AR012952A1 - Derivado de pirazol triciclico y composicion farmaceutica que lo incluye - Google Patents
Derivado de pirazol triciclico y composicion farmaceutica que lo incluyeInfo
- Publication number
- AR012952A1 AR012952A1 ARP980102731A ARP980102731A AR012952A1 AR 012952 A1 AR012952 A1 AR 012952A1 AR P980102731 A ARP980102731 A AR P980102731A AR P980102731 A ARP980102731 A AR P980102731A AR 012952 A1 AR012952 A1 AR 012952A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- atom
- derivative
- straight
- disorders
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 102000014630 G protein-coupled serotonin receptor activity proteins Human genes 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003217 pyrazoles Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000012201 sexual and gender identity disease Diseases 0.000 abstract 1
- 208000015891 sexual disease Diseases 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Gynecology & Obstetrics (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un derivado de pirazol tricíclico representado por la formula general (I), o una sal farmacéuticamente aceptable del mismo, que muestra fuerte afinidady selectividad por el receptor 5-HT(2c) y es util para el tratamiento de enfermedades del sistema nervioso central (por ej., desordenes sexuales,desordenes de la alimentacion, ansiedad, depresion, desordenes del sueno y lo similar). Dicho derivado se incluye en composiciones farmacéuticas. Cadasímbolo de la formula anterior significa losiguiente: Anillo Het: un anillo heterocíclico no saturado de cinco miembros que contiene 1 a 3 heteroátomosseleccionado cada uno del grupo formado por un átomo de nitrogeno, un átomo de oxígeno y un átomo de azufre, A: un grupo alquileno inferior recto oramificado,y R: un átomo de hidrogeno, un grupo alquilo inferior, un átomo de halogeno, un grupo hidroxilo o un grupo alcoxi inferior. El término inferiorsignifica una cadena de carbono recta o ramificada que tiene 1 a 6 átomos de carbono.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15725597 | 1997-06-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR012952A1 true AR012952A1 (es) | 2000-11-22 |
Family
ID=15645662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980102731A AR012952A1 (es) | 1997-06-13 | 1998-06-10 | Derivado de pirazol triciclico y composicion farmaceutica que lo incluye |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6245796B1 (es) |
| EP (1) | EP0990650B8 (es) |
| JP (1) | JP3410478B2 (es) |
| KR (1) | KR19990006912A (es) |
| CN (1) | CN1097054C (es) |
| AR (1) | AR012952A1 (es) |
| AT (1) | ATE302192T1 (es) |
| AU (2) | AU727654B2 (es) |
| BR (1) | BR9802005A (es) |
| CA (1) | CA2291651A1 (es) |
| DE (1) | DE69831236T2 (es) |
| ES (1) | ES2246535T3 (es) |
| HU (1) | HUP9801340A1 (es) |
| ID (1) | ID23173A (es) |
| PL (1) | PL326777A1 (es) |
| RU (1) | RU2191176C2 (es) |
| TW (1) | TW502024B (es) |
| WO (1) | WO1998056768A1 (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7138393B2 (en) | 1998-07-24 | 2006-11-21 | Wyeth | Biologically active vasopressin agonist metabolites |
| JP2002522425A (ja) | 1998-08-07 | 2002-07-23 | カイロン コーポレイション | エストロゲンレセプターモジュレーターとしての置換イソオキサゾール |
| GB9819019D0 (en) * | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds II |
| ATE310566T1 (de) | 1998-09-18 | 2005-12-15 | Alcon Mfg Ltd | 5ht2-agoniste zur behandlung des glaukoms |
| GB9918965D0 (en) | 1999-08-11 | 1999-10-13 | Cerebrus Ltd | Chemical compounds xxi |
| WO2001083487A1 (en) * | 2000-04-28 | 2001-11-08 | Yamanouchi Pharmaceutical Co., Ltd. | Froindazole derivative |
| DE10055093A1 (de) * | 2000-11-07 | 2002-05-16 | Agfa Gevaert Ag | Cyaninfarbstoff |
| KR100831909B1 (ko) | 2000-11-20 | 2008-05-26 | 바이오비트럼 에이비(피유비엘) | 세로토닌 5-ｈｔ2 수용체의 안타고니스트로서의피페라지닐피라진 화합물 |
| SE0004245D0 (sv) | 2000-11-20 | 2000-11-20 | Pharmacia Ab | Novel compounds and their use |
| EP1392658A4 (en) | 2001-06-01 | 2004-10-13 | Alcon Inc | NOVEL FUSED INDAZOLES AND INDOLES AND THEIR USE IN THE TREATMENT OF GLAUCOMES |
| ATE318821T1 (de) * | 2001-06-01 | 2006-03-15 | Alcon Inc | Pyranoindazole und ihre verwendung in der glaukombehandlung |
| AU2002360819A1 (en) * | 2001-12-28 | 2003-07-24 | Bayer Corporation | Cyclohexano- and cycloheptapyrazole derivative compounds, for use in diseases associated with the 5-ht2c receptor |
| NZ536664A (en) | 2002-06-19 | 2007-07-27 | Biovitrum Ab | Piperazinylpyrazine derivative compounds, their use and preparation |
| WO2004054572A2 (en) | 2002-12-13 | 2004-07-01 | Alcon, Inc. | Novel benzopyran analogs and their use for the treatment of glaucoma |
| CL2004000826A1 (es) | 2003-04-25 | 2005-03-04 | Pfizer | Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129 |
| WO2005053688A1 (en) * | 2003-11-26 | 2005-06-16 | Alcon, Inc. | Substituted furo[2,3-g] indazoles for the treatment of glaucoma |
| US7129257B1 (en) | 2003-12-15 | 2006-10-31 | Alcon, Inc. | Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma |
| WO2005058911A2 (en) * | 2003-12-15 | 2005-06-30 | Alcon, Inc. | Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma |
| WO2006028961A2 (en) * | 2004-09-03 | 2006-03-16 | Athersys, Inc. | Tricyclic heteroaryl piperazines, pyrrolidines and azetidines as serotonin receptor modulators |
| EP2343303A1 (de) * | 2004-10-07 | 2011-07-13 | Boehringer Ingelheim International GmbH | PI3-Kinase Inhibitoren |
| TW201118073A (en) * | 2009-10-30 | 2011-06-01 | Merck Sharp & Dohme | Hexahydrocyclopentyl [F] indazole pyridyl ethanols and derivatives thereof as selective glucocorticoid receptor modulators |
| JPWO2011071136A1 (ja) | 2009-12-11 | 2013-04-22 | アステラス製薬株式会社 | 線維筋痛症治療剤 |
| WO2012030953A1 (en) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level |
| US9345703B2 (en) | 2011-09-15 | 2016-05-24 | University Of Kansas | Kappa opioid receptor effectors and uses thereof |
| US8853207B2 (en) | 2012-04-12 | 2014-10-07 | Development Center For Biotechnology | Heterocyclic pyrazole compounds, method for preparing the same and use thereof |
| WO2015066344A1 (en) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
| CA3164963A1 (en) | 2019-12-19 | 2021-06-24 | Bayer Aktiengesellschaft | Furoindazole derivatives |
| WO2022179940A1 (en) | 2021-02-23 | 2022-09-01 | Bayer Aktiengesellschaft | Furoindazole derivatives as gpr84 antagonists |
| WO2022229061A1 (en) | 2021-04-29 | 2022-11-03 | Bayer Aktiengesellschaft | Furoindazole derivatives as antagonists or inhibitors of gpr84 |
| WO2024083705A1 (en) | 2022-10-18 | 2024-04-25 | Bayer Aktiengesellschaft | Furoindazole derivatives for the treatment of pain |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5637984B2 (es) * | 1974-01-31 | 1981-09-03 | ||
| TW334423B (en) | 1993-10-22 | 1998-06-21 | Hoffmann La Roche | Tricyclic 1-aminoethylpyrrole-derivatives |
| TW270114B (es) * | 1993-10-22 | 1996-02-11 | Hoffmann La Roche | |
| GB9326192D0 (en) * | 1993-12-22 | 1994-02-23 | Glaxo Group Ltd | Chemical compounds |
| WO1995032967A1 (en) * | 1994-05-28 | 1995-12-07 | Smithkline Beecham Plc | Amide derivatives having 5ht1d-antagonist activity |
| TW403738B (en) * | 1994-08-12 | 2000-09-01 | Hoffmann La Roche | Tricyclic pyrazole derivatives |
-
1998
- 1998-06-03 AU AU69893/98A patent/AU727654B2/en not_active Ceased
- 1998-06-05 TW TW087108930A patent/TW502024B/zh not_active IP Right Cessation
- 1998-06-10 AR ARP980102731A patent/AR012952A1/es unknown
- 1998-06-10 PL PL98326777A patent/PL326777A1/xx not_active Application Discontinuation
- 1998-06-11 US US09/445,104 patent/US6245796B1/en not_active Expired - Fee Related
- 1998-06-11 AU AU76740/98A patent/AU7674098A/en not_active Abandoned
- 1998-06-11 CA CA002291651A patent/CA2291651A1/en not_active Abandoned
- 1998-06-11 EP EP98924579A patent/EP0990650B8/en not_active Expired - Lifetime
- 1998-06-11 WO PCT/JP1998/002579 patent/WO1998056768A1/ja not_active Ceased
- 1998-06-11 JP JP50209799A patent/JP3410478B2/ja not_active Expired - Fee Related
- 1998-06-11 ES ES98924579T patent/ES2246535T3/es not_active Expired - Lifetime
- 1998-06-11 AT AT98924579T patent/ATE302192T1/de not_active IP Right Cessation
- 1998-06-11 DE DE69831236T patent/DE69831236T2/de not_active Expired - Lifetime
- 1998-06-11 RU RU98111511/04A patent/RU2191176C2/ru not_active IP Right Cessation
- 1998-06-12 BR BR9802005A patent/BR9802005A/pt not_active IP Right Cessation
- 1998-06-12 CN CN98114746A patent/CN1097054C/zh not_active Expired - Fee Related
- 1998-06-12 KR KR1019980021848A patent/KR19990006912A/ko not_active Ceased
- 1998-06-12 HU HU9801340A patent/HUP9801340A1/hu unknown
- 1998-11-06 ID IDW991587A patent/ID23173A/id unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2191176C2 (ru) | 2002-10-20 |
| ES2246535T3 (es) | 2006-02-16 |
| CA2291651A1 (en) | 1998-12-17 |
| TW502024B (en) | 2002-09-11 |
| HU9801340D0 (en) | 1998-08-28 |
| PL326777A1 (en) | 1998-12-21 |
| BR9802005A (pt) | 2000-03-21 |
| CN1203234A (zh) | 1998-12-30 |
| EP0990650B1 (en) | 2005-08-17 |
| AU6989398A (en) | 1998-12-17 |
| AU7674098A (en) | 1998-12-30 |
| EP0990650A4 (en) | 2002-02-13 |
| EP0990650B8 (en) | 2005-10-19 |
| DE69831236T2 (de) | 2006-04-13 |
| EP0990650A1 (en) | 2000-04-05 |
| US6245796B1 (en) | 2001-06-12 |
| WO1998056768A1 (en) | 1998-12-17 |
| AU727654B2 (en) | 2000-12-21 |
| KR19990006912A (ko) | 1999-01-25 |
| ATE302192T1 (de) | 2005-09-15 |
| ID23173A (id) | 2000-03-23 |
| DE69831236D1 (de) | 2005-09-22 |
| CN1097054C (zh) | 2002-12-25 |
| JP3410478B2 (ja) | 2003-05-26 |
| HUP9801340A1 (hu) | 1999-11-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |