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AR035064A1 - 3-(1-metil-3-indolil)-4-(1-metil-6-nitro-3-indolil)-1h-pirrol-2,5-diona, en forma amorfa, procesos para prepararla, composicion farmaceutica que la comprende y uso de dicho compuesto en la fabricacion de medicamentos - Google Patents

3-(1-metil-3-indolil)-4-(1-metil-6-nitro-3-indolil)-1h-pirrol-2,5-diona, en forma amorfa, procesos para prepararla, composicion farmaceutica que la comprende y uso de dicho compuesto en la fabricacion de medicamentos

Info

Publication number
AR035064A1
AR035064A1 ARP010104627A ARP010104627A AR035064A1 AR 035064 A1 AR035064 A1 AR 035064A1 AR P010104627 A ARP010104627 A AR P010104627A AR P010104627 A ARP010104627 A AR P010104627A AR 035064 A1 AR035064 A1 AR 035064A1
Authority
AR
Argentina
Prior art keywords
methyl
indolil
compound
nitro
manufacture
Prior art date
Application number
ARP010104627A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR035064A1 publication Critical patent/AR035064A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Extraction Or Liquid Replacement (AREA)

Abstract

3-(1-metil-3-indolil)-4-(1-metil-6-nitro-3-indolil)-1H-pirrol-2,5-diona de fórmula (1), en forma amorfa, que está sustancialmente libre del compuesto cristalino. Dicho compuesto en forma amorfa es farmacéuticamente activo como inhibidor del ciclo celular y por lo tanto es utilizado en el tratamiento de tumores cancerosos. Además, se dan a conocer: procesos para su preparación, composiciones farmacéuticas que la comprenden, y el uso de tal compuesto en la fabricación de medicamentos.
ARP010104627A 2000-10-03 2001-10-01 3-(1-metil-3-indolil)-4-(1-metil-6-nitro-3-indolil)-1h-pirrol-2,5-diona, en forma amorfa, procesos para prepararla, composicion farmaceutica que la comprende y uso de dicho compuesto en la fabricacion de medicamentos AR035064A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23756300P 2000-10-03 2000-10-03

Publications (1)

Publication Number Publication Date
AR035064A1 true AR035064A1 (es) 2004-04-14

Family

ID=22894259

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010104627A AR035064A1 (es) 2000-10-03 2001-10-01 3-(1-metil-3-indolil)-4-(1-metil-6-nitro-3-indolil)-1h-pirrol-2,5-diona, en forma amorfa, procesos para prepararla, composicion farmaceutica que la comprende y uso de dicho compuesto en la fabricacion de medicamentos

Country Status (15)

Country Link
US (4) US6482847B2 (es)
EP (1) EP1366040B1 (es)
JP (3) JP2004510771A (es)
KR (1) KR100554933B1 (es)
CN (1) CN1250541C (es)
AR (1) AR035064A1 (es)
AT (1) ATE447566T1 (es)
AU (2) AU1396502A (es)
BR (1) BRPI0114156B8 (es)
CA (1) CA2423286C (es)
DE (1) DE60140382D1 (es)
ES (1) ES2334012T3 (es)
MX (1) MXPA03002858A (es)
WO (1) WO2002028855A2 (es)
ZA (1) ZA200301593B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6482847B2 (en) * 2000-10-03 2002-11-19 Hoffmann-La Roche Inc. Amorphous form of cell cycle inhibitor having improved solubility and bioavailability
US20030139373A1 (en) * 2001-11-20 2003-07-24 Breimer Lars Holger Method for cancer therapy
JP4508646B2 (ja) 2002-01-09 2010-07-21 エミスフェアー・テクノロジーズ・インク ４−［（４−クロロ−２−ヒドロキシベンゾイル）アミノ］ブタン酸ナトリウムの多形体
WO2003087335A2 (en) * 2002-04-11 2003-10-23 Medimmune Vaccines, Inc. Preservation of bioactive materials by spray drying
JP2011500724A (ja) * 2007-10-19 2011-01-06 パーデュ リサーチ ファンデーション 結晶性化合物の固体製剤
US8268354B2 (en) 2007-11-07 2012-09-18 Aridis Pharmaceuticals Sonic low pressure spray drying
CA2761255C (en) * 2009-05-12 2017-05-09 Corcept Therapeutics, Inc. Solid forms and process for preparing (r)-4a-ethoxymethyl-1-(4-fluoro-phenyl)-6-(4-trifluoromethyl-benzenesulfonyl)-4,4a,5,6,7,8-hexahydro-1h,1,2,6-triaza-cyclopenta[b]naphthalene
US8969588B2 (en) * 2012-06-05 2015-03-03 Gilead Pharmasset Llc Solid forms of an antiviral compound
JP6339364B2 (ja) * 2013-12-27 2018-06-06 カズマパートナーズ株式会社 無定形ブリモニジン酒石酸塩及びその製造方法
GB201502073D0 (en) * 2015-02-09 2015-03-25 Cubic Pharmaceuticals Ltd And Delta Pharmaceuticals Ltd HDEG technology
PT108370B (pt) * 2015-03-30 2018-10-25 Hovione Farm S A Processo de preparação de brometo de aclidínio
JP6863984B2 (ja) * 2015-12-18 2021-04-21 ガレクト・バイオテック・エイビイ 結晶多形とプロセス

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ280738B6 (cs) * 1988-02-10 1996-04-17 F. Hoffmann - La Roche And Co., Aktiengesellschaft Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi
USRE36736E (en) 1989-02-06 2000-06-13 Hoffman-La Roche Inc. Substituted pyrroles
JPH08208478A (ja) * 1994-10-14 1996-08-13 Japan Energy Corp 抗エイズ薬製剤およびその製造方法
TW487582B (en) * 1995-08-11 2002-05-21 Nissan Chemical Ind Ltd Method for converting sparingly water-soluble medical substance to amorphous state
EP1064279B1 (en) 1998-03-17 2003-06-25 F.Hoffmann-La Roche Ag Substituted bisindolylmaleimides for the inhibition of cell proliferation
US6036736A (en) 1998-04-03 2000-03-14 Wells Manufacturing Company, Inc. Ventilating method and apparatus
US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers
SE9803261D0 (sv) 1998-09-25 1998-09-25 Siemens Elema Ab Andningsapparat
WO2000052037A1 (en) * 1999-03-03 2000-09-08 Eli Lilly And Company Echinocandin/carbohydrate complexes
US6326501B1 (en) 2000-04-19 2001-12-04 Hoffmann-La Roche Inc. Methylation of indole compounds using dimethyl carbonate
US6482847B2 (en) * 2000-10-03 2002-11-19 Hoffmann-La Roche Inc. Amorphous form of cell cycle inhibitor having improved solubility and bioavailability

Also Published As

Publication number Publication date
JP2008056670A (ja) 2008-03-13
MXPA03002858A (es) 2003-07-14
US20020173532A1 (en) 2002-11-21
BRPI0114156B1 (pt) 2018-09-11
ES2334012T3 (es) 2010-03-04
AU1396502A (en) 2002-04-15
JP2012136534A (ja) 2012-07-19
US20020173534A1 (en) 2002-11-21
ZA200301593B (en) 2004-06-22
US6492530B1 (en) 2002-12-10
US6486329B1 (en) 2002-11-26
JP2004510771A (ja) 2004-04-08
ATE447566T1 (de) 2009-11-15
EP1366040A2 (en) 2003-12-03
AU2002213965B2 (en) 2007-07-19
EP1366040B1 (en) 2009-11-04
KR100554933B1 (ko) 2006-03-03
DE60140382D1 (de) 2009-12-17
CN1468231A (zh) 2004-01-14
US20020061922A1 (en) 2002-05-23
US20020173533A1 (en) 2002-11-21
BRPI0114156B8 (pt) 2021-05-25
CA2423286C (en) 2008-10-28
US6469180B1 (en) 2002-10-22
KR20030036872A (ko) 2003-05-09
WO2002028855A2 (en) 2002-04-11
CN1250541C (zh) 2006-04-12
WO2002028855A3 (en) 2003-09-12
BR0114156A (pt) 2003-07-29
JP5341331B2 (ja) 2013-11-13
CA2423286A1 (en) 2002-04-11
US6482847B2 (en) 2002-11-19

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