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AR017588A1 - Compuestos de benzotiazol, inhibidores de la proteina tirosina quinasa, metodo para tratar desordenes asociados con dicha proteina, y las composicionesfarmaceuticas que contienen dichos compuestos - Google Patents

Compuestos de benzotiazol, inhibidores de la proteina tirosina quinasa, metodo para tratar desordenes asociados con dicha proteina, y las composicionesfarmaceuticas que contienen dichos compuestos

Info

Publication number
AR017588A1
AR017588A1 ARP980105676A ARP980105676A AR017588A1 AR 017588 A1 AR017588 A1 AR 017588A1 AR P980105676 A ARP980105676 A AR P980105676A AR P980105676 A ARP980105676 A AR P980105676A AR 017588 A1 AR017588 A1 AR 017588A1
Authority
AR
Argentina
Prior art keywords
compounds
protein
substituted
ptk
inhibitors
Prior art date
Application number
ARP980105676A
Other languages
English (en)
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR017588A1 publication Critical patent/AR017588A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se revelan nuevos benzotiazoles y sales de los mismos, las composiciones farmacéuticas que contienen tales compuestos y los métodos para usar talescompuestos en el tratamiento de desordenes asociados a la proteína quinasa, tal como desordenes inmunologicos. Los nuevos benzotiazoles, que son inhibidores dela tirosina quinasas tienen la formula (I). Las proteínas tirosina cinasas (PTK) son enzimas que, en conjunto con ATP como substrato, fosforilan los residuostirosina en péptidos y proteínas. Estas enzimas son elementos clave en la regulacion de senalizacion celular incluyendo proliferacion de células ydiferenciacion. La actividad aumentada de PTK se ha implicado en una variedad de enfermedades proliferativas de tumores malignos y no malignos. Además, las PTKjuegan un papel central en la regulacion de células del sistema inmune. Los inhibidores de PTK pueden impactar así una variedad amplia de desordenesoncologicos e inmunologicos. De la formula (I): p es 0, 1, 2 o 3; X1 y X2 son cada uno hidrogeno, o juntos forman =O o =S; R1 se selecciona independientementede: hidrogeno o R6, donde R6 es alquilo, alquenilo, alquinilo, cicloalquilo, cicloalquilalquilo, cicloalquenilo, cicloalquenilalquilo, arilo, aralquilo,heterociclo, o heterocicloalquilo, cada uno de los cuales está no sustituido o sustituido con Z1, Z2 y uno o más grupos Z3; -OH o -OR6; -SH o -SR6;-C(O)qH, C(O)qR6, o -O-C(O)qR6, donde q es 1 o 2; -SO3H o -S(O)qR6; halo; ciano; nitro; -Z4-NR7R6; -Z4-N(R9)-Z5-NR10R11; -Z4-N(R12)-Z5-R6; -P(O)(OR6)2;cualquiera de los dos grupos R1 podrían ser juntos alquileno o alquenileno completando un anillo saturado o insaturado de 3- o 8- miembros junto con los átomosde C a los que se une, cuyo anillo es no sustituido o sustituido con Z1, Z2 y Z3; o cualquiera de los dos grupos R1 podrían, junto con los carbonos con los quese unen, forman un grupo heterociclo, cuyo grupo es no sustituido o sustituido con Z1, Z2 y Z3; R2 y R3 son cada uno independientemente hidrogeno o R6; -Z4-R6;-Z13-NR7R8; R4 y R5 son cada uno independientemente hidrogeno o R6; o junto con el átomo de nitrogeno al que se unen completa un anillo saturado o insaturado
ARP980105676A 1997-11-10 1998-11-10 Compuestos de benzotiazol, inhibidores de la proteina tirosina quinasa, metodo para tratar desordenes asociados con dicha proteina, y las composicionesfarmaceuticas que contienen dichos compuestos AR017588A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6504297P 1997-11-10 1997-11-10

Publications (1)

Publication Number Publication Date
AR017588A1 true AR017588A1 (es) 2001-09-12

Family

ID=22059964

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980105676A AR017588A1 (es) 1997-11-10 1998-11-10 Compuestos de benzotiazol, inhibidores de la proteina tirosina quinasa, metodo para tratar desordenes asociados con dicha proteina, y las composicionesfarmaceuticas que contienen dichos compuestos

Country Status (25)

Country Link
US (1) US6825355B2 (es)
EP (1) EP1037632B1 (es)
JP (1) JP2001522800A (es)
KR (1) KR20010031912A (es)
CN (1) CN1290165A (es)
AR (1) AR017588A1 (es)
AT (1) ATE315394T1 (es)
AU (1) AU744281B2 (es)
BR (1) BR9814956A (es)
CA (1) CA2309319A1 (es)
DE (1) DE69833224T2 (es)
ES (1) ES2256969T3 (es)
HU (1) HUP0102101A3 (es)
ID (1) ID24289A (es)
IL (1) IL135176A0 (es)
NO (1) NO20002121L (es)
NZ (1) NZ503491A (es)
PE (1) PE129799A1 (es)
PL (1) PL340727A1 (es)
RU (1) RU2212407C2 (es)
TR (1) TR200001312T2 (es)
TW (1) TW510898B (es)
UY (1) UY25242A1 (es)
WO (1) WO1999024035A1 (es)
ZA (1) ZA9810219B (es)

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