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AR019669A1 - Uso de diazepinas para la preparacion de medicamentos para el tratamiento de estados patologicos o enfermedades en los cuales esta involucrado por lo menosuno de los receptores de somatostatina, diazepinas utilizadas en dicha preparacion y medicamento y composicion farmaceutica que los contienen. - Google Patents

Uso de diazepinas para la preparacion de medicamentos para el tratamiento de estados patologicos o enfermedades en los cuales esta involucrado por lo menosuno de los receptores de somatostatina, diazepinas utilizadas en dicha preparacion y medicamento y composicion farmaceutica que los contienen.

Info

Publication number
AR019669A1
AR019669A1 ARP990102861A ARP990102861A AR019669A1 AR 019669 A1 AR019669 A1 AR 019669A1 AR P990102861 A ARP990102861 A AR P990102861A AR P990102861 A ARP990102861 A AR P990102861A AR 019669 A1 AR019669 A1 AR 019669A1
Authority
AR
Argentina
Prior art keywords
radical
aryl
hydrogen atom
preparation
alkyl
Prior art date
Application number
ARP990102861A
Other languages
English (en)
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Publication of AR019669A1 publication Critical patent/AR019669A1/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/22Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Oncology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Uso para la preparacion de medicamentos para el tratamiento de estados patologicos o enfermedades en los cuales está involucrado por lo menos uno de losreceptores de somatostatina, de diazepinas de formula general (1) en el cual W representa el átomode hidrogeno o un radical de formula R-X-C(Y), R representaun radical arilo o heteroarilo, estando los radicales arilo y heteroarilo sustituidos optativamente; X representa un radical de formula -(CH2)n-Z en el cual Zrepresenta un enlace covalente,NH, O o S y n es un entero de 0 y 2; Y representa O o S, R1 representa uno o más grupos idénticos o diferentes, elegidos entre:un átomo de hidrogeno, hidroxi, un radical halo, un radical alquilo inferior y alcoxi inferior; R2a y R2b representan, independientemente, un átomo dehidrogeno; un radical alquilo inferior, alquenilo inferior o alquinilo inferior, estando los radicales alquilo, alquenilo y alquinilo optativamente sustituidoso un radical R21Z21- en el cual Z21 representa O, C(O), OC(O), S, R21 representa un átomo de hidrogeno, un radical alquilo, arilo o arilalquilo inferior; R3representa un átomo de hidrogeno, un radical halo, nitro o ciano, un radical alquilo con 1 a 10 átomos de carbono, radicales alquenilo inferior, alquiniloinferior, cicloalquilo, cicloalquilalquilo, arilo, arilalquilo, ariloxialquilo inferior, heteroarilo o heteroarilalquilo, estando los radicales alquilo,alquenilo, alquilo, cicloalquilo, arilo y heteroarilo optativamente sustituidos; o un radical R31Z31-en el cual Z31 representa O, C(O), OC(O), S, y R31representa un átomo de hidrogeno, un radical alquilo inferior, arilo o arilalquilo inferior , o una sal de este producto, para la preparacion de un medicamentopara tratar estados patologicos o enfermedades en las cuales están involucrados uno (o más) receptores de somatostatina. Dado que los desordenes patologicosasociados con la somatostatina son numerosos, resulto importante hallar compuesto que tengan afinidad con receptores de somatostatina.Como nuevos compuestoscomprendidos por la formula (1), se encuentran los de la formula general (2) en la cual W representa el átomo de hidrogeno o un radical de formula
ARP990102861A 1998-06-15 1999-06-15 Uso de diazepinas para la preparacion de medicamentos para el tratamiento de estados patologicos o enfermedades en los cuales esta involucrado por lo menosuno de los receptores de somatostatina, diazepinas utilizadas en dicha preparacion y medicamento y composicion farmaceutica que los contienen. AR019669A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9807509A FR2779652B1 (fr) 1998-06-15 1998-06-15 Utilisation de diazepines pour la preparation de medicaments destines a traiter les etats pathologiques ou les maladies dans lesquels un des recepteurs de la somatostatine est implique

Publications (1)

Publication Number Publication Date
AR019669A1 true AR019669A1 (es) 2002-03-13

Family

ID=9527389

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990102861A AR019669A1 (es) 1998-06-15 1999-06-15 Uso de diazepinas para la preparacion de medicamentos para el tratamiento de estados patologicos o enfermedades en los cuales esta involucrado por lo menosuno de los receptores de somatostatina, diazepinas utilizadas en dicha preparacion y medicamento y composicion farmaceutica que los contienen.

Country Status (19)

Country Link
US (1) US7015213B1 (es)
EP (1) EP1087978A1 (es)
JP (1) JP2002518400A (es)
KR (1) KR20010052836A (es)
CN (1) CN100348600C (es)
AR (1) AR019669A1 (es)
AU (1) AU758206B2 (es)
CA (1) CA2335724A1 (es)
FR (1) FR2779652B1 (es)
HK (1) HK1039780A1 (es)
HU (1) HUP0102300A3 (es)
IL (1) IL139954A0 (es)
MY (1) MY118652A (es)
NO (1) NO20006352L (es)
NZ (1) NZ509313A (es)
PL (1) PL344831A1 (es)
RU (1) RU2229299C2 (es)
TW (1) TW513434B (es)
WO (1) WO1999065917A1 (es)

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JP5478262B2 (ja) * 2007-12-28 2014-04-23 田辺三菱製薬株式会社 抗癌剤
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RU2722179C2 (ru) * 2014-02-28 2020-05-28 Тэнша Терапеутикс, Инк. Лечение состояний, ассоциированных с гиперинсулинемией
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KR20180049058A (ko) 2015-09-11 2018-05-10 다나-파버 캔서 인스티튜트 인크. 시아노 티에노트리아졸로디아제핀 및 그의 용도
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Also Published As

Publication number Publication date
EP1087978A1 (fr) 2001-04-04
FR2779652A1 (fr) 1999-12-17
HUP0102300A2 (hu) 2001-11-28
FR2779652B1 (fr) 2001-06-08
NO20006352D0 (no) 2000-12-13
CA2335724A1 (fr) 1999-12-23
WO1999065917A1 (fr) 1999-12-23
RU2229299C2 (ru) 2004-05-27
CN100348600C (zh) 2007-11-14
US7015213B1 (en) 2006-03-21
NO20006352L (no) 2000-12-13
HK1039780A1 (zh) 2002-05-10
JP2002518400A (ja) 2002-06-25
KR20010052836A (ko) 2001-06-25
PL344831A1 (en) 2001-11-19
CN1309657A (zh) 2001-08-22
AU4149599A (en) 2000-01-05
NZ509313A (en) 2002-11-26
HUP0102300A3 (en) 2002-10-28
MY118652A (en) 2004-12-31
AU758206B2 (en) 2003-03-20
TW513434B (en) 2002-12-11
IL139954A0 (en) 2002-02-10

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