AR023400A1 - Metodos para inducir la muerte de celulas cancerosas y la regresion de tumores - Google Patents
Metodos para inducir la muerte de celulas cancerosas y la regresion de tumoresInfo
- Publication number
- AR023400A1 AR023400A1 ARP000101576A ARP000101576A AR023400A1 AR 023400 A1 AR023400 A1 AR 023400A1 AR P000101576 A ARP000101576 A AR P000101576A AR P000101576 A ARP000101576 A AR P000101576A AR 023400 A1 AR023400 A1 AR 023400A1
- Authority
- AR
- Argentina
- Prior art keywords
- cancer cells
- methods
- induce death
- death
- regression
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 5
- 201000011510 cancer Diseases 0.000 title abstract 3
- 230000034994 death Effects 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 230000004611 cancer cell death Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Uso para tratar cáncer en un paciente que necesita dicho tratamiento, que comprende cantidades que son eficaces para inducir un nivel sinérgico de muertede las células cancerosas de (1) un inhibidor de FPT y (2) un inhibidor de vía de senalizacionRa s adicional para inducir regresion del tumor y muerte de lascélulas cancerosas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/289,255 US6316462B1 (en) | 1999-04-09 | 1999-04-09 | Methods of inducing cancer cell death and tumor regression |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR023400A1 true AR023400A1 (es) | 2002-09-04 |
Family
ID=23110723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000101576A AR023400A1 (es) | 1999-04-09 | 2000-04-06 | Metodos para inducir la muerte de celulas cancerosas y la regresion de tumores |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6316462B1 (es) |
| EP (1) | EP1165078B1 (es) |
| JP (1) | JP2003529540A (es) |
| CN (1) | CN100421661C (es) |
| AR (1) | AR023400A1 (es) |
| AT (1) | ATE347360T1 (es) |
| AU (1) | AU783177B2 (es) |
| BR (1) | BR0009670A (es) |
| CA (1) | CA2364675A1 (es) |
| CY (1) | CY1107545T1 (es) |
| DE (1) | DE60032226T2 (es) |
| DK (1) | DK1165078T3 (es) |
| ES (1) | ES2275505T3 (es) |
| HK (1) | HK1038512B (es) |
| HU (1) | HUP0200773A3 (es) |
| MX (1) | MXPA01010211A (es) |
| MY (1) | MY120841A (es) |
| NO (1) | NO329133B1 (es) |
| NZ (1) | NZ514628A (es) |
| PE (1) | PE20010025A1 (es) |
| PT (1) | PT1165078E (es) |
| TW (1) | TWI255184B (es) |
| WO (1) | WO2000061145A1 (es) |
| ZA (1) | ZA200108258B (es) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6524832B1 (en) * | 1994-02-04 | 2003-02-25 | Arch Development Corporation | DNA damaging agents in combination with tyrosine kinase inhibitors |
| US20030064949A1 (en) * | 1998-02-17 | 2003-04-03 | Loretta Nielsen | Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms |
| US20030060434A1 (en) * | 1997-02-18 | 2003-03-27 | Loretta Nielsen | Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms |
| ZA9811162B (en) * | 1997-12-12 | 2000-06-07 | Genentech Inc | Treatment with anti-ERBB2 antibodies. |
| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| ES2377847T3 (es) | 1999-01-13 | 2012-04-02 | Bayer Healthcare Llc | Difenil ureas sustituidas con omega-carboxi arilo como agentes inhibidores de la cinasa p38 |
| US20030086924A1 (en) * | 1999-06-25 | 2003-05-08 | Genentech, Inc. | Treatment with anti-ErbB2 antibodies |
| SI2283867T1 (sl) * | 1999-06-25 | 2014-07-31 | Immunogen, Inc. | Metode zdravljenja z majtanzinoidom konjugiranim protitelesom anti-ErbB |
| US20040013667A1 (en) * | 1999-06-25 | 2004-01-22 | Genentech, Inc. | Treatment with anti-ErbB2 antibodies |
| US6949245B1 (en) * | 1999-06-25 | 2005-09-27 | Genentech, Inc. | Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies |
| US7041292B1 (en) | 1999-06-25 | 2006-05-09 | Genentech, Inc. | Treating prostate cancer with anti-ErbB2 antibodies |
| CA2397657A1 (en) * | 2000-02-29 | 2001-09-07 | Janssen Pharmaceutica Inc. | Farnesyl protein transferase inhibitor combinations with platinum compounds |
| DE10017480A1 (de) * | 2000-04-07 | 2001-10-11 | Transmit Technologietransfer | Verwendung von Substanzen, die als MEK Inhibitor wirken, zur Herstellung eines Arneimittels gegen DNA- und RNA-Viren |
| EP1280923A2 (en) * | 2000-04-28 | 2003-02-05 | Millennium Pharmaceuticals, Inc. | 14094, a human trypsin family member and uses thereof |
| SI1282443T1 (sl) | 2000-05-19 | 2010-01-29 | Genentech Inc | Metoda detekcije gena za izboljšanje verjetnosti učinkovitega odziva na terapijo raka z antagonistom ErbB |
| CN1479630A (zh) * | 2000-10-05 | 2004-03-03 | Q | 诱导癌细胞死亡和肿瘤消退的方法 |
| AU2002211427A1 (en) * | 2000-10-05 | 2002-04-15 | Whitehead Institute For Biomedical Research | Effects of combined administration of farnesyl transferase inhibitors and signal transduction inhibitors |
| EP1353693B1 (en) * | 2001-01-16 | 2005-03-16 | Glaxo Group Limited | Pharmaceutical combination containing a 4-quinazolineamine and paclitaxel, carboplatin or vinorelbine for the treatment of cancer |
| SG144736A1 (en) | 2001-01-18 | 2008-08-28 | Schering Corp | Synthesis of temozolomide and analogs |
| NZ516873A (en) * | 2001-02-12 | 2003-11-28 | Warner Lambert Co | Compositions containing retinoids and erb inhibitors and their use in inhibiting retinoid skin damage |
| US6703400B2 (en) | 2001-02-23 | 2004-03-09 | Schering Corporation | Methods for treating multidrug resistance |
| WO2003047697A2 (en) * | 2001-11-30 | 2003-06-12 | Schering Corporation | Use of an farsenyl protein tranferase inhibitor in combination with other antineoplastic agents for the manufacture of a medicament against cancer |
| EP1453513A1 (en) * | 2001-12-03 | 2004-09-08 | Schering Corporation | Use of fpt inhibitors and at least two antineoplastic agents in the treatment of cancer |
| EP1478358B1 (en) | 2002-02-11 | 2013-07-03 | Bayer HealthCare LLC | Sorafenib tosylate for the treatment of diseases characterized by abnormal angiogenesis |
| US6984389B2 (en) * | 2002-04-25 | 2006-01-10 | University Of Connecticut Health Center | Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality |
| JP2006501147A (ja) | 2002-04-25 | 2006-01-12 | ユニバーシティー オブ コネティカット ヘルス センター | 非ワクチン治療法の治療効果を改善するための熱ショックタンパク質の使用 |
| KR101086533B1 (ko) * | 2002-05-24 | 2011-11-23 | 쉐링 코포레이션 | 중화 사람 항-igfr 항체, 이를 제조하는 방법 및 이를 포함하는 조성물 |
| US20060270643A1 (en) * | 2002-10-31 | 2006-11-30 | Chawnshang Chang | Hyfroxyflutamide induced pathways related to androgen receptor negative prostate cancer cells |
| US20050101576A1 (en) * | 2003-11-06 | 2005-05-12 | Novacea, Inc. | Methods of using vitamin D compounds in the treatment of myelodysplastic syndromes |
| US7557129B2 (en) | 2003-02-28 | 2009-07-07 | Bayer Healthcare Llc | Cyanopyridine derivatives useful in the treatment of cancer and other disorders |
| US8168568B1 (en) | 2003-03-10 | 2012-05-01 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Combinatorial therapy for protein signaling diseases |
| ES2527871T3 (es) * | 2003-05-01 | 2015-02-02 | Imclone Llc | Anticuerpos completamente humanos dirigidos contra el receptor del factor de crecimiento 1 similar a la insulina humana |
| ES2288694T3 (es) | 2003-05-20 | 2008-01-16 | Bayer Pharmaceuticals Corporation | Diaril ureas para enfermedades mediadas por el receptor del factor de crecimiento derivado de plaquetas. |
| KR101139557B1 (ko) | 2003-07-23 | 2012-04-30 | 바이엘 파마슈티칼스 코포레이션 | 질환 및 상태의 치료 및 예방을 위한 플루오로 치환오메가-카르복시아릴 디페닐 우레아 |
| CN1938428A (zh) | 2003-11-12 | 2007-03-28 | 先灵公司 | 多基因表达的质粒系统 |
| WO2005051392A1 (en) | 2003-11-20 | 2005-06-09 | Children's Hospital Medical Center | Gtpase inhibitors and methods of use |
| AR046639A1 (es) * | 2003-11-21 | 2005-12-14 | Schering Corp | Combinaciones terapeuticas de anticuerpo anti- igfr1 |
| US20050171182A1 (en) * | 2003-12-11 | 2005-08-04 | Roger Briesewitz | Methods and compositions for use in the treatment of mutant receptor tyrosine kinase driven cellular proliferative diseases |
| JP2007526455A (ja) * | 2004-02-03 | 2007-09-13 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 癌を特徴付ける、制御する、診断する、および処置するための組成物ならびに方法 |
| US20060205810A1 (en) * | 2004-11-24 | 2006-09-14 | Schering Corporation | Platinum therapeutic combinations |
| JP2008521907A (ja) * | 2004-12-03 | 2008-06-26 | シェーリング コーポレイション | 抗igf1r治療について患者を予め選択するためのバイオマーカー |
| RU2438705C2 (ru) | 2005-01-21 | 2012-01-10 | Дженентек, Инк. | Введение фиксированных доз her-антител |
| CA2596133C (en) | 2005-02-23 | 2016-11-15 | Genentech, Inc. | Extending time to disease progression or survival in cancer patients |
| US7524831B2 (en) * | 2005-03-02 | 2009-04-28 | Schering Corporation | Treatments for Flaviviridae virus infection |
| JP4875064B2 (ja) * | 2005-04-15 | 2012-02-15 | シェーリング コーポレイション | 癌を処置または予防するための方法および組成物 |
| EP2439273B1 (en) * | 2005-05-09 | 2019-02-27 | Ono Pharmaceutical Co., Ltd. | Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics |
| US20060286103A1 (en) * | 2005-06-15 | 2006-12-21 | Parag Kolhe | Stable antibody formulation |
| EP2100618B1 (en) | 2005-06-17 | 2014-02-12 | ImClone LLC | An anti-PDGFRalpha antibody for use in the treatment of metastatic bone cancer |
| US9095581B2 (en) | 2005-07-21 | 2015-08-04 | Ardea Biosciences, Inc. | Combinations of MEK inhibitors and Raf kinase inhibitors and uses thereof |
| US8101799B2 (en) * | 2005-07-21 | 2012-01-24 | Ardea Biosciences | Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK |
| WO2007016539A2 (en) | 2005-07-29 | 2007-02-08 | Children's Hospital Medical Center | Gtpase inhibitors and methods of use and crystal structure of rac-1 gtpase |
| CN101484587B (zh) * | 2006-02-03 | 2014-02-12 | 英克隆有限责任公司 | Igf-ir拮抗剂作为辅药用于前列腺癌的治疗 |
| US7671067B2 (en) * | 2006-02-09 | 2010-03-02 | Enzon Pharmaceuticals, Inc. | Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin |
| US7462627B2 (en) * | 2006-02-09 | 2008-12-09 | Enzon Pharmaceuticals, Inc. | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers |
| EP2405270B1 (en) * | 2006-06-30 | 2013-07-17 | Merck Sharp & Dohme Corp. | IGFBP2-Biomarker |
| EP2076259A2 (en) * | 2006-10-25 | 2009-07-08 | Schering Corporation | Methods of treating ovarian cancer |
| AU2008223069B2 (en) | 2007-03-02 | 2012-12-13 | F. Hoffmann-La Roche Ag | Predicting response to a HER dimerisation inhibitor based on low HER3 expression |
| US20100210700A1 (en) | 2007-05-08 | 2010-08-19 | Schering Corporation | Methods of treatment using intravenous formulations comprising temozolomide |
| PL2171090T3 (pl) | 2007-06-08 | 2013-09-30 | Genentech Inc | Markery ekspresji genów odporności guza na leczenie hamujące HER2 |
| US9551033B2 (en) | 2007-06-08 | 2017-01-24 | Genentech, Inc. | Gene expression markers of tumor resistance to HER2 inhibitor treatment |
| EP2175885B1 (en) * | 2007-07-30 | 2016-10-12 | Ardea Biosciences, Inc. | Combinations of mek inhibitors and raf kinase inhibitors and uses thereof |
| WO2009145852A1 (en) * | 2008-04-17 | 2009-12-03 | Concert Pharmaceuticals, Inc. | Tricyclic benzo[5,6]cyclohepta[1,2-b]pyridine derivatives and uses thereof |
| BRPI0812682A2 (pt) | 2008-06-16 | 2010-06-22 | Genentech Inc | tratamento de cáncer de mama metastático |
| WO2010025337A1 (en) * | 2008-08-29 | 2010-03-04 | Enzon Pharmaceuticals, Inc. | Method of treating ras associated cancer |
| CA2738807A1 (en) * | 2008-10-21 | 2010-04-29 | Enzon Pharmaceuticals, Inc. | Treatment of neuroblastoma with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin |
| AU2010226453B2 (en) | 2009-03-20 | 2013-11-21 | Genentech, Inc. | Bispecific anti-HER antibodies |
| SG10201507044PA (en) | 2009-05-29 | 2015-10-29 | Hoffmann La Roche | Modulators for her2 signaling in her2 expressing patients with gastric cancer |
| WO2011103242A1 (en) | 2010-02-18 | 2011-08-25 | Genentech, Inc. | Neuregulin antagonists and use thereof in treating cancer |
| WO2011146568A1 (en) | 2010-05-19 | 2011-11-24 | Genentech, Inc. | Predicting response to a her inhibitor |
| EP2643353A1 (en) | 2010-11-24 | 2013-10-02 | Novartis AG | Multispecific molecules |
| EP2655413B1 (en) | 2010-12-23 | 2019-01-16 | F.Hoffmann-La Roche Ag | Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery |
| CN103890007A (zh) | 2011-08-17 | 2014-06-25 | 霍夫曼-拉罗奇有限公司 | 神经调节蛋白抗体及其用途 |
| US9327023B2 (en) | 2011-10-25 | 2016-05-03 | The Regents Of The University Of Michigan | HER2 targeting agent treatment in non-HER2-amplified cancers having HER2 expressing cancer stem cells |
| KR20140098834A (ko) | 2011-11-30 | 2014-08-08 | 제넨테크, 인크. | 암에서의 erbb3 돌연변이 |
| WO2013083810A1 (en) | 2011-12-09 | 2013-06-13 | F. Hoffmann-La Roche Ag | Identification of non-responders to her2 inhibitors |
| AU2013240261A1 (en) | 2012-03-27 | 2014-09-18 | Genentech, Inc. | Diagnosis and treatments relating to HER3 inhibitors |
| US9980942B2 (en) | 2012-05-02 | 2018-05-29 | Children's Hospital Medical Center | Rejuvenation of precursor cells |
| MX363188B (es) | 2012-11-30 | 2019-03-13 | Hoffmann La Roche | Identificación de pacientes con necesidad de coterapia del inhibidor de pd-l1. |
