[go: up one dir, main page]

AR025380A1 - Las rutas sinteticas eficientes para la preparacion de los inhibidores de la proteasa del rinovirus. - Google Patents

Las rutas sinteticas eficientes para la preparacion de los inhibidores de la proteasa del rinovirus.

Info

Publication number
AR025380A1
AR025380A1 ARP000104401A ARP000104401A AR025380A1 AR 025380 A1 AR025380 A1 AR 025380A1 AR P000104401 A ARP000104401 A AR P000104401A AR P000104401 A ARP000104401 A AR P000104401A AR 025380 A1 AR025380 A1 AR 025380A1
Authority
AR
Argentina
Prior art keywords
synthetic routes
preparation
inhibitors
rinovirus
proteasa
Prior art date
Application number
ARP000104401A
Other languages
English (en)
Original Assignee
Agouron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharma filed Critical Agouron Pharma
Publication of AR025380A1 publication Critical patent/AR025380A1/es

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/2415—Tubular reactors
    • B01J19/2435—Loop-type reactors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/2475—Membrane reactors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
    • B01J2219/00087—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor
    • B01J2219/00099—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor the reactor being immersed in the heat exchange medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00159—Controlling the temperature controlling multiple zones along the direction of flow, e.g. pre-heating and after-cooling

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Las rutas sintéticas eficientes para la preparacion de inhibidores de la proteasa del rinovirus de la formula 1, así como también los intermedios clavesutiles en esas rutas sintéticas. Los compuestos de la formula 1, así como también lascomposicione s farmacéuticas que contienen esos compuestos, son adecuadospara el tratamiento de pacientes o huéspedes infectados con uno o más picornavirus. Los sustituyentes Z, Z1, R1 a R6 están definidos en la memoria descriptiva.
ARP000104401A 1999-08-24 2000-08-24 Las rutas sinteticas eficientes para la preparacion de los inhibidores de la proteasa del rinovirus. AR025380A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15035899P 1999-08-24 1999-08-24

Publications (1)

Publication Number Publication Date
AR025380A1 true AR025380A1 (es) 2002-11-20

Family

ID=22534156

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000104401A AR025380A1 (es) 1999-08-24 2000-08-24 Las rutas sinteticas eficientes para la preparacion de los inhibidores de la proteasa del rinovirus.

Country Status (20)

Country Link
EP (1) EP1206450A1 (es)
JP (1) JP2003507453A (es)
KR (1) KR20020046283A (es)
CN (1) CN1168713C (es)
AR (1) AR025380A1 (es)
AU (1) AU770221B2 (es)
BR (1) BR0013306A (es)
CA (1) CA2376452A1 (es)
CO (1) CO5200782A1 (es)
CZ (1) CZ2002632A3 (es)
HK (1) HK1049336B (es)
HU (1) HUP0203365A3 (es)
IL (1) IL147674A0 (es)
MX (1) MXPA02001944A (es)
PE (1) PE20010517A1 (es)
PL (1) PL353997A1 (es)
TW (1) TWI245040B (es)
UY (1) UY26307A1 (es)
WO (1) WO2001014329A1 (es)
ZA (1) ZA200200504B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL138609A0 (en) 1998-04-30 2001-10-31 Agouron Pharma Antipicornaviral compounds, their preparation and use
HUP0203108A3 (en) 1999-08-04 2004-07-28 Agouron Pharmaceuticals Inc La Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
PE20020157A1 (es) 1999-12-03 2002-02-22 Agouron Pharma Compuestos derivados de piridona como inhibidores de proteasas de picornaviral 3c, composiciones, sus usos farmaceuticos y materiales para su sintesis
PA8515201A1 (es) 2000-04-14 2002-10-24 Agouron Pharma Compuestos y composiciones antipicornavirales; sus usos farmaceuticos y los materiales para su sintesis
BR0111727A (pt) 2000-06-14 2003-05-27 Agouron Pharma Compostos e composições antipicornavirais, seus usos farmacêuticos, e materiais para a sua sìntese
CN1309712C (zh) * 2004-04-02 2007-04-11 中国科学院上海有机化学研究所 Ag7088类化合物的关键中间体的前体及其合成方法
US20230157998A1 (en) 2020-03-06 2023-05-25 Pfizer Inc. Methods of Inhibiting SARS-CoV-2 Replication and Treating Corona Virus Disease 2019
CN115260074B (zh) * 2022-08-02 2024-06-21 爱斯特（成都）生物制药股份有限公司 一种口服抗病毒药物Paxlovid中间体的制备方法
CN115322130B (zh) * 2022-08-02 2024-05-14 南京正济医药研究有限公司 制备(s)-2-(boc-氨基)-3-[(s)-2-氧代-3-吡咯烷基]丙酸甲酯

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000506903A (ja) * 1996-05-14 2000-06-06 アグロン・ファーマシュウティカルズ・インコーポレーテッド ピコルナウイルス３ｃプロテアーゼの阻害薬ならびにそれらの使用方法および製造方法
CA2289541A1 (en) * 1997-03-28 1998-10-08 Peter S. Dragovich Antipicornaviral compouds, compositions containing them, and methods for their use
US5962487A (en) * 1997-12-16 1999-10-05 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds and methods for their use and preparation
IL138609A0 (en) * 1998-04-30 2001-10-31 Agouron Pharma Antipicornaviral compounds, their preparation and use

Also Published As

Publication number Publication date
HUP0203365A3 (en) 2003-12-29
JP2003507453A (ja) 2003-02-25
AU770221B2 (en) 2004-02-19
PE20010517A1 (es) 2001-05-16
MXPA02001944A (es) 2002-10-31
CA2376452A1 (en) 2001-03-01
CN1168713C (zh) 2004-09-29
WO2001014329A1 (en) 2001-03-01
CN1374947A (zh) 2002-10-16
UY26307A1 (es) 2001-04-30
TWI245040B (en) 2005-12-11
CZ2002632A3 (cs) 2003-04-16
BR0013306A (pt) 2002-05-28
KR20020046283A (ko) 2002-06-20
HK1049336B (zh) 2005-05-20
AU6797100A (en) 2001-03-19
HUP0203365A2 (hu) 2003-02-28
HK1049336A1 (en) 2003-05-09
EP1206450A1 (en) 2002-05-22
CO5200782A1 (es) 2002-09-27
IL147674A0 (en) 2002-08-14
ZA200200504B (en) 2003-03-26
PL353997A1 (en) 2003-12-15

Similar Documents

Publication Publication Date Title
PA8591701A1 (es) Derivados de pirrolopirimidina
CR7743A (es) Nuevos compuestos de oxazol y tiazol como inhibidorea del factor de crecimiento transformador (tgf)
PA8523001A1 (es) Derivados de la 3-indolil-4-fenil-1h-pirrol-2,5-diona como inhibidores de glicogeno sintasa quinasa-3b
CY1116103T1 (el) Υποκατεστημενα παραγωγα 1,2,3,4-τετραϋδροϊσοκινολινης
UY27333A1 (es) Nucleótidos 4` sustituidos
CY1111693T1 (el) Αντιιικοι παραγοντες
AR047529A1 (es) Compuestos de quinolina sustituidos
MX9404749A (es) Heterociclos de fenilo como inhibidores de cox-2.
CU23105A3 (es) DERIVADOS NOVEDOSOS DEL áCIDO AMINODICARBOXILICO CON PROPIEDADES FARMACéUTICAS
ECSP066312A (es) Derivados piridilo y su uso como agentes terapéuticos
UY28691A1 (es) Derivados de difenilazetidona
AR045595A1 (es) Composiciones utiles como inhibidores de proteinas quinasas
UY28885A1 (es) 4-fenilamino-quinazolin-6-il-amidas referencia cruzada a solicitud(es) relacionada(s)
PA8544901A1 (es) Derivados de oxazol
ECSP088099A (es) Nuevos derivados de la 2-azetidinona para el tratamiento de enfermedades hiperlipidémicas
UY28695A1 (es) Derivados de difenilazetidona
AR035651A1 (es) Uso de derivados de indol para la manufactura de un medicamento para reducir la presion intraocular y una composicion
UY27851A1 (es) Difenilazetidinonas sustituidas en anillo, procedimiento para su preparacion, medicamentos que comprenden estos compuestos y su uso.
UY27803A1 (es) Derivados de benzoxazina y usos de los mismos.
AR030540A1 (es) Compuestos antipicornavirales y composiciones, su uso farmaceutico, y materiales para su sintesis
AR025380A1 (es) Las rutas sinteticas eficientes para la preparacion de los inhibidores de la proteasa del rinovirus.
PA8584501A1 (es) Nuevos derivados de oxazol
UY26666A1 (es) Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis
ECSP024377A (es) Derivados de benzo (g) quinolina
UY27399A1 (es) Proceso para la preparación de quinazolinas

Legal Events

Date Code Title Description
FB Suspension of granting procedure