[go: up one dir, main page]

AR027998A1 - Derivados de etilendiamina y los medicamentos y composiciones farmaceuticas que los contienen - Google Patents

Derivados de etilendiamina y los medicamentos y composiciones farmaceuticas que los contienen

Info

Publication number
AR027998A1
AR027998A1 ARP010101613A ARP010101613A AR027998A1 AR 027998 A1 AR027998 A1 AR 027998A1 AR P010101613 A ARP010101613 A AR P010101613A AR P010101613 A ARP010101613 A AR P010101613A AR 027998 A1 AR027998 A1 AR 027998A1
Authority
AR
Argentina
Prior art keywords
ethylendiamine
derivatives
compositions containing
pharmaceutical medicines
medicines
Prior art date
Application number
ARP010101613A
Other languages
English (en)
Original Assignee
Daiichi Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co
Publication of AR027998A1 publication Critical patent/AR027998A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56Amides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ARP010101613A 2000-04-05 2001-04-04 Derivados de etilendiamina y los medicamentos y composiciones farmaceuticas que los contienen AR027998A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2000108047 2000-04-05

Publications (1)

Publication Number Publication Date
AR027998A1 true AR027998A1 (es) 2003-04-23

Family

ID=18620961

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010101613A AR027998A1 (es) 2000-04-05 2001-04-04 Derivados de etilendiamina y los medicamentos y composiciones farmaceuticas que los contienen

Country Status (17)

Country Link
US (3) US7192968B2 (es)
EP (2) EP1270557B1 (es)
JP (2) JP4495896B2 (es)
KR (1) KR100769592B1 (es)
CN (1) CN1293057C (es)
AR (1) AR027998A1 (es)
AU (2) AU2001246835B2 (es)
BR (1) BR0110052A (es)
CA (1) CA2405144A1 (es)
ES (2) ES2389021T3 (es)
IL (1) IL151710A0 (es)
MX (1) MXPA02009805A (es)
NO (1) NO324003B1 (es)
RU (1) RU2268259C2 (es)
TW (2) TWI290136B (es)
WO (1) WO2001074774A1 (es)
ZA (1) ZA200207331B (es)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI290136B (en) * 2000-04-05 2007-11-21 Daiichi Seiyaku Co Ethylenediamine derivatives
WO2002072548A2 (en) 2001-03-09 2002-09-19 Ortho-Mcneil Pharmaceutical, Inc. Heterocyclic compounds and their use as histamine h4 ligands.
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
CN1826333B (zh) * 2001-06-20 2012-12-26 第一三共株式会社 二胺衍生物
WO2003000657A1 (en) * 2001-06-20 2003-01-03 Daiichi Pharmaceutical Co., Ltd. Diamine derivatives
AU2002328596B2 (en) * 2001-08-09 2007-09-20 Daiichi Pharmaceutical Co., Ltd. Diamine derivatives
AR037097A1 (es) 2001-10-05 2004-10-20 Novartis Ag Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento
WO2008011131A2 (en) * 2006-07-21 2008-01-24 Takeda Pharmaceutical Company Limited Amide compounds
CA2478232C (en) * 2002-04-11 2011-06-14 Boehringer Ingelheim Pharmaceuticals, Inc. Heterocyclic amide derivatives as cytokine inhibitors
NZ538401A (en) 2002-09-06 2008-03-28 Janssen Pharmaceutica Nv (1H-benzoimidazol-2-yl)-(piperazinyl)-methanone derivatives and related compounds as histamine H4-receptor antagonists for the treatment of inflammatory and allergic disorders
PE20040804A1 (es) * 2002-12-19 2004-12-31 Boehringer Ingelheim Pharma DERIVADOS DE CARBOXAMIDAS COMO INHIBIDORES DEL FACTOR Xa
EP1577302A4 (en) * 2002-12-24 2010-09-01 Daiichi Seiyaku Co NOVEL ETHYLENEDIAMINE DERIVATIVES
KR20050110612A (ko) * 2002-12-25 2005-11-23 다이이찌 세이야꾸 가부시기가이샤 디아민 유도체
CN1751025B (zh) * 2002-12-25 2010-05-12 第一制药株式会社 二胺衍生物
JP4630267B2 (ja) * 2002-12-25 2011-02-09 第一三共株式会社 ジアミン誘導体
US7205318B2 (en) * 2003-03-18 2007-04-17 Bristol-Myers Squibb Company Lactam-containing cyclic diamines and derivatives as a factor Xa inhibitors
US7230133B2 (en) 2003-05-01 2007-06-12 Bristol-Myers Squibb Company Malonamides and malonamide derivatives as modulators of chemokine receptor activity
US7291615B2 (en) 2003-05-01 2007-11-06 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
EP1670739A4 (en) * 2003-10-08 2007-08-08 Bristol Myers Squibb Co CYCLIC DIAMINES AND DERIVATIVES AS FACTOR XA INHIBITORS
CA2773066A1 (en) * 2003-11-12 2005-05-26 Daiichi Sankyo Company, Limited Process for producing thiazole derivative
US7371743B2 (en) 2004-02-28 2008-05-13 Boehringer Ingelheim International Gmbh Carboxylic acid amides, the preparation thereof and their use as medicaments
BRPI0615775B1 (pt) 2005-09-16 2021-08-10 Daiichi Sankyo Company, Limited Processos para a produção de compostos derivados de diamida oticamente ativos
JP5187901B2 (ja) 2006-08-30 2013-04-24 塩野義製薬株式会社 ヒドラジンアミド誘導体
CN104324015B (zh) 2007-03-29 2018-08-28 第一三共株式会社 药物组合物
TW200909437A (en) * 2007-06-21 2009-03-01 Daiichi Sankyo Co Ltd Process for the preparation of diamine-derivatives
US20100015306A1 (en) * 2008-07-15 2010-01-21 Pepsico, Inc. Method for Preparing a Low Viscosity Whole Grain Flour Slurry
CA2747427C (en) 2008-12-17 2015-10-13 Daiichi Sankyo Company, Limited Method for producing diamine derivative
JPWO2010082531A1 (ja) 2009-01-13 2012-07-05 第一三共株式会社 活性化血液凝固因子阻害剤
US20100178400A1 (en) * 2009-01-13 2010-07-15 Pepsico, Inc. Method of Preparing a Whole Grain Beverage
CN102348688B (zh) 2009-03-10 2014-07-09 第一三共株式会社 用于制备二胺衍生物的方法
EP2407450B1 (en) 2009-03-13 2015-04-22 Daiichi Sankyo Company, Limited Method for producing optically active diamine derivative
SG176934A1 (en) 2009-06-18 2012-01-30 Daiichi Sankyo Co Ltd Pharmaceutical composition having improved solubility
ES2560955T3 (es) 2010-03-19 2016-02-23 Daiichi Sankyo Company, Limited Cristal de derivado de diamina y procedimiento de producción del mismo
EP2548556B1 (en) 2010-03-19 2016-08-10 Daiichi Sankyo Company, Limited Method for improving dissolvability of anticoagulant
KR101795096B1 (ko) 2010-07-02 2017-12-01 다이이찌 산쿄 가부시키가이샤 광학 활성 디아민 유도체의 염의 제조 방법
JPWO2013022059A1 (ja) 2011-08-10 2015-03-05 第一三共株式会社 ジアミン誘導体含有医薬組成物
CN102516249A (zh) * 2011-12-08 2012-06-27 成都苑东药业有限公司 一种抗凝血的二胺衍生物
CN102731316B (zh) * 2012-05-21 2014-04-16 南通市华峰化工有限责任公司 一种1,2-n,n`二甲基环己二胺的生产方法
CA2896338A1 (en) 2013-03-29 2014-10-02 Daiichi Sankyo Company, Limited Method for producing (1s,4s,5s)-4-bromo-6-oxabicyclo[3.2.1]octan-7-one
TWI602803B (zh) 2013-03-29 2017-10-21 第一三共股份有限公司 光學活性二胺衍生物之製造方法
CA2940001C (en) * 2014-02-18 2019-01-15 Daiichi Sankyo Company, Limited Method for producing inhibitor of activated blood coagulation factor x (fxa)
BR112016022785B8 (pt) 2014-04-04 2020-09-15 Iomet Pharma Ltd composto inibidor de triptofano-2,3-dioxigenase (tdo) e/ou indoleamina-2,3-dioxigenase (ido), composição farmacêutica, e, uso de composto inibidor de triptofano-2,3-dioxigenase (tdo) e/ou indoleamina-2,3dioxigenase (ido) ou de um sal farmaceuticamente aceitável do mesmo para fabricação de um medicamento
CN104163802B (zh) * 2014-07-08 2016-04-27 浙江大学 2-氨基噻唑-4-甲酸乙酯的制备方法
CA2960275A1 (en) * 2014-09-10 2016-03-17 Epizyme, Inc. Smyd inhibitors
US10858319B2 (en) 2016-10-03 2020-12-08 Iomet Pharma Ltd. Indole derivatives for use in medicine
CN108689878B (zh) * 2017-04-10 2023-05-09 浙江九洲药业股份有限公司 光学活性二氨基衍生物的制备方法
CN108840816A (zh) * 2018-05-25 2018-11-20 郑州依米花手性药物研究有限公司 酰亚胺类中间体化合物及其制备方法和应用

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4707440A (en) 1984-01-30 1987-11-17 Enzo Biochem, Inc. Nucleic acid hybridization assay and detectable molecules useful in such assay
IL100576A (en) 1991-01-18 1995-11-27 Eli Lilley And Company Cephalosporin antibiotics
AU2913292A (en) 1991-11-14 1993-06-15 Bernard Derek Frutin A pressurised container
US5264457A (en) 1992-02-14 1993-11-23 G. D. Searle & Co. Phenyl amidines sulfonamides useful as platelet aggregation inhibitors
JP2875930B2 (ja) * 1992-12-02 1999-03-31 富士写真フイルム株式会社 旋光フイルムおよびそれを用いた液晶表示装置
US5430150A (en) * 1992-12-16 1995-07-04 American Cyanamid Company Retroviral protease inhibitors
CA2157412A1 (en) 1993-03-03 1994-09-15 Julia Marie Heerding Balanoids
DK0641770T3 (da) 1993-03-17 1998-06-02 Meiji Seika Co Hidtil ukendte forbindelser med blodpladeaggegationsinhiberende aktivitet
US5707994A (en) * 1993-10-19 1998-01-13 Sumitomo Pharmaceuticals Company, Limited 2,3-diaminopropionic acid derivative
TW270114B (es) 1993-10-22 1996-02-11 Hoffmann La Roche
CA2174838A1 (en) * 1993-11-24 1995-06-01 John Wityak Novel isoxazoline and isoxazole fibrinogen receptor antagonists
US5849736A (en) * 1993-11-24 1998-12-15 The Dupont Merck Pharmaceutical Company Isoxazoline and isoxazole fibrinogen receptor antagonists
US5563158A (en) * 1993-12-28 1996-10-08 The Dupont Merck Pharmaceutical Company Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists
WO1995032965A1 (en) 1994-06-01 1995-12-07 Yamanouchi Pharmaceutical Co. Ltd. Oxadiazole derivative and medicinal composition thereof
IL115420A0 (en) 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
US5719144A (en) * 1995-02-22 1998-02-17 Merck & Co., Inc. Fibrinogen receptor antagonists
ATE242231T1 (de) 1995-04-07 2003-06-15 Schering Corp Carbonyl-piperaznyl und piperidinyl derivate zur hemmung farnesyl protein transferase
DE19516954C1 (de) 1995-05-12 1996-12-19 Max Planck Gesellschaft Verfahren zum ortsaufgelösten immunhistochemischen Nachweis von Steroidrezeptoren
ZA963391B (en) * 1995-05-24 1997-10-29 Du Pont Merck Pharma Isoxazoline fibrinogen receptor antagonists.
IL118007A0 (en) 1995-05-24 1996-08-04 Du Pont Merck Pharma Isoxazoline compounds pharmaceutical compositions containing them and their use
US5726126A (en) 1995-06-02 1998-03-10 American Cyanamid Company 1-(3-heterocyclyphenyl)-S-triazine-2,6,6-oxo or thiotrione herbicidal agents
US5741819A (en) 1995-06-07 1998-04-21 3-Dimensional Pharmaceuticals, Inc. Arylsulfonylaminobenzene derivatives and the use thereof as factor Xa inhibitors
GB9516709D0 (en) 1995-08-15 1995-10-18 Zeneca Ltd Medicament
US5852045A (en) * 1995-10-19 1998-12-22 Merck & Co., Inc. Fibrinogen receptor antagonists
JPH11513686A (ja) * 1995-10-19 1999-11-24 メルク エンド カンパニー インコーポレーテッド 線維素原受容体拮抗薬
US6274715B1 (en) 1995-11-08 2001-08-14 Abbott Laboratories Tricyclic erythromycin derivatives
GB9602294D0 (en) 1996-02-05 1996-04-03 Zeneca Ltd Heterocyclic compounds
AU2733997A (en) 1996-04-17 1997-11-07 Du Pont Pharmaceuticals Company N-(amidinophenyl)-n'-(subst.)-3h-2,4-benzodiazepin-3-one derivatives as factor xa inhibitors
US5668159A (en) 1996-05-08 1997-09-16 The Dupont Merck Pharmaceutical Company 1,3,4-thiadiazoles and 1,3,4-oxadiazoles as IIb/IIIa antagonists
WO1997048395A1 (en) * 1996-06-19 1997-12-24 Du Pont Pharmaceuticals Company Iontophoretic delivery of integrin inhibitors
WO1998006720A1 (fr) 1996-08-09 1998-02-19 Eisai Co., Ltd. Derives de benzopiperidine
JP2000516602A (ja) 1996-08-14 2000-12-12 ゼネカ・リミテッド 置換ピリミジン誘導体および薬剤としてのそれらの使用
US6004955A (en) * 1996-08-15 1999-12-21 Dupont Pharmaceuticals Company Cyclic carbamates and isoxazolidines as IIb/IIIa antagonists
JP2000516230A (ja) 1996-08-15 2000-12-05 デュポン ファーマシューティカルズ カンパニー Iib/iiia拮抗薬としての環状カルバメート類およびイソオキサゾリジン類
US5871762A (en) * 1996-10-07 1999-02-16 The Procter & Gamble Company Cosmetic applicators which contain stable oil-in-water emulsions
UA56197C2 (uk) 1996-11-08 2003-05-15 Зенека Лімітед Гетероциклічні похідні
EP0966460A1 (en) 1997-02-13 1999-12-29 Zeneca Limited Heterocyclic compounds useful as oxido-squalene cyclase inhibitors
IT1291823B1 (it) * 1997-04-08 1999-01-21 Menarini Ricerche Spa Composti pseudo-peptidici, loro preparazione ed uso in formulazioni farmaceutiche
AR012443A1 (es) 1997-04-16 2000-10-18 Uriach & Cia Sa J Nuevas carboxamidas como inhibidores de la agregacion plaquetaria, procedimiento para su preparacion, composiciones farmaceuticas que loscontienen y uso de los mismos en la manufactura de medicamentos
ATE334975T1 (de) 1997-05-30 2006-08-15 Takeda Pharmaceutical Sulfonamidderivate, ihre herstellung und verwendung
US6207679B1 (en) 1997-06-19 2001-03-27 Sepracor, Inc. Antimicrobial agents uses and compositions related thereto
EP0991623A2 (en) * 1997-06-19 2000-04-12 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
WO1999000127A1 (en) 1997-06-26 1999-01-07 Eli Lilly And Company Antithrombotic agents
CA2295153A1 (en) 1997-06-26 1999-01-07 Gerald Floyd Smith Antithrombotic agents
AU8270898A (en) 1997-06-26 1999-01-19 Eli Lilly And Company Antithrombotic agents
GB9715895D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds
GB9715894D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic derivatives
ID23991A (id) 1997-09-30 2000-06-14 Daiichi Seiyaku Co Turunan-turunan sulfonil
AR013693A1 (es) 1997-10-23 2001-01-10 Uriach & Cia Sa J Nuevas piperidinas y piperazinas como inhibidores de la agregacion plaquetaria
EP0937723A1 (de) 1998-02-18 1999-08-25 Roche Diagnostics GmbH Neue Sulfonamide, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
EP0937711A1 (de) 1998-02-18 1999-08-25 Roche Diagnostics GmbH Neue Thiobenzamide, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
EP1061934A1 (en) * 1998-03-09 2000-12-27 Merck & Co., Inc. Fibrinogen receptor antagonists
TR200003200T2 (tr) 1998-05-02 2001-02-21 Astrazeneca Ab Faktör XA'yı önleyen heterosiklik türevler.
GB9809350D0 (en) 1998-05-02 1998-07-01 Zeneca Ltd Novel salt
GB9809349D0 (en) 1998-05-02 1998-07-01 Zeneca Ltd Heterocyclic derivatives
JP2000086659A (ja) * 1998-07-14 2000-03-28 Takeda Chem Ind Ltd オクタヒドロピリド[1,2―a]ピラジン誘導体
FR2781221B1 (fr) * 1998-07-17 2000-10-13 Lafon Labor Piperazinones substituees en alpha
US6303625B1 (en) 1998-07-27 2001-10-16 Ortho-Mcneil Pharmaceutical, Inc. Triazolopyridines for the treatment of thrombosis disorders
JP2000119253A (ja) 1998-08-11 2000-04-25 Dai Ichi Seiyaku Co Ltd 新規なスルホニル誘導体
EP1104754A1 (en) 1998-08-11 2001-06-06 Daiichi Pharmaceutical Co., Ltd. Novel sulfonyl derivatives
DE69907962T2 (de) * 1998-12-14 2004-05-19 Vertex Pharmaceuticals (San Diego) Llc, San Diego Optische molekularsensoren für cytochrome p-450 aktivität
WO2000039117A1 (en) 1998-12-23 2000-07-06 Eli Lilly And Company HETEROROAROMATIC AMIDES AS INHIBITOR OF FACTOR Xa
EP1140903B1 (en) 1998-12-23 2004-08-04 Eli Lilly And Company Aromatic amides
JP2004522689A (ja) 1998-12-23 2004-07-29 イーライ・リリー・アンド・カンパニー 抗血栓アミド類
DE69915687T2 (de) 1998-12-24 2005-02-10 Eli Lilly And Co., Indianapolis Heterocyclische amide als inhibitoren von faktor xa
GB9902989D0 (en) 1999-02-11 1999-03-31 Zeneca Ltd Heterocyclic derivatives
AU766089B2 (en) * 1999-03-11 2003-10-09 Du Pont Pharmaceuticals Company Treatment of thrombosis by combined use of a factor Xa inhibitor and aspirin, tissue plasminogen activator (TPA), a GPIIb/IIIa antagonist, low molecular weight heparin or heparin
AU2241400A (en) * 1999-04-06 2000-10-12 Yamanouchi Pharmaceutical Co., Ltd. Novel thiazolobenzoimidazole derivative
JP4390024B2 (ja) 1999-04-23 2009-12-24 アステラス製薬株式会社 新規なジアゼパン誘導体又はその塩
AU5284000A (en) 1999-05-24 2000-12-12 Cor Therapeutics, Inc. Inhibitors of factor xa
AU5414000A (en) 1999-06-14 2001-01-02 Eli Lilly And Company Compounds
GB9914342D0 (en) 1999-06-19 1999-08-18 Zeneca Ltd Compound
JP2001011071A (ja) * 1999-06-25 2001-01-16 Mochida Pharmaceut Co Ltd アミノアルキルスルホンアミド誘導体
GB9917344D0 (en) 1999-07-24 1999-09-22 Zeneca Ltd Novel salt
BR0013926A (pt) 1999-09-13 2002-07-23 Dimensional Pharm Inc Inibidores de serina protease de azacicloalcanona
BR0014078A (pt) 1999-09-17 2002-12-31 Millennium Pharm Inc Inibidores de fator xa
JP4744050B2 (ja) 1999-09-17 2011-08-10 ミレニアム・ファーマシューティカルズ・インコーポレイテッド ベンズアミドおよび関連するXa因子阻害剤
WO2001027090A1 (fr) * 1999-10-08 2001-04-19 Meiji Seika Kaisha, Ltd. DERIVES D'ACIDE BENZOIQUE A SUBSTITUTION m PRESENTANT UN ANTAGONISME CONTRE L'INTEGRINE αvβ¿3?
AU1770001A (en) 1999-11-24 2001-06-04 Cor Therapeutics, Inc. Beta-amino acid-, aspartic acid- and diaminopropionic-based inhibitors of factorxa
US6376515B2 (en) 2000-02-29 2002-04-23 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor Xa
TWI290136B (en) * 2000-04-05 2007-11-21 Daiichi Seiyaku Co Ethylenediamine derivatives
US6586418B2 (en) 2000-06-29 2003-07-01 Bristol-Myers Squibb Company Thrombin or factor Xa inhibitors
AU2001294824A1 (en) 2000-09-29 2002-04-08 Millennium Pharmaceuticals, Inc. Piperazine based inhibitors of factor xa
WO2002026712A2 (en) 2000-09-29 2002-04-04 Millennium Pharmaceuticals, Inc. Quaternary amines and related inhibitors of factor xa
US20040072860A1 (en) 2000-09-29 2004-04-15 Bing-Yan Zhu Piperazin-2-one amides as inhibitors of factor xa
US6710058B2 (en) 2000-11-06 2004-03-23 Bristol-Myers Squibb Pharma Company Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
PT1336605E (pt) 2000-11-22 2006-06-30 Astellas Pharma Inc Derivados de fenol substituidos ou seus sais como inibidores do factor x de coagulacao
CA2432369A1 (en) 2000-12-20 2002-08-08 Bristol-Myers Squibb Pharma Company Cyclic derivatives as modulators of chemokine receptor activity
WO2002079145A1 (en) 2001-03-30 2002-10-10 Millennium Pharmaceuticals, Inc. BENZAMIDE INHIBITORS OF FACTOR Xa
CN1826333B (zh) 2001-06-20 2012-12-26 第一三共株式会社 二胺衍生物
WO2003000657A1 (en) * 2001-06-20 2003-01-03 Daiichi Pharmaceutical Co., Ltd. Diamine derivatives
AU2002328596B2 (en) 2001-08-09 2007-09-20 Daiichi Pharmaceutical Co., Ltd. Diamine derivatives
CN101357914A (zh) 2001-09-21 2009-02-04 百时美施贵宝公司 含有内酰胺的化合物及其衍生物作为Xa因子的抑制剂
US7030141B2 (en) 2001-11-29 2006-04-18 Christopher Franklin Bigge Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
AU2002350217A1 (en) 2001-12-04 2003-06-17 Bristol-Myers Squibb Company Glycinamides as factor xa inhibitors
EP1577302A4 (en) 2002-12-24 2010-09-01 Daiichi Seiyaku Co NOVEL ETHYLENEDIAMINE DERIVATIVES
KR20050110612A (ko) 2002-12-25 2005-11-23 다이이찌 세이야꾸 가부시기가이샤 디아민 유도체

Also Published As

Publication number Publication date
EP1270557A4 (en) 2008-12-03
HK1056876A1 (en) 2004-03-05
ES2389021T3 (es) 2012-10-22
KR100769592B1 (ko) 2007-10-23
EP2431370B1 (en) 2013-06-19
EP2431370A1 (en) 2012-03-21
EP1270557B1 (en) 2012-07-25
ES2417860T3 (es) 2013-08-09
JP2010120953A (ja) 2010-06-03
KR20030005249A (ko) 2003-01-17
EP1270557A1 (en) 2003-01-02
US7192968B2 (en) 2007-03-20
IL151710A0 (en) 2003-04-10
RU2268259C2 (ru) 2006-01-20
JP5113200B2 (ja) 2013-01-09
AU4683501A (en) 2001-10-15
MXPA02009805A (es) 2003-03-27
CN1438993A (zh) 2003-08-27
US20090227789A1 (en) 2009-09-10
US20040122063A1 (en) 2004-06-24
TW200738629A (en) 2007-10-16
TWI290136B (en) 2007-11-21
BR0110052A (pt) 2005-05-10
JP4495896B2 (ja) 2010-07-07
ZA200207331B (en) 2003-09-12
NO20024766L (no) 2002-11-28
AU2001246835B2 (en) 2006-08-31
CA2405144A1 (en) 2001-10-11
NO324003B1 (no) 2007-07-30
CN1293057C (zh) 2007-01-03
NO20024766D0 (no) 2002-10-03
US7935824B2 (en) 2011-05-03
US20060004009A1 (en) 2006-01-05
WO2001074774A1 (en) 2001-10-11
TWI288745B (en) 2007-10-21

Similar Documents

Publication Publication Date Title
AR027998A1 (es) Derivados de etilendiamina y los medicamentos y composiciones farmaceuticas que los contienen
DK1263720T3 (da) Azetidinderivater, fremstilling deraf samt farmaceutiske sammensætninger, der indeholder samme
DE69924999D1 (de) Lipasehemmer enthaltende pharmazeutische zusammensetzungen
DK1329456T3 (da) Glucopyranosyloxybenzylbenzenderivater og medicinske sammensætninger indeholdende samme
IL152451A0 (en) 2-chloro-2-nitrophenylcarboxamide derivatives and pharmaceutical compositions containing the same
IL153123A0 (en) N-ureidoheterocycloalkyl-piperidine derivatives and pharmaceutical compositions containing the same
AT7729U3 (de) Pharmazeutische zusammensetzungen enthaltend amlodipinmaleat
DK1353919T3 (da) Hidtil ukendte quinuclidinderivater og medicinale sammensætninger indeholdende samme
IS5046A (is) Lyfjasamsetningar
NO20015175D0 (no) Farmasöytisk sammensetning
AR028204A1 (es) Composiciones farmaceuticas electrohiladas
FI20105657L (fi) Farmaseuttisia koostumuksia
IL152718A0 (en) Piperidine derivatives and pharmaceutical compositions containing the same
PT1242087E (pt) Composicoes farmaceuticas
DK1524266T3 (da) Farmaceutisk sammensætning
ITMI20010748A0 (it) Composizioni farmaceutiche
EE05020B1 (et) Glburiidi ravimkoostis
HUP0400558A3 (en) Substituted benzene derivatives or salts thereof and pharmaceutical compositions containing them
IL150905A0 (en) Andrographolide derivatives and pharmaceutical compositions containing the same
NO20026123L (no) Farmasöytiske sammensetninger
HUP0303184A3 (en) Substituted c-cyclohexylmethylamine derivatives and pharmaceutical compositions containing them
PT1239832E (pt) Composicoes farmaceuticas
NO20031095D0 (no) Farmasöytiske sammensetninger
EE200300135A (et) Trüptamiini derivaadid ja analoogsed ühendid ningneid sisaldavad farmatseutilised preparaadid
EE9900206A (et) N-sulfonüülindoliiniderivaate sisaldavad farmatseutilised kompositsioonid

Legal Events

Date Code Title Description
FA Abandonment or withdrawal