AR029217A1 - Derivados de 1-(aril o heteroaril)-4-fenil-piperazino,-diazepan,-piperidino o tetrahidropiridino,composiciones farmaceuticas que los comprenden y el uso de los mismos para la fabricacion de un medicamento. - Google Patents
Derivados de 1-(aril o heteroaril)-4-fenil-piperazino,-diazepan,-piperidino o tetrahidropiridino,composiciones farmaceuticas que los comprenden y el uso de los mismos para la fabricacion de un medicamento.Info
- Publication number
- AR029217A1 AR029217A1 ARP000106990A ARP000106990A AR029217A1 AR 029217 A1 AR029217 A1 AR 029217A1 AR P000106990 A ARP000106990 A AR P000106990A AR P000106990 A ARP000106990 A AR P000106990A AR 029217 A1 AR029217 A1 AR 029217A1
- Authority
- AR
- Argentina
- Prior art keywords
- diazepan
- piperazino
- piperidino
- derivatives
- manufacture
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 2
- VSWICNJIUPRZIK-UHFFFAOYSA-N 2-piperideine Chemical class C1CNC=CC1 VSWICNJIUPRZIK-UHFFFAOYSA-N 0.000 abstract 1
- 102000003962 Dopamine D4 receptors Human genes 0.000 abstract 1
- 108090000357 Dopamine D4 receptors Proteins 0.000 abstract 1
- 208000011688 Generalised anxiety disease Diseases 0.000 abstract 1
- 208000019022 Mood disease Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- 230000016571 aggressive behavior Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000029364 generalized anxiety disease Diseases 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Se refiere a derivados de 1-(aril o heteroaril)-4-fenil-piperazino, - diazepan, - piperidino o tetrahidropiridino sustituido que tienen la formula (1) en la cual X, Z, Y, U, V, Alk, W, Ra, R?, Rl, Raa, Ra?, Ral, n, m y la línea de puntos son como se los definio en la memoria descriptiva. Los compuestos de la invencion son ligandos del receptor D4 de la dopamina y, por lo tanto, son utiles para el tratamiento de ciertos trastornos psiquiátricos y neurologicos, entre los que se incluye la psicosis. Se describen además composiciones farmacéuticas que los comprenden y el uso de los mismos para la fabricacion de un medicamento util para el tratamiento de la psicosis, los síntomas positivos y negativos de la esquizofrenia y los trastornos afectivos, como el trastorno generalizado de ansiedad, el trastorno de pánico, el trastorno obsesivo compulsivo, la depresion y la agresion. v
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA199901886 | 1999-12-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR029217A1 true AR029217A1 (es) | 2003-06-18 |
Family
ID=8108810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000106990A AR029217A1 (es) | 1999-12-30 | 2000-12-28 | Derivados de 1-(aril o heteroaril)-4-fenil-piperazino,-diazepan,-piperidino o tetrahidropiridino,composiciones farmaceuticas que los comprenden y el uso de los mismos para la fabricacion de un medicamento. |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20030083336A1 (es) |
| EP (1) | EP1246815B1 (es) |
| JP (1) | JP2003519223A (es) |
| KR (1) | KR20020067589A (es) |
| CN (1) | CN1437596A (es) |
| AR (1) | AR029217A1 (es) |
| AT (1) | ATE261958T1 (es) |
| AU (1) | AU2152001A (es) |
| BG (1) | BG106961A (es) |
| BR (1) | BR0016951A (es) |
| CA (1) | CA2395867A1 (es) |
| DE (1) | DE60009154D1 (es) |
| EA (1) | EA200200731A1 (es) |
| HU (1) | HUP0203645A3 (es) |
| IL (1) | IL150337A0 (es) |
| IS (1) | IS6431A (es) |
| MX (1) | MXPA02006499A (es) |
| NO (1) | NO20023149D0 (es) |
| NZ (1) | NZ519692A (es) |
| PL (1) | PL355540A1 (es) |
| SK (1) | SK11062002A3 (es) |
| TR (1) | TR200201684T2 (es) |
| WO (1) | WO2001049677A1 (es) |
| ZA (1) | ZA200204970B (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040002488A1 (en) * | 2002-05-29 | 2004-01-01 | Cowart Marlon D. | Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction |
| EP1927594A1 (en) * | 2003-01-14 | 2008-06-04 | Arena Pharmaceuticals, Inc. | 1,2,3-Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia |
| CN102558155A (zh) * | 2003-01-14 | 2012-07-11 | 阿伦纳药品公司 | 作为代谢调节剂的芳基和杂芳基衍生物及其所涉及的疾病如糖尿病和高血糖症的预防和治疗 |
| AR045047A1 (es) | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
| AU2004303461B2 (en) | 2003-12-23 | 2011-04-28 | H. Lundbeck A/S | 2-(1H-indolylsulfanyl)-benzyl amine derivatives as SSRI |
| AR052308A1 (es) | 2004-07-16 | 2007-03-14 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto |
| JP2008526715A (ja) * | 2005-01-03 | 2008-07-24 | ユニベルシタ デグリ ストゥディ ディ シエナ | 神経精神障害の治療のためのアリールピペラジン誘導体 |
| US7629473B2 (en) | 2005-06-17 | 2009-12-08 | H. Lundbeck A/S | 2-(1H-indolylsulfanyl)-aryl amine derivatives |
| KR100868353B1 (ko) * | 2007-03-08 | 2008-11-12 | 한국화학연구원 | 도파민 ｄ4 수용체 길항제인 신규 피페라지닐프로필피라졸유도체, 이의 제조방법 및 이를 포함하는 약학적 조성물 |
| EA201390421A1 (ru) | 2010-09-22 | 2013-09-30 | Арена Фармасьютикалз, Инк. | Модуляторы рецептора gpr119 и лечение связанных с ним нарушений |
| WO2015090235A1 (en) | 2013-12-20 | 2015-06-25 | Sunshine Lake Pharma Co., Ltd. | Substituted piperazine compounds and methods of use thereof |
| WO2015169180A1 (en) * | 2014-05-04 | 2015-11-12 | Sunshine Lake Pharma Co., Ltd. | Substituted piperazine compounds and methods and use thereof |
| CN105085491B (zh) * | 2014-05-05 | 2019-06-25 | 广东东阳光药业有限公司 | 取代的吲哚化合物及其使用方法和用途 |
| GB201416351D0 (en) | 2014-09-16 | 2014-10-29 | Shire Internat Gmbh | Heterocyclic derivatives |
| GB201416352D0 (en) | 2014-09-16 | 2014-10-29 | Shire Internat Gmbh | Spirocyclic derivatives |
| CN105732591B (zh) * | 2014-12-31 | 2019-10-25 | 广东东阳光药业有限公司 | 取代的哌嗪化合物及其使用方法和用途 |
| EP4445956A3 (en) | 2015-01-06 | 2024-12-04 | Arena Pharmaceuticals, Inc. | Compound for use in treating conditions related to the s1p1 receptor |
| PL3310760T3 (pl) | 2015-06-22 | 2023-03-06 | Arena Pharmaceuticals, Inc. | Krystaliczna sól L-argininy kwasu (R)-2-(7-(4-cyklopentylo-3-(trifluorometylo)benzyloksy)- 1,2,3,4-tetrahydrocyklo-penta[b]indol-3-ilo)octowego do zastosowania w zaburzeniach związanych z receptorem S1P1 |
| WO2017012579A1 (zh) * | 2015-07-23 | 2017-01-26 | 广东东阳光药业有限公司 | 取代的吲哚化合物及其使用方法和用途 |
| WO2017025058A1 (zh) * | 2015-08-13 | 2017-02-16 | 广东东阳光药业有限公司 | 取代的吲哚化合物及其使用方法和用途 |
| CN110520124A (zh) | 2017-02-16 | 2019-11-29 | 艾尼纳制药公司 | 用于治疗原发性胆汁性胆管炎的化合物和方法 |
| CA3102136A1 (en) | 2018-06-06 | 2019-12-12 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the s1p1 receptor |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8830312D0 (en) * | 1988-12-28 | 1989-02-22 | Lundbeck & Co As H | Heterocyclic compounds |
| GB9305623D0 (en) * | 1993-03-18 | 1993-05-05 | Merck Sharp & Dohme | Therapeutic agents |
| GB9306578D0 (en) * | 1993-03-30 | 1993-05-26 | Merck Sharp & Dohme | Therapeutic agents |
| AU6435594A (en) * | 1993-04-15 | 1994-11-08 | Merck Sharp & Dohme Limited | Indole derivatives as dopamine d4 antagonists |
| AU694212B2 (en) * | 1994-04-28 | 1998-07-16 | Merck Sharp & Dohme Limited | Benzofuran derivatives as d4 receptor antagonists |
| DK0775118T3 (da) * | 1994-08-05 | 2003-09-29 | Pfizer | Benzimidazolderivater, der har dopaminerg aktivitet |
| USH2007H1 (en) * | 1996-01-19 | 2001-12-04 | Fmc Corporation | Insecticidal N-heterocyclylalkyl-or N-[(polycyclyl)alkyl]-N′substituted piperazines |
-
2000
- 2000-12-20 CA CA002395867A patent/CA2395867A1/en not_active Abandoned
- 2000-12-20 EA EA200200731A patent/EA200200731A1/ru unknown
- 2000-12-20 PL PL00355540A patent/PL355540A1/xx not_active Application Discontinuation
- 2000-12-20 HU HU0203645A patent/HUP0203645A3/hu unknown
- 2000-12-20 WO PCT/DK2000/000720 patent/WO2001049677A1/en not_active Ceased
- 2000-12-20 CN CN00819202A patent/CN1437596A/zh active Pending
- 2000-12-20 AU AU21520/01A patent/AU2152001A/en not_active Abandoned
- 2000-12-20 JP JP2001550217A patent/JP2003519223A/ja not_active Withdrawn
- 2000-12-20 NZ NZ519692A patent/NZ519692A/en not_active Application Discontinuation
- 2000-12-20 MX MXPA02006499A patent/MXPA02006499A/es unknown
- 2000-12-20 KR KR1020027008602A patent/KR20020067589A/ko not_active Withdrawn
- 2000-12-20 DE DE60009154T patent/DE60009154D1/de not_active Expired - Lifetime
- 2000-12-20 TR TR2002/01684T patent/TR200201684T2/xx unknown
- 2000-12-20 IL IL15033700A patent/IL150337A0/xx unknown
- 2000-12-20 EP EP00984923A patent/EP1246815B1/en not_active Expired - Lifetime
- 2000-12-20 BR BR0016951-0A patent/BR0016951A/pt not_active IP Right Cessation
- 2000-12-20 AT AT00984923T patent/ATE261958T1/de not_active IP Right Cessation
- 2000-12-20 SK SK1106-2002A patent/SK11062002A3/sk unknown
- 2000-12-28 AR ARP000106990A patent/AR029217A1/es not_active Application Discontinuation
-
2002
- 2002-06-19 IS IS6431A patent/IS6431A/is unknown
- 2002-06-20 ZA ZA200204970A patent/ZA200204970B/en unknown
- 2002-06-25 US US10/183,963 patent/US20030083336A1/en not_active Abandoned
- 2002-06-28 NO NO20023149A patent/NO20023149D0/no not_active Application Discontinuation
- 2002-07-26 BG BG106961A patent/BG106961A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20023149L (no) | 2002-06-28 |
| BR0016951A (pt) | 2003-02-25 |
| CA2395867A1 (en) | 2001-07-12 |
| HUP0203645A2 (hu) | 2003-02-28 |
| TR200201684T2 (tr) | 2002-10-21 |
| AU2152001A (en) | 2001-07-16 |
| KR20020067589A (ko) | 2002-08-22 |
| IS6431A (is) | 2002-06-19 |
| NZ519692A (en) | 2004-05-28 |
| ZA200204970B (en) | 2004-01-26 |
| WO2001049677A1 (en) | 2001-07-12 |
| US20030083336A1 (en) | 2003-05-01 |
| EP1246815A1 (en) | 2002-10-09 |
| SK11062002A3 (sk) | 2002-12-03 |
| DE60009154D1 (de) | 2004-04-22 |
| ATE261958T1 (de) | 2004-04-15 |
| EP1246815B1 (en) | 2004-03-17 |
| MXPA02006499A (es) | 2002-11-29 |
| NO20023149D0 (no) | 2002-06-28 |
| EA200200731A1 (ru) | 2002-12-26 |
| CN1437596A (zh) | 2003-08-20 |
| PL355540A1 (en) | 2004-05-04 |
| IL150337A0 (en) | 2002-12-01 |
| JP2003519223A (ja) | 2003-06-17 |
| BG106961A (en) | 2003-04-30 |
| HUP0203645A3 (en) | 2004-01-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |