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AR027571A1 - Derivados de cromano como compuestos estrogenicos y su uso en la fabricacion de medicamentos para tratamientos relacionados con los receptores deestrogenos - Google Patents

Derivados de cromano como compuestos estrogenicos y su uso en la fabricacion de medicamentos para tratamientos relacionados con los receptores deestrogenos

Info

Publication number
AR027571A1
AR027571A1 ARP010100917A ARP010100917A AR027571A1 AR 027571 A1 AR027571 A1 AR 027571A1 AR P010100917 A ARP010100917 A AR P010100917A AR P010100917 A ARP010100917 A AR P010100917A AR 027571 A1 AR027571 A1 AR 027571A1
Authority
AR
Argentina
Prior art keywords
manufacture
compounds
strogens
strogen
medicines
Prior art date
Application number
ARP010100917A
Other languages
English (en)
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of AR027571A1 publication Critical patent/AR027571A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compuestos de cromano que tienen la formula (1) donde R1 es (1C-4C)alquilo, (2C-4C)alquenilo o (2C-4C)alquinilo e independientemente R1 tiene unaorientacion cis en relacion con el grupo fenilo exocíclico en la posicion 2 del esqueleto; R4 es Hal, CF3 , OH 6 (1C-2C)alquiloxi; R2, R3 y R5 sonindependientemente H, Hal, CF3, (1C-cC9alquilo, (2C-4C)-alquenilo o (2C-4C)alquinilo, y profármacos de los mismos, para la fabricacion de un medicamento paratratamientos relacionados con los receptores estrogen os.
ARP010100917A 2000-03-01 2001-02-28 Derivados de cromano como compuestos estrogenicos y su uso en la fabricacion de medicamentos para tratamientos relacionados con los receptores deestrogenos AR027571A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00200713 2000-03-01

Publications (1)

Publication Number Publication Date
AR027571A1 true AR027571A1 (es) 2003-04-02

Family

ID=8171123

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010100917A AR027571A1 (es) 2000-03-01 2001-02-28 Derivados de cromano como compuestos estrogenicos y su uso en la fabricacion de medicamentos para tratamientos relacionados con los receptores deestrogenos

Country Status (9)

Country Link
US (3) US7214706B2 (es)
EP (1) EP1282615B1 (es)
JP (1) JP4896335B2 (es)
AR (1) AR027571A1 (es)
AT (1) ATE529419T1 (es)
AU (1) AU2001256164A1 (es)
CO (1) CO5261596A1 (es)
PE (1) PE20011077A1 (es)
WO (1) WO2001064665A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1448544T1 (sl) * 2001-11-19 2007-10-31 Lilly Co Eli Substituirani benzopirani kot selektivni agonistiestrogenskega receptorja beta
US7217734B2 (en) 2001-11-19 2007-05-15 Eli Lilly And Company Substituted benzopyrans as selective estrogen receptor-beta agonists
US6630508B1 (en) 2002-02-11 2003-10-07 Eli Lilly And Company Substituted benzopyrans as selective estrogen receptor β agonists
AU2003212856A1 (en) * 2002-03-01 2003-09-16 Eli Lilly And Company Substituted benzopyrans as selective estrogen receptor-beta agonists
BRPI0409588A (pt) * 2003-04-21 2006-04-18 Lilly Co Eli composto, composição farmacêutica, métodos para ligar seletivamente ao receptor beta de estrogênio em um paciente, para tratar um paciente acometido de uma condição de enfermidade mediada com um receptor beta de estrogênio, para tratar cáncer de próstata e hiperplasia prostática benigna em um paciente, e, uso de um composto
US7279499B2 (en) 2003-04-21 2007-10-09 Eli Lilly And Company Substituted benzopyrans as selective estrogen receptor-beta agonists
WO2006029146A2 (en) 2004-09-07 2006-03-16 Wyeth 6H-[1]BENZOPYRANO[4,3-b]QUINOLINES AND THEIR USE AS ESTROGENIC AGENTS
ATE504582T1 (de) 2004-10-18 2011-04-15 Lilly Co Eli Substituierte benzopyrane als selektive östrogenrezeptor-beta-agonisten
US9623021B2 (en) * 2007-01-22 2017-04-18 Gtx, Inc. Nuclear receptor binding agents
KR101763674B1 (ko) 2007-01-22 2017-08-01 지티엑스, 인코포레이티드 핵 수용체에 결합하는 물질
US9604931B2 (en) 2007-01-22 2017-03-28 Gtx, Inc. Nuclear receptor binding agents
TW201043595A (en) * 2009-03-13 2010-12-16 Organon Nv Tetrahydronaphthalen-2-ol derivatives
US8063102B2 (en) 2009-03-13 2011-11-22 N.V. Organon Tetrahydronaphthalen-2-ol derivatives
EP3490653B1 (en) 2016-07-28 2025-08-27 Biogen MA Inc. Implantable intraventricular sampling and infusion access device
US20190151239A1 (en) 2016-07-28 2019-05-23 Cerebral Therapeutics LLC Infusing drug solution directly into brain fluid

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3340276A (en) 1964-04-01 1967-09-05 Ciba Geigy Corp 3, 4-diphenyl-chromans
DE1543749A1 (de) 1966-02-16 1969-12-11 Merck Ag E Verfahren zur Herstellung von 3,4-cis-4-Aryl-isoflavanen
US5395842A (en) * 1988-10-31 1995-03-07 Endorecherche Inc. Anti-estrogenic compounds and compositions
US5280040A (en) * 1993-03-11 1994-01-18 Zymogenetics, Inc. Methods for reducing bone loss using centchroman derivatives
US5407955A (en) 1994-02-18 1995-04-18 Eli Lilly And Company Methods for lowering serum cholesterol and inhibiting smooth muscle cell proliferation, restenosis, endometriosis, and uterine fibroid disease
HUP9702244A3 (en) 1995-01-13 1999-12-28 Novo Nordisk As Use of 3,4-diphenyl chromans for manufacture of a pharmaceutical composition for treatment or prophylaxis of gynaecological disorders
CA2200423C (en) 1996-03-26 2006-12-19 Sietse Mosselman Novel estrogen receptor
ZA979645B (en) * 1996-10-28 1998-04-28 Novo Nordisk As Heterocyclic compounds, compositions and uses.
US6465445B1 (en) * 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors

Also Published As

Publication number Publication date
WO2001064665A1 (en) 2001-09-07
PE20011077A1 (es) 2001-12-12
JP4896335B2 (ja) 2012-03-14
US7214706B2 (en) 2007-05-08
US20060160889A1 (en) 2006-07-20
CO5261596A1 (es) 2003-03-31
AU2001256164A1 (en) 2001-09-12
ATE529419T1 (de) 2011-11-15
EP1282615A1 (en) 2003-02-12
US20090221695A1 (en) 2009-09-03
EP1282615B1 (en) 2011-10-19
US7531571B2 (en) 2009-05-12
JP2003525285A (ja) 2003-08-26
US7846966B2 (en) 2010-12-07
US20030069303A1 (en) 2003-04-10

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