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AR024068A1 - Un metodo para separar compuestos de elevado peso molecular que contienen lactona y presentan respectivamente un grupo alquilo o alquelino como cadena lateral. - Google Patents

Un metodo para separar compuestos de elevado peso molecular que contienen lactona y presentan respectivamente un grupo alquilo o alquelino como cadena lateral.

Info

Publication number
AR024068A1
AR024068A1 ARP000102504A ARP000102504A AR024068A1 AR 024068 A1 AR024068 A1 AR 024068A1 AR P000102504 A ARP000102504 A AR P000102504A AR P000102504 A ARP000102504 A AR P000102504A AR 024068 A1 AR024068 A1 AR 024068A1
Authority
AR
Argentina
Prior art keywords
molecular weight
side chain
separating
group
alkeline
Prior art date
Application number
ARP000102504A
Other languages
English (en)
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of AR024068A1 publication Critical patent/AR024068A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Recycling of the fraction to be distributed
    • B01D15/1821—Simulated moving beds
    • B01D15/185—Simulated moving beds characterised by the components to be separated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/04—Processes using organic exchangers
    • B01J39/05—Processes using organic exchangers in the strongly acidic form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/08—Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/16—Organic material
    • B01J39/18—Macromolecular compounds
    • B01J39/20—Macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/26—Cation exchangers for chromatographic processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Recycling of the fraction to be distributed
    • B01D15/1821—Simulated moving beds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Sustainable Development (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

Se revela un método para separar un compuesto de elevado peso molecular que contiene lactona y que presenta un grupo alquilo como su cadena lateral de uncompuesto de elevado peso molecular que contiene lactona y que presenta un grupo alquenilo comos u cadena lateral, teniendo los compuestos de elevado pesomolecular que contienen lactona una estructura química básica comun, utilizando una resina fuerte de intercambio cationico conteniendo grupos de ácidosulfonico pre-tratada con iones plata.Se d escribe además la resina de intercambio ionico de aplicacion en dicho método.
ARP000102504A 1999-05-25 2000-05-23 Un metodo para separar compuestos de elevado peso molecular que contienen lactona y presentan respectivamente un grupo alquilo o alquelino como cadena lateral. AR024068A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14510399 1999-05-25

Publications (1)

Publication Number Publication Date
AR024068A1 true AR024068A1 (es) 2002-09-04

Family

ID=15377455

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000102504A AR024068A1 (es) 1999-05-25 2000-05-23 Un metodo para separar compuestos de elevado peso molecular que contienen lactona y presentan respectivamente un grupo alquilo o alquelino como cadena lateral.

Country Status (26)

Country Link
US (1) US6492513B1 (es)
EP (1) EP1183261B1 (es)
JP (1) JP3750527B2 (es)
KR (1) KR100443048B1 (es)
CN (1) CN1154651C (es)
AR (1) AR024068A1 (es)
AT (1) ATE275150T1 (es)
AU (1) AU775075C (es)
BR (1) BR0011597B1 (es)
CA (1) CA2374999C (es)
CZ (1) CZ300783B6 (es)
DE (1) DE60013434T2 (es)
DK (1) DK1183261T3 (es)
ES (1) ES2223514T3 (es)
HU (1) HU228268B1 (es)
IL (2) IL146285A0 (es)
MX (1) MXPA01011566A (es)
NO (1) NO321407B1 (es)
NZ (1) NZ515462A (es)
PL (1) PL199512B1 (es)
PT (1) PT1183261E (es)
RU (1) RU2234509C2 (es)
TR (1) TR200103360T2 (es)
TW (1) TW500725B (es)
WO (1) WO2000071546A1 (es)
ZA (1) ZA200109093B (es)

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US7452692B2 (en) 2002-02-13 2008-11-18 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method for extracting a macrolide from biomatter
JP4261365B2 (ja) 2002-02-13 2009-04-30 テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ 生物学的物質からのマクロライドの抽出方法
US7645876B2 (en) * 2004-12-01 2010-01-12 TEVA Gyógyszergyár Zártkörúen Müködö Részvénytársaság Processes for producing crystalline macrolides
SI1697383T1 (sl) * 2003-12-05 2014-09-30 Biocon Limited Postopek za čiščenje takrolimusa
WO2005098011A1 (en) * 2004-04-12 2005-10-20 Biocon Limited Process for the production of macrolides using a novel strain, streptomyces sp. bicc 7522
US20080312447A1 (en) * 2004-09-10 2008-12-18 Ivax Pharmaceuticals S.R.O. Process for Isolation of Crystalline Tacrolimus
CN101031654A (zh) * 2004-09-10 2007-09-05 伊瓦克斯制药有限公司 结晶他克莫司的分离方法
ITMI20042098A1 (it) * 2004-11-03 2005-02-03 Antibioticos Spa Processo per la purificazione di tacrolimus
TW200637834A (en) * 2004-12-22 2006-11-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Method of purifying macrolides
MX2007006119A (es) * 2005-01-05 2007-07-19 Teva Gyogyszergyar Zartkoruen Tacrolimus amorfo y preparacion de el.
WO2007013017A1 (en) * 2005-07-29 2007-02-01 Ranbaxy Laboratories Limited A process for purification of macrolides
ITMI20051549A1 (it) * 2005-08-05 2007-02-06 Antibioticos Spa Purificazione del tacrolimus su supporti dimorigine vegetale
WO2007075499A2 (en) * 2005-12-16 2007-07-05 Archer-Daniels-Midland Company Method of preparing a composition using argentation chromatography
EP1896488B1 (en) * 2006-03-15 2010-05-19 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Process for purifying tacrolimus
TW200815458A (en) * 2006-03-15 2008-04-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Process for purifying Tacrolimus
KR100859670B1 (ko) * 2006-09-13 2008-09-23 동국제약 주식회사 타크로리무스를 고수율 및 고순도로 정제하는 방법
KR20090094090A (ko) * 2006-12-28 2009-09-03 리머릭 바이오파르마 인코오포레이티드 치료를 위한 방법 및 조성물
MX2010001141A (es) * 2007-07-31 2010-03-01 Limerick Biopharma Inc Analogos fosforiladosde pirona y metodos.
KR101003042B1 (ko) 2008-03-17 2010-12-21 종근당바이오 주식회사 고순도 타크로리무스의 정제 방법
KR100910165B1 (ko) 2008-09-18 2009-07-30 (주) 제노텍 은 이온 용액 추출을 이용한 불포화 알킬기를 가진 락톤 화합물 정제방법
US20110318277A1 (en) 2010-06-25 2011-12-29 APT Pharmaceuticals, Inc. University of Maryland, Baltimore Tacrolimus compositions for aerosol administration
TWI428167B (zh) * 2011-12-29 2014-03-01 Univ Ishou 一種以模擬移動床分離不同分子量高分子之方法
US8470755B1 (en) 2012-03-23 2013-06-25 The Procter & Gamble Company Liquid cleaning and disinfecting compositions comprising a zinc inorganic salt
US9133417B2 (en) 2012-03-23 2015-09-15 The Procter & Gamble Company Liquid cleaning and disinfecting compositions comprising an assymetrically branched amine oxide
CN104428308B (zh) * 2012-07-06 2016-11-09 合同酒精株式会社 环状大环内酯类化合物的分离方法
CN106083892B (zh) * 2016-06-13 2019-02-19 杭州中美华东制药有限公司 他克莫司化合物及其制备方法
RU2694354C1 (ru) * 2018-09-25 2019-07-11 Закрытое акционерное общество "БиоХимМак СТ" Способ сорбционно-хроматографического выделения и очистки такролимуса
CN111909176B (zh) * 2020-08-14 2022-03-15 卓和药业集团股份有限公司 一种从他克莫司分离废液中回收子囊霉素、他克莫司8-丙基类似物的方法

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JPS4988801A (es) * 1972-12-29 1974-08-24
US4826603A (en) 1986-09-09 1989-05-02 United States Of America As Represented By The Secretary Of The Air Force Hydrocarbon group-type analyzer system
JPH06185397A (ja) * 1992-12-15 1994-07-05 Mazda Motor Corp 燃料噴射式エンジンの燃料噴射量制御装置
KR970002037B1 (ko) 1994-12-09 1997-02-21 농촌진흥청 들깨유로부터 α-리놀렌산(ALA)을 분리, 정제하는 방법
US5616595A (en) * 1995-06-07 1997-04-01 Abbott Laboratories Process for recovering water insoluble compounds from a fermentation broth
KR100244164B1 (ko) * 1997-07-15 2000-03-02 김용옥 수용성 고분자-타크로리무스 접합체 화합물 및 그의 제조 방법

Also Published As

Publication number Publication date
ES2223514T3 (es) 2005-03-01
NO20015579D0 (no) 2001-11-15
RU2234509C2 (ru) 2004-08-20
HK1050528A1 (en) 2003-06-27
EP1183261A1 (en) 2002-03-06
CA2374999A1 (en) 2000-11-30
JP3750527B2 (ja) 2006-03-01
MXPA01011566A (es) 2002-06-04
CA2374999C (en) 2009-03-10
AU4615400A (en) 2000-12-12
CN1154651C (zh) 2004-06-23
KR20020032423A (ko) 2002-05-03
US6492513B1 (en) 2002-12-10
BR0011597A (pt) 2002-03-05
NO20015579L (no) 2002-01-17
KR100443048B1 (ko) 2004-08-04
WO2000071546A1 (en) 2000-11-30
HUP0201481A2 (en) 2002-08-28
NO321407B1 (no) 2006-05-08
CN1378548A (zh) 2002-11-06
ZA200109093B (en) 2003-09-23
DK1183261T3 (da) 2005-01-17
JP2004505749A (ja) 2004-02-26
CZ20014209A3 (cs) 2002-04-17
PL199512B1 (pl) 2008-09-30
ATE275150T1 (de) 2004-09-15
AU775075C (en) 2005-02-24
NZ515462A (en) 2004-05-28
TR200103360T2 (tr) 2002-10-21
DE60013434D1 (de) 2004-10-07
BR0011597B1 (pt) 2011-03-22
IL146285A0 (en) 2002-07-25
IL146285A (en) 2009-11-18
CZ300783B6 (cs) 2009-08-12
AU775075B2 (en) 2004-07-15
TW500725B (en) 2002-09-01
DE60013434T2 (de) 2005-01-20
PL357015A1 (en) 2004-07-12
PT1183261E (pt) 2004-11-30
HU228268B1 (en) 2013-02-28
EP1183261B1 (en) 2004-09-01

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