| EP3134436A4 (en) * | 2014-04-25 | 2017-12-27 | Memorial Sloan Kettering Cancer Center | Treatment of h-ras-driven tumors |
| US10028503B2 (en) | 2014-06-18 | 2018-07-24 | Children's Hospital Medical Center | Platelet storage methods and compositions for same |
| US20190151346A1 (en) | 2016-05-10 | 2019-05-23 | INSERM (Institute National de la Santé et de la Recherche Médicale) | Combinations therapies for the treatment of cancer |
| EP4461315A3 (en) | 2019-08-16 | 2025-03-05 | Children's Hospital Medical Center | Cdc-42 inhibitors for use in the treatment of age-related depression, sarcopenia or frailty |
| EP4426303B1 (en) | 2021-11-02 | 2025-10-08 | Semmelweis Egyetem | Farnesyl-transferase inhibitors and kras inhibitors for treating kras mutant cancers |
| CN120053663B (zh) * | 2024-04-15 | 2025-12-12 | 天津医科大学 | Sp/klf转录因子抑制剂与去乙酰化酶抑制剂组合的制药用途 |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2546577B2 (de) | 1975-10-17 | 1981-04-02 | Sandoz-Patent-GmbH, 7850 Lörrach | Feste Stoffe aus Polyvinylpyrrolidon und Ergotalkaloiden |
| EP0214092A1 (en) | 1985-08-08 | 1987-03-11 | Ciba-Geigy Ag | Enhanced absorption of psychoactive 2-aryl-pyrazolo quinolines as a solid molecular dispersion in polyvinylpyrrolidone |
| US4764378A (en) | 1986-02-10 | 1988-08-16 | Zetachron, Inc. | Buccal drug dosage form |
| US4826853A (en) | 1986-10-31 | 1989-05-02 | Schering Corporation | 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use |
| US5089496A (en) | 1986-10-31 | 1992-02-18 | Schering Corporation | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies |
| JP3040121B2 (ja) | 1988-01-12 | 2000-05-08 | ジェネンテク,インコーポレイテッド | 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法 |
| ATE108453T1 (de) | 1988-04-28 | 1994-07-15 | Schering Corp | Benzopyridopiperidin, -piperidyliden und - piperazin-verbindungen, zusammensetzungen, methoden zur herstellung und verwendung. |
| US5393890A (en) | 1988-06-02 | 1995-02-28 | Ajinomoto Co., Inc. | Piperidine derivatives and hypotensives containing the same |
| DE3830353A1 (de) | 1988-09-07 | 1990-03-15 | Basf Ag | Verfahren zur kontinuierlichen herstellung von festen pharmazeutischen formen |
| JPH06504772A (ja) * | 1990-12-18 | 1994-06-02 | ザ ウエルカム ファウンデーション リミテッド | 抗癌剤の薬効を増強し抗多剤耐性を有する薬剤 |
| AU3921493A (en) | 1992-03-27 | 1993-11-08 | Schering Corporation | Bridged bis-aryl carbinol derivatives, compositions and methods of use |
| US5512293A (en) | 1992-07-23 | 1996-04-30 | Alza Corporation | Oral sustained release drug delivery device |
| FR2698560B1 (fr) | 1992-11-30 | 1995-02-03 | Virbac Laboratoires | Principes actifs pulvérulents stabilisés, compositions les contenant, leur procédé d'obtention et leurs applications. |
| ZA947970B (en) | 1993-10-15 | 1996-07-12 | Schering Corp | Tricyclic carbamate compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| IL111235A (en) | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
| US5661152A (en) | 1993-10-15 | 1997-08-26 | Schering Corporation | Tricyclic sulfonamide compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| US5719148A (en) | 1993-10-15 | 1998-02-17 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| US5721236A (en) | 1993-10-15 | 1998-02-24 | Schering Corporation | Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| US5464840A (en) | 1993-12-06 | 1995-11-07 | Schering Corporation | Tricyclic derivatives, compositions and methods of use |
| US5523095A (en) | 1993-12-15 | 1996-06-04 | Eastman Chemical Company | Controlled release matrix system using cellulose acetate/polyvinylpyrrolidone blends |
| TW406022B (en) | 1994-12-19 | 2000-09-21 | Daiichi Seiyaku Co | Method for producing slow-release granular agents |
| US5684013A (en) | 1995-03-24 | 1997-11-04 | Schering Corporation | Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| US5700806A (en) | 1995-03-24 | 1997-12-23 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| IL117798A (en) | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them |
| US5712280A (en) | 1995-04-07 | 1998-01-27 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| ATE302613T1 (de) | 1995-08-09 | 2005-09-15 | Banyu Pharma Co Ltd | Proteinfarnesyltransferase-inhibitoren in kombination mit hmgcoa-reduktase-inhibitoren zur behandlung von aids |
| EP1380581A1 (en) | 1995-12-22 | 2004-01-14 | Schering Corporation | Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative diseases |
| US5874442A (en) | 1995-12-22 | 1999-02-23 | Schering-Plough Corporation | Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease |
| JP2000504023A (ja) | 1996-04-03 | 2000-04-04 | メルク エンド カンパニー インコーポレーテッド | 癌治療方法 |
| JP2000508661A (ja) | 1996-04-15 | 2000-07-11 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | 放射線および化学療法に対する細胞の感作 |
| CA2251955A1 (en) | 1996-04-18 | 1997-10-23 | Nancy E. Kohl | A method of treating cancer |
| WO1997045412A1 (en) | 1996-05-30 | 1997-12-04 | Merck & Co., Inc. | A method of treating cancer |
| US5972381A (en) | 1996-06-28 | 1999-10-26 | Schering Corporation | Solid solution of an antifungal agent with enhanced bioavailability |
| DE69730241T2 (de) | 1996-06-28 | 2005-08-11 | Schering Corp. | Feste lösung eines fungizids mit erhöhter bioverfügbarkeit |
| US5945429A (en) | 1996-09-13 | 1999-08-31 | Schering Corporation | Compounds useful for inhibition of farnesyl protein transferase |
| US6071907A (en) | 1996-09-13 | 2000-06-06 | Schering Corporation | Tricyclic compounds useful as FPT inhibitors |
| US5861395A (en) | 1996-09-13 | 1999-01-19 | Schering Corporation | Compounds useful for inhibition of farnesyl proteins transferase |
| US6030982A (en) | 1996-09-13 | 2000-02-29 | Schering Corporationm | Compounds useful for inhibition of farnesyl protein transferase |
| US5985879A (en) | 1996-09-13 | 1999-11-16 | Schering Corporation | Compounds useful for inhibition of farnesyl protein transferase |
| CN1237164A (zh) | 1996-09-13 | 1999-12-01 | 先灵公司 | 用作法呢基-蛋白转移酶抑制剂的化合物 |
| US5958890A (en) | 1996-09-13 | 1999-09-28 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| US6040305A (en) | 1996-09-13 | 2000-03-21 | Schering Corporation | Compounds useful for inhibition of farnesyl protein transferase |
| US5965570A (en) | 1996-09-13 | 1999-10-12 | Schering Corporation | Tricyclic piperidinyl compounds useful as inhibitors of farnesyl-protein transferase |
| KR100688409B1 (ko) | 1997-02-18 | 2007-03-02 | 캔지, 인크. | 신생물에 대한 종양 억제 유전자 요법 및 화학 요법의 조합치료 방법 |
| GB9801231D0 (en) | 1997-06-05 | 1998-03-18 | Merck & Co Inc | A method of treating cancer |
| US5925639A (en) | 1997-06-17 | 1999-07-20 | Schering Corporation | Keto amide derivatives useful as farnesyl protein transferase inhibitors |
| US5877177A (en) | 1997-06-17 | 1999-03-02 | Schering Corporation | Carboxy piperidylacetamide tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| US5939416A (en) | 1997-06-17 | 1999-08-17 | Schering Corporation | Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors |
| US5852034A (en) | 1997-06-17 | 1998-12-22 | Schering Corporation | Benzo(5,6)cycloheptapyridine cyclic ureas and lactams useful as farnesyl protein transferase inhibitors |
| US5958940A (en) | 1997-09-11 | 1999-09-28 | Schering Corporation | Tricyclic compounds useful as inhibitors of farnesyl-protein transferase |
| ZA9811162B (en) | 1997-12-12 | 2000-06-07 | Genentech Inc | Treatment with anti-ERBB2 antibodies. |
| MY126580A (en) | 1997-12-22 | 2006-10-31 | Merck Sharp & Dohme | Molecular dispersion composition with enchanced bioavailabity |
-
1999
- 1999-04-09 US US09/289,255 patent/US6316462B1/en not_active Expired - Fee Related
-
2000
- 2000-04-06 TW TW089106323A patent/TWI255184B/zh not_active IP Right Cessation
- 2000-04-06 HK HK02100132.7A patent/HK1038512B/en not_active IP Right Cessation
- 2000-04-06 WO PCT/US2000/009124 patent/WO2000061145A1/en not_active Ceased
- 2000-04-06 DK DK00921765T patent/DK1165078T3/da active
- 2000-04-06 AU AU42041/00A patent/AU783177B2/en not_active Ceased
- 2000-04-06 NZ NZ514628A patent/NZ514628A/xx not_active IP Right Cessation
- 2000-04-06 CA CA002364675A patent/CA2364675A1/en not_active Abandoned
- 2000-04-06 CN CNB008085293A patent/CN100421661C/zh not_active Expired - Fee Related
- 2000-04-06 JP JP2000610478A patent/JP2003529540A/ja active Pending
- 2000-04-06 HU HU0200773A patent/HUP0200773A3/hu unknown
- 2000-04-06 MX MXPA01010211A patent/MXPA01010211A/es active IP Right Grant
- 2000-04-06 PT PT00921765T patent/PT1165078E/pt unknown
- 2000-04-06 ES ES00921765T patent/ES2275505T3/es not_active Expired - Lifetime
- 2000-04-06 AR ARP000101576A patent/AR023400A1/es unknown
- 2000-04-06 AT AT00921765T patent/ATE347360T1/de not_active IP Right Cessation
- 2000-04-06 BR BR0009670-9A patent/BR0009670A/pt not_active IP Right Cessation
- 2000-04-06 EP EP00921765A patent/EP1165078B1/en not_active Expired - Lifetime
- 2000-04-06 DE DE60032226T patent/DE60032226T2/de not_active Expired - Lifetime
- 2000-04-07 PE PE2000000317A patent/PE20010025A1/es not_active Application Discontinuation
- 2000-04-07 MY MYPI20001455A patent/MY120841A/en unknown
-
2001
- 2001-10-08 NO NO20014897A patent/NO329133B1/no not_active IP Right Cessation
- 2001-10-08 ZA ZA200108258A patent/ZA200108258B/xx unknown
-
2007
- 2007-03-01 CY CY20071100296T patent/CY1107545T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO329133B1 (no) | 2010-08-30 |
| WO2000061145A1 (en) | 2000-10-19 |
| ZA200108258B (en) | 2003-03-26 |
| JP2003529540A (ja) | 2003-10-07 |
| PE20010025A1 (es) | 2001-02-05 |
| AU4204100A (en) | 2000-11-14 |
| AU783177B2 (en) | 2005-09-29 |
| MY120841A (en) | 2005-11-30 |
| ATE347360T1 (de) | 2006-12-15 |
