AR012250A1 - Derivados de 2-(iminometil)amino-fenilo, procedimientos para su preparacion, intermediarios utilizados en dichos procedimientos, medicamento y composicion farmaceutica que contienen a dichos derivados y uso de estos derivados para manufacturar un medicamento - Google Patents
Derivados de 2-(iminometil)amino-fenilo, procedimientos para su preparacion, intermediarios utilizados en dichos procedimientos, medicamento y composicion farmaceutica que contienen a dichos derivados y uso de estos derivados para manufacturar un medicamentoInfo
- Publication number
- AR012250A1 AR012250A1 ARP980102907A ARP980102907A AR012250A1 AR 012250 A1 AR012250 A1 AR 012250A1 AR P980102907 A ARP980102907 A AR P980102907A AR P980102907 A ARP980102907 A AR P980102907A AR 012250 A1 AR012250 A1 AR 012250A1
- Authority
- AR
- Argentina
- Prior art keywords
- thiazoline
- derivatives
- radical
- branched
- linear
- Prior art date
Links
- -1 AMINO-PHENYL Chemical class 0.000 title abstract 8
- 238000000034 method Methods 0.000 title 2
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- CBDKQYKMCICBOF-UHFFFAOYSA-N thiazoline Chemical compound C1CN=CS1 CBDKQYKMCICBOF-UHFFFAOYSA-N 0.000 abstract 35
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 5
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 4
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 4
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 229930192474 thiophene Natural products 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- MDTUWBLTRPRXBX-UHFFFAOYSA-N 1,2,4-triazol-3-one Chemical compound O=C1N=CN=N1 MDTUWBLTRPRXBX-UHFFFAOYSA-N 0.000 abstract 1
- FKASFBLJDCHBNZ-UHFFFAOYSA-N 1,3,4-oxadiazole Chemical compound C1=NN=CO1 FKASFBLJDCHBNZ-UHFFFAOYSA-N 0.000 abstract 1
- RITLDOUXOBAADN-UHFFFAOYSA-N 1,3-thiazole;1,3-thiazolidine Chemical compound C1CSCN1.C1=CSC=N1 RITLDOUXOBAADN-UHFFFAOYSA-N 0.000 abstract 1
- IMSODMZESSGVBE-UHFFFAOYSA-N 2-Oxazoline Chemical compound C1CN=CO1 IMSODMZESSGVBE-UHFFFAOYSA-N 0.000 abstract 1
- WEQPBCSPRXFQQS-UHFFFAOYSA-N 4,5-dihydro-1,2-oxazole Chemical compound C1CC=NO1 WEQPBCSPRXFQQS-UHFFFAOYSA-N 0.000 abstract 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 abstract 1
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- HXJUTPCZVOIRIF-UHFFFAOYSA-N sulfolane Chemical compound O=S1(=O)CCCC1 HXJUTPCZVOIRIF-UHFFFAOYSA-N 0.000 abstract 1
- RAOIDOHSFRTOEL-UHFFFAOYSA-N tetrahydrothiophene Chemical compound C1CCSC1 RAOIDOHSFRTOEL-UHFFFAOYSA-N 0.000 abstract 1
- 150000003536 tetrazoles Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D521/00—Heterocyclic compounds containing unspecified hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Furan Compounds (AREA)
Abstract
Derivados de 2-(iminometil)amino-fenilo de la formula general (I): en la cual A es un átomo de hidrogeno o preferiblmente un aromático que tiene lasestructuras de formula (II), en donde R1 y R2 representan, independientemente, hidrogeno, halogeno ,CH, un radical alquilo C1-C6 lineal o ramificado, unradical alcoxi C1-C6 lineal o ramificado, R3 representa hidrogeno, un radical alquilo C1-C6 lineal o ramificado o un radical -COR4, representando R4 unradical alqulo C1-C6 de formula (III), o Brepresenta n radical alqulo C1-C6 lineal o ramificado, fenilo, piridinilo o un heterociclo con 5 miembros conteniendo 1 a 4 heteroátomos elegidos de O, S, N y más particularmente: tiofeno, furano, pirrol o tiazol, cuyos átomos de carbono está nopcionalmentesubstituídos por uno o más grupos elegidos de un radical alquilo C1-C6 lineal o ramificado; un radical alcoxi C1-C6 o halogeno; X representa -CO-N(R3)-X-, -NH-CO-X, -CH=, -CO- o un enlace representando X el resto -CH2)n-, siendo n unentero de 0 a 6, Y representa -Y-, -CO-NH-Y-, -Y-NH-CO, -CO-Y-, -N(R3)-Y,-Y-N(R3)-, -Y-CH2-N(R3)-CO-, -O-Y-,Y-O-, -Y-S-, -Y-O-Y, -Y-N(R3)-Y- o un enlace, Yrepresenta -(CH2)n siendo n un entero de 0 a 6; Het representa unheterociclo que contiene de1 a 5 heteroátomos elegidos de O, N, S, los cuales pueden estar sustituidos por uno o más sustituyentes X-OR3, X-NR3, X-S-R3,tal como por ejemplo: exetano, pirrol, pirrolidina, furano, tetrahidrofurano, tiofeno, tetrahidrotiofeno, sulfolano, imidazol, imidazolina, dihidroimidazol-2-ona, dihidroimidazol-2-tiona, oxazol, isoxazol, oxazolina, isoxazolina, oxaxolidina, oxazoolidinona, tiazol, tiazolina, tiazolidina, tiazolidinona,hidantoina, 1,2,4-tiazol, 1,3,4-oxadiazol, 1,1-dioxido-1,2,5-tiadiazolidina, 1,2,4-triazol-3-ona, tetrazol, tetrahidropirina, con la excepcion de los ..2
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9707701A FR2764889B1 (fr) | 1997-06-20 | 1997-06-20 | Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR012250A1 true AR012250A1 (es) | 2000-09-27 |
Family
ID=9508226
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980102907A AR012250A1 (es) | 1997-06-20 | 1998-06-18 | Derivados de 2-(iminometil)amino-fenilo, procedimientos para su preparacion, intermediarios utilizados en dichos procedimientos, medicamento y composicion farmaceutica que contienen a dichos derivados y uso de estos derivados para manufacturar un medicamento |
Country Status (28)
| Country | Link |
|---|---|
| EP (1) | EP0991654B1 (es) |
| JP (1) | JP2002507965A (es) |
| KR (2) | KR100618478B1 (es) |
| CN (1) | CN1195762C (es) |
| AR (1) | AR012250A1 (es) |
| AT (1) | ATE297935T1 (es) |
| AU (1) | AU737964B2 (es) |
| BR (1) | BR9810197B1 (es) |
| CA (1) | CA2294809C (es) |
| CZ (1) | CZ299237B6 (es) |
| DE (1) | DE69830584T2 (es) |
| DK (1) | DK0991654T3 (es) |
| ES (1) | ES2244068T3 (es) |
| FR (1) | FR2764889B1 (es) |
| HU (1) | HUP0002425A3 (es) |
| IL (1) | IL133223A (es) |
| MY (1) | MY123193A (es) |
| NO (1) | NO315321B1 (es) |
| NZ (1) | NZ501656A (es) |
| PL (1) | PL191987B1 (es) |
| PT (1) | PT991654E (es) |
| RU (1) | RU2202543C2 (es) |
| SK (1) | SK286911B6 (es) |
| TR (1) | TR199903175T2 (es) |
| TW (1) | TW422842B (es) |
| UA (1) | UA70921C2 (es) |
| WO (1) | WO1998058934A1 (es) |
| ZA (1) | ZA985392B (es) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9801990D0 (sv) | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl propionic acid derivatives and analogs |
| AR019190A1 (es) * | 1998-07-08 | 2001-12-26 | Sod Conseils Rech Applic | Derivados de 2-aminopiridinas, productos intermedios para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y su uso para preparar medicamentos |
| CA2339662A1 (en) * | 1998-08-07 | 2000-02-17 | Takeda Chemical Industries, Ltd. | Benzothiepin derivatives, their production and use |
| FR2783519B1 (fr) * | 1998-09-23 | 2003-01-24 | Sod Conseils Rech Applic | Nouveaux derives d'amidines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
| FR2798127A1 (fr) | 1999-09-03 | 2001-03-09 | Expansia Sa | Nouveau procede de preparation d'amidines derivees de l'acide 6-hydroxy-2,5,7,8-tetramethylchrommane-2-carboxy- lique |
| RU2380362C2 (ru) * | 1999-10-11 | 2010-01-27 | Сосьете Де Консей Де Решерш З | Производные пятичленных гетероциклов, способ их получения и их применение в качестве лекарственных средств |
| FR2799461B1 (fr) * | 1999-10-11 | 2002-01-04 | Sod Conseils Rech Applic | Derives d'heterocycles a 5 chainons, leur preparation et leur application a titre de medicaments |
| TWI292316B (en) * | 1999-10-11 | 2008-01-11 | Sod Conseils Rech Applic | Pharmaceutical composition of thiazole derivatives intended to inhibit mao and/or lipidic peroxidation and/or to act as modulators of sodium channels and the use thereof |
| FR2812546B1 (fr) * | 2000-08-01 | 2008-11-21 | Sod Conseils Rech Applic | Derives d'heterocycles a 5 chainons, leur preparation et leur application a titre de medicaments |
| FR2801053B1 (fr) * | 1999-11-16 | 2004-06-25 | Sod Conseils Rech Applic | Nouveaux derives d'amidines, leur preparation et leur application a titre de medicaments |
| SE9904676D0 (sv) * | 1999-12-20 | 1999-12-20 | Astra Ab | Novel compounds |
| SE9904677D0 (sv) * | 1999-12-20 | 1999-12-20 | Astra Ab | Novel compounds |
| GB0019006D0 (en) * | 2000-08-04 | 2000-09-20 | Astrazeneca Ab | Novel compounds |
| WO2002020511A1 (en) * | 2000-09-05 | 2002-03-14 | Astrazeneca Ab | Amidine derivatives which are inhibitors of nitric oxide synthase |
| TWI248438B (en) * | 2001-04-10 | 2006-02-01 | Sod Conseils Rech Applic | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments |
| EP1411930B1 (en) | 2001-06-08 | 2013-01-16 | Cytokine Pharmasciences, Inc. | Isoxazoline compounds having mif antagonist activity |
| HU228783B1 (en) * | 2001-07-26 | 2013-05-28 | Greenearth Cleaning | Dry cleaning apparatus and method capable of utilizing a siloxane solvent |
| WO2003082841A1 (en) * | 2002-04-03 | 2003-10-09 | Novartis Ag | 5-substituted 1,1-dioxo-`1,2,5!thiazolidine-3-one derivatives as ptpase 1b inhibitors |
| DE10233817A1 (de) * | 2002-07-25 | 2004-02-12 | Aventis Pharma Deutschland Gmbh | Substituierte Diarylheterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US7141561B2 (en) | 2002-07-25 | 2006-11-28 | Sanofi-Aventis Deutschland Gmbh | Substituted diaryl heterocycles, process for their preparation and their use as medicaments |
| FR2842808B1 (fr) | 2002-07-25 | 2004-09-10 | Sod Conseils Rech Applic | Nouveaux derives d'arylimidazoles, leur preparation et leurs applications therapeutiques |
| WO2005094329A2 (en) * | 2004-03-26 | 2005-10-13 | Cytokine Pharmasciences, Inc. | Compouns, compositions, processes of making, and methods of use related to inhibiting macrophage migration inhibitory factor |
| WO2006022442A1 (ja) * | 2004-08-24 | 2006-03-02 | Santen Pharmaceutical Co., Ltd. | ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体 |
| CN101163693B (zh) * | 2005-02-18 | 2013-03-06 | 阿斯利康(瑞典)有限公司 | 抗菌哌啶衍生物 |
| SG162773A1 (en) | 2005-03-11 | 2010-07-29 | Florey Howard Inst | Flavonoid compounds and uses thereof |
| CA2773038A1 (en) | 2009-09-04 | 2011-03-10 | P. Jeffrey Conn | Mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| WO2011058766A1 (en) * | 2009-11-16 | 2011-05-19 | Raqualia Pharma Inc. | Aryl carboxamide derivatives as ttx-s blockers |
| JP6292721B2 (ja) * | 2012-07-12 | 2018-03-14 | コンドリオン アイピー ビー．ブイ．Ｋｈｏｎｄｒｉｏｎ Ｉｐ Ｂ．Ｖ． | ミトコンドリア病を治療するためのクロマニル誘導体 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9127376D0 (en) * | 1991-12-24 | 1992-02-19 | Wellcome Found | Amidino derivatives |
| EP0713483B1 (en) * | 1993-08-12 | 2003-01-15 | AstraZeneca AB | Amidine derivatives with nitric oxide synthetase activities |
| US5807886A (en) * | 1994-05-07 | 1998-09-15 | Astra Aktiebolag | Bicyclic amidine dervatives as inhibitors of nitric oxide synthetase |
-
1997
- 1997-06-20 FR FR9707701A patent/FR2764889B1/fr not_active Expired - Fee Related
-
1998
- 1998-06-10 TW TW087109245A patent/TW422842B/zh not_active IP Right Cessation
- 1998-06-15 IL IL13322398A patent/IL133223A/en not_active IP Right Cessation
- 1998-06-15 DE DE69830584T patent/DE69830584T2/de not_active Expired - Lifetime
- 1998-06-15 ES ES98932205T patent/ES2244068T3/es not_active Expired - Lifetime
- 1998-06-15 PT PT98932205T patent/PT991654E/pt unknown
- 1998-06-15 KR KR1020057016237A patent/KR100618478B1/ko not_active Expired - Fee Related
- 1998-06-15 UA UA99126913A patent/UA70921C2/uk unknown
- 1998-06-15 CN CNB988073927A patent/CN1195762C/zh not_active Expired - Fee Related
- 1998-06-15 NZ NZ501656A patent/NZ501656A/en not_active IP Right Cessation
- 1998-06-15 PL PL337499A patent/PL191987B1/pl not_active IP Right Cessation
- 1998-06-15 EP EP98932205A patent/EP0991654B1/fr not_active Expired - Lifetime
- 1998-06-15 JP JP50387199A patent/JP2002507965A/ja active Pending
- 1998-06-15 BR BRPI9810197-8A patent/BR9810197B1/pt not_active IP Right Cessation
- 1998-06-15 RU RU2000101328/04A patent/RU2202543C2/ru not_active IP Right Cessation
- 1998-06-15 SK SK1796-99A patent/SK286911B6/sk not_active IP Right Cessation
- 1998-06-15 AT AT98932205T patent/ATE297935T1/de active
- 1998-06-15 CZ CZ0459799A patent/CZ299237B6/cs not_active IP Right Cessation
- 1998-06-15 AU AU82189/98A patent/AU737964B2/en not_active Ceased
- 1998-06-15 WO PCT/FR1998/001250 patent/WO1998058934A1/fr not_active Ceased
- 1998-06-15 DK DK98932205T patent/DK0991654T3/da active
- 1998-06-15 KR KR1019997012010A patent/KR100545946B1/ko not_active Expired - Fee Related
- 1998-06-15 CA CA002294809A patent/CA2294809C/fr not_active Expired - Fee Related
- 1998-06-15 TR TR1999/03175T patent/TR199903175T2/xx unknown
- 1998-06-15 HU HU0002425A patent/HUP0002425A3/hu unknown
- 1998-06-18 AR ARP980102907A patent/AR012250A1/es active IP Right Grant
- 1998-06-19 MY MYPI98002787A patent/MY123193A/en unknown
- 1998-06-19 ZA ZA985392A patent/ZA985392B/xx unknown
-
1999
- 1999-12-15 NO NO19996208A patent/NO315321B1/no not_active IP Right Cessation
Also Published As
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