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AR035716A1 - Compuestos agonistas del receptor beta3-adrenergico, uso de los mismos en la fabricacion de medicamentos y composiciones farmaceuticas conteniendo los mismos - Google Patents

Compuestos agonistas del receptor beta3-adrenergico, uso de los mismos en la fabricacion de medicamentos y composiciones farmaceuticas conteniendo los mismos

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Publication number
AR035716A1
AR035716A1 ARP010104923A ARP010104923A AR035716A1 AR 035716 A1 AR035716 A1 AR 035716A1 AR P010104923 A ARP010104923 A AR P010104923A AR P010104923 A ARP010104923 A AR P010104923A AR 035716 A1 AR035716 A1 AR 035716A1
Authority
AR
Argentina
Prior art keywords
compounds
nr9so2r10
prodrugs
stereoisomers
halogen
Prior art date
Application number
ARP010104923A
Other languages
English (en)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AR035716A1 publication Critical patent/AR035716A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A—HUMAN NECESSITIES
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    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
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    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Chemical & Material Sciences (AREA)
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  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
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  • Obesity (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
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  • AIDS & HIV (AREA)
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  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se proporcionan además productos intermedios útiles para la preparación de los compuestos de Fórmula (1); combinaciones de los compuestos de Fórmula (1), los estereoisómeros y profármacos de los mismos, y las sales farmacéuticamente aceptables de los compuestos, estereoisómeros y profármacos, con agentes antiobesidad; composiciones farmacéuticas que comprenden los compuestos de Fórmula (1), los estereoisómeros y profármacos de los mismos, y las sales farmacéuticamente aceptables de los compuestos, estereoisómeros y profármacos, o composiciones farmacéuticas que comprenden los compuestos de la Fórmula (1), los estereoisómeros y profármacos de los mismos, y las sales farmacéuticamente aceptables de los compuestos, estereoisómeros y profármacos, y agentes antiobesidad; y uso de los compuestos para preparar medicamentos para tratar enfermedades, estados o trastornos mediados por el receptor beta3-adrenérgico en un mamífero. Reivindicación 1: Un compuesto caracterizado porque es de la fórmula (1), los estereoisómeros y profármacos del mismo, y las sales farmacéuticamente aceptables de dichos compuestos, estereoisómeros y profármacos, fórmula en la cual Ar es piridilo o fenilo; R es hidrógeno, hidroxilo, halógeno, -CF3, -alquilo (C1-6), -alcoxilo (C1-6), -cicloalquilo (C3-8), -NR9R10, -NR9SO2R10, -NR9COR10, ó -SO2R9; R1 es hidrógeno, -alquilo (C1-6), halógeno, -alcoxilo (C1-6), o hidroxilo; R2, R3 y R4 son independientemente hidrógeno, o -alquilo (C1-6); R5 es un heterociclo aromático con anillo de 5 ó 6 miembros, que tiene de 1 a 4 heteroátomos seleccionados del grupo que consiste en oxígeno, azufre y nitrógeno; R6 y R7 son independientemente hidrógeno, halógeno, ciano, -acilo (C1-6), -CO2R9, -NR9R10, hidroxilo, -alcoxilo (C1-6), -CONR9R10, -NR9SO2R10, -SO2NR9R10, ó -SO2R9; -alquilo (C1-6) opcionalmente sustituido con -cicloalquilo (C3-8), halógeno, arilo, alcoxilo (C1-6), -haloalquilo (C1-6), alquilalcoxilo, hidroxilo, -NR9R10, -NR9SO2R10, -SO2NR9R10, -SO2R9, o heterociclo; -cicloalquilo (C3-8) opcionalmente sustituido con -alquilo (C1-6), -cicloalquilo (C3-8), halógeno, arilo, alcoxilo (C1-6), -haloalquilo (C1-6), alquilalcoxilo, hidroxilo, -NR9R10, -NR9SO2R10, -SO2NR9R10, -SO2R9, o heterociclo; arilo opcionalmente sustituido con -alquilo (C1-6), -cicloalquilo (C3-7), halógeno, arilo, -alcoxilo (C1-6), -haloalquilo (C1-6), alquilalcoxilo, hidroxilo, -NR9R10, -NR9SO2R10, -SO2NR9R10, -SO2R9, o heterociclo; o heterociclo opcionalmente sustituido con -alquilo (C1-6), -cicloalquilo (C3-8), halógeno, arilo, -alcoxilo (C1-6), -haloalquilo (C1-6), alquilacoxilo, hidroxilo, -NR9R10, -NR9SO2R10, -SO2NR9R10, -SO2R9, o heterociclo; R8 es hidrógeno, -alquilo (C1-4) o halógeno; y R9 y R10 son independientemente hidrógeno, -alquilo (C1-6), alquilalcoxilo, -cicloalquilo (C3-8), -haloalquilo (C1-6), -alcoxilo (C1-6), arilo, o heterociclo; X es un enlace directo u oxígeno; e Y es un enlace directo, -alquilo (C1-6), -OCH2-, -CH2O- u oxígeno; con tal que: (i) cuando Ar sea fenilo, R sea -NR9SO2R10, -SO2NR9R10, o -SO2R9, y (ii) cuando Ar sea fenilo, -NR9SO2R10, y tanto R6 como R7 sean hidrógeno, R5 no sea entonces imidazolilo. Reivindicación 2: Un compuesto de acuerdo con la reivindicación 1, caracterizado porque Ar es piridilo; R, R1, R2, R3, R4 y R8 son hidrógeno; X es oxígeno; Y es un enlace directo; y R5 es un heterociclo con anillo de cinco o seis miembros, seleccionado del grupo que consiste en imidazolilo, isotiazolilo, isoxazolilo, oxadiazolilo, oxazolilo, pirazolilo, tiadiazolilo, tiazolilo, triazinilo y triazolilo.
ARP010104923A 2000-10-20 2001-10-19 Compuestos agonistas del receptor beta3-adrenergico, uso de los mismos en la fabricacion de medicamentos y composiciones farmaceuticas conteniendo los mismos AR035716A1 (es)

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US24227400P 2000-10-20 2000-10-20

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AR035716A1 true AR035716A1 (es) 2004-07-07

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ARP010104923A AR035716A1 (es) 2000-10-20 2001-10-19 Compuestos agonistas del receptor beta3-adrenergico, uso de los mismos en la fabricacion de medicamentos y composiciones farmaceuticas conteniendo los mismos

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US (2) US6566377B2 (es)
EP (1) EP1326861A1 (es)
JP (1) JP2004511555A (es)
KR (1) KR20030044013A (es)
CN (1) CN1469876A (es)
AP (1) AP2001002307A0 (es)
AR (1) AR035716A1 (es)
AU (1) AU2001292161A1 (es)
BG (1) BG107652A (es)
BR (1) BR0114836A (es)
CA (1) CA2423792A1 (es)
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