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AR018303A1 - DERIVADOS DE AZOLES, PROCESO PARA SU FABRICACIoN, SU USO PARA LA PREPARACION DE UN MEDICAMENTO PARA EL TRATAMIENTO DE INFECIONES FUNGALES Y MICOSIS. - Google Patents

DERIVADOS DE AZOLES, PROCESO PARA SU FABRICACIoN, SU USO PARA LA PREPARACION DE UN MEDICAMENTO PARA EL TRATAMIENTO DE INFECIONES FUNGALES Y MICOSIS.

Info

Publication number
AR018303A1
AR018303A1 ARP990100912A ARP990100912A AR018303A1 AR 018303 A1 AR018303 A1 AR 018303A1 AR P990100912 A ARP990100912 A AR P990100912A AR P990100912 A ARP990100912 A AR P990100912A AR 018303 A1 AR018303 A1 AR 018303A1
Authority
AR
Argentina
Prior art keywords
azoles
formula
treatment
fungal infections
compounds
Prior art date
Application number
ARP990100912A
Other languages
English (en)
Original Assignee
Basilea Pharmaceutica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica Ag filed Critical Basilea Pharmaceutica Ag
Publication of AR018303A1 publication Critical patent/AR018303A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Derivados de azol de formula (I), en los que R14 y R15 son cada uno independientemente hidrogeno o fluor, T es un grupo de formula (T1) o (T2), en la queR9 es pirrolidinilo o un grupo A-NH-B-; A es hidrogeno o alquilo C1-5 de cadena lineal o ramificada, B es alquileno C1-4 de cadena lineal o ramificada, -CH2-CONH-CH2 o -CH2CH2CH2-CH(NH2); y X- es un anion farmacéuticamente aceptable; y sales farmacéuticamente aceptables de dichos compuestos, e hidratos y solvatosde los compuestos de formula (I)y las sales de los mismos; composicion antifungica que los contiene, proceso para su fabricacion y su uso en la produccion demedicamentos para el tratamiento de infecciones fungicas y micosis. Los nuevos azoles de la formula (I) anterior tienen menorsusceptibilidad a la interaccionmetabolica, lo cual constituye una clara ventaja clínica. Los azoles de formula (I) en los que T es un grupo T1 son compuestos solubles en agua utiles para eltratamiento de micosis sistémicas, y son adecuados tanto para la administracion oral como en particular para la administracion parenteral. De estemodo, los azoles se destinan para la terapia de las infecciones fungicas y micosis, que comprende la administracion al organismo infectado de una cantidadefectivade los nuevos compuestos de azol.
ARP990100912A 1998-03-06 1999-03-04 DERIVADOS DE AZOLES, PROCESO PARA SU FABRICACIoN, SU USO PARA LA PREPARACION DE UN MEDICAMENTO PARA EL TRATAMIENTO DE INFECIONES FUNGALES Y MICOSIS. AR018303A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98104036 1998-03-06
EP98123310 1998-12-08
EP99101360 1999-01-26

Publications (1)

Publication Number Publication Date
AR018303A1 true AR018303A1 (es) 2001-11-14

Family

ID=27239027

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990100912A AR018303A1 (es) 1998-03-06 1999-03-04 DERIVADOS DE AZOLES, PROCESO PARA SU FABRICACIoN, SU USO PARA LA PREPARACION DE UN MEDICAMENTO PARA EL TRATAMIENTO DE INFECIONES FUNGALES Y MICOSIS.

Country Status (6)

Country Link
US (1) US6300353B1 (es)
AR (1) AR018303A1 (es)
AU (1) AU2931399A (es)
MA (1) MA27677A1 (es)
PE (1) PE20000328A1 (es)
WO (1) WO1999045008A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6812238B1 (en) 1999-11-02 2004-11-02 Basilea Pharmaceutica Ag N-substituted carbamoyloxyalkyl-azolium derivatives
KR100449797B1 (ko) * 1999-11-02 2004-09-30 바실리어 파마슈티카 아게 Ｎ-치환된 카바모일옥시알킬-아졸리움 유도체
HUP0303249A3 (en) 2001-02-22 2007-03-28 Sankyo Co Water-soluble triazole fungicide compounds and pharmaceutical compositions containing them
AU2002351388A1 (en) 2001-12-14 2003-06-30 The University Of Wyoming Methods and compositions for controlled release of drugs
US7582781B2 (en) 2003-07-18 2009-09-01 Kaneka Corporation Optically active halohydrin derivative and process for producing optically active epoxy alcohol derivative from the same
JP4404611B2 (ja) * 2003-11-27 2010-01-27 住友化学株式会社 エポキシトリアゾール化合物の製造方法及びその中間体
DE102004059725A1 (de) 2004-12-11 2006-06-22 Bayer Cropscience Ag 2-Alkyl-cycloalk(en)yl-carboxamide
PL1954264T3 (pl) * 2005-12-01 2010-02-26 Basilea Pharmaceutica Ag Sposób wytwarzania epoksybutanolowych związków pośrednich
CA2697328C (en) 2007-08-21 2015-08-11 Basilea Pharmaceutica Ag Antifungal composition
US8207352B2 (en) * 2009-10-08 2012-06-26 Drug Process Licensing Associates LLC Process for the manufacture of enantiomerically pure antifungal azoles as ravuconazole and isavuconazole
WO2014023623A1 (en) 2012-08-07 2014-02-13 Basilea Pharmaceutica Ag Process for the manufacture of isavuconazole or ravuconazole
WO2015150947A1 (en) * 2014-03-29 2015-10-08 Wockhardt Limited A process for the preparation of isavuconazole and its intermediates
WO2016055918A1 (en) 2014-10-08 2016-04-14 Wockhardt Limited Novel stable polymorphs of isavuconazole or its salt thereof
CN106565699B (zh) * 2015-10-10 2019-07-26 江苏正大丰海制药有限公司 一种艾沙康唑硫酸盐晶体及其制备方法
CN105367528A (zh) * 2015-11-10 2016-03-02 南通诺泰生物医药技术有限公司 一种三唑类药物中间体(d)-1-(1-环烷仲胺基)-2-(2-四氢吡喃基)氧-1-丙酮类化合物及合成方法
CN105777740B (zh) * 2016-02-24 2018-03-27 苏州金点生物科技有限公司 一种艾沙康唑的制备方法
EP3584245A4 (en) 2017-02-17 2020-08-26 Wuhan LL Science And Technology Development Co., Ltd. TRIAZOLE ANTIBACTERIAL DERIVATIVE, ASSOCIATED PHARMACEUTICAL COMPOSITION AND USE
CN108558846B (zh) * 2018-05-17 2020-07-07 天津莱茵泰克生物科技有限公司 艾莎康唑中间体的合成方法及其应用
CN110498774A (zh) * 2018-05-18 2019-11-26 上海医药工业研究院 一种艾沙康唑中间体的制备方法
WO2021245590A1 (en) * 2020-06-04 2021-12-09 Metrochem Api Private Limited An improved process for the preparation of triazole derivatives
CN115215850B (zh) * 2021-04-19 2024-08-16 同济大学 一种四氮唑醇类化合物、制备方法以及一种抗真菌药物
JP7454905B2 (ja) * 2021-09-28 2024-03-25 旭化成ファーマ株式会社 有効成分であるイサブコナゾール又はそのプロドラッグを含有する真菌症治療及び／又は予防剤
WO2025114603A1 (en) 2023-11-30 2025-06-05 Basilea Pharmaceutica International Ag, Allschwil Pharmaceutical combinations for use in the treatment of fungal infections

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4861879A (en) 1983-02-28 1989-08-29 Janssen Pharmaceutica N.V. [[4-[4-Phenyl-1-piperazinyl)phenoxymethyl]-1-3-dioxolan-2-yl]-methyl]-1H-imidazoles and 1H-1,2,4-triazoles
GB9107055D0 (en) * 1991-04-04 1991-05-22 Pfizer Ltd Triazole antifungal agents
NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
AU726495B2 (en) * 1996-09-09 2000-11-09 F. Hoffmann-La Roche Ag N-benzylazolium derivatives
NZ328607A (en) 1996-09-09 1999-08-30 Hoffmann La Roche Heterocyclically substituted n-benzyl-azolium derivatives and fungicidal compositions

Also Published As

Publication number Publication date
PE20000328A1 (es) 2000-05-08
US6300353B1 (en) 2001-10-09
WO1999045008A1 (en) 1999-09-10
MA27677A1 (fr) 2006-01-02
AU2931399A (en) 1999-09-20

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