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AR036029A1 - Derivados de fenilurea sustituidos con carbonamida, procedimiento para preparacion, medicamentos y su empleo para la preparacion de medicamentos para el tratamiento de la diabetes tipo ii - Google Patents

Derivados de fenilurea sustituidos con carbonamida, procedimiento para preparacion, medicamentos y su empleo para la preparacion de medicamentos para el tratamiento de la diabetes tipo ii

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Publication number
AR036029A1
AR036029A1 ARP020101919A ARP020101919A AR036029A1 AR 036029 A1 AR036029 A1 AR 036029A1 AR P020101919 A ARP020101919 A AR P020101919A AR P020101919 A ARP020101919 A AR P020101919A AR 036029 A1 AR036029 A1 AR 036029A1
Authority
AR
Argentina
Prior art keywords
alkyl
phenyl
coo
alkenyl
alkynyl
Prior art date
Application number
ARP020101919A
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English (en)
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10125567A external-priority patent/DE10125567B4/de
Priority claimed from DE10207369A external-priority patent/DE10207369A1/de
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of AR036029A1 publication Critical patent/AR036029A1/es

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract

Derivados de fenilurea sustituidos con carbonamida, caracterizados porque comprenden compuesto de la fórmula (1) en donde significan: A es fenilo, naftilo, pudiendo estar sustituido el radical fenilo o naftilo, hasta tres veces, con F, Cl, Br, OH, CF3, NO2, CN, OCF3, O-alquilo C1-6, O-alquenilo C2-6, O-alquinilo C2-6, S-alquilo C1-6, S-alquenilo C2-6, S-alquinilo C2-6, SO-alquilo C1-6, SO2-alquilo C1-6, SO2-NH2, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-7, cicloalquil C3-7-alquileno C1-4, alquilen C0-6-COOH, alquilen C0-6-COO-alquilo C1-7, alquilen C0-6-COO-alquenilo C2-7, CONH2, CONH-alquilo C1-6, CON-[alquilo C1-6]2, CONH-cicloalquilo C3-6, alquilen C0-6-NH2, alquilen C0-6-NH-alquilo C2-6, alquilen C0-6-N-[alquilo C1-6]2, NH-CO alquilo C1-6, NH-CO-fenilo, NH-SO2-fenilo, pudiendo estar sustituido el anillo de fenilo, hasta dos veces, con F, Cl, CN, OH, alquilo C1-6, O-alquilo C1-6, CF3, OCF3, COOH, COO-alquilo C1-6 o CONH2; R1 y R2, independientemente uno de otro, H, alquilo C1-6, O-alquilo C1-6, CO-alquilo C1-6, COO-alquilo C1-6; R3, R4, R5, R6, independientemente uno de otro, H, F, Cl, Br, OH, CF3, NO2, CN, OCF3, O-alquilo C1-6, O-alquenilo C2-6, O-alquinilo C2-6, S-alquilo C1-6, S-alquenilo C2-6, S-alquinilo C2-6, SO-alquilo C1-6, SO2-alquilo C1-6, SO2-NH2, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-7, cicloalquil C3-7-alquileno C1-4, COOH, COO-alquilo C1-6, CO-NH2, CO-NH-alquilo C1-6, CON-N-[alquilo C1-6]2, CO-NH-cicloalquilo C3-7, NH2, NH-alquilo C1-6, N-[alquilo C1-6]2, NH-CO-alquilo C1-6, NH-CO-fenilo, NH-SO2-fenilo, pudiendo estar sustituido el anillo de fenilo, hasta dos veces con F, Cl, CN, OH, alquilo C1-6, O-alquilo C1-6, CF3, OCF3, COOH, COO-alquilo C1-6 o CO-NH2; R7 es H, alquilo C1-6, CO-alquilo C1-6; R8 es H, alquilo C1-10, pudiendo estar sustituido alquilo, hasta 3 veces, con OH, CF3, CN, COOH, COO-alquilo C1-6, CO-NH2, NH2, NH-alquilo C1-6, N-[alquilo C1-6]2, NCO-alquilo C1-6, NCOO-alquilo C1-6, NCOO-alquenilo C1-6, NCOO-alquinilo C1-6, o NCOO-alquilen C1-4-arilo C6-10, (CH2)m- arilo, pudiendo ser m = 0-6 y pudiendo ser arilo igual fenilo, O-fenilo, CO- fenilo, benzo[1,3]dioxolilo, heterocicloalquilo, piridilo, indolilo, piperidinilo, tetrahidronaftilo, naftilo, 2,3-dihidrobenzo[1,4]dioxinilo, benzo[1,2,5]tiadiazolilo, pirrolidinilo, morfolinilo, y pudiendo estar sustituido el radical arilo, una o varias veces, con R9; R9 es F, Cl, Br, OH, NO2, CF3, OCF3, alquilo C1-6, alquil C1-6-OH, O-alquilo C1-6, S-alquilo C1-6, alquil C1-4-fenilo, COOH, COO-alquilo C1-6; así como sus sales fisiológicamente compatibles, así como procedimientos para su preparación, medicamentos y el uso de dichos compuestos para la preparación de medicamentos para el tratamiento de la diabetes tipo II.
ARP020101919A 2001-05-25 2002-05-23 Derivados de fenilurea sustituidos con carbonamida, procedimiento para preparacion, medicamentos y su empleo para la preparacion de medicamentos para el tratamiento de la diabetes tipo ii AR036029A1 (es)

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