AR028958A1 - INHIBIDORES DE TRANSCRIPTASA INVERSA NO NUCLEoSIDOS - Google Patents
INHIBIDORES DE TRANSCRIPTASA INVERSA NO NUCLEoSIDOSInfo
- Publication number
- AR028958A1 AR028958A1 ARP010102870A ARP010102870A AR028958A1 AR 028958 A1 AR028958 A1 AR 028958A1 AR P010102870 A ARP010102870 A AR P010102870A AR P010102870 A ARP010102870 A AR P010102870A AR 028958 A1 AR028958 A1 AR 028958A1
- Authority
- AR
- Argentina
- Prior art keywords
- nucleosidos
- formula
- group
- inhibitors
- inverse
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 238000003874 inverse correlation nuclear magnetic resonance spectroscopy Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Se proporcionan compuestos de la formula general (1) en donde R2 se selecciona del grupo que consiste en H, F, Cl, alquilo (C1-4), cicloalquilo (C3-4) y CF3; R4 es H o Me; R5 es H, Me o Et, con la condicion de que R4 y R5 no sean ambos Me y si R4 es Me, entonces R5 no puede ser Et; R11 es Et, ciclopropilo, propilo, isopropilo o isobutilo; y Q se selecciona del grupo de formula (2) y sus sales farmacéuticamente aceptables, como inhibidores de la transcriptasa inversa de VIHH, cepas de tipo salvaje,y varias cepas mutantes. Una composicion farmacéutica que contiene al compuesto de formula (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21232900P | 2000-06-16 | 2000-06-16 | |
| US25663800P | 2000-12-18 | 2000-12-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR028958A1 true AR028958A1 (es) | 2003-05-28 |
Family
ID=26907019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010102870A AR028958A1 (es) | 2000-06-16 | 2001-06-15 | INHIBIDORES DE TRANSCRIPTASA INVERSA NO NUCLEoSIDOS |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US6420359B1 (es) |
| EP (1) | EP1294720B1 (es) |
| JP (1) | JP3923894B2 (es) |
| KR (1) | KR20030017540A (es) |
| CN (1) | CN1178939C (es) |
| AR (1) | AR028958A1 (es) |
| AT (1) | ATE322492T1 (es) |
| AU (2) | AU7037001A (es) |
| BG (1) | BG107348A (es) |
| BR (1) | BR0102377A (es) |
| CA (1) | CA2411766C (es) |
| CZ (1) | CZ20024114A3 (es) |
| DE (1) | DE60118560T2 (es) |
| DK (1) | DK1294720T3 (es) |
| EA (1) | EA005598B1 (es) |
| EE (1) | EE200200690A (es) |
| ES (1) | ES2261433T3 (es) |
| HR (1) | HRP20021003A2 (es) |
| HU (1) | HUP0301105A2 (es) |
| IL (1) | IL152819A0 (es) |
| MX (1) | MXPA02012205A (es) |
| MY (1) | MY130375A (es) |
| NO (1) | NO323830B1 (es) |
| NZ (1) | NZ523549A (es) |
| PE (1) | PE20020083A1 (es) |
| PL (1) | PL360370A1 (es) |
| PT (1) | PT1294720E (es) |
| SA (1) | SA01220202B1 (es) |
| SK (1) | SK17722002A3 (es) |
| TW (1) | TWI270547B (es) |
| UA (1) | UA74834C2 (es) |
| UY (1) | UY26767A1 (es) |
| WO (1) | WO2001096338A1 (es) |
| YU (1) | YU94202A (es) |
| ZA (1) | ZA200209807B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6716836B2 (en) | 2001-03-22 | 2004-04-06 | Boehringer Ingelheim (Canada) Ltd. | Non-nucleoside reverse transcriptase inhibitors |
| US6673791B2 (en) * | 2001-07-30 | 2004-01-06 | Boehringer Ingelheim (Canada) Ltd. | Non-nucleoside reverse transcriptase inhibitors |
| US6706706B2 (en) * | 2002-03-27 | 2004-03-16 | Boehringer Ingelheim International Gmbh | Non-nucleoside reverse transcriptase inhibitors |
| US6806265B2 (en) * | 2002-05-16 | 2004-10-19 | Boehringer Ingelheim International Gmbh | Non-nucleoside reverse transcriptase inhibitors |
| US6759533B2 (en) * | 2002-06-28 | 2004-07-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | Process and intermediates for making non-nucleoside HIV-1 reverse transcriptase inhibitors |
| US7642277B2 (en) | 2002-12-04 | 2010-01-05 | Boehringer Ingelheim International Gmbh | Non-nucleoside reverse transcriptase inhibitors |
| KR20050085681A (ko) * | 2002-12-16 | 2005-08-29 | 베링거 인겔하임 인터내셔날 게엠베하 | 프로테아제 억제제와 같은 사이토크롬 ｐ450의 억제제와함께 비-뉴클레오시드 역전사효소 억제제(ｎｎｒｔｉ)를함유하는 배합물의 용도 |
| WO2004087140A1 (en) * | 2003-03-27 | 2004-10-14 | Boehringer Ingelheim International Gmbh | Antiviral combination of a dipyridodiazepinone and a further antiretroviral compound |
| US7309700B2 (en) * | 2004-04-02 | 2007-12-18 | Boehringer Ingelheim International Gmbh | Crystalline forms of 5,11-dihydro-11-ethyl-5-methyl-8-{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-dipyrido[3,2-b:2′,3′-e] [1,4]diazepin-6-one |
| US20060025480A1 (en) | 2004-08-02 | 2006-02-02 | Boehringer Ingelheim International Gmbh | Benzoic acid derivatives as non nucleoside reverse transcriptase inhibitors |
| US7151174B2 (en) | 2004-11-05 | 2006-12-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Process for making a non-nucleoside HIV-1 reverse transcriptase inhibitor |
| WO2007067844A1 (en) * | 2005-12-05 | 2007-06-14 | Boehringer Ingelheim International Gmbh | Process for making 5,11-dihydro-11-ethyl-5-methyl-8-{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6h-di pyrido[3,2-b:2',3'-e][1,4]diazepin-6-one |
| EP2085390A1 (en) | 2008-01-31 | 2009-08-05 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Labelled analogues of halobenzamides as multimodal radiopharmaceuticals and their precursors |
| JP5643290B2 (ja) * | 2009-04-09 | 2014-12-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｈｉｖ複製の阻害薬 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5366972A (en) * | 1989-04-20 | 1994-11-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection |
| US5705499A (en) * | 1995-10-06 | 1998-01-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | 8-arylalkyl- and 8-arylheteroalkyl-5,11-dihydro-6H-dipyrido 3,2-B:2',3'-e! 1!diazepines and their use in the treatment of HIV-1 infection |
-
2001
- 2001-05-30 TW TW090113049A patent/TWI270547B/zh not_active IP Right Cessation
- 2001-06-12 BR BR0102377-2A patent/BR0102377A/pt not_active IP Right Cessation
- 2001-06-12 US US09/879,447 patent/US6420359B1/en not_active Expired - Lifetime
- 2001-06-13 UY UY26767A patent/UY26767A1/es not_active Application Discontinuation
- 2001-06-14 EE EEP200200690A patent/EE200200690A/xx unknown
- 2001-06-14 HR HR20021003A patent/HRP20021003A2/hr not_active Application Discontinuation
- 2001-06-14 SK SK1772-2002A patent/SK17722002A3/sk not_active Application Discontinuation
- 2001-06-14 DE DE60118560T patent/DE60118560T2/de not_active Expired - Lifetime
- 2001-06-14 CA CA002411766A patent/CA2411766C/en not_active Expired - Fee Related
- 2001-06-14 CZ CZ20024114A patent/CZ20024114A3/cs unknown
- 2001-06-14 NZ NZ523549A patent/NZ523549A/en unknown
- 2001-06-14 EA EA200201255A patent/EA005598B1/ru not_active IP Right Cessation
- 2001-06-14 YU YU94202A patent/YU94202A/sh unknown
- 2001-06-14 MX MXPA02012205A patent/MXPA02012205A/es active IP Right Grant
- 2001-06-14 IL IL15281901A patent/IL152819A0/xx unknown
- 2001-06-14 AU AU7037001A patent/AU7037001A/xx active Pending
- 2001-06-14 PL PL36037001A patent/PL360370A1/xx not_active Application Discontinuation
- 2001-06-14 UA UA2003010387A patent/UA74834C2/uk unknown
- 2001-06-14 AU AU2001270370A patent/AU2001270370B2/en not_active Ceased
- 2001-06-14 EP EP01949124A patent/EP1294720B1/en not_active Expired - Lifetime
- 2001-06-14 WO PCT/CA2001/000890 patent/WO2001096338A1/en not_active Ceased
- 2001-06-14 JP JP2002510480A patent/JP3923894B2/ja not_active Expired - Lifetime
- 2001-06-14 PE PE2001000560A patent/PE20020083A1/es not_active Application Discontinuation
- 2001-06-14 PT PT01949124T patent/PT1294720E/pt unknown
- 2001-06-14 KR KR1020027017173A patent/KR20030017540A/ko not_active Abandoned
- 2001-06-14 ES ES01949124T patent/ES2261433T3/es not_active Expired - Lifetime
- 2001-06-14 HU HU0301105A patent/HUP0301105A2/hu unknown
- 2001-06-14 DK DK01949124T patent/DK1294720T3/da active
- 2001-06-14 CN CNB018112692A patent/CN1178939C/zh not_active Expired - Fee Related
- 2001-06-14 AT AT01949124T patent/ATE322492T1/de active
- 2001-06-15 MY MYPI20012820A patent/MY130375A/en unknown
- 2001-06-15 AR ARP010102870A patent/AR028958A1/es unknown
- 2001-07-07 SA SA01220202A patent/SA01220202B1/ar unknown
-
2002
- 2002-12-03 BG BG107348A patent/BG107348A/bg unknown
- 2002-12-03 ZA ZA200209807A patent/ZA200209807B/en unknown
- 2002-12-05 NO NO20025844A patent/NO323830B1/no unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |