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AR026475A1 - Una pirazolotriazina sustituida como agonista inverso selectivo apra el subtipo de receptor de gaba-a alfa 5 - Google Patents

Una pirazolotriazina sustituida como agonista inverso selectivo apra el subtipo de receptor de gaba-a alfa 5

Info

Publication number
AR026475A1
AR026475A1 ARP000106016A ARP000106016A AR026475A1 AR 026475 A1 AR026475 A1 AR 026475A1 AR P000106016 A ARP000106016 A AR P000106016A AR P000106016 A ARP000106016 A AR P000106016A AR 026475 A1 AR026475 A1 AR 026475A1
Authority
AR
Argentina
Prior art keywords
subtipe
pirazolotriazina
apra
invested
gaba
Prior art date
Application number
ARP000106016A
Other languages
English (en)
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of AR026475A1 publication Critical patent/AR026475A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se describen 3-terc-butil-7-(5-metilisoxazol-3-il)-2-(2-metil-2H-[1.2.4]triazol-3-ilmetoxi)pirazolo[1,5-d][1.2.4]triazina, composiciones farmacéuticas quela comprenden, su uso para estimular la cognicion y en procedimientos de tratamiento de sujetos que sufren cognicion reducida.
ARP000106016A 1999-11-19 2000-11-15 Una pirazolotriazina sustituida como agonista inverso selectivo apra el subtipo de receptor de gaba-a alfa 5 AR026475A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19955800 1999-11-19

Publications (1)

Publication Number Publication Date
AR026475A1 true AR026475A1 (es) 2003-02-12

Family

ID=7929686

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000106016A AR026475A1 (es) 1999-11-19 2000-11-15 Una pirazolotriazina sustituida como agonista inverso selectivo apra el subtipo de receptor de gaba-a alfa 5

Country Status (10)

Country Link
US (1) US6515139B1 (es)
EP (1) EP1230221A1 (es)
JP (1) JP2003514800A (es)
AR (1) AR026475A1 (es)
AU (1) AU1702601A (es)
CA (1) CA2391907A1 (es)
HU (1) HUP0302107A3 (es)
IL (1) IL149265A0 (es)
TW (1) TW553935B (es)
WO (1) WO2001036389A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1320527E (pt) * 2000-09-29 2008-10-24 Basf Se Processo para a preparação de 5-cloro-4-metilpirazóis 1-substituídos
US8290338B2 (en) * 2009-05-27 2012-10-16 Panasonic Corporation Recording medium, playback device, encoding device, integrated circuit, and playback output device

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58185568A (ja) 1982-04-24 1983-10-29 Nissan Chem Ind Ltd ピラゾ−ル誘導体，その製造方法および該誘導体を含有する選択性除草剤
JPH0730031B2 (ja) 1986-04-02 1995-04-05 日産化学工業株式会社 ２―ピラゾリン―５―オン類の製造法

Also Published As

Publication number Publication date
HUP0302107A2 (hu) 2003-09-29
US6515139B1 (en) 2003-02-04
EP1230221A1 (de) 2002-08-14
WO2001036389A1 (de) 2001-05-25
AU1702601A (en) 2001-05-30
HUP0302107A3 (en) 2005-10-28
TW553935B (en) 2003-09-21
JP2003514800A (ja) 2003-04-22
IL149265A0 (en) 2002-11-10
CA2391907A1 (en) 2001-05-25

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