AR026434A1 - Peptidos para el tratamiento de la disfuncion erectil. - Google Patents
Peptidos para el tratamiento de la disfuncion erectil.Info
- Publication number
- AR026434A1 AR026434A1 ARP000105948A ARP000105948A AR026434A1 AR 026434 A1 AR026434 A1 AR 026434A1 AR P000105948 A ARP000105948 A AR P000105948A AR P000105948 A ARP000105948 A AR P000105948A AR 026434 A1 AR026434 A1 AR 026434A1
- Authority
- AR
- Argentina
- Prior art keywords
- tryptophan
- methyl
- peptides
- treatment
- alanine
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 208000010228 Erectile Dysfunction Diseases 0.000 title 1
- 201000001881 impotence Diseases 0.000 title 1
- BXJSOEWOQDVGJW-SNVBAGLBSA-N (2r)-2-azaniumyl-3-(2-methyl-1h-indol-3-yl)propanoate Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=C(C)NC2=C1 BXJSOEWOQDVGJW-SNVBAGLBSA-N 0.000 abstract 3
- -1 alpha-aminoisobutyryl Chemical group 0.000 abstract 3
- 229930182827 D-tryptophan Natural products 0.000 abstract 2
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 230000001856 erectile effect Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 210000003016 hypothalamus Anatomy 0.000 abstract 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
- 230000018052 penile erection Effects 0.000 abstract 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/095—Oxytocins; Vasopressins; Related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
Se describen pequenos péptidos que provocan erecciones del pene en los animales machos cuando se inyectan en los nucleos paraventriculares del hipotálamo ocuando se administran sistémicamente (por vía intravenosa o subcutánea), a dichos animales. Est os péptidos resultan de utilidad para el tratamiento de ladisfunsion erectíl y tiene la siguiente formula: X-A-B-C-Y--NH2 en la cual X es alfa-aminoisobutirilo, tranexamilo (es decir, 4-(aminometilo)ciclohexancarbonilo); isonipecotinilo; gama- aminobu tirilo; hidrogeno o imidazolilacetilo, A es D-2-metil-triptofano, D-beta-(2-naftil) alanina; o D-triptofano;B es D-2-metil-triptofano; D-beta-(2-naftil) alanina; D-tripofano; o bien está ausente Ces D-2-metil-triptofano, fenilalanina; o está ausente; Y es lisina oarginina; donde D representa el dextro isomero; o una sal de adicion farmacéuticamente aceptable del péptido, en un nivel que tiene eficacia para provocar lacitada ereccion.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/437,147 US6211156B1 (en) | 1999-11-10 | 1999-11-10 | Peptides for treatment of erectile dysfunction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR026434A1 true AR026434A1 (es) | 2003-02-12 |
Family
ID=23735278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000105948A AR026434A1 (es) | 1999-11-10 | 2000-11-10 | Peptidos para el tratamiento de la disfuncion erectil. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6211156B1 (es) |
| EP (1) | EP1246836A2 (es) |
| JP (1) | JP2003513930A (es) |
| KR (1) | KR20020058003A (es) |
| CN (1) | CN1255426C (es) |
| AR (1) | AR026434A1 (es) |
| AU (1) | AU776994B2 (es) |
| BG (1) | BG106735A (es) |
| BR (1) | BR0015446A (es) |
| CA (1) | CA2390854A1 (es) |
| CZ (1) | CZ20021539A3 (es) |
| HK (1) | HK1050205A1 (es) |
| HU (1) | HUP0203181A3 (es) |
| IL (1) | IL149200A0 (es) |
| MX (1) | MXPA02004118A (es) |
| NO (1) | NO20022101L (es) |
| NZ (1) | NZ519062A (es) |
| PL (1) | PL354613A1 (es) |
| RU (1) | RU2264823C2 (es) |
| SK (1) | SK6222002A3 (es) |
| UA (1) | UA74170C2 (es) |
| WO (1) | WO2001034171A2 (es) |
| ZA (1) | ZA200203069B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10344848A1 (de) * | 2003-09-26 | 2005-04-14 | Solvay Pharmaceuticals Gmbh | Amidomethyl-substituierte l-(Carboxyalkyl)-cyclopentylcarbonylamino-benzazepin-N-essigsäurederivate, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enhaltende Arzneimittel |
| RU2324703C1 (ru) * | 2006-09-07 | 2008-05-20 | Владимир Хацкелевич Хавинсон | Пептидное соединение, стимулирующее функцию половой системы, фармацевтическая композиция на его основе и способ ее применения |
| CN101302246B (zh) * | 2007-05-09 | 2011-05-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 黑色素皮质激素受体七肽类激动剂及其制备方法和用途 |
| RU2404793C1 (ru) | 2009-06-04 | 2010-11-27 | Общество с ограниченной ответственностью Био Пептид | Стимулятор половой, сексуальной и репродуктивной функции |
| RU2507212C3 (ru) | 2012-03-28 | 2022-05-04 | Общество С Ограниченной Ответственностью "Айвикс" | Способ получения рекомбинантного пептида и полученный пептид |
| WO2017168174A1 (en) | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | New pharmaceutical forms of sildenafil |
| RU2626002C1 (ru) | 2016-10-24 | 2017-07-21 | Общество С Ограниченной Ответственностью "Айвикс" | Новая группа пептидов для лечения женской сексуальной дисфункции |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3943519A1 (de) * | 1989-04-27 | 1991-01-17 | Stief Georg | Arzneimittel zur behandlung erektiler dysfunktionen |
| US5236904A (en) * | 1989-09-18 | 1993-08-17 | Senetek, Plc | Erection-inducing methods and compositions |
| US5872100A (en) * | 1990-05-11 | 1999-02-16 | Deghenghi; Romano | Peptides containing D-2-Alkyl-Tryptophan |
| DE69429768T2 (de) * | 1993-04-05 | 2002-09-19 | Competitive Technologies, Inc. | Diagnose und behandlung von erektilen funktionsstörungen |
| EP0783521B8 (en) * | 1994-09-27 | 2003-04-09 | Ardana Bioscience Limited | Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone |
| CA2158425C (en) * | 1995-09-15 | 2003-01-28 | Mac E. Hadley | Diagnostic and treatment of erectile dysfunction |
| IT1277113B1 (it) * | 1995-12-20 | 1997-11-04 | Romano Deghenghi | Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita |
| US5807985A (en) * | 1996-06-11 | 1998-09-15 | Deghenghi; Romano | Oligopeptide compounds containing D-2-alkyltryptophan capable of promoting the release of growth hormone |
| US6124263A (en) * | 1998-11-16 | 2000-09-26 | Asta Medica Ag | Treatment of tumors by administration of growth hormone releasing compounds and their antagonists |
| US5932548A (en) * | 1998-06-03 | 1999-08-03 | Deghenghi; Romano | Lysine containing peptides for treatment of heart disease |
-
1999
- 1999-11-10 US US09/437,147 patent/US6211156B1/en not_active Expired - Fee Related
-
2000
- 2000-04-11 UA UA2002064655A patent/UA74170C2/uk unknown
- 2000-11-04 CZ CZ20021539A patent/CZ20021539A3/cs unknown
- 2000-11-04 IL IL14920000A patent/IL149200A0/xx unknown
- 2000-11-04 RU RU2002115662/15A patent/RU2264823C2/ru not_active IP Right Cessation
- 2000-11-04 CN CNB008155410A patent/CN1255426C/zh not_active Expired - Fee Related
- 2000-11-04 PL PL00354613A patent/PL354613A1/xx not_active Application Discontinuation
- 2000-11-04 EP EP00974507A patent/EP1246836A2/en not_active Withdrawn
- 2000-11-04 HK HK03101739.1A patent/HK1050205A1/zh unknown
- 2000-11-04 AU AU12786/01A patent/AU776994B2/en not_active Ceased
- 2000-11-04 HU HU0203181A patent/HUP0203181A3/hu unknown
- 2000-11-04 BR BR0015446-6A patent/BR0015446A/pt not_active IP Right Cessation
- 2000-11-04 CA CA002390854A patent/CA2390854A1/en not_active Abandoned
- 2000-11-04 JP JP2001536168A patent/JP2003513930A/ja active Pending
- 2000-11-04 WO PCT/EP2000/010879 patent/WO2001034171A2/en not_active Ceased
- 2000-11-04 MX MXPA02004118A patent/MXPA02004118A/es unknown
- 2000-11-04 KR KR1020027005980A patent/KR20020058003A/ko not_active Abandoned
- 2000-11-04 NZ NZ519062A patent/NZ519062A/xx unknown
- 2000-11-04 SK SK622-2002A patent/SK6222002A3/sk unknown
- 2000-11-10 AR ARP000105948A patent/AR026434A1/es unknown
-
2002
- 2002-04-18 ZA ZA200203069A patent/ZA200203069B/xx unknown
- 2002-05-02 NO NO20022101A patent/NO20022101L/no unknown
- 2002-05-22 BG BG106735A patent/BG106735A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU776994B2 (en) | 2004-09-30 |
| PL354613A1 (en) | 2004-02-09 |
| RU2264823C2 (ru) | 2005-11-27 |
| KR20020058003A (ko) | 2002-07-12 |
| CZ20021539A3 (cs) | 2003-08-13 |
| IL149200A0 (en) | 2002-11-10 |
| WO2001034171A2 (en) | 2001-05-17 |
| SK6222002A3 (en) | 2004-03-02 |
| HUP0203181A2 (hu) | 2003-02-28 |
| BG106735A (bg) | 2003-02-28 |
| RU2002115662A (ru) | 2004-01-27 |
| US6211156B1 (en) | 2001-04-03 |
| UA74170C2 (uk) | 2005-11-15 |
| NZ519062A (en) | 2003-10-31 |
| JP2003513930A (ja) | 2003-04-15 |
| CN1390230A (zh) | 2003-01-08 |
| HUP0203181A3 (en) | 2003-11-28 |
| CA2390854A1 (en) | 2001-05-17 |
| EP1246836A2 (en) | 2002-10-09 |
| CN1255426C (zh) | 2006-05-10 |
| BR0015446A (pt) | 2002-07-09 |
| WO2001034171A3 (en) | 2001-12-13 |
| ZA200203069B (en) | 2002-11-27 |
| HK1050205A1 (zh) | 2003-06-13 |
| AU1278601A (en) | 2001-06-06 |
| MXPA02004118A (es) | 2003-02-12 |
| NO20022101D0 (no) | 2002-05-02 |
| NO20022101L (no) | 2002-05-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |