AR022235A1 - Derivados de monosacaridos como inhibidores de la adhesion celular - Google Patents
Derivados de monosacaridos como inhibidores de la adhesion celularInfo
- Publication number
- AR022235A1 AR022235A1 ARP000100086A ARP000100086A AR022235A1 AR 022235 A1 AR022235 A1 AR 022235A1 AR P000100086 A ARP000100086 A AR P000100086A AR P000100086 A ARP000100086 A AR P000100086A AR 022235 A1 AR022235 A1 AR 022235A1
- Authority
- AR
- Argentina
- Prior art keywords
- derivatives
- monosacarids
- inhibitors
- xyl
- isopropylidene
- Prior art date
Links
- 230000001413 cellular effect Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 230000021164 cell adhesion Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 239000008196 pharmacological composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
- C07H9/04—Cyclic acetals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Rheumatology (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Surgery (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Se refiere en general a compuestos y procesos para sintetizar derivados del ácido 2-3 -O-isopropiliden-alfa-L-xilo- 2-hexulofuranosonico. Los compuestos deinvencion son utiles entre otras cosas, para la inhibicion y prevencion de la adhesion celulary patologías mediadas por adhesion celular, incluyendoenfermedades inflamatorias y autoinmunes, como por ejemplo asma bronquial, artritis reumatoidea, diabetes tipo 1, esclerosis multiple, rechazo de aloinjertos ypsoriasis. Esta invencion también serefiere a composiciones farmacologicas que contienen derivados del ácido 2-3-O-isopropiliden-alfa-L-xilo-2-hexulofuranosonico de formula (1) donde R, R1 y R2 son como están definidos en la memoria, y a los métodos para tratar dichas patologías comos e enumeroanteriormente.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN86DE1999 IN190975B (es) | 1999-01-15 | 1999-01-15 | |
| US09/276,368 US6590085B1 (en) | 1999-01-15 | 1999-03-25 | Derivatives of monosaccharides as cell adhesion inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR022235A1 true AR022235A1 (es) | 2002-09-04 |
Family
ID=11088155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000100086A AR022235A1 (es) | 1999-01-15 | 2000-01-10 | Derivados de monosacaridos como inhibidores de la adhesion celular |
Country Status (30)
| Country | Link |
|---|---|
| US (5) | US6590085B1 (es) |
| EP (1) | EP1147119B1 (es) |
| JP (1) | JP2002534530A (es) |
| CN (1) | CN1167707C (es) |
| AR (1) | AR022235A1 (es) |
| AT (1) | ATE250074T1 (es) |
| AU (1) | AU768511B2 (es) |
| BG (1) | BG105745A (es) |
| BR (1) | BR0007553A (es) |
| CA (1) | CA2359986A1 (es) |
| CO (1) | CO5180591A1 (es) |
| CR (1) | CR6423A (es) |
| CZ (1) | CZ20012540A3 (es) |
| DE (1) | DE60005300T2 (es) |
| DK (1) | DK1147119T3 (es) |
| ES (1) | ES2206176T3 (es) |
| HR (1) | HRP20010529B1 (es) |
| HU (1) | HUP0105116A3 (es) |
| ID (1) | ID30351A (es) |
| IN (1) | IN190975B (es) |
| MA (1) | MA25342A1 (es) |
| MX (1) | MXPA01007187A (es) |
| MY (1) | MY121135A (es) |
| NZ (2) | NZ527483A (es) |
| PA (1) | PA8489901A1 (es) |
| PT (1) | PT1147119E (es) |
| SK (1) | SK284241B6 (es) |
| TR (1) | TR200102043T2 (es) |
| WO (1) | WO2000042054A1 (es) |
| YU (1) | YU50701A (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN190975B (es) * | 1999-01-15 | 2003-09-06 | Ranbaxy Lab Ltd | |
| CA2526730A1 (en) | 2003-05-30 | 2004-12-09 | Ranbaxy Laboratories Limited | Substituted pyrrole derivatives |
| US20090221515A1 (en) * | 2004-09-02 | 2009-09-03 | Viswajanani Jitendra Sattigeri | Monosaccharide derivatives |
| US20100113371A9 (en) * | 2004-12-22 | 2010-05-06 | Ranbaxy Laboratories Limited Inc. | Derivatives Of Pentose Monosaccharides As Anti-Inflammatory Compounds |
| EP1915160A2 (en) * | 2005-07-22 | 2008-04-30 | Ranbaxy Laboratories Limited | Derivatives of monosaccharides for the treatment of copd and allergic rhinitis |
| JP2009514851A (ja) * | 2005-11-08 | 2009-04-09 | ランバクシー ラボラトリーズ リミテッド | （３ｒ，５ｒ）−７−［２−（４−フルオロフェニル）−５−イソプロピル−３−フェニル−４−［（４−ヒドロキシメチルフェニルアミノ）カルボニル］−ピロール−１−イル］−３，５−ジヒドロキシ−ヘプタン酸ヘミカルシウム塩の製法 |
| WO2008020314A2 (en) * | 2006-03-14 | 2008-02-21 | Ranbaxy Laboratories Limited | Statin stabilizing dosage formulations |
| US20080114031A1 (en) * | 2006-03-29 | 2008-05-15 | Sattigeri Viswajanani J | Monosaccharide derivatives |
| EP1864992A2 (en) * | 2006-05-30 | 2007-12-12 | Ranbaxy Laboratories, Ltd. | Monosaccharide derivatives |
| US20080300196A1 (en) * | 2006-10-03 | 2008-12-04 | Ashwani Kumar Verma | Monosaccharide derivatives |
| US10034995B2 (en) * | 2007-09-20 | 2018-07-31 | Resmed Limited | Retractable tube for CPAP |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2715121A (en) | 1950-09-09 | 1955-08-09 | American Home Prod | Alkyl sugar derivatives and their preparation |
| US4056322A (en) | 1973-12-14 | 1977-11-01 | Strategic Medical Research Corporation | Preparation of ethers of monosaccharides |
| US4735934A (en) | 1981-02-17 | 1988-04-05 | Greenwich Pharmaceuticals Incorporated | Method of therapeutically treating a warm blooded animal afflicted with an autoimmune disease |
| US4996195A (en) | 1989-01-09 | 1991-02-26 | Greenwich Pharmaceuticals Inc. | Derivatives of α,D-glucofuranose or α,D-allofuranose and intermediates for preparing these derivatives |
| US5010058A (en) * | 1989-06-22 | 1991-04-23 | 501 Greenwich Pharmaceuticals Incorporated | 3,5,6-substituted derivatives of 1,2-O-isopropylidene-α,D-glucofuranose and intermediates for preparing these derivatives |
| FR2652540B1 (fr) | 1989-10-02 | 1995-06-02 | Imaje Sa | Circuit d'encre notamment destine a la mise en pression d'une encre a pigments pour imprimante a jet d'encre. |
| US5192746A (en) | 1990-07-09 | 1993-03-09 | Tanabe Seiyaku Co., Ltd. | Cyclic cell adhesion modulation compounds |
| US5258402A (en) | 1992-06-11 | 1993-11-02 | Mcneil-Ppc, Inc. | Imidate derivatives of pharmaceutically useful anticonvulsant sulfamates |
| US5432163A (en) | 1992-11-13 | 1995-07-11 | Greenwich Pharmaceuticals Incorporated | Anti-proliferative and anti-inflammatory compounds: derivatives of pentose monosaccharides |
| US5637570A (en) * | 1995-05-09 | 1997-06-10 | Chemora Pharmochem | Disubstituted and trisubstituted derivatives of 2,3:4,6-di-O-isopropylidene-α-L-xylo-2-hexulofuranosonic acid having anti-cancer, anti-inflammatory and anti-proliferative activity |
| IN190975B (es) * | 1999-01-15 | 2003-09-06 | Ranbaxy Lab Ltd |
-
1999
- 1999-01-15 IN IN86DE1999 patent/IN190975B/en unknown
- 1999-03-25 US US09/276,368 patent/US6590085B1/en not_active Expired - Fee Related
-
2000
- 2000-01-10 CN CNB008048525A patent/CN1167707C/zh not_active Expired - Fee Related
- 2000-01-10 ES ES00900088T patent/ES2206176T3/es not_active Expired - Lifetime
- 2000-01-10 AR ARP000100086A patent/AR022235A1/es not_active Application Discontinuation
- 2000-01-10 CA CA002359986A patent/CA2359986A1/en not_active Abandoned
- 2000-01-10 ID IDW00200101520A patent/ID30351A/id unknown
- 2000-01-10 DK DK00900088T patent/DK1147119T3/da active
- 2000-01-10 SK SK10132001A patent/SK284241B6/sk unknown
- 2000-01-10 MX MXPA01007187A patent/MXPA01007187A/es not_active IP Right Cessation
- 2000-01-10 DE DE60005300T patent/DE60005300T2/de not_active Expired - Fee Related
- 2000-01-10 YU YU50701A patent/YU50701A/sh unknown
- 2000-01-10 HR HR20010529A patent/HRP20010529B1/xx not_active IP Right Cessation
- 2000-01-10 AU AU18861/00A patent/AU768511B2/en not_active Ceased
- 2000-01-10 HU HU0105116A patent/HUP0105116A3/hu unknown
- 2000-01-10 TR TR2001/02043T patent/TR200102043T2/xx unknown
- 2000-01-10 PT PT00900088T patent/PT1147119E/pt unknown
- 2000-01-10 WO PCT/IB2000/000022 patent/WO2000042054A1/en not_active Ceased
- 2000-01-10 JP JP2000593621A patent/JP2002534530A/ja active Pending
- 2000-01-10 AT AT00900088T patent/ATE250074T1/de not_active IP Right Cessation
- 2000-01-10 EP EP00900088A patent/EP1147119B1/en not_active Expired - Lifetime
- 2000-01-10 BR BR0007553-1A patent/BR0007553A/pt not_active IP Right Cessation
- 2000-01-10 NZ NZ527483A patent/NZ527483A/en unknown
- 2000-01-10 NZ NZ512852A patent/NZ512852A/xx unknown
- 2000-01-10 CZ CZ20012540A patent/CZ20012540A3/cs unknown
- 2000-01-14 MY MYPI20000121A patent/MY121135A/en unknown
- 2000-01-14 CO CO00001575A patent/CO5180591A1/es not_active Application Discontinuation
- 2000-01-14 PA PA20008489901A patent/PA8489901A1/es unknown
-
2001
- 2001-07-12 CR CR6423A patent/CR6423A/xx not_active Application Discontinuation
- 2001-07-12 MA MA26266A patent/MA25342A1/fr unknown
- 2001-07-26 BG BG105745A patent/BG105745A/xx unknown
-
2003
- 2003-07-01 US US10/611,091 patent/US20040018995A1/en not_active Abandoned
- 2003-07-01 US US10/611,386 patent/US7005516B2/en not_active Expired - Fee Related
- 2003-07-01 US US10/610,719 patent/US7037899B2/en not_active Expired - Fee Related
- 2003-07-01 US US10/611,093 patent/US7005422B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |