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AR036017A1 - Proceso para la preparacion de cilastatina sodica pura en una forma amorfa - Google Patents

Proceso para la preparacion de cilastatina sodica pura en una forma amorfa

Info

Publication number
AR036017A1
AR036017A1 ARP020101853A ARP020101853A AR036017A1 AR 036017 A1 AR036017 A1 AR 036017A1 AR P020101853 A ARP020101853 A AR P020101853A AR P020101853 A ARP020101853 A AR P020101853A AR 036017 A1 AR036017 A1 AR 036017A1
Authority
AR
Argentina
Prior art keywords
preparation
cylastatin
amorphy
pure sodium
homogeneous mixture
Prior art date
Application number
ARP020101853A
Other languages
English (en)
Inventor
Yatendra Kumar
Om Dutt Tyagi
Amit Rohtagi
Original Assignee
Ranbaxy Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd
Publication of AR036017A1 publication Critical patent/AR036017A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/02—Monohydroxylic acyclic alcohols
    • C07C31/04—Methanol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Steroid Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Un proceso de efectividad del costo e industrialmente ventajoso para la preparación de cilastatina sódica amorfa. El proceso comprende la recuperación de cilastatina sódica de una solución de la misma que contiene un solvente orgánico, mezcla homogénea de solventes orgánicos, o mezcla homogénea de solventes orgánicos y agua, mediante precipitación de solvente.
ARP020101853A 2001-05-18 2002-05-20 Proceso para la preparacion de cilastatina sodica pura en una forma amorfa AR036017A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN593DE2001 2001-05-18

Publications (1)

Publication Number Publication Date
AR036017A1 true AR036017A1 (es) 2004-08-04

Family

ID=11097060

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020101853A AR036017A1 (es) 2001-05-18 2002-05-20 Proceso para la preparacion de cilastatina sodica pura en una forma amorfa

Country Status (24)

Country Link
US (1) US20040152780A1 (es)
EP (1) EP1395530A4 (es)
JP (1) JP2004526805A (es)
KR (1) KR20040044409A (es)
CN (1) CN1522235A (es)
AP (2) AP2003002912A0 (es)
AR (1) AR036017A1 (es)
BG (1) BG108447A (es)
BR (1) BR0209843A (es)
CA (1) CA2447788A1 (es)
CZ (1) CZ20033352A3 (es)
EA (1) EA005947B1 (es)
EE (1) EE200300567A (es)
HR (1) HRP20031052A2 (es)
HU (1) HUP0400825A2 (es)
IL (1) IL158945A0 (es)
MX (1) MXPA03010547A (es)
NO (1) NO20035138D0 (es)
NZ (1) NZ529625A (es)
OA (1) OA12607A (es)
PL (1) PL367937A1 (es)
SK (1) SK15082003A3 (es)
WO (1) WO2002094742A1 (es)
ZA (1) ZA200309287B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8134026B2 (en) * 2005-11-09 2012-03-13 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of Cilastatin and sodium salt
WO2011080648A1 (en) * 2010-01-01 2011-07-07 Orchid Chemicals And Pharmaceuticals Limited An improved process for the preparation of cilastatin sodium
CN102675175B (zh) * 2011-03-08 2014-02-19 深圳市海滨制药有限公司 一种西司他丁的分离纯化方法
CA3044334A1 (en) 2016-11-18 2018-05-24 Institut D'investigacions Biomediques August Pi I Sunyer- Idibaps Combined cd6 and imipenem therapy for treatment of infectious diseases and related inflammatory processes

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5147868A (en) * 1978-07-24 1992-09-15 Merck & Co., Inc. Thienamycin renal peptidase inhibitors
US4292436A (en) * 1980-06-25 1981-09-29 Merck & Co., Inc. Process for the preparation of N-protected N-formimidoyl 2-aminoethanethiol
EP0441371B1 (en) * 1990-02-08 1995-01-25 Sumitomo Chemical Company, Limited Process for preparing haloketo acid derivatives
US5166417A (en) * 1990-09-04 1992-11-24 Lonza Ltd. Process for resolution of racemates of 2,2-dimethylcyclopropanecarboxylic acid
CA2056840A1 (en) * 1990-12-17 1992-06-18 Thomas Meul Process for the production of dimethylcyclopropanecarboxylic acid
ATE172248T1 (de) * 1991-07-26 1998-10-15 Lonza Ag Gentechnologisches verfahren zur herstellung von s-(+)-2,2-dimethylcyclopropancarboxamid mittels mikroorganismen
US5245069A (en) * 1992-10-27 1993-09-14 Merck & Co., Inc. Process for the preparation of bis(aryl)-phosphorohalidates
IN191798B (es) * 2000-11-03 2004-01-03 Ranbaxy Lab Ltd

Also Published As

Publication number Publication date
NO20035138D0 (no) 2003-11-18
US20040152780A1 (en) 2004-08-05
BR0209843A (pt) 2004-08-24
SK15082003A3 (sk) 2004-06-08
AP1511A (en) 2005-12-20
HRP20031052A2 (en) 2004-06-30
CA2447788A1 (en) 2002-11-28
OA12607A (en) 2006-06-08
AP2003002913A0 (en) 2003-12-31
IL158945A0 (en) 2004-05-12
CN1522235A (zh) 2004-08-18
JP2004526805A (ja) 2004-09-02
NZ529625A (en) 2006-02-24
EA005947B1 (ru) 2005-08-25
WO2002094742A1 (en) 2002-11-28
ZA200309287B (en) 2004-07-22
HUP0400825A2 (hu) 2004-08-30
EA200301225A1 (ru) 2004-06-24
EP1395530A1 (en) 2004-03-10
EP1395530A4 (en) 2006-01-18
EE200300567A (et) 2004-04-15
MXPA03010547A (es) 2004-05-27
KR20040044409A (ko) 2004-05-28
CZ20033352A3 (en) 2004-06-16
BG108447A (en) 2005-03-31
AP2003002912A0 (en) 2002-05-17
PL367937A1 (en) 2005-03-07

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal