AR011125A1 - Procedimiento para preparar eprosartano - Google Patents
Procedimiento para preparar eprosartanoInfo
- Publication number
- AR011125A1 AR011125A1 ARP980100585A ARP980100585A AR011125A1 AR 011125 A1 AR011125 A1 AR 011125A1 AR P980100585 A ARP980100585 A AR P980100585A AR P980100585 A ARP980100585 A AR P980100585A AR 011125 A1 AR011125 A1 AR 011125A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- formula
- eprosartan
- preparation
- pharmaceutically acceptable
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 3
- 239000002080 C09CA02 - Eprosartan Substances 0.000 abstract 2
- OROAFUQRIXKEMV-LDADJPATSA-N eprosartan Chemical compound C=1C=C(C(O)=O)C=CC=1CN1C(CCCC)=NC=C1\C=C(C(O)=O)/CC1=CC=CS1 OROAFUQRIXKEMV-LDADJPATSA-N 0.000 abstract 2
- 229960004563 eprosartan Drugs 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000001647 Renal Insufficiency Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 abstract 1
- 229940126317 angiotensin II receptor antagonist Drugs 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 201000006370 kidney failure Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Un procedimiento para la preparacion de eprosartano, un compuesto de formula (I): o una de sus sales farmacéuticamente aceptables, que comprendehacer reaccionar un compuesto de formul (II): o una de sus sales de adicion de ácidos o bases conun compuesto de formula (III): en la que R es alquilo C1-C4a presion reducida en presencia de un catalizador y, después de esto, hidrolizar el éster R y opcionalmente formar una sal farmacéuticamenteaceptable. Este compuesto es unantagonis ta del receptor de la angiotensina II util en el tratamiento de la hipertension, insuficiencia cardíaca congestiva einsuficiencia renal. Además se describe un procedimiento alternativo para la preparacion de eprosartano.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3819597P | 1997-02-14 | 1997-02-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR011125A1 true AR011125A1 (es) | 2000-08-02 |
Family
ID=21898583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980100585A AR011125A1 (es) | 1997-02-14 | 1998-02-10 | Procedimiento para preparar eprosartano |
Country Status (41)
| Country | Link |
|---|---|
| US (1) | US6172237B1 (es) |
| EP (1) | EP0970073B1 (es) |
| JP (1) | JP4537499B2 (es) |
| KR (1) | KR100573638B1 (es) |
| CN (1) | CN1085208C (es) |
| AP (1) | AP1128A (es) |
| AR (1) | AR011125A1 (es) |
| AT (1) | ATE280765T1 (es) |
| AU (1) | AU730383B2 (es) |
| BG (1) | BG63804B1 (es) |
| BR (1) | BR9808664A (es) |
| CA (1) | CA2281708C (es) |
| CO (1) | CO4950550A1 (es) |
| CY (1) | CY2555B1 (es) |
| CZ (1) | CZ296349B6 (es) |
| DE (1) | DE69827240T2 (es) |
| DK (1) | DK0970073T3 (es) |
| EA (1) | EA001659B1 (es) |
| EG (1) | EG23935A (es) |
| ES (1) | ES2231963T3 (es) |
| HU (1) | HU228781B1 (es) |
| ID (1) | ID23181A (es) |
| IL (1) | IL131309A (es) |
| IN (2) | IN187999B (es) |
| MA (1) | MA24470A1 (es) |
| MY (1) | MY118704A (es) |
| NO (1) | NO317194B1 (es) |
| NZ (1) | NZ337180A (es) |
| OA (1) | OA11146A (es) |
| PE (1) | PE59299A1 (es) |
| PL (1) | PL192838B1 (es) |
| PT (1) | PT970073E (es) |
| RO (1) | RO119719B1 (es) |
| SA (1) | SA98190082B1 (es) |
| SI (1) | SI0970073T1 (es) |
| SK (1) | SK285036B6 (es) |
| TR (1) | TR199901936T2 (es) |
| TW (1) | TW399050B (es) |
| UA (1) | UA54487C2 (es) |
| WO (1) | WO1998035963A1 (es) |
| ZA (1) | ZA981207B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2097408A4 (en) * | 2006-12-27 | 2010-08-25 | Hetero Drugs Ltd | IMPROVED PROCESS FOR THE PREPARATION OF EPROSARTAN |
| EP2295431A3 (en) * | 2007-07-25 | 2011-08-03 | Hetero Drugs Limited | Substantially pure eprosartan free base |
| US8361507B2 (en) * | 2007-07-25 | 2013-01-29 | Hetero Drugs Limited | Eprosartan mesylate crystalline particles and a process for preparing pure eprosartan |
| WO2009084028A2 (en) * | 2007-12-03 | 2009-07-09 | Neuland Laboratories Ltd | Improved process for manufacturing anhydrous (e)-3-[2-butyl-1- {(4-carboxyphenyl) methyl}-1h-imidazole-5-yl]-(thiophen-2- ylmethyl)prop-2-enoic acid methane sulfonate |
| CN101215284B (zh) * | 2007-12-31 | 2010-10-13 | 浙江华海药业股份有限公司 | 一种改进的依普罗沙坦的制备方法 |
| WO2009122421A2 (en) * | 2008-03-31 | 2009-10-08 | Hetero Research Foundation | Improved process for eprosartan intermediate |
| WO2010023688A2 (en) * | 2008-08-25 | 2010-03-04 | Matrix Laboratories Limited | An improved process for the preparation of eprosartan |
| WO2011004384A2 (en) | 2009-06-05 | 2011-01-13 | Glochem Industries Limited | Process for the preparation of eprosartan |
| WO2011051975A1 (en) | 2009-10-30 | 2011-05-05 | Matrix Laboratories Ltd | An improved process for the preparation of pure eprosartanand its pharmaceutical acceptable salts |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5185351A (en) * | 1989-06-14 | 1993-02-09 | Smithkline Beecham Corporation | Imidazolyl-alkenoic acids useful as angiotensin II receptor antagonists |
| NZ239161A (en) * | 1990-07-31 | 1994-01-26 | Smithkline Beecham Corp | Substituted [1h-imidazol-5-yl] alkanoic acid derivatives; medicaments, |
| WO1992010189A1 (en) * | 1990-12-14 | 1992-06-25 | Smithkline Beecham Corporation | Imidazolyl-alkenoic acids |
| US5395847A (en) * | 1993-12-02 | 1995-03-07 | Smithkline Beecham Corporation | Imidazolyl-alkenoic acids |
| US5719293A (en) * | 1994-05-20 | 1998-02-17 | Smithkline Beecham Corporation | Intermediate for preparing a pharmaceutically active compound |
-
1998
- 1998-02-10 AR ARP980100585A patent/AR011125A1/es active IP Right Grant
- 1998-02-11 EG EG15598A patent/EG23935A/xx active
- 1998-02-12 PE PE1998000101A patent/PE59299A1/es not_active Application Discontinuation
- 1998-02-12 IN IN360DE1998 patent/IN187999B/en unknown
- 1998-02-12 MA MA24961A patent/MA24470A1/fr unknown
- 1998-02-12 MY MYPI98000577A patent/MY118704A/en unknown
- 1998-02-13 AT AT98906229T patent/ATE280765T1/de active
- 1998-02-13 PT PT98906229T patent/PT970073E/pt unknown
- 1998-02-13 DK DK98906229T patent/DK0970073T3/da active
- 1998-02-13 ES ES98906229T patent/ES2231963T3/es not_active Expired - Lifetime
- 1998-02-13 RO RO99-00885A patent/RO119719B1/ro unknown
- 1998-02-13 CN CN98802484A patent/CN1085208C/zh not_active Expired - Fee Related
- 1998-02-13 UA UA99084635A patent/UA54487C2/uk unknown
- 1998-02-13 CO CO98007700A patent/CO4950550A1/es unknown
- 1998-02-13 US US09/355,185 patent/US6172237B1/en not_active Expired - Lifetime
- 1998-02-13 WO PCT/US1998/002412 patent/WO1998035963A1/en not_active Ceased
- 1998-02-13 TR TR1999/01936T patent/TR199901936T2/xx unknown
- 1998-02-13 PL PL335075A patent/PL192838B1/pl unknown
- 1998-02-13 JP JP52813798A patent/JP4537499B2/ja not_active Expired - Fee Related
- 1998-02-13 CZ CZ0285299A patent/CZ296349B6/cs not_active IP Right Cessation
- 1998-02-13 EA EA199900740A patent/EA001659B1/ru not_active IP Right Cessation
- 1998-02-13 AP APAP/P/1999/001620A patent/AP1128A/en active
- 1998-02-13 ZA ZA981207A patent/ZA981207B/xx unknown
- 1998-02-13 BR BR9808664-2A patent/BR9808664A/pt not_active IP Right Cessation
- 1998-02-13 CA CA002281708A patent/CA2281708C/en not_active Expired - Fee Related
- 1998-02-13 SK SK1087-99A patent/SK285036B6/sk not_active IP Right Cessation
- 1998-02-13 HU HU0001994A patent/HU228781B1/hu not_active IP Right Cessation
- 1998-02-13 DE DE69827240T patent/DE69827240T2/de not_active Expired - Lifetime
- 1998-02-13 NZ NZ337180A patent/NZ337180A/xx unknown
- 1998-02-13 EP EP98906229A patent/EP0970073B1/en not_active Expired - Lifetime
- 1998-02-13 ID IDW990839A patent/ID23181A/id unknown
- 1998-02-13 AU AU61508/98A patent/AU730383B2/en not_active Ceased
- 1998-02-13 KR KR1019997007273A patent/KR100573638B1/ko not_active Expired - Fee Related
- 1998-02-13 IL IL13130998A patent/IL131309A/en not_active IP Right Cessation
- 1998-02-13 SI SI9830722T patent/SI0970073T1/xx unknown
- 1998-04-15 TW TW087101969A patent/TW399050B/zh not_active IP Right Cessation
- 1998-05-24 SA SA98190082A patent/SA98190082B1/ar unknown
-
1999
- 1999-08-10 BG BG103650A patent/BG63804B1/bg unknown
- 1999-08-13 NO NO19993913A patent/NO317194B1/no not_active IP Right Cessation
- 1999-08-13 OA OA9900179A patent/OA11146A/en unknown
-
2002
- 2002-01-28 IN IN58DE2002 patent/IN192743B/en unknown
-
2006
- 2006-04-07 CY CY0600011A patent/CY2555B1/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |