NO995711D0 - Kinolin-4-karboksamid-derivater som NK-2 og NK-3-reseptorantagonister - Google Patents

Kinolin-4-karboksamid-derivater som NK-2 og NK-3-reseptorantagonister

Info

Publication number: NO995711D0
Authority: NO; Norway
Prior art keywords: quinoline; receptor antagonists; carboxamide derivatives; carboxamide; derivatives
Prior art date: 1997-05-23

Application number

NO995711A

Other languages

English (en)

Other versions

NO995711L (no

Inventor

Giuseppe Arnaldo Mari Giardina

Mario Grugni

Davide Graziani

Luca Francesco Raveglia

Original Assignee

Smithkline Beecham Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-23

Filing date

1999-11-22

Publication date

1999-11-22

1997-05-23 Priority claimed from GBGB9710750.2A external-priority patent/GB9710750D0/en

1997-10-17 Priority claimed from IT002354 external-priority patent/IT1295358B1/it

1997-12-16 Priority claimed from ITMI972775 external-priority patent/IT1296976B1/it

1999-11-22 Application filed by Smithkline Beecham Spa filed Critical Smithkline Beecham Spa

1999-11-22 Publication of NO995711D0 publication Critical patent/NO995711D0/no

2000-01-19 Publication of NO995711L publication Critical patent/NO995711L/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
- C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pulmonology (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO995711A 1997-05-23 1999-11-22 Kinolin-4-karboksamid-derivater som NK-2 og NK-3- reseptorantagonister NO995711L (no)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB9710750.2A GB9710750D0 (en)	1997-05-23	1997-05-23	Novel compounds
IT002354 IT1295358B1 (it)	1997-10-17	1997-10-17	Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3
ITMI972775 IT1296976B1 (it)	1997-12-16	1997-12-16	Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3
PCT/EP1998/003014 WO1998052942A1 (en)	1997-05-23	1998-05-18	Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists

Publications (2)

Publication Number	Publication Date
NO995711D0 true NO995711D0 (no)	1999-11-22
NO995711L NO995711L (no)	2000-01-19

Family

ID=27268859

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO995711A NO995711L (no)	1997-05-23	1999-11-22	Kinolin-4-karboksamid-derivater som NK-2 og NK-3- reseptorantagonister

Country Status (26)

Country	Link
EP (1)	EP0983262B1 (no)
JP (1)	JP2002500645A (no)
CN (1)	CN1264378A (no)
AP (1)	AP9901695A0 (no)
AR (1)	AR012732A1 (no)
AT (1)	ATE244711T1 (no)
AU (1)	AU8209898A (no)
BG (1)	BG104009A (no)
BR (1)	BR9809652A (no)
CA (1)	CA2291111A1 (no)
CO (1)	CO4950515A1 (no)
DE (1)	DE69816290T2 (no)
DZ (1)	DZ2498A1 (no)
EA (1)	EA199901062A1 (no)
ES (1)	ES2201509T3 (no)
HU (1)	HUP0002300A3 (no)
ID (1)	ID22876A (no)
IL (1)	IL133036A0 (no)
MA (1)	MA26501A1 (no)
NO (1)	NO995711L (no)
OA (1)	OA11515A (no)
PE (1)	PE75199A1 (no)
PL (1)	PL336942A1 (no)
SK (1)	SK159299A3 (no)
TR (1)	TR199902883T2 (no)
WO (1)	WO1998052942A1 (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9825554D0 (en) *	1998-11-20	1999-01-13	Smithkline Beecham Spa	Novel Compounds
US6780875B2 (en) *	1998-11-20	2004-08-24	Smithkline Beecham S.P.A.	Quinoline-4-carboxamide derivatives as NK-3 and NK-2 receptor antagonists
EP1131295A1 (en) *	1998-11-20	2001-09-12	Smithkline Beecham S.p.A.	Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists
EP1165542B1 (en)	1999-03-29	2003-08-20	Neurogen Corporation	4-substituted quinoline derivatives as nk-3 and/or gaba(a) receptor ligands
AU4802500A (en)	1999-04-26	2000-11-10	Neurogen Corporation	2-aminoquinolinecarboxamides: neurokinin receptor ligands
AU2001276556A1 (en) *	2000-08-11	2002-02-25	Smithkline Beecham P.L.C.	Novel pharmaceutical use of quinnoline derivatives
WO2002038547A1 (en) *	2000-11-13	2002-05-16	Glaxosmithkline Spa	Quinoline derivatives as nk-3 and nk-2 antagonists
WO2002044165A1 (en) *	2000-11-28	2002-06-06	Glaxosmithkline Spa	Quinoline derivatives as nk-3 antagonists
GB0028964D0 (en) *	2000-11-28	2001-01-10	Smithkline Beecham Spa	Novel compounds
US6540733B2 (en)	2000-12-29	2003-04-01	Corazon Technologies, Inc.	Proton generating catheters and methods for their use in enhancing fluid flow through a vascular site occupied by a calcified vascular occlusion
GB0109122D0 (en) *	2001-04-11	2001-05-30	Smithkline Beecham Spa	Novel compounds
JP2004525184A (ja) *	2001-04-11	2004-08-19	グラクソスミスクライン・ソシエタ・ペル・アチオニ	Ｎｋ−３およびｎｋ−２受容体アンタゴニストとしての３−置換キノリン−４−カルボキサミド誘導体
MY134211A (en) *	2001-05-18	2007-11-30	Smithkline Beecham Corp	Novel use
GB0425076D0 (en) *	2004-11-12	2004-12-15	Smithkline Beecham Corp	Novel compounds
GB0425075D0 (en) *	2004-11-12	2004-12-15	Smithkline Beecham Corp	Novel compounds
GB0425077D0 (en) *	2004-11-12	2004-12-15	Smithkline Beecham Corp	Novel compounds
CN101189211A (zh) *	2005-06-03	2008-05-28	阿斯利康(瑞典)有限公司	作为nk3拮抗剂的喹啉衍生物
GB0515580D0 (en)	2005-07-29	2005-09-07	Merck Sharp & Dohme	Therapeutic compounds
AR057130A1 (es)	2005-09-21	2007-11-14	Astrazeneca Ab	Quinolinas de alquilsulfoxido y una composicion farmaceutica
DE202007017299U1 (de) *	2007-12-12	2009-04-23	Drebo Werkzeugfabrik Gmbh	Bohrer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2227769T3 (es) *	1994-05-27	2005-04-01	Glaxosmithkline S.P.A.	Derivados de quinolina como antagonistas del receptor nk3 de taquiquinina.
AR004735A1 (es) *	1995-11-24	1999-03-10	Smithkline Beecham Spa	Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento.

1998
- 1998-05-18 CN CN98807356A patent/CN1264378A/zh active Pending
- 1998-05-18 CA CA002291111A patent/CA2291111A1/en not_active Abandoned
- 1998-05-18 HU HU0002300A patent/HUP0002300A3/hu unknown
- 1998-05-18 BR BR9809652-4A patent/BR9809652A/pt not_active IP Right Cessation
- 1998-05-18 IL IL13303698A patent/IL133036A0/xx unknown
- 1998-05-18 EA EA199901062A patent/EA199901062A1/ru unknown
- 1998-05-18 AP APAP/P/1999/001695A patent/AP9901695A0/en unknown
- 1998-05-18 AT AT98932069T patent/ATE244711T1/de not_active IP Right Cessation
- 1998-05-18 SK SK1592-99A patent/SK159299A3/sk unknown
- 1998-05-18 TR TR1999/02883T patent/TR199902883T2/xx unknown
- 1998-05-18 ID IDW991432A patent/ID22876A/id unknown
- 1998-05-18 EP EP98932069A patent/EP0983262B1/en not_active Expired - Lifetime
- 1998-05-18 DE DE69816290T patent/DE69816290T2/de not_active Expired - Fee Related
- 1998-05-18 ES ES98932069T patent/ES2201509T3/es not_active Expired - Lifetime
- 1998-05-18 AU AU82098/98A patent/AU8209898A/en not_active Abandoned
- 1998-05-18 JP JP54996798A patent/JP2002500645A/ja not_active Ceased
- 1998-05-18 PL PL98336942A patent/PL336942A1/xx unknown
- 1998-05-18 WO PCT/EP1998/003014 patent/WO1998052942A1/en not_active Ceased
- 1998-05-19 DZ DZ980108A patent/DZ2498A1/xx active
- 1998-05-20 PE PE1998000398A patent/PE75199A1/es not_active Application Discontinuation
- 1998-05-21 AR ARP980102363A patent/AR012732A1/es not_active Application Discontinuation
- 1998-05-21 MA MA25086A patent/MA26501A1/fr unknown
- 1998-05-22 CO CO98029024A patent/CO4950515A1/es unknown
1999
- 1999-11-22 NO NO995711A patent/NO995711L/no not_active Application Discontinuation
- 1999-11-23 OA OA9900253A patent/OA11515A/en unknown
- 1999-12-14 BG BG104009A patent/BG104009A/xx unknown

Also Published As

Publication number	Publication date
TR199902883T2 (xx)	2000-05-22
DE69816290D1 (de)	2003-08-14
SK159299A3 (en)	2000-06-12
AU8209898A (en)	1998-12-11
BR9809652A (pt)	2001-09-11
WO1998052942A1 (en)	1998-11-26
MA26501A1 (fr)	2004-12-20
DZ2498A1 (fr)	2003-01-25
ES2201509T3 (es)	2004-03-16
HUP0002300A2 (hu)	2001-06-28
NO995711L (no)	2000-01-19
OA11515A (en)	2004-02-04
DE69816290T2 (de)	2004-05-27
EA199901062A1 (ru)	2000-08-28
BG104009A (en)	2000-07-31
ATE244711T1 (de)	2003-07-15
ID22876A (id)	1999-12-16
AP9901695A0 (en)	1999-12-31
PE75199A1 (es)	1999-10-22
EP0983262B1 (en)	2003-07-09
PL336942A1 (en)	2000-07-17
AR012732A1 (es)	2000-11-08
JP2002500645A (ja)	2002-01-08
IL133036A0 (en)	2001-03-19
CO4950515A1 (es)	2000-09-01
EP0983262A1 (en)	2000-03-08
HUP0002300A3 (en)	2002-01-28
CA2291111A1 (en)	1998-11-26
CN1264378A (zh)	2000-08-23

Publication	Publication Date	Title
NO20012473L (no)	2001-07-18	Kinolin-4-karboksamidderivater som NK-3 og NK-2 reseptorantagonister
NO995711D0 (no)	1999-11-22	Kinolin-4-karboksamid-derivater som NK-2 og NK-3-reseptorantagonister
NO982333L (no)	1998-07-22	Kinolinkarboksamid-derivater, deres fremstilling og deres anvendelse som Neurokinin 3 (NK-3)- og Neurokinin 2 (NK-2) reseptorantagonister
NO965036L (no)	1997-01-24	Kinolinderivater som techykinin NK3 reseptor-antagonister
NO20013809D0 (no)	2001-08-03	Indolderivater og anvendelse derav som MCP-1 antagonister
NO20032797L (no)	2003-08-19	Substituerte pyridoindoler som serotonin agonister og antagonister
DK1035115T3 (da)	2005-01-24	4-phenylpyridinderivater og anvendelse deraf som NK-1-receptorantagonister
DK0901470T3 (da)	2004-07-12	Indolderivater egnede som endothelinreceptorantagonister
ID19623A (id)	1998-07-23	Antagonis reseptor vitronektin
FI19992312L (fi)	2001-04-08	Laite palon sammuttamiseksi
DK0922034T3 (da)	2002-11-18	Tetrahydroquinolinderivater som EAA-antagonister
NO996115D0 (no)	1999-12-10	Azetidinylpropylpiperidin-derivater, intermediater og anvendelse som tachykinin-antagonister
NO990786L (no)	1999-03-25	Acylaminoalkenylen-amidderivater som NK1 og NK2 antagonister
DK1216250T3 (da)	2004-02-23	Thienoisoxazolyl- og thienylpyrazolyl-phenoxy- substituerede propylderivater som D4-antagonister
NO20026103D0 (no)	2002-12-19	1-amino-alkylcycloheksaner som 5-HT3 og neuronal nikotinreseptorantagonister
AU2002215043A1 (en)	2002-05-21	Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists
NO963331D0 (no)	1996-08-09	5-Heteroarylindol-derivater som benzodiazepin-reseptorsete-agonister og antagonister
DE69703242D1 (de)	2000-11-09	Indolin-derivate verwendbar als 5-ht-2c rezeptor-antagonisten
NO994679D0 (no)	1999-09-24	Quinolin-2-karboksylsyrederivat og anvendelse derav som eksitatorisk aminosyreantagonist
DE69717449D1 (de)	2003-01-09	Indolin-derivate verwendbar als 5-ht-2c rezeptor-antagonisten
NO20011779D0 (no)	2001-04-06	Ureidopiperidinderivater som selektive humane NK3 reseptor antagonister
HK1028236A (en)	2001-02-09	Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists
AU2002310838A1 (en)	2002-10-28	Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists
NO20021249D0 (no)	2002-03-13	Tienoisoksazolfenoksyusubstituerte etyl- og propylderivater som D4antagonister
AU2002308138A1 (en)	2002-10-28	3-substituted quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists

Legal Events

Date	Code	Title	Description
2003-01-27	FC2A	Withdrawal, rejection or dismissal of laid open patent application