Diseases 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- KJQBHOJNTQICKU-UHFFFAOYSA-N pyrano[2,3-g]indazole Chemical class O1C=CC=C2C3=NN=CC3=CC=C21 KJQBHOJNTQICKU-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 150000002431 hydrogen Chemical group 0.000 abstract 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 150000001356 alkyl thiols Chemical class 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000004406 elevated intraocular pressure Effects 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 230000004493 normal intraocular pressure Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- -1 pyranoindazole compound Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un compuesto piranoindazol representado por la fórmula (1), en la cual: R1 y R2 son seleccionados, independientemente, entre hidrógeno o un grupo alquilo; R3 y R4 son independientemente hidrógeno o un grupo alquilo; o R3 y R4 y el átomo de carbono al cual están unidos forman un anillo de cicloalquilo; o R2 y R3 juntos forman un heterociclo (CH2)m saturado; R5 es hidrógeno, halógeno o un grupo alquilo sustituido o insustituido; R6 y R7 son independientemente hidrógeno, halógeno, ciano, un alquiltio o un grupo alquilo sustituido o insustituido; R8 y R9 son independientemente hidrógeno, hidroxilo, un grupo alquilo sustituido o insustituido, un alcoxi, =O, NR10R11, OC(=O)NR1R2, OC(=O)alquilo C1-4, o un alquiltiol; R10 y R11 son independientemente hidrógeno, un grupo alquilo sustituido o insustituido, C(=O)alquilo C1-4, C(=O)Oalquilo C1-4, o C(=O)NR1R2, o R10 y R11 en forma conjunta completan un anillo heterocíclico de 5 ó 6 miembros saturado, el cual incluye optativamente un heteroátomo adicional seleccionado entre N, O u S cuando es un anillo de 6 miembros; A es (CH2)n, C=O, o CHalquilo C1-4; B es un enlace simple o doble, en donde cuando B es un enlace doble, R8 y R9 se seleccionan entre hidrógeno, o un grupo alquilo sustituido o insustituido; m = 2-4; n = 0-2; X e Y son N ó C, en donde X e Y son diferentes; y los enlaces de rayas denotan un enlace simple y doble adecuadamente designado. También se describe el uso de dichos compuestos para la manufactura de un medicamento para la reducción y el control de la presión intraocular normal o elevada como así también para el tratamiento del glaucoma.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29542901P | 2001-06-01 | 2001-06-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR036044A1 true AR036044A1 (es) | 2004-08-04 |
Family
ID=23137684
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020102050A AR036044A1 (es) | 2001-06-01 | 2002-05-31 | Compuestos piranoindazoles, composiciones farmaceuticas y su uso para la manufactura de un medicamento para el tratamiento del glaucoma |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US6696476B2 (es) |
| EP (1) | EP1392292B1 (es) |
| JP (1) | JP2004535418A (es) |
| KR (1) | KR100626255B1 (es) |
| CN (1) | CN100384417C (es) |
| AR (1) | AR036044A1 (es) |
| AT (1) | ATE318821T1 (es) |
| AU (1) | AU2002305732B2 (es) |
| BR (1) | BR0210241A (es) |
| CA (1) | CA2447480A1 (es) |
| DE (1) | DE60209486T2 (es) |
| DK (1) | DK1392292T3 (es) |
| ES (1) | ES2258631T3 (es) |
| MX (1) | MXPA03010807A (es) |
| PL (1) | PL366636A1 (es) |
| PT (1) | PT1392292E (es) |
| RU (1) | RU2273641C2 (es) |
| WO (1) | WO2002098350A2 (es) |
| ZA (1) | ZA200309034B (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6960579B1 (en) | 1998-05-19 | 2005-11-01 | Alcon Manufacturing, Ltd. | Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders |
| US7005443B1 (en) * | 2000-03-17 | 2006-02-28 | Alcon, Inc. | 5-Hydroxy indazole derivatives for treating glaucoma |
| DE60117247D1 (de) * | 2000-03-31 | 2006-04-20 | Purdue Research Foundation West Lafayette | Phosphoramidat-prodrugs |
| EP1392292B1 (en) * | 2001-06-01 | 2006-03-01 | Alcon, Inc. | Pyranoindazoles and their use for the treatment of glaucoma |
| TW593302B (en) | 2001-12-20 | 2004-06-21 | Alcon Inc | Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma |
| WO2003057213A2 (en) * | 2001-12-28 | 2003-07-17 | Bayer Pharmaceuticals Corporation | Cyclohexano- and cycloheptapyrazole derivative compounds, for use in diseases associated with the 5-ht2c receptor |
| MXPA05002259A (es) * | 2002-08-30 | 2005-07-05 | Alcon Inc | Compuestos de 5-croman-5-il-etilamina sustituidos y uso para el tratamiento de glaucoma. |
| WO2004054572A2 (en) | 2002-12-13 | 2004-07-01 | Alcon, Inc. | Novel benzopyran analogs and their use for the treatment of glaucoma |
| AU2004271978B2 (en) * | 2003-09-04 | 2009-02-05 | Merck & Co., Inc. | Ophthalmic compositions for treating ocular hypertension |
| WO2005053688A1 (en) * | 2003-11-26 | 2005-06-16 | Alcon, Inc. | Substituted furo[2,3-g] indazoles for the treatment of glaucoma |
| US7338972B1 (en) | 2003-12-15 | 2008-03-04 | Alcon, Inc. | Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma |
| US6989445B2 (en) | 2003-12-15 | 2006-01-24 | Alcon, Inc. | Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma |
| US7129257B1 (en) | 2003-12-15 | 2006-10-31 | Alcon, Inc. | Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma |
| US8685924B2 (en) | 2004-08-25 | 2014-04-01 | Takeda Pharmaceutical Company Limited | Preventives/remedies for stress urinary incontinence and method of screening the same |
| US20060073172A1 (en) * | 2004-10-01 | 2006-04-06 | Schneider L W | Stabilized ophthalmic solution for the treatment of glaucoma and lowering intraocular pressure |
| US7425572B2 (en) | 2004-12-08 | 2008-09-16 | Alcon, Inc. | Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma |
| TW200744567A (en) * | 2005-09-23 | 2007-12-16 | Alcon Inc | Phenylethylamine analogs and their use for treating glaucoma |
| JP5528699B2 (ja) | 2006-05-16 | 2014-06-25 | 武田薬品工業株式会社 | 縮合複素環化合物およびその用途 |
| WO2007149728A2 (en) * | 2006-06-20 | 2007-12-27 | Alcon Research, Ltd. | Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma |
| AU2007279766A1 (en) * | 2006-07-31 | 2008-02-07 | Senju Pharmaceutical Co., Ltd. | Aqueous liquid preparation containing amide compound |
| WO2008016989A1 (en) * | 2006-08-01 | 2008-02-07 | Alcon Research, Ltd. | Process for preparing pyranoindazole serotonergic receptor agonists |
| US20080033184A1 (en) * | 2006-08-01 | 2008-02-07 | Alcon Manufacturing, Ltd. | Intermediates and methods for serotonergic agonist synthesis |
| WO2008028021A2 (en) * | 2006-08-31 | 2008-03-06 | Alcon, Inc. | Pyranoindazole cyclic carbonates and their use |
| JP5520051B2 (ja) | 2007-11-15 | 2014-06-11 | 武田薬品工業株式会社 | 縮合ピリジン誘導体およびその用途 |
| US20120253036A1 (en) | 2009-12-11 | 2012-10-04 | Yukinori Nagakura | Agent for treating fibromyalgia |
| US20180030251A1 (en) * | 2015-03-05 | 2018-02-01 | Bridgestone Corporation | Rubber composition, method for producing diene-based polymer, and tire |
| TW201815766A (zh) * | 2016-09-22 | 2018-05-01 | 美商普雷辛肯公司 | 用於ｉｄｏ及ｔｄｏ調節之化合物及方法以及其適應症 |
| JPWO2019131902A1 (ja) | 2017-12-27 | 2020-12-10 | 武田薬品工業株式会社 | 腹圧性尿失禁および便失禁の治療薬 |
| CN112119072A (zh) | 2018-03-20 | 2020-12-22 | 普莱希科公司 | 用于ido和tdo调节的化合物和方法，以及其适应症 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2534580A1 (fr) * | 1982-10-13 | 1984-04-20 | Synthelabo | Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent |
| US5151444B1 (en) * | 1987-09-18 | 1999-07-06 | R Tech Ueno Ltd | Ocular hypotensive agents |
| US5296504A (en) * | 1988-09-06 | 1994-03-22 | Kabi Pharmacia | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| ATE101342T1 (de) * | 1988-09-06 | 1994-02-15 | Kabi Pharmacia Ab | Prostaglandinderivate zur behandlung des gruenen stars oder einer okularen hypertension. |
| US5578612A (en) * | 1990-10-15 | 1996-11-26 | Pfizer Inc. | Indole derivatives |
| WO1992020338A1 (en) | 1991-05-10 | 1992-11-26 | Merrell Dow Pharmaceuticals Inc. | Method for the treatment of glaucoma |
| CA2110574A1 (en) * | 1991-06-21 | 1993-01-07 | Lawrence I. Kruse | Tryptamine analogues, their synthesis and their use as 5-ht1-like or 5-ht2 receptor agonists |
| US5352708A (en) * | 1992-09-21 | 1994-10-04 | Allergan, Inc. | Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
| GB9224169D0 (en) * | 1992-11-18 | 1993-01-06 | Lilly Industries Ltd | Pharmaceutical compounds |
| US5922773A (en) | 1992-12-04 | 1999-07-13 | The Children's Medical Center Corp. | Glaucoma treatment |
| US5510383A (en) * | 1993-08-03 | 1996-04-23 | Alcon Laboratories, Inc. | Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension |
| TW270114B (es) * | 1993-10-22 | 1996-02-11 | Hoffmann La Roche | |
| TW334423B (en) * | 1993-10-22 | 1998-06-21 | Hoffmann La Roche | Tricyclic 1-aminoethylpyrrole-derivatives |
| US5874477A (en) * | 1994-08-12 | 1999-02-23 | The University Of Hawaii | Method of treatment for malaria utilizing serotonin receptor ligands |
| TW403738B (en) * | 1994-08-12 | 2000-09-01 | Hoffmann La Roche | Tricyclic pyrazole derivatives |
| US5998467A (en) | 1995-10-25 | 1999-12-07 | Mitsubishi Chemical Corporation | Medicine for oculopathy |
| AU2104097A (en) | 1996-03-13 | 1997-10-01 | Glaxo Group Limited | Medicaments comprising 5ht1-like receptor agonists with an increased absorption |
| US5902815A (en) * | 1996-09-03 | 1999-05-11 | Washington University | Use of 5HT-2A serotonin agonists to prevent adverse effects of NMDA receptor hypofunction |
| AU4249297A (en) * | 1996-10-31 | 1998-05-22 | Alcon Laboratories, Inc. | Opthalmological compositions containing serotonin 5-ht1a receptor agonist and their use in the treatment of glaucoma |
| JP3560986B2 (ja) | 1997-01-13 | 2004-09-02 | 山之内製薬株式会社 | ５―ｈｔ２ｃ受容体作用薬及びアミノアルキルインダゾール誘導体 |
| GB9700899D0 (en) | 1997-01-17 | 1997-03-05 | Smithkline Beecham Plc | Novel treatment |
| AU727654B2 (en) * | 1997-06-13 | 2000-12-21 | Yamanouchi Pharmaceutical Co., Ltd. | Tricyclic pyrazole derivative |
| GB9819033D0 (en) | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds VI |
| GB9819035D0 (en) | 1998-09-01 | 1998-10-28 | Cerebrus Res Ltd | Chemical compounds VII |
| TR200100754T2 (tr) | 1998-09-18 | 2001-10-22 | Alcon Laboratories, Inc. | Glausomanın tedavi edilmesi için serotonerjik 5HT2. |
| HUP0104773A3 (en) | 1998-12-17 | 2004-10-28 | Wyeth Corp | 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)quinoxalin-5(6h)one derivates being 5ht2c agonists, process for their preparation and medicaments containing them |
| GB9902047D0 (en) | 1999-01-29 | 1999-03-17 | Cerebrus Ltd | Chemical compounds XI |
| US6713471B1 (en) * | 1999-06-15 | 2004-03-30 | Bristol-Myers Squibb Pharma Company | Substituted heterocycle fused gamma-carbolines |
| JP4863591B2 (ja) * | 1999-06-15 | 2012-01-25 | ブリストル−マイヤーズ スクイブ ファーマ カンパニー | 置換複素環縮合ガンマーカルボリン |
| AU1918001A (en) | 2000-03-17 | 2001-10-03 | Alcon Universal Ltd | 5-hydroxy indazole derivatives for treating glaucoma |
| WO2001083487A1 (en) * | 2000-04-28 | 2001-11-08 | Yamanouchi Pharmaceutical Co., Ltd. | Froindazole derivative |
| EP1392292B1 (en) * | 2001-06-01 | 2006-03-01 | Alcon, Inc. | Pyranoindazoles and their use for the treatment of glaucoma |
-
2002
- 2002-05-30 EP EP02734575A patent/EP1392292B1/en not_active Expired - Lifetime
- 2002-05-30 PL PL02366636A patent/PL366636A1/xx unknown
- 2002-05-30 RU RU2003137825/04A patent/RU2273641C2/ru not_active IP Right Cessation
- 2002-05-30 DE DE60209486T patent/DE60209486T2/de not_active Expired - Fee Related
- 2002-05-30 AT AT02734575T patent/ATE318821T1/de not_active IP Right Cessation
- 2002-05-30 CN CNB02814774XA patent/CN100384417C/zh not_active Expired - Fee Related
- 2002-05-30 KR KR1020037015621A patent/KR100626255B1/ko not_active Expired - Fee Related
- 2002-05-30 CA CA002447480A patent/CA2447480A1/en not_active Abandoned
- 2002-05-30 BR BR0210241-2A patent/BR0210241A/pt not_active IP Right Cessation
- 2002-05-30 ES ES02734575T patent/ES2258631T3/es not_active Expired - Lifetime
- 2002-05-30 WO PCT/US2002/016861 patent/WO2002098350A2/en not_active Ceased
- 2002-05-30 MX MXPA03010807A patent/MXPA03010807A/es active IP Right Grant
- 2002-05-30 PT PT02734575T patent/PT1392292E/pt unknown
- 2002-05-30 DK DK02734575T patent/DK1392292T3/da active
- 2002-05-30 AU AU2002305732A patent/AU2002305732B2/en not_active Ceased
- 2002-05-30 JP JP2003501392A patent/JP2004535418A/ja active Pending
- 2002-05-31 AR ARP020102050A patent/AR036044A1/es unknown
- 2002-12-11 US US10/316,600 patent/US6696476B2/en not_active Expired - Lifetime
-
2003
- 2003-11-20 ZA ZA200309034A patent/ZA200309034B/en unknown
- 2003-11-24 US US10/722,042 patent/US6881749B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| PL366636A1 (en) | 2005-02-07 |
| DK1392292T3 (da) | 2006-05-29 |
| US20030171418A1 (en) | 2003-09-11 |
| DE60209486T2 (de) | 2006-08-03 |
| EP1392292A4 (en) | 2004-08-11 |
| AU2002305732B2 (en) | 2007-02-01 |
| CA2447480A1 (en) | 2002-12-12 |
| RU2273641C2 (ru) | 2006-04-10 |
| WO2002098350A2 (en) | 2002-12-12 |
| US20040106609A1 (en) | 2004-06-03 |
| WO2002098350A3 (en) | 2003-02-27 |
| KR20040010669A (ko) | 2004-01-31 |
| DE60209486D1 (de) | 2006-04-27 |
| HK1061212A1 (en) | 2004-09-10 |
| PT1392292E (pt) | 2006-05-31 |
| ATE318821T1 (de) | 2006-03-15 |
| RU2003137825A (ru) | 2005-04-20 |
| US6696476B2 (en) | 2004-02-24 |
| ES2258631T3 (es) | 2006-09-01 |
| US6881749B2 (en) | 2005-04-19 |
| CN100384417C (zh) | 2008-04-30 |
| MXPA03010807A (es) | 2004-11-22 |
| JP2004535418A (ja) | 2004-11-25 |
| KR100626255B1 (ko) | 2006-09-21 |
| CN1592619A (zh) | 2005-03-09 |
| ZA200309034B (en) | 2004-07-16 |
| EP1392292A2 (en) | 2004-03-03 |
| EP1392292B1 (en) | 2006-03-01 |
| BR0210241A (pt) | 2004-08-10 |
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