| MXPA01010211A (es) | 2002-09-18 |
| DK1165078T3 (da) | 2007-04-16 |
| HK1038512B (en) | 2007-04-27 |
| DE60032226D1 (de) | 2007-01-18 |
| EP1165078A1 (en) | 2002-01-02 |
| CA2364675A1 (en) | 2000-10-19 |
| CN1364084A (zh) | 2002-08-14 |
| NO20014897L (no) | 2001-12-10 |
| HK1038512A1 (en) | 2002-03-22 |
| US6316462B1 (en) | 2001-11-13 |
| CY1107545T1 (el) | 2013-03-13 |
| EP1165078B1 (en) | 2006-12-06 |
| NO20014897D0 (no) | 2001-10-08 |
| ES2275505T3 (es) | 2007-06-16 |
| BR0009670A (pt) | 2002-01-15 |
| HUP0200773A3 (en) | 2003-04-28 |
| PT1165078E (pt) | 2007-02-28 |
| NZ514628A (en) | 2004-01-30 |
| CN100421661C (zh) | 2008-10-01 |
| TWI255184B (en) | 2006-05-21 |
| DE60032226T2 (de) | 2007-10-11 |
| HUP0200773A2 (hu) | 2002-07-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR023400A1 (es) | Metodos para inducir la muerte de celulas cancerosas y la regresion de tumores | |
| ES2191192T3 (es) | Tienopirimidinas. | |
| ECSP045407A (es) | Benzazoles sustituidos y el uso del mismo como inhibidores de quinasa raf | |
| BR112022020817A2 (pt) | Inibidores de kif18a para tratamento de doenças neoplásicas | |
| ES2071484T3 (es) | Derivados de 2,4-diaminoquinazolinas para aumentar la actividad antitumoral. | |
| MY121548A (en) | Compounds and methods for the treatment of cancer | |
| ATE339957T1 (de) | Verwendung von egfr tyrosine kinase hemmern zur behandlung von brustkrebs | |
| BRPI0409919A (pt) | combinações para o tratamento de doenças envolvendo proliferação, migração ou apoptose celular de células de células de mieloma, ou angiogênese | |
| PT933995E (pt) | Metodo para tratamento de lesao endotelial | |
| AR054094A1 (es) | Tratamientos de cancer | |
| IL138979A0 (en) | Use of cannabinoids as anti-inflammatory agents | |
| SV1995000007A (es) | Derivados del acido micofenolico 5-substituidos. | |
| EA200200990A1 (ru) | Ингибиторы фосфатидилинозитол-3-киназы дельта человека | |
| ATE372341T1 (de) | Inhibitoren von mitotischem kinesin | |
| ES2154693T3 (es) | Combinacion de sustancias inductoras de necrosis con sustancias que son activadas por necrosis, para la terapia selectiva de tumores y enfermedades inflamatorias. | |
| BR0010702A (pt) | Novas quinonas como terapias de doenças | |
| ES2156107T3 (es) | Un fgf-4 no glicosilado y composiciones que lo contienen. | |
| EA200600921A1 (ru) | Способы и композиции с применением талидомида для лечения и менеджмента рака и других заболеваний | |
| BR0315942A (pt) | Tratamento de doenças e condições mediadas pelo aumento de fosforilação | |
| ATE327973T1 (de) | Polyamin-analoge als cytotoxische wirkstoffe | |
| ES2164899T3 (es) | Uso de alcaloides de la clase lamellarina en metodos de tratamiento. | |
| NZ524936A (en) | Methods of inducing cancer cell death and tumor regression using a FTP inhibitor and a tyrosine kinase inhibitor | |
| DK0841912T3 (da) | 2-Aminocarbonyl-1,2-bis-(methylsulfonyl)-1-(substituerede)-hydraziner med antitumor-virkning | |
| PT971710E (pt) | Utilizacao de queleritrina e radiacao para terapia de tumores | |
| TR200101693T2 (tr) | Lemfotoksin (LT) sentezlenme yolunun inhibitörleri kullanılarak foliküler lemfomaların tedavisi. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |