AR011153A1 - Derivados de cromano sustituido con sulfonamida, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que los contiene - Google Patents
Derivados de cromano sustituido con sulfonamida, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que los contieneInfo
- Publication number
- AR011153A1 AR011153A1 ARP980100729A ARP980100729A AR011153A1 AR 011153 A1 AR011153 A1 AR 011153A1 AR P980100729 A ARP980100729 A AR P980100729A AR P980100729 A ARP980100729 A AR P980100729A AR 011153 A1 AR011153 A1 AR 011153A1
- Authority
- AR
- Argentina
- Prior art keywords
- medicinal product
- phenyl
- atoms
- substituted
- imidazolyl
- Prior art date
Links
- VZWXIQHBIQLMPN-UHFFFAOYSA-N chromane Chemical group C1=CC=C2CCCOC2=C1 VZWXIQHBIQLMPN-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000032 diagnostic agent Substances 0.000 title abstract 2
- 229940039227 diagnostic agent Drugs 0.000 title abstract 2
- 229940124530 sulfonamide Drugs 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 2
- 150000003456 sulfonamides Chemical group 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000002883 imidazolyl group Chemical group 0.000 abstract 3
- 125000004076 pyridyl group Chemical group 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000001544 thienyl group Chemical group 0.000 abstract 3
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 230000005764 inhibitory process Effects 0.000 abstract 2
- 125000005004 perfluoroethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 abstract 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 206010012735 Diarrhoea Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010030216 Oesophagitis Diseases 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000006881 esophagitis Diseases 0.000 abstract 1
- 230000027119 gastric acid secretion Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000005009 perfluoropropyl group Chemical group FC(C(C(F)(F)F)(F)F)(F)* 0.000 abstract 1
- 125000005936 piperidyl group Chemical group 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000565 sulfonamide group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- 231100000397 ulcer Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
Abstract
Derivados de cromano sustituido con sulfonamida que comprenden la formula (I), en la que significan: R(1) y R(2) tal como figuran en lareivindicacion 1 y R(2) son tal como figura en la cláusula 1; R(3) R(9)-CnH2n[N R(11)]m-; R(9) eshidroge no o cicloalquilo con 3,4,5,6,7 u 8 átomos de C; n, mR(11) y R(9) son tal como figuran en la memoria descriptiva; R(4), R(12)-CrH2r; R(12) es hidrogeno, cicloalquilo con 3,4,5,6,7 u 8 átomos de C, piperidilo,1-pirrolidinilo, N-morfolino,N-metil-pipe razino, CF3, C2F5, C3F7, piridilo, tienilo, imidazolilo o fenilo, estando los piridilo, tienilo, imidazolilo ofenilo, estando los piridilo, tienilo, imidazolilo o fenilo sin sustuir o sustituidos con 1 o 2 sustituyentes talcomo figura en la memoria descriptiva;r es tal como figura en la memoria descriptiva; R(5), R(6),R(7) y R(8) son independientemente unos de otros, hidrogeno, F, Cl, Br, I, alquilo con 1,2,3,4,5, o 6 átomos de C, cicloalquilo con 3,4,5,6,7 u 8átomos de C, -CN, - CF3, C2F5, -C3F7, -N3, -NO2, -CONR(13)R(14), -COOR(15), R(16)-CsH2s-Y- o fenilo, queestá sin sustituir o sustituido con 1 o 2 sustiuyentes tal como figura en la memoria descriptiva; R(13), R(14) y R(15), s, Y son tal comofiguran en lamemoria descriptiva, pero con la condicion de que dos de los sustituyentes R(5) , R(6),R(7) y R(8) no han de ser hidrogeno; y sus sales fisiologicamentecompatibles; su utilizacion como medicamento o agente de diagnostico, así comomedicamento que los conti ene destinado al tratamiento y a la inhibicion ycontrol de todos los tipos de arritmias, al bloqueo del canal de K+, a la inhibicion de secrecion de ácidos gástricos, al tratamiento de ulceras yreflujo-esofagitis, altratamiento de enfermedades de diarrea.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19706675A DE19706675A1 (de) | 1997-02-20 | 1997-02-20 | Sulfonamid-substituierte Chromane, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR011153A1 true AR011153A1 (es) | 2000-08-02 |
Family
ID=7820907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980100729A AR011153A1 (es) | 1997-02-20 | 1998-02-18 | Derivados de cromano sustituido con sulfonamida, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que los contiene |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6071953A (es) |
| EP (1) | EP0860440A1 (es) |
| JP (1) | JPH10231293A (es) |
| KR (1) | KR19980071530A (es) |
| CN (1) | CN1194982A (es) |
| AR (1) | AR011153A1 (es) |
| AU (1) | AU5539798A (es) |
| BR (1) | BR9800708A (es) |
| CA (1) | CA2229947A1 (es) |
| CZ (1) | CZ48598A3 (es) |
| DE (1) | DE19706675A1 (es) |
| HR (1) | HRP980086A2 (es) |
| HU (1) | HUP9800374A3 (es) |
| IL (1) | IL123360A0 (es) |
| NO (1) | NO980694L (es) |
| NZ (1) | NZ329788A (es) |
| PL (1) | PL324942A1 (es) |
| SK (1) | SK20998A3 (es) |
| TR (1) | TR199800253A2 (es) |
| TW (1) | TW474929B (es) |
| ZA (1) | ZA981376B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0895994A3 (de) * | 1997-08-05 | 1999-12-15 | Hoechst Marion Roussel Deutschland GmbH | Sulfonamid-substituierte Pyranopyridine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19742509A1 (de) * | 1997-09-26 | 1999-04-01 | Hoechst Marion Roussel De Gmbh | Sulfonamid-substituierte Chromane, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen |
| DE19742508A1 (de) | 1997-09-26 | 1999-04-01 | Hoechst Marion Roussel De Gmbh | Sulfonamid-substituierte Chromane, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen |
| DE19748469A1 (de) * | 1997-11-03 | 1999-05-06 | Hoechst Marion Roussel De Gmbh | Sulfonamid-substituierte Benzopyranderivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| WO2000014084A1 (en) * | 1998-09-04 | 2000-03-16 | The Procter & Gamble Company | Substituted dihydrobenzopyrans useful as antiarrhythmic agents |
| DE19858253A1 (de) * | 1998-12-17 | 2000-06-21 | Aventis Pharma Gmbh | Verwendung von Inhibitoren des KQt1-Kanals zur Herstellung eines Medikaments zur Behandlung von Krankheiten, die durch Helminthen und Ektoparasiten hervorgerufen werden |
| AU2830800A (en) * | 1999-03-25 | 2000-10-16 | Nissan Chemical Industries Ltd. | Chroman derivatives |
| TW200403058A (en) * | 2002-04-19 | 2004-03-01 | Bristol Myers Squibb Co | Heterocyclo inhibitors of potassium channel function |
| US7368582B2 (en) | 2003-10-17 | 2008-05-06 | Solvay Pharmaceuticals Gmbh | Amidomethyl-substituted 2-(4-sulfonylamino)-3-hydroxy-3,4-dihydro-2H-chromen-6-yl compounds, a process and intermediates for their production, and pharmaceutical compositions containing them |
| WO2012012473A1 (en) | 2010-07-19 | 2012-01-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Use of delta tocopherol for the treatment of lysosomal storage disorders |
| JP6367211B2 (ja) | 2012-11-16 | 2018-08-01 | ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | リソソーム蓄積症の改善物質としてのトコフェロール誘導体およびトコフェリルキノン誘導体 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0279803B1 (fr) * | 1987-02-13 | 1991-09-18 | CENTRE DE RECHERCHES METALLURGIQUES CENTRUM VOOR RESEARCH IN DE METALLURGIE Association sans but lucratif | Installation pour la fabrication en continu d'une feuille métallique extra-mince par dépôt électrolytique |
| FR2639349B1 (fr) * | 1988-11-23 | 1991-02-22 | Sanofi Sa | Nouveaux derives du chromane actifs sur le systeme nerveux central, leur procede de preparation et les compositions pharmaceutiques en contenant |
| US5104890A (en) * | 1989-03-28 | 1992-04-14 | Fujisawa Pharmaceutical Company, Ltd. | Benzopyran derivatives and processes for preparation thereof |
| US5382587A (en) * | 1993-06-30 | 1995-01-17 | Merck & Co., Inc. | Spirocycles |
| EP0807629B1 (de) * | 1996-05-15 | 2004-03-03 | Aventis Pharma Deutschland GmbH | Sulfonamid-substituierte Chromane, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
-
1997
- 1997-02-20 DE DE19706675A patent/DE19706675A1/de not_active Withdrawn
-
1998
- 1998-02-16 EP EP98102621A patent/EP0860440A1/de not_active Withdrawn
- 1998-02-18 NZ NZ329788A patent/NZ329788A/xx unknown
- 1998-02-18 TR TR1998/00253A patent/TR199800253A2/xx unknown
- 1998-02-18 CZ CZ98485A patent/CZ48598A3/cs unknown
- 1998-02-18 SK SK209-98A patent/SK20998A3/sk unknown
- 1998-02-18 AR ARP980100729A patent/AR011153A1/es unknown
- 1998-02-19 HR HR19706675.5A patent/HRP980086A2/hr not_active Application Discontinuation
- 1998-02-19 ZA ZA981376A patent/ZA981376B/xx unknown
- 1998-02-19 BR BR9800708A patent/BR9800708A/pt not_active IP Right Cessation
- 1998-02-19 US US09/026,513 patent/US6071953A/en not_active Expired - Fee Related
- 1998-02-19 CA CA002229947A patent/CA2229947A1/en not_active Abandoned
- 1998-02-19 AU AU55397/98A patent/AU5539798A/en not_active Abandoned
- 1998-02-19 IL IL12336098A patent/IL123360A0/xx unknown
- 1998-02-19 NO NO980694A patent/NO980694L/no not_active Application Discontinuation
- 1998-02-19 CN CN98108030A patent/CN1194982A/zh active Pending
- 1998-02-19 JP JP10037116A patent/JPH10231293A/ja active Pending
- 1998-02-20 PL PL98324942A patent/PL324942A1/xx unknown
- 1998-02-20 KR KR1019980005252A patent/KR19980071530A/ko not_active Withdrawn
- 1998-02-20 HU HU9800374A patent/HUP9800374A3/hu unknown
- 1998-03-23 TW TW087102218A patent/TW474929B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| NO980694D0 (no) | 1998-02-19 |
| DE19706675A1 (de) | 1998-08-27 |
| HRP980086A2 (en) | 1998-10-31 |
| JPH10231293A (ja) | 1998-09-02 |
| CZ48598A3 (cs) | 1998-09-16 |
| HU9800374D0 (en) | 1998-04-28 |
| BR9800708A (pt) | 1999-07-20 |
| TW474929B (en) | 2002-02-01 |
| KR19980071530A (ko) | 1998-10-26 |
| AU5539798A (en) | 1998-08-27 |
| HUP9800374A3 (en) | 2001-02-28 |
| PL324942A1 (en) | 1998-08-31 |
| CA2229947A1 (en) | 1998-08-20 |
| EP0860440A1 (de) | 1998-08-26 |
| HUP9800374A2 (en) | 2000-07-28 |
| IL123360A0 (en) | 1998-09-24 |
| SK20998A3 (en) | 1998-10-07 |
| TR199800253A2 (xx) | 1998-09-21 |
| NZ329788A (en) | 1999-06-29 |
| US6071953A (en) | 2000-06-06 |
| CN1194982A (zh) | 1998-10-07 |
| ZA981376B (en) | 1998-08-20 |
| NO980694L (no) | 1998-08-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |