AR029320A1 - Acidos aril carboxilicos y derivados de tetrazol, un proceso para su fabricacion, una composicion farmaceutica y el uso de los mismos para la produccion de un medicamento - Google Patents
Acidos aril carboxilicos y derivados de tetrazol, un proceso para su fabricacion, una composicion farmaceutica y el uso de los mismos para la produccion de un medicamentoInfo
- Publication number
- AR029320A1 AR029320A1 ARP990106638A ARP990106638A AR029320A1 AR 029320 A1 AR029320 A1 AR 029320A1 AR P990106638 A ARP990106638 A AR P990106638A AR P990106638 A ARP990106638 A AR P990106638A AR 029320 A1 AR029320 A1 AR 029320A1
- Authority
- AR
- Argentina
- Prior art keywords
- manufacture
- production
- pharmaceutical composition
- derivatives
- aril
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 4
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- CWRVKFFCRWGWCS-UHFFFAOYSA-N Pentrazole Chemical class C1CCCCC2=NN=NN21 CWRVKFFCRWGWCS-UHFFFAOYSA-N 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical compound O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 abstract 1
- 229960001123 epoprostenol Drugs 0.000 abstract 1
- 150000003536 tetrazoles Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
Acidos arilcarboxílicos y derivados de tetrazol, que comprende un compuesto de Formula 1 en donde Ra, R?, Rl, R4; R5, A y B tienen los significados dados en la memoria descriptiva, un proceso para su fabricacion, una composicion farmacéutica y el uso de los mismos para la produccion de un medicamento util para el tratamiento de un estado de enfermedad asociado con el receptor (IP) prostaglandina I2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11344698P | 1998-12-23 | 1998-12-23 | |
| US15181499P | 1999-08-30 | 1999-08-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR029320A1 true AR029320A1 (es) | 2003-06-25 |
Family
ID=26811078
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990106638A AR029320A1 (es) | 1998-12-23 | 1999-12-21 | Acidos aril carboxilicos y derivados de tetrazol, un proceso para su fabricacion, una composicion farmaceutica y el uso de los mismos para la produccion de un medicamento |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6335459B1 (es) |
| EP (1) | EP1013639B1 (es) |
| JP (1) | JP3415085B2 (es) |
| KR (1) | KR100378335B1 (es) |
| CN (1) | CN1167670C (es) |
| AR (1) | AR029320A1 (es) |
| AT (1) | ATE251125T1 (es) |
| AU (1) | AU735640B2 (es) |
| BR (1) | BR9905974A (es) |
| CA (1) | CA2292921C (es) |
| DE (1) | DE69911726T2 (es) |
| DK (1) | DK1013639T3 (es) |
| ES (1) | ES2207108T3 (es) |
| HR (1) | HRP990394A2 (es) |
| HU (1) | HUP9904659A3 (es) |
| ID (1) | ID25983A (es) |
| IL (1) | IL133578A (es) |
| MA (1) | MA26713A1 (es) |
| NO (1) | NO316171B1 (es) |
| NZ (1) | NZ501891A (es) |
| PE (1) | PE20001368A1 (es) |
| PL (1) | PL337419A1 (es) |
| PT (1) | PT1013639E (es) |
| RU (1) | RU2179969C2 (es) |
| SG (1) | SG90086A1 (es) |
| TR (1) | TR199903310A3 (es) |
| TW (1) | TWI221834B (es) |
| UY (1) | UY25876A1 (es) |
| YU (1) | YU69699A (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9828442D0 (en) | 1998-12-24 | 1999-02-17 | Karobio Ab | Novel thyroid receptor ligands and method II |
| SE0100158D0 (sv) * | 2001-01-19 | 2001-01-19 | Synphora Ab | Novel method and composition for local treatment of Meniere´s disease and tinnitus |
| JP2004526721A (ja) * | 2001-03-02 | 2004-09-02 | エフ．ホフマン−ラ ロシュ アーゲー | Ｉｐアンタゴニストとしてのアルコキシカルボニルアミノヘテロアリールカルボン酸誘導体 |
| WO2004098611A1 (ja) | 2003-05-09 | 2004-11-18 | Toray Industries Inc. | 増強剤 |
| RU2268037C1 (ru) * | 2004-04-22 | 2006-01-20 | Германов Евгений Павлович | Лекарственное средство |
| UA93548C2 (uk) | 2006-05-05 | 2011-02-25 | Айерем Елелсі | Сполуки та композиції як модулятори хеджхогівського сигнального шляху |
| US9669381B2 (en) | 2007-06-27 | 2017-06-06 | Hrd Corporation | System and process for hydrocracking |
| HUE023239T4 (en) | 2008-03-18 | 2016-05-30 | Arena Pharm Inc | Modulators of the prostacycline (PGI2) receptor that can be used to treat related diseases |
| ES2532858T3 (es) * | 2008-07-23 | 2015-04-01 | Toray Industries, Inc. | Agente terapéutico para insuficiencia renal crónica |
| WO2011154827A2 (en) | 2010-06-11 | 2011-12-15 | Rhodes Technologies | Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof |
| JP2013529595A (ja) | 2010-06-11 | 2013-07-22 | ローズ テクノロジーズ | 第３級アミンのｎ−脱アルキル化方法 |
| WO2018160882A1 (en) | 2017-03-01 | 2018-09-07 | Arena Pharmaceuticals, Inc. | Compositions comprising pgi2-receptor agonists and processes for the preparation thereof |
| CA3248736A1 (en) | 2022-02-15 | 2023-08-24 | United Therapeutics Corporation | CRYSTALLINE PROSTACYCLINE (IP) RECEPTOR AGONIST AND ITS USES |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1079414A (en) | 1965-06-30 | 1967-08-16 | Smith & Nephew | Derivatives of acetic acid and a process for their preparation |
| GB1185539A (en) | 1967-11-03 | 1970-03-25 | Smith & Nephew | Substituted Tetrazoles |
| DE2432560A1 (de) | 1974-07-06 | 1976-01-22 | Boehringer Mannheim Gmbh | Neue phenoxyalkylcarbonsaeurederivate und verfahren zur herstellung derselben |
| JPS5832859A (ja) | 1981-08-20 | 1983-02-25 | Dainippon Pharmaceut Co Ltd | Ｎ，ｎ−ジメチルカルバミン酸ベンジルエステル誘導体 |
| JPH0725725B2 (ja) | 1987-07-23 | 1995-03-22 | 保土谷化学工業株式会社 | ベンズアミド誘導体 |
| US5084466A (en) | 1989-01-31 | 1992-01-28 | Hoffmann-La Roche Inc. | Novel carboxamide pyridine compounds which have useful pharmaceutical utility |
| CA2090283A1 (en) | 1992-02-28 | 1993-08-29 | Nobuyuki Hamanaka | Phenoxyacetic acid derivatives |
| CN1145076A (zh) | 1994-02-10 | 1997-03-12 | 小野药品工业株式会社 | 前列腺素i2受体 |
| EP0749424B1 (en) | 1994-03-10 | 2001-09-12 | Fujisawa Pharmaceutical Co., Ltd. | Naphthalene derivatives as prostaglandin i2 agonists |
| US5753700A (en) | 1994-12-28 | 1998-05-19 | Ono Pharmaceutical Co., Ltd. | Naphthyloxyacetic acid derivatives |
| TW401408B (en) | 1995-07-21 | 2000-08-11 | Fujisawa Pharmaceutical Co | Heterocyclic compounds having prostaglandin I2 agonism |
| US6018068A (en) | 1995-07-26 | 2000-01-25 | Ono Pharmaceutical Co., Ltd. | Naphthyloxyacetic acid derivatives and drugs comprising the same as active ingredients |
| DE19619445C1 (de) * | 1996-05-14 | 1997-09-25 | Bayer Ag | Verfahren zur Herstellung von optisch aktiver N-Phenylcarbamat-milchsäure |
| AUPP029197A0 (en) | 1997-11-10 | 1997-12-04 | Fujisawa Pharmaceutical Co., Ltd. | Benzocycloheptene derivatives |
| AUPP109097A0 (en) | 1997-12-22 | 1998-01-22 | Fujisawa Pharmaceutical Co., Ltd. | Napthalene derivatives |
-
1999
- 1999-12-07 US US09/456,167 patent/US6335459B1/en not_active Expired - Fee Related
- 1999-12-15 PT PT99125027T patent/PT1013639E/pt unknown
- 1999-12-15 AT AT99125027T patent/ATE251125T1/de not_active IP Right Cessation
- 1999-12-15 DK DK99125027T patent/DK1013639T3/da active
- 1999-12-15 ES ES99125027T patent/ES2207108T3/es not_active Expired - Lifetime
- 1999-12-15 EP EP99125027A patent/EP1013639B1/en not_active Expired - Lifetime
- 1999-12-15 DE DE69911726T patent/DE69911726T2/de not_active Expired - Fee Related
- 1999-12-17 NZ NZ501891A patent/NZ501891A/en unknown
- 1999-12-17 IL IL13357899A patent/IL133578A/en not_active IP Right Cessation
- 1999-12-17 AU AU65340/99A patent/AU735640B2/en not_active Ceased
- 1999-12-17 SG SG9906425A patent/SG90086A1/en unknown
- 1999-12-20 MA MA25866A patent/MA26713A1/fr unknown
- 1999-12-20 HR HR990394A patent/HRP990394A2/hr not_active Application Discontinuation
- 1999-12-20 HU HU9904659A patent/HUP9904659A3/hu unknown
- 1999-12-21 NO NO19996366A patent/NO316171B1/no unknown
- 1999-12-21 PE PE1999001307A patent/PE20001368A1/es not_active Application Discontinuation
- 1999-12-21 AR ARP990106638A patent/AR029320A1/es not_active Application Discontinuation
- 1999-12-22 RU RU99127329/04A patent/RU2179969C2/ru not_active IP Right Cessation
- 1999-12-22 CA CA002292921A patent/CA2292921C/en not_active Expired - Fee Related
- 1999-12-22 UY UY25876A patent/UY25876A1/es unknown
- 1999-12-22 KR KR10-1999-0060163A patent/KR100378335B1/ko not_active Expired - Fee Related
- 1999-12-22 ID IDP991169D patent/ID25983A/id unknown
- 1999-12-22 JP JP36452099A patent/JP3415085B2/ja not_active Expired - Fee Related
- 1999-12-23 TW TW088122774A patent/TWI221834B/zh not_active IP Right Cessation
- 1999-12-23 TR TR1999/03310A patent/TR199903310A3/tr unknown
- 1999-12-23 BR BR9905974-6A patent/BR9905974A/pt not_active IP Right Cessation
- 1999-12-23 CN CNB991277953A patent/CN1167670C/zh not_active Expired - Fee Related
- 1999-12-23 YU YU69699A patent/YU69699A/sh unknown
- 1999-12-23 PL PL99337419A patent/PL337419A1/xx not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |