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CR7074A - Derivados de mercaptoacetylamida y proceso para su preparacion y uso - Google Patents

Derivados de mercaptoacetylamida y proceso para su preparacion y uso

Info

Publication number
CR7074A
CR7074A CR7074A CR7074A CR7074A CR 7074 A CR7074 A CR 7074A CR 7074 A CR7074 A CR 7074A CR 7074 A CR7074 A CR 7074A CR 7074 A CR7074 A CR 7074A
Authority
CR
Costa Rica
Prior art keywords
compounds
inhibitory activity
heart failure
relates
present
Prior art date
Application number
CR7074A
Other languages
English (en)
Inventor
A Flynn Gary
Mehdi Shujaath
Roger Koehl Jack
Ann Anderson Barbara
Gerken Manfred
Jablonka Bernd
Kleeman Heinz-Werner
Linz Wolfgang
Seiz Werner
Seuring Bernhard
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of CR7074A publication Critical patent/CR7074A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invencion se refiere a nuevos compuestos que poseen tanto actividad inhibidora de la enzima convertidota de angiotensina, como actividad inhibidora de la endopeptidasa neutra, y a metodos para preparar dichos compuestos. La presente invencion se refiere asi mismo a composiciones farmaceuticas que contienen dichos compuestos inhibidores dobles o sus sales farmaceuticamente aceptables y a su uso en la fabricacion de medicamentos usados en la insuficiencia cardiaca, para reducir la mortalidad en pacientes con insuficiencia cardiaca (ICC) o con disfuncion ventricular izquierda, tras un infarto del miocardio, insuficiencia renal, hipertension esencial y la cirrosis.
CR7074A 2001-04-12 2003-09-12 Derivados de mercaptoacetylamida y proceso para su preparacion y uso CR7074A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28330501P 2001-04-12 2001-04-12
GBGB0119305.1A GB0119305D0 (en) 2001-04-12 2001-08-08 Mercaptoacetylamide derivatives,a process for their preparation and their use

Publications (1)

Publication Number Publication Date
CR7074A true CR7074A (es) 2007-12-04

Family

ID=23085405

Family Applications (1)

Application Number Title Priority Date Filing Date
CR7074A CR7074A (es) 2001-04-12 2003-09-12 Derivados de mercaptoacetylamida y proceso para su preparacion y uso

Country Status (17)

Country Link
US (1) US6602866B2 (es)
KR (1) KR100910929B1 (es)
AR (1) AR034307A1 (es)
CR (1) CR7074A (es)
DK (1) DK1381605T3 (es)
EC (1) ECSP034782A (es)
GB (1) GB0119305D0 (es)
GT (1) GT200200069A (es)
IL (1) IL158289A (es)
MY (1) MY128226A (es)
PE (1) PE20021079A1 (es)
RS (1) RS50919B (es)
TN (1) TNSN03083A1 (es)
TW (1) TWI319764B (es)
UA (1) UA75647C2 (es)
UY (1) UY27255A1 (es)
ZA (1) ZA200307096B (es)

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US8449890B2 (en) 2011-02-17 2013-05-28 Theravance, Inc. Neprilysin inhibitors
CA2835216A1 (en) 2011-05-31 2012-12-06 Theravance, Inc. Neprilysin inhibitors
CN103582630B (zh) 2011-05-31 2016-08-17 施万生物制药研发Ip有限责任公司 脑啡肽酶抑制剂
WO2012166389A1 (en) 2011-05-31 2012-12-06 Theravance, Inc. Neprilysin inhibitors
TWI560172B (en) 2011-11-02 2016-12-01 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
CN104350052B (zh) 2012-05-31 2017-05-31 施万生物制药研发Ip有限责任公司 一氧化氮供体脑啡肽酶抑制剂
KR102102197B1 (ko) 2012-06-08 2020-04-20 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 네프릴리신 억제제
EP2858650B1 (en) 2012-06-08 2018-11-14 Theravance Biopharma R&D IP, LLC Neprilysin inhibitors
EP2882716B9 (en) 2012-08-08 2018-12-26 Theravance Biopharma R&D IP, LLC Neprilysin inhibitors
RS56300B1 (sr) 2013-03-05 2017-12-29 Theravance Biopharma R&D Ip Llc Inhibitori neprilizina
KR20160113291A (ko) 2014-01-30 2016-09-28 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 네프리리신 저해제
US9585882B2 (en) 2014-01-30 2017-03-07 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
BR112017017317B1 (pt) 2015-02-11 2023-02-14 Theravance Biopharma R&D Ip, Llc Composto, forma cristalina, composições farmacêuticas, forma de dosagem oral ou intravenosa, processos para a preparação do composto ou da forma cristalina e uso
KR102573351B1 (ko) 2015-02-19 2023-09-01 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 (2r, 4r)-5-(5'-클로로-2'-플루오로비페닐-4-일)-2-히드록시-4-[(5-메틸옥사졸-2-카르보닐)아미노]펜타노익산
JP7306828B2 (ja) 2016-03-08 2023-07-11 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー 結晶性（２ｓ，４ｒ）－５－（５’－クロロ－２’－フルオロ－［１，１’－ビフェニル］－４－イル）－２－（エトキシメチル）－４－（３－ヒドロキシイソオキサゾール－５－カルボキサミド）－２－メチルペンタン酸およびその使用

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Also Published As

Publication number Publication date
RS50919B (sr) 2010-08-31
PE20021079A1 (es) 2003-02-19
GB0119305D0 (en) 2001-10-03
IL158289A (en) 2010-11-30
ECSP034782A (es) 2003-12-01
US20020193589A1 (en) 2002-12-19
YU78703A (sh) 2006-05-25
TNSN03083A1 (en) 2005-12-23
ZA200307096B (en) 2004-09-06
UA75647C2 (en) 2006-05-15
TWI319764B (en) 2010-01-21
GT200200069A (es) 2002-12-17
MY128226A (en) 2007-01-31
UY27255A1 (es) 2002-07-31
DK1381605T3 (da) 2005-05-09
KR20040008153A (ko) 2004-01-28
KR100910929B1 (ko) 2009-08-06
US6602866B2 (en) 2003-08-05
AR034307A1 (es) 2004-02-18

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)