AR012732A1 - Derivados de fenilquinolinas, procedimientos para su preparacion, composiciones farmaceuticas, y su uso para la fabricacion de medicamentos - Google Patents
Derivados de fenilquinolinas, procedimientos para su preparacion, composiciones farmaceuticas, y su uso para la fabricacion de medicamentosInfo
- Publication number
- AR012732A1 AR012732A1 ARP980102363A ARP980102363A AR012732A1 AR 012732 A1 AR012732 A1 AR 012732A1 AR P980102363 A ARP980102363 A AR P980102363A AR P980102363 A ARP980102363 A AR P980102363A AR 012732 A1 AR012732 A1 AR 012732A1
- Authority
- AR
- Argentina
- Prior art keywords
- 6alkyl
- alkyl
- group
- optionally substituted
- amino
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
- -1 C3-7cycloalkyl-alkyl Chemical group 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 1
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
- 125000006705 (C5-C7) cycloalkyl group Chemical group 0.000 abstract 1
- FSEXLNMNADBYJU-UHFFFAOYSA-N 2-phenylquinoline Chemical class C1=CC=CC=C1C1=CC=C(C=CC=C2)C2=N1 FSEXLNMNADBYJU-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000006620 amino-(C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000005518 carboxamido group Chemical group 0.000 abstract 1
- 125000001485 cycloalkadienyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
- C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Derivados de fenilquinolinas o un solvato o una sal de formula (I) en la que Ar es un grupo arilo o cicloalcadienilo C5-7 opcionalmente sustituido, o ungrupo cicloalquilo C5-7 o un grupo hetercíclico aromático de anillo unico o condensado opcionalmente sustituido; R es alquilo C1-6, cicloalquilo C3-7,cicloalquil C3-7-alquilo, fenilo o fenil-alquilo C1-6 opcionalmente sustituido un anillo heteroaromático de cinco miembros, opcionalmente sustituido, quecomprende hasta 4 heteroátomos seleccionados ente O y N, hidroxi-alquilo C1-6, amino-alquilo C1-6, alquil C1-6-aminoalquilo, di-alquil C1-6-aminoalquilo, acilC1-6-aminoalquilo, alcoxi C1-6-alquilo, alquil C1-6-carbonilo, carboxi, alcoxi C1-6-carbonilo, alcoxi C1-6-carbonil-alquilo C1-6, aminocarbonilo,alquil C1-6-aminocarbonilo, di-alquil C1-6-aminocarbonio, halogeno-alquilo C1-6; o R es un grupo -(CH2)p-en que p es 2 o 3, cuyo grupo forma un anillo con un átomos decarbono de Ar; R1 representa hidrogeno o hasta cuatro sustituyentes opcionales seleccionados entre la lista que consta de: alquilo C1-6, alquenilo C1-6, ariloalcoxi C1-6, hidroxi, halogeno, nitro ciano, carboxi, carboxamido, sulfonamido, alcoxi C1-6-carbonilo, trifluorometilo, aciloxi, ftalmido, amino o mono- ydi-alquil C1-6-amino; R2 representa un resto -(CH2)n-NY1Y2 en que n es un numero entero en el margen de 1 a 9, Y1 e Y2 se seleccionan independientemente entrehidrogeno, alquilo C1-6; alqluilo C1-6 sustituido con hidroxi, alquil C1-6 amino obis (alquil C1-6)-amino; alquenilo C1-6; arilo o aril-alquilo C1-6, oY1 e Y2 conjuntamente con el átomo de nitrogeno al que están unidos, representan un grupo heterecíclico simple o condensado enlazado en N yopcionalmente sustituido; R3 esalquilo C1-6 ramificado o lineal, cicloalquilo C3-7, cicloalquilo C4-7, arilo opcionalmente sustituido, o un grupo
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9710750.2A GB9710750D0 (en) | 1997-05-23 | 1997-05-23 | Novel compounds |
| IT002354 IT1295358B1 (it) | 1997-10-17 | 1997-10-17 | Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3 |
| ITMI972775 IT1296976B1 (it) | 1997-12-16 | 1997-12-16 | Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR012732A1 true AR012732A1 (es) | 2000-11-08 |
Family
ID=27268859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980102363A AR012732A1 (es) | 1997-05-23 | 1998-05-21 | Derivados de fenilquinolinas, procedimientos para su preparacion, composiciones farmaceuticas, y su uso para la fabricacion de medicamentos |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP0983262B1 (es) |
| JP (1) | JP2002500645A (es) |
| CN (1) | CN1264378A (es) |
| AP (1) | AP9901695A0 (es) |
| AR (1) | AR012732A1 (es) |
| AT (1) | ATE244711T1 (es) |
| AU (1) | AU8209898A (es) |
| BG (1) | BG104009A (es) |
| BR (1) | BR9809652A (es) |
| CA (1) | CA2291111A1 (es) |
| CO (1) | CO4950515A1 (es) |
| DE (1) | DE69816290T2 (es) |
| DZ (1) | DZ2498A1 (es) |
| EA (1) | EA199901062A1 (es) |
| ES (1) | ES2201509T3 (es) |
| HU (1) | HUP0002300A3 (es) |
| ID (1) | ID22876A (es) |
| IL (1) | IL133036A0 (es) |
| MA (1) | MA26501A1 (es) |
| NO (1) | NO995711L (es) |
| OA (1) | OA11515A (es) |
| PE (1) | PE75199A1 (es) |
| PL (1) | PL336942A1 (es) |
| SK (1) | SK159299A3 (es) |
| TR (1) | TR199902883T2 (es) |
| WO (1) | WO1998052942A1 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9825554D0 (en) * | 1998-11-20 | 1999-01-13 | Smithkline Beecham Spa | Novel Compounds |
| US6780875B2 (en) * | 1998-11-20 | 2004-08-24 | Smithkline Beecham S.P.A. | Quinoline-4-carboxamide derivatives as NK-3 and NK-2 receptor antagonists |
| EP1131295A1 (en) * | 1998-11-20 | 2001-09-12 | Smithkline Beecham S.p.A. | Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists |
| EP1165542B1 (en) | 1999-03-29 | 2003-08-20 | Neurogen Corporation | 4-substituted quinoline derivatives as nk-3 and/or gaba(a) receptor ligands |
| AU4802500A (en) | 1999-04-26 | 2000-11-10 | Neurogen Corporation | 2-aminoquinolinecarboxamides: neurokinin receptor ligands |
| AU2001276556A1 (en) * | 2000-08-11 | 2002-02-25 | Smithkline Beecham P.L.C. | Novel pharmaceutical use of quinnoline derivatives |
| WO2002038547A1 (en) * | 2000-11-13 | 2002-05-16 | Glaxosmithkline Spa | Quinoline derivatives as nk-3 and nk-2 antagonists |
| WO2002044165A1 (en) * | 2000-11-28 | 2002-06-06 | Glaxosmithkline Spa | Quinoline derivatives as nk-3 antagonists |
| GB0028964D0 (en) * | 2000-11-28 | 2001-01-10 | Smithkline Beecham Spa | Novel compounds |
| US6540733B2 (en) | 2000-12-29 | 2003-04-01 | Corazon Technologies, Inc. | Proton generating catheters and methods for their use in enhancing fluid flow through a vascular site occupied by a calcified vascular occlusion |
| GB0109122D0 (en) * | 2001-04-11 | 2001-05-30 | Smithkline Beecham Spa | Novel compounds |
| JP2004525184A (ja) * | 2001-04-11 | 2004-08-19 | グラクソスミスクライン・ソシエタ・ペル・アチオニ | Ｎｋ−３およびｎｋ−２受容体アンタゴニストとしての３−置換キノリン−４−カルボキサミド誘導体 |
| MY134211A (en) * | 2001-05-18 | 2007-11-30 | Smithkline Beecham Corp | Novel use |
| GB0425076D0 (en) * | 2004-11-12 | 2004-12-15 | Smithkline Beecham Corp | Novel compounds |
| GB0425075D0 (en) * | 2004-11-12 | 2004-12-15 | Smithkline Beecham Corp | Novel compounds |
| GB0425077D0 (en) * | 2004-11-12 | 2004-12-15 | Smithkline Beecham Corp | Novel compounds |
| CN101189211A (zh) * | 2005-06-03 | 2008-05-28 | 阿斯利康(瑞典)有限公司 | 作为nk3拮抗剂的喹啉衍生物 |
| GB0515580D0 (en) | 2005-07-29 | 2005-09-07 | Merck Sharp & Dohme | Therapeutic compounds |
| AR057130A1 (es) | 2005-09-21 | 2007-11-14 | Astrazeneca Ab | Quinolinas de alquilsulfoxido y una composicion farmaceutica |
| DE202007017299U1 (de) * | 2007-12-12 | 2009-04-23 | Drebo Werkzeugfabrik Gmbh | Bohrer |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2227769T3 (es) * | 1994-05-27 | 2005-04-01 | Glaxosmithkline S.P.A. | Derivados de quinolina como antagonistas del receptor nk3 de taquiquinina. |
| AR004735A1 (es) * | 1995-11-24 | 1999-03-10 | Smithkline Beecham Spa | Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento. |
-
1998
- 1998-05-18 CN CN98807356A patent/CN1264378A/zh active Pending
- 1998-05-18 CA CA002291111A patent/CA2291111A1/en not_active Abandoned
- 1998-05-18 HU HU0002300A patent/HUP0002300A3/hu unknown
- 1998-05-18 BR BR9809652-4A patent/BR9809652A/pt not_active IP Right Cessation
- 1998-05-18 IL IL13303698A patent/IL133036A0/xx unknown
- 1998-05-18 EA EA199901062A patent/EA199901062A1/ru unknown
- 1998-05-18 AP APAP/P/1999/001695A patent/AP9901695A0/en unknown
- 1998-05-18 AT AT98932069T patent/ATE244711T1/de not_active IP Right Cessation
- 1998-05-18 SK SK1592-99A patent/SK159299A3/sk unknown
- 1998-05-18 TR TR1999/02883T patent/TR199902883T2/xx unknown
- 1998-05-18 ID IDW991432A patent/ID22876A/id unknown
- 1998-05-18 EP EP98932069A patent/EP0983262B1/en not_active Expired - Lifetime
- 1998-05-18 DE DE69816290T patent/DE69816290T2/de not_active Expired - Fee Related
- 1998-05-18 ES ES98932069T patent/ES2201509T3/es not_active Expired - Lifetime
- 1998-05-18 AU AU82098/98A patent/AU8209898A/en not_active Abandoned
- 1998-05-18 JP JP54996798A patent/JP2002500645A/ja not_active Ceased
- 1998-05-18 PL PL98336942A patent/PL336942A1/xx unknown
- 1998-05-18 WO PCT/EP1998/003014 patent/WO1998052942A1/en not_active Ceased
- 1998-05-19 DZ DZ980108A patent/DZ2498A1/xx active
- 1998-05-20 PE PE1998000398A patent/PE75199A1/es not_active Application Discontinuation
- 1998-05-21 AR ARP980102363A patent/AR012732A1/es not_active Application Discontinuation
- 1998-05-21 MA MA25086A patent/MA26501A1/fr unknown
- 1998-05-22 CO CO98029024A patent/CO4950515A1/es unknown
-
1999
- 1999-11-22 NO NO995711A patent/NO995711L/no not_active Application Discontinuation
- 1999-11-23 OA OA9900253A patent/OA11515A/en unknown
- 1999-12-14 BG BG104009A patent/BG104009A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TR199902883T2 (xx) | 2000-05-22 |
| DE69816290D1 (de) | 2003-08-14 |
| SK159299A3 (en) | 2000-06-12 |
| AU8209898A (en) | 1998-12-11 |
| BR9809652A (pt) | 2001-09-11 |
| WO1998052942A1 (en) | 1998-11-26 |
| MA26501A1 (fr) | 2004-12-20 |
| DZ2498A1 (fr) | 2003-01-25 |
| ES2201509T3 (es) | 2004-03-16 |
| HUP0002300A2 (hu) | 2001-06-28 |
| NO995711L (no) | 2000-01-19 |
| OA11515A (en) | 2004-02-04 |
| DE69816290T2 (de) | 2004-05-27 |
| EA199901062A1 (ru) | 2000-08-28 |
| BG104009A (en) | 2000-07-31 |
| ATE244711T1 (de) | 2003-07-15 |
| ID22876A (id) | 1999-12-16 |
| AP9901695A0 (en) | 1999-12-31 |
| PE75199A1 (es) | 1999-10-22 |
| EP0983262B1 (en) | 2003-07-09 |
| PL336942A1 (en) | 2000-07-17 |
| JP2002500645A (ja) | 2002-01-08 |
| IL133036A0 (en) | 2001-03-19 |
| NO995711D0 (no) | 1999-11-22 |
| CO4950515A1 (es) | 2000-09-01 |
| EP0983262A1 (en) | 2000-03-08 |
| HUP0002300A3 (en) | 2002-01-28 |
| CA2291111A1 (en) | 1998-11-26 |
| CN1264378A (zh) | 2000-08-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |